About the Authors

David Westaway

david.westaway@ualberta.ca (DW); gac@mri.montana.edu (GAC)

Affiliations Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada, Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

Sacha Genovesi

Contributed equally to this work with: Sacha Genovesi, Nathalie Daude, Rebecca Brown

Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

Nathalie Daude

Contributed equally to this work with: Sacha Genovesi, Nathalie Daude, Rebecca Brown

Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

Rebecca Brown

Contributed equally to this work with: Sacha Genovesi, Nathalie Daude, Rebecca Brown

Affiliation McLaughlin Research Institute, Great Falls, Montana, United States of America

Agnes Lau

Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

Inyoul Lee

Affiliation Institute for Systems Biology, University of Washington, Seattle, Washington, United States of America

Charles E. Mays

Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

Janaky Coomaraswamy

Affiliation Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany

Brenda Canine

Affiliation McLaughlin Research Institute, Great Falls, Montana, United States of America

Rose Pitstick

Affiliation McLaughlin Research Institute, Great Falls, Montana, United States of America

Allen Herbst

Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

Jing Yang

Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

Kerry W. S. Ko

Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

Gerold Schmitt-Ulms

Affiliations Centre for Research in Neurodegenerative Diseases, University of Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada

Stephen J. DeArmond

Affiliation Department of Pathology, University of California San Francisco, San Francisco, California, United States of America

Debbie McKenzie

Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

Leroy Hood

Affiliation Institute for Systems Biology, University of Washington, Seattle, Washington, United States of America

George A. Carlson

david.westaway@ualberta.ca (DW); gac@mri.montana.edu (GAC)

Affiliation McLaughlin Research Institute, Great Falls, Montana, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DW SG ND AL IL CEM JC AH KWSK GSU GAC. Performed the experiments: SG ND RB AL IL CEM JC BC RP AH JY KWSK. Analyzed the data: DW SG ND AL IL CEM GSU SJD DM LH GAC. Contributed reagents/materials/analysis tools: IL KWSK. Wrote the paper: DW ND AL KWSK DM GAC.