About the Authors

Margaret A. Scull

mscull@rockefeller.edu (MAS); ricec@rockefeller.edu (CMR)

Affiliation Center for the Study of Hepatitis C, The Rockefeller University, New York, New York, United States of America

William M. Schneider

Affiliation Center for the Study of Hepatitis C, The Rockefeller University, New York, New York, United States of America

Brenna R. Flatley

Contributed equally to this work with: Brenna R. Flatley, Robert Hayden

Affiliation Center for the Study of Hepatitis C, The Rockefeller University, New York, New York, United States of America

Robert Hayden

Contributed equally to this work with: Brenna R. Flatley, Robert Hayden

Affiliation Center for the Study of Hepatitis C, The Rockefeller University, New York, New York, United States of America

Canny Fung

Affiliation Center for the Study of Hepatitis C, The Rockefeller University, New York, New York, United States of America

Christopher T. Jones

Current Address: Novartis Institutes of BioMedical Research, Emeryville, California, United States of America

Affiliation Center for the Study of Hepatitis C, The Rockefeller University, New York, New York, United States of America

Marieke van de Belt

Affiliation Center for the Study of Hepatitis C, The Rockefeller University, New York, New York, United States of America

François Penin

Affiliation Bases Moléculaires et Structurales des Systèmes Infectieux, IBCP, Labex Ecofect, Université Lyon 1, France; CNRS, UMR 5086, Lyon, France

Charles M. Rice

mscull@rockefeller.edu (MAS); ricec@rockefeller.edu (CMR)

Affiliation Center for the Study of Hepatitis C, The Rockefeller University, New York, New York, United States of America

Competing Interests

The authors declare the following conflicts of interest, which are managed under the Rockefeller University’s policy: CMR has equity in Apath, LLC, which holds commercial licenses for the Huh-7.5 cell line and HCV cell culture system. This does not alter our adherence to all PLOS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MAS CTJ FP CMR. Performed the experiments: MAS WMS BRF RH CF FP. Analyzed the data: MAS FP. Contributed reagents/materials/analysis tools: CTJ MvdB WMS. Wrote the paper: MAS FP.