https://orcid.org/0000-0002-8052-2751
Figures
Abstract
Background & importance
This patient and public-involved systematic review originally focused on arachnoiditis, a supposedly rare “iatrogenic chronic meningitis” causing permanent neurologic damage and intractable pain. We sought to prove disease existence, causation, symptoms, and inform future directions. After 63 terms for the same pathology were found, the study was renamed Diseases of the Leptomeninges (DLMs). We present results that nullify traditional clinical thinking about DLMs, answer study questions, and create a unified path forward.
Methods
The prospective PRISMA protocol is published at Arcsology.org. We used four platforms, 10 sources, extraction software, and critical review with ≥2 researchers at each phase. All human sources to 12/6/2020 were eligible for qualitative synthesis utilizing R. Weekly updates since cutoff strengthen conclusions.
Results
Included were 887/14286 sources containing 12721 DLMs patients. Pathology involves the subarachnoid space (SAS) and pia. DLMs occurred in all countries as a contributor to the top 10 causes of disability-adjusted life years lost, with communicable diseases (CDs) predominating. In the USA, the ratio of CDs to iatrogenic causes is 2.4:1, contradicting arachnoiditis literature. Spinal fusion surgery comprised 54.7% of the iatrogenic category, with rhBMP-2 resulting in 2.4x more DLMs than no use (p<0.0001). Spinal injections and neuraxial anesthesia procedures cause 1.1%, and 0.2% permanent DLMs, respectively. Syringomyelia, hydrocephalus, and arachnoid cysts are complications caused by blocked CSF flow. CNS neuron death occurs due to insufficient arterial supply from compromised vasculature and nerves traversing the SAS. Contrast MRI is currently the diagnostic test of choice. Lack of radiologist recognition is problematic.
Discussion & conclusion
DLMs are common. The LM clinically functions as an organ with critical CNS-sustaining roles involving the SAS-pia structure, enclosed cells, lymphatics, and biologic pathways. Cases involve all specialties. Causes are numerous, symptoms predictable, and outcomes dependent on time to treatment and extent of residual SAS damage. An international disease classification and possible treatment trials are proposed.
Citation: Palackdkharry CS, Wottrich S, Dienes E, Bydon M, Steinmetz MP, Traynelis VC (2022) The leptomeninges as a critical organ for normal CNS development and function: First patient and public involved systematic review of arachnoiditis (chronic meningitis). PLoS ONE 17(9): e0274634. https://doi.org/10.1371/journal.pone.0274634
Editor: Panagiotis Kerezoudis, Mayo Clinic, UNITED STATES
Received: February 2, 2022; Accepted: August 31, 2022; Published: September 30, 2022
Copyright: © 2022 Palackdkharry et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: Table 5 contains all included baseline data and associated references. The complete table, with all data and references, is available from our public Arcsology site (https://arcsology.org/the-complete-sr-dataset).
Funding: No researchers were compensated. Software and ongoing reference repository fees were provided by contributions to Arcsology,® a 501c3 organization. Open access publication fees provided by the A. Watson Armour and Sarah Armour Presidential Endowed Chair of Vincent C. Traynelis MD.The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: Dr. Palackdharry: none Stephanie Wottrich: none. Dr. Dienes: none. Dr. Bydon: none Dr. Steinmetz: Elsevier: royalties; Globus: consultant; Medtronic: honorarium; Zimmer Biomet: royalties. Dr. Traynelis: Medtronic: consultant, royalties; NuVasive: consultant This does not alter our adherence to PLOS ONE policies on sharing data and materials.
Introduction
Objectives
This is a unique global patient and public involved (PPI) study. The topic was contentious when we started in 2018. Lawsuits had been filed and settled. Certain procedures or devices even made a Consumer Reports issue [1]. The PPI—multi-institution neurosurgery team objective was to perform an exhaustive prospective PRISMA systematic review (PSR) to address a presumed iatrogenic disease called arachnoiditis causing permanent disability and intractable neuropathic pain (NPP) after procedures for common events such as childbirth or back pain. Chronic meningitis (CM), the original but non-specific name, has the same International Classification of Diseases (ICD) 10 code, thus was included. After 63 disease names for the same inflammatory or fibrotic subarachnoid space (SAS) and pia pathologies was reached, a major protocol modification changed the study name and objective to Diseases of the Leptomeninges (DLMs), doubling search returns.
Rationale
The PPI group was composed of >20 medical, scientific, and biostatistical doctorates, as well as nurses and other clinicians trained in systematic review methodology, representing >15K Facebook (FB) members with arachnoiditis as either patients themselves or family. No quality published reviews on arachnoiditis existed and only three reputable internet sources were available from USA search engines in 2018: the National Organization for Rare Diseases [2]; the National Institute of Neurologic Disorders and Stroke [3]; and the Genetic and Rare Diseases Information Center [4]. All described a rare, iatrogenic disease of the arachnoid membrane with no known treatment, resulting in progressive intractable NPP and neurologic loss.
Five pre-planned steps made the seminal conclusions from this PSR possible: (1) using internet search engines to find additional terms for arachnoiditis and chronic meningitis prior to creating structured searches; (2) hand searching and capturing alternative terminology; (3) understanding biases and limitations of published literature and incorporating additional resources; (4) concurrently capturing animal and molecular studies in a separate database to inform future directions; and (5) the study team experiencing, causing, or witnessing the same unusual set of symptoms reported by 15K FB patients with arachnoiditis documented in source after source for 200 years. Fig 1 shows the PRISMA diagram.
Diagram includes searches of databases, registers and other sources, and pre-clinical studies for leptomeningeal pathology review.
DLMs go by yet another name in the spinal intervention space, explaining the difficulty finding information about this “iatrogenic disease.” In 1978 neurosurgeon Charles Burton MD, founder of the North American Spine Society, recommended the term “radiculitis” to differentiate acute arachnoiditis from “adhesive arachnoiditis” as the cause of new neurologic symptoms immediately postoperative or post-myelogram [5]. Burton demonstrated the surgical appearance of each entity with operative photographs (Fig 2). This term still predominates in the spine surgery and procedure spaces.
(5) Each section contains an operative picture of his proposed 3 phases, followed by his illustration and description. The first section shows nerve inflammation of the cauda equina, which he termed “radiculitis” to differentiate this stage from “adhesive arachnoiditis” shown in the second panel. Burton proposed adhesive arachnoiditis as a middle phase with clearly visible nerve root clumping and early nerve atrophy. The final phase, often termed “empty thecal sac” appearance on MRI is characterized by nerve roots permanently adhered to the dura and covered with fibrotic tissue.
