About the Authors

Brian C. VanderVen

bcv8@cornell.edu

Affiliation Department of Microbiology and Immunology, Cornell University, Ithaca, New York, United States of America

Ruth J. Fahey

Affiliation Department of Microbiology and Immunology, Cornell University, Ithaca, New York, United States of America

Wonsik Lee

Affiliation Department of Microbiology and Immunology, Cornell University, Ithaca, New York, United States of America

Yancheng Liu

Affiliation Department of Microbiology and Immunology, Cornell University, Ithaca, New York, United States of America

Robert B. Abramovitch

Affiliation Department of Microbiology and Immunology, Cornell University, Ithaca, New York, United States of America

Christine Memmott

Affiliation Vertex Pharmaceuticals Incorporated, Boston, Massachusetts, United States of America

Adam M. Crowe

Affiliation Departments of Microbiology and Biochemistry, University of British Columbia, Vancouver, British Columbia, Canada

Lindsay D. Eltis

Affiliation Departments of Microbiology and Biochemistry, University of British Columbia, Vancouver, British Columbia, Canada

Emanuele Perola

Affiliation Vertex Pharmaceuticals Incorporated, Boston, Massachusetts, United States of America

David D. Deininger

Affiliation Vertex Pharmaceuticals Incorporated, Boston, Massachusetts, United States of America

Tiansheng Wang

Affiliation Vertex Pharmaceuticals Incorporated, Boston, Massachusetts, United States of America

Christopher P. Locher

Affiliation Vertex Pharmaceuticals Incorporated, Boston, Massachusetts, United States of America

David G. Russell

Affiliation Department of Microbiology and Immunology, Cornell University, Ithaca, New York, United States of America

Competing Interests

The authors CM EP DDD TW CPL are employees of Vertex Pharmaceuticals Incorporated. This does not alter our adherence to all PLOS policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BCV DGR. Performed the experiments: BCV RJF WL YL RBA AMC LDE. Analyzed the data: BCV RJF CM EP DDD TW CPL AMC LDE. Contributed reagents/materials/analysis tools: BCV CM EP DDD TW CPL AMC LDE. Wrote the paper: BCV DGR.