About the Authors

Nobuhiro Nakamoto

Affiliations Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, United States of America, Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Hyosun Cho

Affiliations Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, United States of America, Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Abraham Shaked

Affiliation Department of Surgery, Penn Liver Transplant Center, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Kim Olthoff

Affiliation Department of Surgery, Penn Liver Transplant Center, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Mary E. Valiga

Affiliations Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, United States of America, Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Mary Kaminski

Affiliation Department of Surgery, Penn Liver Transplant Center, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Emma Gostick

Affiliation Department of Medical Biochemistry and Immunology, Cardiff University School of Medicine, Cardiff, United Kingdom

David A. Price

Affiliation Department of Medical Biochemistry and Immunology, Cardiff University School of Medicine, Cardiff, United Kingdom

Gordon J. Freeman

Affiliation Department of Medical Oncology, Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

E. John Wherry

Affiliation Immunology Program, The Wistar Institute, Philadelphia, Pennsylvania, United States of America

Kyong-Mi Chang

kmchang@mail.med.upenn.edu

Affiliations Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, United States of America, Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Competing Interests

G.J.F. has a patent licensing arrangement for antibodies blocking the PD-1/PD-L pathways.

Author Contributions

Conceived and designed the experiments: NN KMC. Performed the experiments: NN HC. Analyzed the data: NN HC GJF KMC. Contributed reagents/materials/analysis tools: HC AS KO MEV MK EG DAP GJF EJW KMC. Wrote the paper: NN DAP GJF EJW KMC.