Quantifying iatrogenic harm is known to be veiled in most publications. Author—commercial ties may impact willingness to report negative outcomes from sponsored researchers [6]. Adverse events (AE) from drug and medical devices are not accurately reflected in the medical literature due to lawsuits settled with confidentiality orders [7,8]. AE reported to both public and hidden government databases are not indexed. Thus, we also included case reports, government sources, legal literature, websites, investigative reporting, and other prospectively defined grey literature.
Although arachnoiditis is also called chronic meningitis, a 2021 expert review of chronic meningitis does not mention arachnoiditis, stating “general statements about prognosis are difficult to make” [9]. However World Health Organization (WHO) data demonstrate frequent permanent disabilities from arachnoiditis, many resulting from communicable diseases (CDs), accounting for ≥2 of the top 10 causes of disability-adjusted life years lost (DALY) in most countries [10]. Furthermore, specific neurotrophic infection-related causes of permanent neurologic damage generally are referred to by a causative organism name. Two of many examples are TBM (tuberculosis meningitis) and neuroborreliosis (NB) for Lyme disease neurologic manifestations, with neurologic damage from both classified as arachnoiditis.
Little has changed since study inception. Weekly data updates since the cutoff date further strengthen results. The newest WHO data show in South Africa, sequelae of DLMs from HIV, TBM, interpersonal violence, and road accidents are all in the top 10 causes of DALY. In the USA, injury from violence and “legal intervention” is number six and sequelae from meningitis is number 10.
We synthesized > 60 different LM disease names into a spectrum of organ damage, thereby presenting a cohesive picture of the clinical impact of DLMs throughout life. These results nullify previous clinical teaching about the LM and for the first time, clinically verify laboratory neuroscience advances.
Methods
Patient-public involvement
PPI permeated this study. The 17-member e-Delphi group included nine patients and caregivers: eight doctors (six physicians, one molecular geneticist, 1 biostatistician), and a computer engineer. The nine PPI e-Delphi members were engaged in every aspect of the study and two are authors. Five FB group leaders surveyed their collective 15K members and prospectively collated specific patient questions and symptoms to research (Table 1).
Eligibility criteria and information sources
Table 2 summarizes eligibility requirements, search modifications, databases used, included grey literature, and lists all disease terms with proven leptomeningeal (LM) pathology. Full text sources, including “Unpaywall” are shown [11]. Qualitative synthesis utilized data from database inception through the 12/6/2020 all-database search. Weekly updates of PubMed searches are current through 7/6/2022, with new reports further confirming synthesized data. Inability to obtain free full text resulted in exclusion. No full text was retrievable in 73/1913 (3.8%) articles; 70 were case reports published prior to 1980 and the remaining three dated before 1948.
Search strategies
The entire PSR protocol, including structured searches, returns, and modifications, is published at Arcsology.org [12]. Prospero did not register this complicated methodology in 2018. Alternative terminologies for DLMs were captured in a software text field during screening and hand searching.
After finding 34 disease names not picked up by search#1, despite pathology demonstrating involvement of the subarachnoid space (SAS) and pia, search#2 was added and protocol modification in April 2019 changed the study name to DLMs. Members of the PPI group performed Google and Google Scholar searches.
Source selection
The PSR Flow 2020 diagram is shown in Fig 1. Sources were evaluated by ≥2 independent clinicians at every phase of the PSR using the inclusion, exclusion, and quality criteria shown in Tables 2 and 3. A standardized process for disagreement resolution was used. Each patient was knowingly included only once, thus multiple publications on the same patient population were not eligible.
These questions were used in our quality and bias tool.
Given the presumption of iatrogenic causes of arachnoiditis in 2018, the dramatic increases in rhBMP-2 (recombinant human bone morphogenetic protein 2), and widely questioned data integrity and AE in initial studies, we closely examined rhBMP-2 as a possible contributing source. One of the two manufacturer-commissioned YODA (Yale Open Data Access) systematic reviews attempting to address safety was included [13,14]. All rhBMP-2 studies not included were eligible, as was a Food and Drug Administration (FDA)) AE report released to the Star Tribune in 2016 through the Freedom of Information Act which adds AE to spinal fusion surgery results, challenging rhBMP-2 safety [15].
The database reportedly contains 1039 postoperative complications in 3647 patients undergoing cervical, thoracic, or lumbosacral spinal fusions with rhBMP-2 from 26 study sites but is not pristine due to “batching” of later AE. The AE were extracted in duplicate per protocol. All authors reviewed the data, with substantial neurosurgeon debate on abbreviated terminology used in portions of the file. There was unanimous e-Delphi agreement to include 632/1039 AE patients with documented new postoperative motor or sensory deficits, most also with new NPP consistent with radiculitis. Unanimous agreement was not reached on an additional 236/1039 AE patients with only new neurologic pain due to vague documentation in latter parts of the file, thus these patients were not included as neurologic AE.
Although this is a deviation from protocol which allowed inclusion if ≥75% e-Delphi approval, due to the impact of this body of data on results, we required a unanimous vote for inclusion. We used protocol-dictated critical review parameters for all other iatrogenic causes of DLMs such as myelogram dye, intrathecal and intraventricular chemotherapy, neuraxial anesthesia, and spinal injections. Only studies and data passing critical review were included, as discussed below.
Data collection
Zotero is the reference repository [16]. Human studies were imported into Covidence 1.0 software for full text review and extraction [17]. Due to software limitations, studies were sorted into major and subcategories prior to extraction. Standardized data forms were created for each category through an intensely iterative process. Covidence manually configured and exported this rich body of data.
Apart from Covidence’s workarounds, all authors and the Chief Data Integrity Officer had continual database oversight and attest to the integrity of the data.
Data items
Table 4 lists collected data elements and timeframes. The attempt to assess individual social determinants of health (SDOH) proved futile as they were rarely presented. We collected and used the Organization for Economic Co-operation and Development (OECD) status as a surrogate to divide countries into more (OECD members) and less-economically developed (non-member of OECD, N-OECD) [18]. We collected specialty-specific data, also shown in Table 4. Oncology was the only area standard study data required replacement with different metrics.
Standard data elements were captured for all sources if present. Specialized baseline characteristics were charted on in the listed population, in addition to standardized elements.
Synthesis methods and effect measures
A qualitative synthesis was performed on data from all 887 studies, shown in Table 5. Given heterogeneity of results dependent on cause, treatment, or imaging diagnosis, data were first grouped by categories and subcategories, with weighted means and totals calculated. Data cleaning and table calculations were conducted using R (R Core Team, 2019). Occurrence or reoccurrence of DLMs and baseline characteristics are included in this dataset.
