Quantitative and Qualitative Deficits in Neonatal Lung-Migratory Dendritic Cells Impact the Generation of the CD8+ T Cell Response

Tracy J. Ruckwardt; Allison M. W. Malloy; Kaitlyn M. Morabito; Barney S. Graham

doi:10.1371/journal.ppat.1003934

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Open Access

Peer-reviewed

Research Article

Quantitative and Qualitative Deficits in Neonatal Lung-Migratory Dendritic Cells Impact the Generation of the CD8+ T Cell Response

Tracy J. Ruckwardt,

Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Allison M. W. Malloy,

Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Kaitlyn M. Morabito,

Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Barney S. Graham

* E-mail: bgraham@nih.gov

Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Quantitative and Qualitative Deficits in Neonatal Lung-Migratory Dendritic Cells Impact the Generation of the CD8+ T Cell Response

Tracy J. Ruckwardt,
Allison M. W. Malloy,
Kaitlyn M. Morabito,
Barney S. Graham

Published: February 13, 2014
https://doi.org/10.1371/journal.ppat.1003934

About the Authors

Tracy J. Ruckwardt

Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

Allison M. W. Malloy

Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

Kaitlyn M. Morabito

Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

Barney S. Graham

* E-mail: bgraham@nih.gov

Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TJR AMWM BSG. Performed the experiments: TJR AMWM KMM BSG. Analyzed the data: TJR AMWM BSG. Wrote the paper: TJR BSG.

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Cytotoxic T cells
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T cells
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Respiratory infections
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Dendritic cells
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Immune response
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Lymph nodes
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Mouse models
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Antigen-presenting cells
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