About the Authors

Richard Brad Jones

Affiliations The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Boston, Massachusetts, United States of America, Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts, United States of America

Rachel O'Connor

Affiliation The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Boston, Massachusetts, United States of America

Stefanie Mueller

Affiliations The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Boston, Massachusetts, United States of America, Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts, United States of America

Maria Foley

Affiliations Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts, United States of America, Department of Biological Engineering, MIT, Cambridge, Massachusetts, United States of America

Gregory L. Szeto

Affiliations Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts, United States of America, Department of Biological Engineering, MIT, Cambridge, Massachusetts, United States of America

Dan Karel

Affiliation The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Boston, Massachusetts, United States of America

Mathias Lichterfeld

Affiliation Massachusetts General Hospital, Boston, Massachusetts, United States of America

Colin Kovacs

Affiliations The Maple Leaf Medical Clinic, Toronto, Ontario, Canada, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

Mario A. Ostrowski

Affiliations The Maple Leaf Medical Clinic, Toronto, Ontario, Canada, Department of Medicine, University of Toronto, Toronto, Ontario, Canada, Li Ka Shing Medical Institute, St. Michael's Hospital, Toronto, Ontario, Canada

Alicja Trocha

Affiliation The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Boston, Massachusetts, United States of America

Darrell J. Irvine

Affiliations The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Boston, Massachusetts, United States of America, Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts, United States of America, Department of Biological Engineering, MIT, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

Bruce D. Walker

bwalker@partners.org

Affiliations The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Boston, Massachusetts, United States of America, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RBJ GLS MF ML DJI BDW. Performed the experiments: RBJ RO SM GLS DK ML AT. Analyzed the data: RBJ RO SM GLS. Contributed reagents/materials/analysis tools: ML. Wrote the paper: RBJ. Contributed patient samples: MAO CK. Supervised the project: DJI BDW.