This table contains all data charted for the study and used for synthesis, with references. Data are sorted into major category, then subcategory. (NOTE: The reference numbers are specific to this table and do not correspond to article reference numbers). The year span of papers within a subcategory is included to help the reader understand that changes in therapy over time may have occurred and as a gauge as to when LM damage from diseases were first identified.
Difference in weighted means was used as the effect measure for categorized data. Fig 3 shows distribution of articles and patients per article per year. P values were used to calculate the impact of removal of biased or incorrect data sources. Removal of studies generating a statistically significant impact on results (p≤0.05) were independently scrutinized by all authors, requiring unanimous agreement.
In both regions the number of papers published has increased over time indicating that research in the area is intensifying. The scatter plot displays the number of subjects diagnosed with DLMs per paper over time. The increase in variation over time exhibits the change from mostly case reports to larger scale observational studies and randomized controlled trials.
Bias determination and maintaining study integrity
This is the consolidated PRISMA 2020 bias section. Every source of data underwent study bias assessment, extraction, and data check by ≥2 independent reviewers using systematic review software designed to blind researchers to each other’s responses until the final “disagreement resolution” phase. Disagreements at any part of the PSR were settled by modified Delphi processes and author vote.
Bias and critical appraisal for study inclusion.
Table 3 contains the questions and results for bias, performed on each study. As part of critical appraisal, we verified study data calculation and coding. For studies with data mistakes or questionable results, investigators were contacted. Of eight questionable sources, none were included. Six authors did not reply. General biases such as short follow-up and incomplete neurologic status reporting were seen in nearly all studies and did not result in exclusion.
Two heavily utilized treatments among patients in FB groups were excluded after websites were reviewed and physicians contacted. The first involved 2018 versions of frequently changed cocktails of “neuro-steroids and neurohormones” called “Tennant Protocols” [893]. While we obtained a list of older animal studies no objective results in human patients were provided for analysis. The second involves commercial use of neural stem cells (NSC) with reported dramatic resolution of arachnoiditis symptoms in patients. No response was received to request for data [894].
Five studies excluded due to quality or bias deserve mention as they might be included in attempts to repeat this PSR without doing critical review. Each study had a statistically significant impact on results, four with p<0.0001 and one with a p = 0.01. Every author independently appraised each article. Three large spinal fusion ± rhBMP-2 studies with thousands of patients each were excluded from analysis—one with unexplained data errors after author discussion [895], one missing arachnoiditis codes [896], and one considered financially biased with unexplained doubled AE in the control group [897]. Two other studies were excluded due to serious methodology errors [898,899].
Risk of bias in included studies.
As shown in Table 5, studies ranged from 1828–2021 (due to e-publication ahead of print), without time-period breakdown. During this span of 200 years, multiple advances were made across all areas of medicine. A study limited to the past 20 years would better represent real world data today.
Bias from lack of reporting in studies.
No assumptions were made. Missing information was recorded as absent. Mean follow-up < 12 months was common in surgery patients and <1 month for pain injections and neuraxial anesthesia (NAA). This was particularly problematic in studies using surgical lysis of adhesions as attempted treatment for LM fibrosis(LMF). Both positive and negative neurologic findings at “reported study points” were rarely complete. Two large anesthesiology studies were dependent on voluntary reporting and returned surveys, with bias likely. Sexual dysfunction was regularly reported for males but never for females.
Bias in our results due to handling of missing data.
Many spinal surgery studies were funded by manufacturers of a study component, leading to disincentives to report negative outcomes. When results were missing, we counted them as zero, absent, not improved, or not performed. No assumptions that unreported data were normal were made. Few studies addressed patient sense of quality of life (QOL) with their disabilities or permanent sequelae, or whether pain was adequately palliated.
Methodology certainty assessment
We have high certainty in the body of evidence due to: (1) the experience of the author team; (2) rigorous adherence to ≥2-person methodology; (3) access to macroscopic, microscopic, and molecular pathology; (4) an abstract review team composed of multiple nurse-patients trained in systematic review in addition to the modified e-Delphi team; (5) a modified e-Delphi team composed of three academic neurosurgeons, a practicing neurologist, a PhD-level molecular geneticist/patient, a PhD-level biostatistician/caregiver, multiple methodologists, and six additional physician/patients.
Results and discussion
Studies included
Baseline characteristics of each included source as well as references are in Table 5. The PRISMA diagram (Fig 1) shows 14774 studies screened, with 6% (887) included. Case reports accounted for 41.9% (372/887) of sources, 0.3% (372/133261) of total patients, and 2.9% (372/12721) of DLM patients. Most reports (59.9%) involved causation, not including cranial and cranial nerve cases, accounting for 66.9% (8506/12721) DLMs patients. Non-database sources in Fig 1 contain of 127 hand-retrieved studies, and gray sources. Fig 3 shows trends in individual studies. In both N-EOCD and EOCD, number of papers and patients per paper have increased yearly, reflecting more and larger studies with time.
Key aspects of meningeal formation and anatomy
The brain and spinal cord arise from neural tube ectoderm. The meninges are of mesenchymal origin. The dura has no tight junctions between cells and is not the CSF-blood/body barrier. Chemicals, inflammatory chemokines, biologics, and many small substances easily pass through the dura [900,901]. The arachnoid and pia maters together make up the leptomenix (singular) or leptomeninges (LM) when plural. Fig 4A shows the location of the arachnoid barrier layer (arachnoid membrane) in the cauda equina [902]. The nerve roots within the cauda equina cistern are covered only by pia, therefore enhancement of the covering of swollen nerve roots on MRI represents acute pial inflammation (or leptomeningitis) but not arachnoiditis.
(A) shows a human autopsy specimen at the level of the cauda equina, demonstrating the arachnoid closely following the dura. The nerve roots are wrapped in the pia membrane.† (B) is a cross-section of a mouse spinal cord with surrounding meninges, demonstrating how many critical structures traverse the SAS.† (C) is a SEM of an arachnoid trabecula {b*} traversing from arachnoid barrier layer {a} to pia {c} showing the porous nature of the trabecula.† (D) The glymphatic schematic and BBB demonstrating the critical role of unimpaired CSF flow into the CNS from and back to the SAS.§ Pictures: † Courtesy of C. Cohen PhD, Curator of The Brain Museum, University of Buffalo NY, used with written permission. § Micrograph and illustration ©F. Fornai MD (31) used with written permission.
