Glypican-1 Mediates Both Prion Protein Lipid Raft Association and Disease Isoform Formation

David R. Taylor; Isobel J. Whitehouse; Nigel M. Hooper

doi:10.1371/journal.ppat.1000666

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Open Access

Peer-reviewed

Research Article

Glypican-1 Mediates Both Prion Protein Lipid Raft Association and Disease Isoform Formation

David R. Taylor,

Affiliation Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, and Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, United Kingdom
⨯
Isobel J. Whitehouse,

Affiliation Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, and Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, United Kingdom
⨯
Nigel M. Hooper

* E-mail: n.m.hooper@leeds.ac.uk

Affiliation Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, and Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, United Kingdom
⨯

Glypican-1 Mediates Both Prion Protein Lipid Raft Association and Disease Isoform Formation

David R. Taylor,
Isobel J. Whitehouse,
Nigel M. Hooper

Published: November 20, 2009
https://doi.org/10.1371/journal.ppat.1000666

About the Authors

David R. Taylor

Affiliation Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, and Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, United Kingdom

Isobel J. Whitehouse

Nigel M. Hooper

* E-mail: n.m.hooper@leeds.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DRT NMH. Performed the experiments: DRT IJW. Analyzed the data: DRT IJW. Wrote the paper: DRT NMH.

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Small interfering RNA
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Heparin
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Lipids
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Endocytosis
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Immunoprecipitation
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Animal prion diseases
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Sulfates
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Co-immunoprecipitation
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