HCV Induces the Expression of Rubicon and UVRAG to Temporally Regulate the Maturation of Autophagosomes and Viral Replication

Linya Wang; Yongjun Tian; Jing-hsiung James Ou

doi:10.1371/journal.ppat.1004764

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Open Access

Peer-reviewed

Research Article

HCV Induces the Expression of Rubicon and UVRAG to Temporally Regulate the Maturation of Autophagosomes and Viral Replication

Linya Wang,

Affiliation Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, California, United States of America
⨯
Yongjun Tian,

Affiliation Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, California, United States of America
⨯
Jing-hsiung James Ou

* E-mail: jamesou@hsc.usc.edu

Affiliation Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, California, United States of America
⨯

HCV Induces the Expression of Rubicon and UVRAG to Temporally Regulate the Maturation of Autophagosomes and Viral Replication

Linya Wang,
Yongjun Tian,
Jing-hsiung James Ou

Published: March 25, 2015
https://doi.org/10.1371/journal.ppat.1004764

About the Authors

Linya Wang

Affiliation Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, California, United States of America

Yongjun Tian

Affiliation Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, California, United States of America

Jing-hsiung James Ou

* E-mail: jamesou@hsc.usc.edu

Affiliation Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LW JHJO. Performed the experiments: LW YT. Analyzed the data: LW YT JHJO. Wrote the paper: LW JHJO.

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Small interfering RNA
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Transfection
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Viral replication
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Hepatitis C virus
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Autophagic cell death
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Lysosomes
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Plasmid construction
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Luciferase
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