The inner arachnoid layer is composed of different arachnoid fibroblastic-type cells which form the arachnoid trabeculae to pia structures that create the SAS, the open framework through which the pial perineuronal vascular plexus, nerves, and CSF pass (Fig 4B and 4C at the spinal cord level). The SAS contains macrophages and the NSC niches. NSC migrate throughout life into the adjacent CNS to replace injured neurons removed by autophagy [903]. Destruction of the LM with loss of local NSC means the anterior and posterior horns of the spinal cord and brainstem, as well as the neurons near the surface of the brain die from spinal cord injury (SCI), without replacement. The pia encases blood vessels and nerves until just before the nerves exit the foramen, where the arachnoid and pia join [901,904]. Fig 4C is a scanning electron micrograph of the SAS of a rat brain showing the differences between the arachnoid barrier layer (a), arachnoid trabecula (*) and pia mater (c) [905].
Substances in or around the dura or paraspinal area can diffuse into the spinal blood vessels prior to entry into the LM. They enter the SAS via receptors or diffusion as shown in Fig 4D. Alternatively, substances can be directly injected into the SAS or into the ventricles where they will eventually be distributed into the SAS. The illustration in Fig 4D shows the role of the glymphatics, CSF, and vasculature [906,907]. The glymphatics are part of the NVU and contribute to nutrient provision and waste removal critical to sustaining CNS neuron life [906]. All figures are used with written permission from original creators.
A question important to the DLMs patient communities has been, “are spinal DLMs considered a SCI?” Patients report the medical community shows more compassion towards patients diagnosed with a SCI. No patient wants to have to explain arachnoiditis or be coded as having “chronic pain,” after which care is tainted with the underlying question of drug seeking behavior. There is clinical, autopsy, and pathology proof areas of the brain and spinal cord with inadequate collateral blood supply die when blood vessels and nerves traversing the SAS are destroyed, as detailed in recent neuroscience reviews [900,906–909]. Patients with DLMs and upper neuron localization have resultant SCI. However, CSN diseases can occur in the absence of DLMs.
The term “arachnoiditis” missed 43% of dlms patients
Table 2 shows 42/63 (66.7%) terms for DLMs did not containing the term arachnoiditis. As shown in Table 5, “arachnoiditis” alone or combined with another term yielded 7153 patients, while the full search for DLMs returned 12721 patients. Thus 43.4% (5518/12721) of DLMs patients would have been missed without our rigorous strategy. Only 62/5588 (1.1%) cases not using arachnoiditis were diagnosed exclusively as chronic meningitis. A landmark paper from 1943 had 11 different terms for LMDs presented and stated “arachnoiditis” was incorrect terminology, had “Arachnoiditis (Diffuse Proliferative Leptomeningitis)” as the title [19].
Table 6B (column 5) shows iatrogenic DLMs from spinal fusion surgery are called radiculitis 99.1% of the time, as are 71.5% of spinal injection DLMs, and 55.1% of spinal non-fusion surgery DLMs. Non-procedural causes with well-ingrained names and significant incidences include: subarachnoid hemorrhage (SAH), TBM, NB (from various forms of Lyme), neurocysticercosis (NCC), neurobrucellosis, neurosarcoidosis, “neurologic syndromes” from arthropod-transmitted diseases (arboviruses such as Chikungunya and Zika) [272], chemical meningitis, carcinomatous meningitis, and less common terms.
Part A shows numbers of papers, total patients, and numbers from N-OECD and OECD. Part B shows papers, sources, those who had diagnoses of DLMs (without the term “arachnoiditis”), and % of total population in the specific subcategory who had diagnoses of DLMs (inclusive of arachnoiditis). Of 887 sources, 2 had undeclared location of patients, removed from economic columns for clarity.
Regardless of names, autopsy [19–22] and innumerable microscopic reports contained in the PSR are clear and consistent. The areas involved are the SAS + pia components of the LM, not the outer arachnoid layer or membrane. In humans, clinical symptoms of acute inflammation may lead to symptoms of LMF if the inflammatory to fibrotic cascades are not stopped.
DLMs and associated symptoms are not rare
Using 2020 USA and global population numbers, and disease incidence (prior to SARS-CoV2), we calculate >3.7M global and >311.8K cases in the USA annually. The annual incidence of DLMs for the limited etiologies in Table 7, globally and in the USA, are 94x and 190x the “rare disease” designation of 0.5:100K, respectively. Global numbers are artificially low as unavailable data is counted as zero.
Δ Data is based on minimum incidences of DLMs noted in the PSR* or published X 2020 population numbers. The incidence of DLMs is far greater than the “rare disease” threshold of 1:200K or 39,500 annually in the US.
Results indicate three “basic areas” of similar symptomatology. Table 8 contains the most common symptoms described in the 12721 patients. Dozens of case reports document the diagnosis of DLMs up to a decades after the presumed inciting event.
Symptoms were remarkable similar across the 3 areas presented (spine, base of brain, brain). Spine and CN DLMs produce the same types of symptoms but localized to the area involved during early phases. If available, response to CDs therapy is included.
In brain meningitis, the high incidence of upper and lower extremity radiculitis might be related to occult spinal disease, but this is an interesting finding indicting the need to fully image the neuroaxis in worsening patients. Cerebral and base of brain leptomeningitis involves the spine in 80% of patients, particularly in TB and HIV+ patients [185]. In the majority of cases, MRI of the spine is not performed, despite neurological symptoms relating to the spine. Even in cured bacterial leptomeningitis 20–80% will have permanent neurologic or cognitive difficulties [920,924].
DLMs are common, have many causes as shown in Tables 5 and 8, and every physician should learn to recognize the symptoms then perform a thorough history to determine whether MRI and lumbar puncture (LP) are needed to rule out curable causes in the chronic setting. The use of next generation sequencing (NGS), where available, can make a diagnosis in the face of negative cultures, serology, and pathology [28,667].
Non-iatrogenic causes of DLMs
Communicable diseases.
The most common cause of DLMs in the PSR was CDs, tabulated in the final column of Table 6B, accounting for 50.4% of patients in the “causes” category. This result surprised us, as we assumed iatrogenic causes would predominate, as stated on all reputable USA websites in 2018. WHO and CDC yearly incidence reports were used for Table 7, demonstrating in 2021, CDs make up almost roughly 53% of global and 60% of USA cases of chronic DLMs. The global data is skewed by missing cases of iatrogenic causes in non-US OECDs. The rapidly rising incidence of tick-borne diseases contributes to both columns. The full range of CDs identified are in Table 5, with infectious causes spanning from 1828–2021. Many diseases included are now routinely cured or controlled in OECDs. Studies demonstrated in >70% of acute leptomeningitis, the spine was also involved, although it is rarely imaged. The USA Center for Disease Control (CDC) reports even in fully cured acute meningococcal meningitis, long term disability occurs in 20% of patients [924].
