About the Authors

Jan Balzarini

jan.balzarini@rega.kuleuven.be

Affiliation Rega Institute for Medical Research, KU Leuven, Leuven, Belgium

Graciela Andrei

Affiliation Rega Institute for Medical Research, KU Leuven, Leuven, Belgium

Emanuela Balestra

Affiliation Department of Experimental Medicine and Biochemical Science, University of Roma Tor Vergata, Rome, Italy

Dana Huskens

Affiliation Rega Institute for Medical Research, KU Leuven, Leuven, Belgium

Christophe Vanpouille

Affiliation Program of Physical Biology, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America

Andrea Introini

Affiliation Program of Physical Biology, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America

Sonia Zicari

Affiliation Program of Physical Biology, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America

Sandra Liekens

Affiliation Rega Institute for Medical Research, KU Leuven, Leuven, Belgium

Robert Snoeck

Affiliation Rega Institute for Medical Research, KU Leuven, Leuven, Belgium

Antonín Holý

Professor Antonín Holý suddenly died on July 16, 2012. The co-authors would like to dedicate this paper to his memory.

Affiliation Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

Carlo-Federico Perno

Affiliation Department of Experimental Medicine and Biochemical Science, University of Roma Tor Vergata, Rome, Italy

Leonid Margolis

Affiliation Program of Physical Biology, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America

Dominique Schols

Affiliation Rega Institute for Medical Research, KU Leuven, Leuven, Belgium

Competing Interests

Jan Balzarini and Antonin Holý are co-inventors of the acyclic nucleoside phosphonates. This did not alter our adherence to all PLOS Pathogens policies on sharing data and materials. The other authors declare no competing financial interests.

Author Contributions

Conceived and designed the experiments: JB GA RS EB CFP DH SL DS CV AI SZ LM AH. Performed the experiments: JB GA EB DH SL CV AI SZ. Analyzed the data: JB GA CFP DS LM. Contributed reagents/materials/analysis tools: AH. Wrote the paper: JB GA DS LM.