Extreme Sequence Divergence but Conserved Ligand-Binding Specificity in Streptococcus pyogenes M Protein

Jenny Persson; Bernard Beall; Sara Linse; Gunnar Lindahl

doi:10.1371/journal.ppat.0020047

Loading metrics

Open Access

Peer-reviewed

Research Article

Extreme Sequence Divergence but Conserved Ligand-Binding Specificity in Streptococcus pyogenes M Protein

Jenny Persson,

Affiliation Division of Medical Microbiology, Department of Laboratory Medicine, Lund University, Lund, Sweden
⨯
Bernard Beall,

Affiliation Centers for Disease Control and Prevention, Respiratory Diseases Branch, Atlanta, Georgia, United States of America
⨯
Sara Linse,

Affiliation Department of Biophysical Chemistry, Chemical Center, Lund University, Lund, Sweden
⨯
Gunnar Lindahl

*To whom correspondence should be addressed. E-mail: gunnar.lindahl@med.lu.se

Affiliation Division of Medical Microbiology, Department of Laboratory Medicine, Lund University, Lund, Sweden
⨯

Extreme Sequence Divergence but Conserved Ligand-Binding Specificity in Streptococcus pyogenes M Protein

Jenny Persson,
Bernard Beall,
Sara Linse,
Gunnar Lindahl

Published: May 26, 2006
https://doi.org/10.1371/journal.ppat.0020047

About the Authors

Jenny Persson

Affiliation Division of Medical Microbiology, Department of Laboratory Medicine, Lund University, Lund, Sweden

Bernard Beall

Affiliation Centers for Disease Control and Prevention, Respiratory Diseases Branch, Atlanta, Georgia, United States of America

Sara Linse

Affiliation Department of Biophysical Chemistry, Chemical Center, Lund University, Lund, Sweden

Gunnar Lindahl

*To whom correspondence should be addressed. E-mail: gunnar.lindahl@med.lu.se

Affiliation Division of Medical Microbiology, Department of Laboratory Medicine, Lund University, Lund, Sweden

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JP and GL conceived and designed the experiments. JP performed the experiments with help from SL. BB supplied essential material. JP, SL, and GL analyzed the data. JP and GL wrote the paper.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Streptococcus pyogenes
Is the Subject Area "Streptococcus pyogenes" applicable to this article?

Thanks for your feedback.
Protein expression
Is the Subject Area "Protein expression" applicable to this article?

Thanks for your feedback.
Binding analysis
Is the Subject Area "Binding analysis" applicable to this article?

Thanks for your feedback.
Antigenic variation
Is the Subject Area "Antigenic variation" applicable to this article?

Thanks for your feedback.
Streptococcus
Is the Subject Area "Streptococcus" applicable to this article?

Thanks for your feedback.
Bacterial pathogens
Is the Subject Area "Bacterial pathogens" applicable to this article?

Thanks for your feedback.
Sequence alignment
Is the Subject Area "Sequence alignment" applicable to this article?

Thanks for your feedback.
Antigens
Is the Subject Area "Antigens" applicable to this article?

Thanks for your feedback.