Not included in the study data but worth mentioning is the virus SARS-CoV-2 is neurotrophic with neurologic symptoms as a common manifestation and LM involvement documented [925–927]. One review demonstrates the virus infects tissue via the ACE2 receptor, also expressed on vascular endothelial cells that allows infected lymphocytes to enter the SAS. The virus is reported to move up nerves, crossing synapses, and entering the CNS via a “Trojan Horse” mechanism [928]. Neuroimaging, brain autopsy, and LPs demonstrate spinal cord and LM involvement are consistent with neurologic residuals in recovered patients [929–931].
Subarachnoid hemorrhage.
Of 32 sources on SAH synthesized, the death rate was 13.6–25%. Rate of LMF was 75.3% (122/162) of survivors. Most patients who survived developed LMF symptoms 1–10 months post SAH and stabilized or improved over time. The PSR incidence of SAH was only 1.4% of all causes. However, using current data, Table 7 shows incidence rates for SAH, with 30K and >624K cases per year in the USA and globally, respectively [919], making SAH from ruptured aneurysm the second most common of DLMs globally. In the USA, SAH is third, after spinal fusion surgery.
Free blood in the SAS initiates a complex reaction of neuroinflammation, collagen deposition, and arachnoid fibrosis. Multiple factors are involved, beyond the scope of this review [932]. The CSF has low-to-absent plasminogen and high levels of plasminogen activator inhibitors leading to inefficient fibrinolysis of blood clots [933]. The end result is LMF, with significant disability and NPP.
Trauma from road accidents causing spinal cord injury (SCI).
The PSR returned 12 sources with 88 patients affirming most traumatic SCIs also involve LM injury. Time span was 1945–2016. We speculate the 50% incidence is low due to unavailability of MRI for much of the time frame. Disruption of spinal cord blood flow that enters through SAS vasculature is responsible for further demise after initial injury [934]. Table 7 shows globally, trauma from road injury is third most common cause of irreversible DLMs and resultant spinal cord ischemia globally. The rate is especially high in areas where transportation safety requirements are substandard due to poor restraints and road conditions. Data from hundreds of sources demonstrate improvement in spinal cord function from NSC. We reviewed the actual pictures in these sources. Spinal cord architecture and function improved in many NSC trials, but none demonstrate regeneration of the LM, which are critical to attain or maintain normal function after SCI.
Treatment or prophylaxis for LM cancer.
Review of oncology intra-CNS therapy data revealed the need to align neurological toxicity with consistent descriptions of DLMs symptoms. In the past, “arachnoiditis” has been separated from nerve changes, which is now known to be contrary to the disease process. Per Table 5, oncology data was further divided into primary CNS cancers, metastatic solid tumors, and leukemia or lymphoma trials. This division was an attempt to assess long term neurologic consequences in patients getting attempted curative therapy, generally childhood hematologic malignancy patients.
The 54 trials had 8798 patients, with leukemia constituting 93.3% (8208/8798), spanning 1973–2019. The toxicity grading system is different than any other field and changes every few years. Determining the incidence of acute DLMs is impossible from past publications and would require chart or EMR review using updated neurologic toxicity definitions.
In hematologic malignancies intrathecal (IT) therapy is often used prophylactically to prevent CNS relapse in children with curable malignancies. There were 104 instances (1.3.%) of long-term neurologic deficits after CNS prophylactic therapy, but oncology-specific neurologic criteria were used. Standardized criteria could yield different results. Route of administration may be an issue for further research. The same dose is given intraventricularly via Ommaya reservoirs as is used IT via LP, despite differences in CSF volume of distribution and cellular make-up of the 2 compartments. We consulted with two renowned hematologic malignancy experts, Richard Larson MD (email July 23, 2021) and Dieter Hoelzer MD PhD (email April 6, 2021) with both concurring little is known about the clinical impact of differences in routes of administration for therapeutic or prophylactic IT treatment. There is still work to be done in this area.
Neurotoxicity of cancer immunomodulators.
Rare but potentially life-threatening toxicities associated with immune-modulating drugs used in cancer treatment occur, including neurotoxicity. The 3 studies of neurotoxicity from checkpoint inhibition and/or ipilimumab, demonstrated 89% (17/19) of the neurologic symptoms were due to DLMs. Considering the widespread use of these drugs, this is an important issue. For immune-related AE, oncology guidelines are available to assist with when to stop treatment as well as when to use steroids, infliximab, or other anti-interleukin therapies [935].
Iatrogenic causes or associations
Early myelogram dye indisputably caused diffuse LMF.
Results from the myelogram dye studies in Table 5 represent a fraction of the global suffering that resulted from diffuse LMF caused by SAS injection of non-resorbable oil-based and early water-based myelogram dye. Law suits were settled with government health authorities in multiple countries, with details on incidence not in medical literature [936]. Multiple myelogram agents caused diffuse, permanent “adhesive arachnoiditis” or “arachnoiditis ossificans” in addition to iophendylate (Pantopaque in the USA, Myodil in other countries), including Dimer-X, Kontrast U, Conray 60, Thorotrast, and others.
There were 37 studies with 5212 patients using different dyes. In total, 22.5% (1174/5212) cases of severe, progressive LMF were reported. In the USA, iophendylate was FDA approved under the 510K device law. Iophendylate myelogram dye was not withdrawn from the US market until 1987, years after initial publications on DLMs. We found no reported cases of DLMs with the current myelogram dye, iohexol.
DLMs from spinal fusion surgery.
There were 515/1395 DLM cases in 30 reports (36.9%) of corrective non-fusion spine surgery, with multiple procedures per patient. Most had baseline congenital, traumatic, neoplastic, or previous scoliosis correction surgery with extensive hardware revisions, as well as high numbers of pre-surgery LMF. No articles discussed the impact of symptoms of DLMs on quality of life. The high incidence of DLMs in patients with multiple spine surgeries and revisions has significant implications for diagnosis and treatment. Recurrent symptoms may not be surgically correctable but related to LMF. As MRI techniques and radiologist recognition improve, such patients found to have DLMs are ideal candidates for clinical trials.
Elective spinal fusion surgery using rhBMP-2 (recombinant human bone morphogenetic protein-2) has been controversial. Tables 7B and 8 show of included studies, the weighted means of occurrence of DLMs is 6.0% in the 1427 patients without rhBMP-2 and 14.6% in the 7897 patients receiving rhBMP-2 (p<0.0001). In most cases of lumbar surgery, the rhBMP-2 was used off-label. There are other FDA approved biologics on the market which may not have sufficient clinical safety and efficacy data to know whether their use may be associated with DLM. Ongoing studies utilizing lower doses of rhBMP-2 may determine if adverse events are dose-dependent.
Neuraxial anesthesia.
