About the Authors
- Yuichi Hirata
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Affiliation Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo, Japan
- Kazutaka Ikeda
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Affiliations Department of Metabolome, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan, Institute for Advanced Biosciences, Keio University, Kakuganji, Tsuruoka, Yamagata, Japan
- Masayuki Sudoh
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Affiliation Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan
- Yuko Tokunaga
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Affiliation Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo, Japan
- Akemi Suzuki
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Affiliation Institute of Glycoscience, Tokai University, Hiratsuka-shi, Kanagawa, Japan
- Leiyun Weng
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Affiliation Unit of Viral Genome Regulation, Institut Pasteur of Shanghai, Key Laboratory of Molecular Virology & Immunology, Chinese Academy of Sciences, Shanghai, China
- Masatoshi Ohta
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Affiliation Institute for Advanced Biosciences, Keio University, Kakuganji, Tsuruoka, Yamagata, Japan
- Yoshimi Tobita
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Affiliation Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo, Japan
- Ken Okano
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Affiliation Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
- Kazuhisa Ozeki
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Affiliation Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
- Kenichi Kawasaki
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Affiliation Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan
- Takuo Tsukuda
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Affiliation Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan
- Asao Katsume
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Affiliation Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan
- Yuko Aoki
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Affiliation Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan
- Takuya Umehara
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Affiliation Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo, Japan
- Satoshi Sekiguchi
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Affiliation Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo, Japan
- Tetsuya Toyoda
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Affiliation Unit of Viral Genome Regulation, Institut Pasteur of Shanghai, Key Laboratory of Molecular Virology & Immunology, Chinese Academy of Sciences, Shanghai, China
- Kunitada Shimotohno
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Affiliation Research Institute, Chiba Institute of Technology, Narashino, Chiba, Japan
- Tomoyoshi Soga
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Affiliation Institute for Advanced Biosciences, Keio University, Kakuganji, Tsuruoka, Yamagata, Japan
- Masahiro Nishijima
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Affiliations National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan, Showa Pharmaceutical University, Machidashi, Tokyo, Japan
- Ryo Taguchi
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Affiliations Department of Metabolome, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi, Japan
- Michinori Kohara
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* E-mail: kohara-mc@igakuken.or.jp
Affiliation Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo, Japan
Competing Interests
M. Sudoh, A. Katsume, K. Okano, K. Ozeki, K. Kawasaki, T. Tsukuda, and Y. Aoki are employees of Chugai Pharmaceutical Co. Ltd. This does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: M. Kohara. Wrote the paper: Y. Hirata. Y. Hirata performed the experiment of chimeric mice and HCV-infected cells. K. Ikeda, M. Ohta, T. Soga, and R. Taguchi performed lipid analysis by MS spectrometry. M. Sudoh, A. Katsume, and Y. Aoki evaluated the antiviral effects of NA808, K. Okano and K. Ozeki examined the tissue distribution of NA808. K. Kawasaki and T. Tsukuda synthesized derivatives from natural compounds. Y. Tokunaga, Y. Tobita, T. Umehara, and S. Sekiguchi performed some experiments on the chimeric mice. L. Weng and T. Toyoda conducted the experiments on the interaction between RdRp and SM. M. Kohara and Y. Hirata performed data analysis on the chimeric mice and cells. K. Ikeda, M. Ohta, T. Soga, and R. Taguchi performed data analysis on the result of MS spectrometry. A. Suzuki, K. Shimotohno, and M. Nishijima provided tools and expert information.