We identified 39 sources with 186 patients who developed severe neurologic complications and LMF after NAA “misadventure.” Blood patches used for dural leaks accidentally injected into the SAS can also cause LMF [937]. The incidence of LMF from post-obstetrical NAA was 0.2% (182/73303). The two largest trials were dependent upon voluntary physician reporting of AE. Speculation of cause ranged from skin cleaning solutions to anesthetic concentration. Incidence of complications appears related to the level of individual experience and volume of procedures done, with high volumes associated with better results. References for Table 7 also indicate DLMs are higher for patients with obesity, more comorbidities, procedures performed in teaching or rural hospitals, and in non-obstetrical vascular surgery.
Interestingly, 2/3 of patients developing LMF post NAA complained about neurologic symptoms at the time of needle placement [393]. A recent anesthesia review states pre-existing neuropathy places patients at higher risk for immediate complications and permanent new neurologic deficits post NAA [938]. We recommend not performing blind NAA in patients with DLMs. In a patient with advanced lumbosacral DLMs, blood vessels and nerves may not be mobile, thus are unable to move out of the way of the needle.
Spinal pain injections.
The PSR incidence of DLM after epidural steroid and transforaminal injections is 1.1% (123/10879) in 10 sources, although long term follow up is inadequate. Reports range from transient paralysis and acute DLM to permanent cauda equina syndrome. A 2021 systematic review of transforaminal injections, not included in our data, discusses but does not quantify resultant LMF [939]. In 2016 major insurers required a trial of ESI prior to approving lumbar spine surgery. This is no longer the case as of January 2022 for several companies.
FBSS and additional surgical procedures in those with DLMs.
There were 3 studies with 99 patients addressing whether FBSS represents DLMs. DLMs occurred in 30% (30/99). However, 70% had surgically correctable lesions. These patients should be evaluated at centers with radiologists, spine surgeons, and patient advocates expert in dealing with DLMs if a surgically correctable cause is also suspected. We found no evidence that adjacent-level operative procedures or LP in non-DLM involved areas worsens existing disease.
N-EOCD vs OECD incidences
Table 6A divides results by number of sources, patients, and economic distribution. Using N-OECD:OECD ratio, sources discussing causation of DLMs where overwhelmingly from OECD countries with a ratio of 1:7.1. Total data sources in the PSR also favored publication from OECD at 1:3 (Table 5). Many Injuries, deaths, and diseases in N-OECD often are unreported in English-translatable literature searches. This leads to disparities and inaccuracies. In this PSR, N-OECD data predominated results for NCC, neurobrucellosis, TBM, and other worms and parasites. All of these are curable diseases with chemotherapy and adequate water sanitation.
In Table 7 we estimate real-world contemporary incidences using current incidence rates with CDC and WHO published disease and total population information. When available, we used the most current incidence data, as cited, otherwise we used the incidence data calculated from our study, shown with an * for identification. Minimum incidence of DLMs, in the limited diseases included, demonstrate rates of >0.10% (95:100K) and >0.05 (47:100K) in the USA and globally, respectively. The global numbers are falsely low as we used zero (0) when unable to find global (including non-USA OECD) data. Epidurals for childbirth are routine in other OECD, but almost never used in N-OECD due to lack of trained anesthesiologists. A similar situation exists for epidural and transforaminal pain injections.
Other disparities impacting high N-OECD rates of DALY due to DLMs include previously discussed right rates of SCI from automobile accidents, lack of HAART for HIV+ individuals, high rates of death from acute infectious meningitis due to lack of basic antibiotics, and now high rates of Covid deaths due to lack of availability of vaccines. Chronic DLMs with permanent sequelae are far from rare both in the US and globally, with an incidence of roughly 200 and 100x the rare disease standard of 0.5:100K. Additional analysis of PSR data by economic status will be presented separately.
Diagnostic studies for DLMs
Pre-MRI imaging studies.
For the PSR, all imaging studies were included. There were 71 studies containing 3255 patients spanning from 1928–2020. The earliest study reported was the use of iodized oils to image “lesions of the spinal cord” from the research and translational lab producing them in Stockholm [350]. The earliest article on imaging and suggested treatment of arachnoiditis via air injection was published in 1942 [658]. The procedure was used to treat arachnoid cystic lesions blocking CSF flow (1/6 cases responded and 3/3 attempted laminectomies had no response). Studies published in the 1960’s-70 reported oil and early water-based dyes, all causing high incidences of diffuse LMF. The first CT of the lumbar spine was in 1976 [631], but it was the first MRI in 1985 that significantly changed CNS and spinal cord imaging [940]. CT demonstrates osseous structures of the spine better than MRI and is still used.
MRI with contrast.
MRI techniques continue to advance, and ≥1.5T MRI with contrast is the current test of choice for DLMs. Recent small studies confirm the frequently quoted 1990 Delamarter arachnoiditis staging is outdated [643]. Instead arachnoid cysts, nerve root clumping, enhancement or displacement are more reliable [644,941].
A 2021 study looks at interrater reliability (IRR) in classifying 1.5 and 3T MRIs in 96 patients with known DLMs between three neuroradiologists and two musculoskeletal radiologists. IRR was very poor for staging or synechiae, however in the “most experienced” readers, was strong for synechiae [942]. One study suggesting MRI in prone position is helpful to detect clumping and adhesion since normal cauda equina nerves tend to follow gravity when free-floating [943]. A newer technology, constructive interference in steady-state (CISS) and fast imaging employing steady-state acquisition with phase cycling (FIESTa–c) has excellent visualization of CSF flow and DLMs, but a high learning curve to interpret correctly [944]. When the cause of radicular pain is in question, we recommend high quality MRI with contrast in the prone position when looking for DLMs. Currently MRI is indispensable for diagnosis of DLMs but is only as good as the experience ability of the reader.
Not included in the PSR but presented for completeness is an systematic review of MRI LM enhancement (LME) of the brain in multiple sclerosis and other neuroinflammatory diseases e-published prior to print January 2022 [945]. DLMs were not specifically included. A large differential of inflammatory diseases of the LM did have MRI LME consistent with clinical symptoms. Normal controls showed 6/163 (3.7%) LME. The occurrence of LME in “normal controls” has been used by a by two physicians claiming arachnoiditis or DLMs are not a real entity [686,946]. Our results and conclusions remain unimpacted. MRI can detect DLMs in the inflammatory stage when there is a possibility of preventing progression to LMF. Radiologists should be provided with as much history as possible to encourage attention to the area of interest.
Performing a diagnostic LP when DLMs is known or suspected.
We found multiple studies where no known precipitating factor was present (prior brain or spine procedure, trauma, meningitis, IT chemotherapy or craniospinal axis radiation). Since actionable results can be obtained from CSF sampling in patients without prior procedures, we recommend LP if peripheral exam and work up does not yield a diagnosis. In two patients with chronic fever and symptoms of chronic leptomeningitis, but multiple negative LPs, diagnosis was made by LP with next generation sequencing (NGS) in both, which is increasingly available and useful [28,667]. Blind endoscopic leptomeningeal biopsy was found to be ineffective pre-MRI, as shown by multiple studies (Table 5). A 2017 N-OECD report of open MRI-guided LM biopsy yielded TBM (NGS was not available).
The PSR demonstrated multiple etiologies can cause LMF. When acute infection is not a concern, after thorough exam and studies looking for a systemic cause of neurologic disease, we recommend a contrast MRI of the lumbosacral spine (as well as brain if symptomatic or immunocompromised). The reason for the spine MRI is to determine if there is LMF and to what extent. If the MRI demonstrates “peripheralization” or “empty sac” of the cauda equina nerve roots, consider cisternal CSF sampling. With LMF and empty sac, pia-enclosed vascular bundles, and nerves of the cauda equina are adherent to the dural sac, so they cannot move out of the way of a needle as would normally occur. Putting a needle through this area could result in catastrophic worsening of disease. Preparation should be made ahead of time to obtain all samples needed, including cultures, gram stain, cytology, immune studies, pathology, and NGS if needed. No reports of successful ultrasound guided in LMF without vascular trauma were found. The PSR yielded 3 reports of arachnoiditis caused by traumatic LP [390–392].
Suspected acute CD leptomeningitis in a patient with known LMF.
This PSR specifically excluded acute leptomeningitis. Acute infectious leptomeningitis is a medical emergency, however LP in a patient with known lumbar LMF can lead to catastrophic complications, as in the above section. The spinal cord ends in most people at T12-L1. If the location of the LMF is shown to be localized to L4/5 or lower, there is a chance of cauda equina mobility at the L2 or L3 interspace. If previous diagnostic MRI is not available for review, we recommend cisternal puncture for CSF sampling if the patient does not have an implanted CSF reservoir (Ommaya).
Disease course and prognosis
This PSR yielded 2718 patients with permanent spinal DLMs from large studies (myelogram dye, spine fusion surgery, neuraxial anesthesia, and spinal injections). Many case reports and smaller case series increase this number to >3000. Infectious causes added another >4000 cases. Adding in base of the brain, of the nearly 8600 cases, the striking similarity of area per area symptoms of spinal DLMs allows us to report common features and adverse events.
Acute DLMs can be fatal.
Acute CD leptomeningitis, brain or brainstem SAH, acute hydrocephalus from CSF flow blockage, head or high cervical spinal trauma can all be fatal. Fatalities from acute CD leptomeningitis are far higher in N-OECD than OECD. A “Defeat by 2030” WHO goal is elimination of vaccine-preventable leptomeningitis deaths as shown in Table 7. We purposefully excluded acute CD-related leptomeningitis from this PSR due to lack of follow-up in the current system of inpatient-only hospitalists.
The only study on “lifespan” was excluded for major methodology flaws. There is no evidence non-progressive LMF per se reduces survival, but epidemiology studies show patients with mobility limitations have a higher risk for SDOH that contribute to earlier death, such as obesity, Type 2 diabetes, and cardiac deconditioning [947]. Non-opioid medications used for NPP may be associated with weight gain. Walking distances can be difficult because of neurogenic claudication. Other exercises should be substituted. Depression is common after developing a serious chronic illness. Teaching coping skills and using multidisciplinary support teams is important, particularly for intractable NPP patients.
Most patients do not have a continually progressive course.
We found 6 patients in 3 reports documenting progression, with 2/6 occurring after NAA, and 4/6 years after neonatal meningitis. Both NAA patients also had oil-based myelograms as part of their post-NAA injury work-up. Two of 4 of the post meningitis cases occurred after attempted NAA made them dramatically worse [767–769]. In all 6, progression occurred after a second SAS insult.
In the chronic setting, everything progressive or toxic can be fatal, as can suicide due to lack of palliation for those with intractable chronic NPP. Outside of these situations, we found no evidence chronic DLMs continually progress in the absence of continual pathologic stimulation. However, CNS neuron death due to many causes can occur. With no repair mechanism, those cells will die and cause symptom progression.
For iatrogenic cases, the PSR spinal surgery data generated 49 studies with >10K patients, with all articles claiming the majority who developed a new acute post-operative leptomeningitis (current term radiculitis) resolved by 3–6 months (Table 5). Given the biphasic nature of some cases of LMF, no statements about overall progression to permanent DLMs can be made. Adequate follow up for these studies is lacking.
The population-based NB study in Denmark yielded 431 documented cases of DLM, 16 also with encephalitis. Only 14 (3.2%) had no treatment response. When treatment ended, 101 (28.1%) had residual symptoms, with 52 (51.5) being radicular pain. There was a significant incidence difference between those who delayed treatment >30 days (28.2% in delayed vs 4.9% p<0.001), suggesting there is a period during which acute leptomeningitis can be prevented from becoming permanent LMF. Steroids were not used in the study [127]. Long term data from cured childhood brain tumor studies indicate early neurologic deficits are irreversible.
Outcomes and complications
Stopping fibrotic transformation, blockage of CSF flow, and subsequent consequences should be a high priority target for future research. Without development of new treatments, those who develop LMF are unlikely to resolve, and clinical course will depend on amount of CSF flow blockage. Table 8 lists typical characteristics brain, brainstem and CN, and spine involvement. Disability from CDs, SAH, trauma, and iatrogenic causes appear in ≥ 2 of the top 10 disabilities in every country we examined in the WHO list of DALY [10,948].
Paradoxical reaction to TBM treatment.
There were 8 studies with 163 patients describing a paradoxical reaction to TBM treatment. This important manifestation was first recognized in AIDS patients not on HAART presenting with TBM. Reconstitution of the immune response increases or causes new symptoms due to inflammatory LM reactions, despite concurrent TBM treatment. The most concerning consequences are the possibility of vision loss, severe hydrocephalus, and acute spinal cord compression. HIV treatment for the untreated HIV+ patient is not started until weeks after TB treatment is initiated. It also occurs in HIV negative malnourished children and adults, a common occurrence in N-OECD. Managed appropriately, it does not adversely impact outcome [186]. Recently, the impending vision loss from a paradoxical reaction in a 7-year-old has been successfully managed with infliximab [187,188].
Flares.
All patients who join the dedicated FB groups learn about “flares,” a common manifestation of DLMs and one of the greatest causes of distress to patients. The PSR yielded no specific article on flares, although several detailed early case reports described the typical painful manifestations post-provocation occurring days later. During a flare, symptoms get worse for days to weeks, then return to baseline. Patients report flares to be triggered by overactivity, prolonged sitting, atmospheric pressure changes and airplane travel.
Flares also cause anxiety and fear about progression. One 2022 arachnoiditis review, not included in the PSR, discusses “flare-ups.” [949] Every member of the PPI has flares, requiring escalation of treatment for a short time, at times with no known provocations as noted above. They are a frequent cause for ER visits for parenteral steroids and repeat MRIs. No data on best approaches were identified.
Fasciculations and muscle spasms occur in LMF.
Fasciculations and uncontrolled muscle spasms occur in patients with spinal involvement [950–953]. Daily episodes involving radicular units respond well to diazepam and stretching. Additional recommendations from the American Association of Neurological Surgeons include (1) removable casting or bracing, though many patients find this cumbersome; (2) muscle relaxants such as baclofen, cyclobenzaprine, methocarbamol, or tizanidine; (3) botulinum toxin injections; (4) IT baclofen or selective dorsal rhizotomy for recalcitrant spasticity [954]. Many patients have worsening episodes at night, finding foot flexor to knee braces uncomfortable. Mayo Clinic spinal injury rehabilitation unit recommends placing pillows between the footboard and feet to keep feet flexed during sleep, as well as staying well hydrated (author consultation).
Sexual activity is impacted by severe DLMS, stressing relationships.
This was a measure we attempted to capture since relationship support is foundational to dealing with severe chronic disease. Several reports in Table 5 discussed decreased sexual performance or impotence in men upon diagnosis. No source reported female sexual function. There are other contributing factors, such as depression, which is common in patients with serious and complex illnesses. Drugs used to treat either NPP or depression have known side effects on sexual function.
DLM patients have painful muscle spasms that occur with certain positions commonly used during sexual activity. The PSR revealed a single case report of a 60 y/o man who developed repeated episodes of painful priapism requiring surgical decompression of the penis followed by myelogram demonstrating a complete block at L3-4 and laminectomy demonstrating central LMF of the cauda equina, with nerves stuck together. Post operatively he did well with normal sexual function [719].
After SCI, unless the sacral nerves are involved, physiologically >50% can achieve male ejaculation or female orgasm [955]. Sacral nerve injury S2 and below drastically decreases chances of orgasm in both males and females to 0–17%. Autonomic dysreflexia can occur with injuries above T7 [956–958]. Bowel and bladder sphincter disturbances pose additional challenges. Resources can assist practitioners with communication of techniques and sex toys if uncomfortable with this topic [955].
SAS cysts and webs, hydrocephalus and syringomyelia are proven sequala of DLMs.
There were 146 papers with 59.4% (1325/2229) patients developing serious permanent complications of LMF with CSF block. Eight articles demonstrated arachnoid cysts and webs in 30/169 (17.8%) patients, all also having syrinxes. Arachnoid webs appear to be remnants of arachnoid cysts. Hydrocephalus is commonly reported with both acute and chronic DLMs with 58/877 (6.6%) sources reporting feasibility and outcomes of various types of shunts for hydrocephalus as the primary intervention. Of 11 with LMF in the title, 136/206 (66%) had extensive pathology sampling demonstrating abolished SAS architecture causing CSF block.
The PSR yielded 77 sources with 1029/1679 (66.6%) patients developing syringomyelia due to LMF with CSF block. Patients with symptomatic syringomyelia underwent neurosurgical management, with most recurring within the first 10 years, depending on degree of lysis of arachnoid adhesions performed.
SAS cysts and webs that disrupt flow, when fenestrated, can provide temporary relief from some symptoms for many years [959]. If new neurologic changes occur after the first years of stable LMF, patients should be evaluated for progression to arachnoid cysts, syringomyelia, or hydrocephalus.
Is chronic cauda equina syndrome (CES) from DLMs ± flare considered a surgical emergency?
There are still multiple patient and physician resources that state all CES is a surgical emergency. Acute or sub-acute compressive CES is a surgical emergency. With the recognition of DLMs, much literature will have to be revised appropriately [960–963]. Chronic CES from iatrogenic LMF is very distressing to patients, particularly those moving in and out of bowel and bladder sphincter control with disease fluctuation, but is not a surgical emergency [963,964] unless there is colonic atonia and the patient is in danger of ruptured bowel, or a similar life threatening condition—in which case the condition is the emergency, not the cauda equina.
Compressive abscesses caused by CDs are a surgical emergency. However, in non-compressive CES caused by acute CD leptomeningitis, therapy consists appropriate anti-infective therapy, ± evidence-based immunomodulators (i.e., etanercept, infliximab, thalidomide) if available or on a clinical trial, ± dexamethasone.
A similar approach would be appropriate for most primary or metastatic cancer to the leptomeninges causing CES. A few malignancies causing compressive CES are extremely cancer-therapy sensitive, thus surgery may not be immediately necessary (e.g., lymphoma, testicular cancer, small cell lung cancer), depending on institutional practices. Most solid tumors causing compression will require surgery. Cancers causing CES or other nerve dysfunction confined to the SAS can be treated with intra-CSF chemotherapy or cranial-spinal radiation therapy.
When caused by LMF, we found no published randomized studies demonstrating open decompressive surgery or steroids are superior to supportive care. Results of recent use of intra-SAS neuroendoscopic lysis of adhesions are awaited. Educational emergency “self-help plans,” appropriate supplies (self-catheter for urine, gloves for manual stool removal), training on how to use them, and a steroid pack if they respond to steroids helps patients manage at home [961,963,965].
Treatment
Lack of successful treatment for acute, iatrogenic non-CD leptomeningitis.
There were 3233 cases of iatrogenic acute leptomeningitis in 108 reports, occurring hours to days after intervention. Some were large clinical trials or population studies. Yet no trials report successful interventions to stop permanent LMF once acute symptoms have started. Although patient groups believe steroids started within days of initial symptoms prevent permanent LMF, this is not supported by peer-reviewed evidence. Spinal fusion surgeons strongly discourage use of steroids and even non-steroidal anti-inflammatory drugs post fusion due to proven risk of decreased fusion. Fusion outcomes are sometimes even used for quality reporting. Further discourse within spinal intervention specialties is needed.
Promising biologic or immune therapies in TBM and NCC trials.
A 2019 study shows progress is being made in LMF caused by NCC in immigrants to the USA with apparent longstanding infections. Although 41% required permanent shunt for symptomatic hydrocephalus, improvement of other neurologic deficits was seen when immunosuppressants (methotrexate, steroids, etanercept) were added to extended term cysticidal therapy, with 14/33 (42.4%) having no post-treatment sequelae at 4.2 years. The remaining 57.6% had residual neurologic symptoms with 8/33 (24.2%) disabled, 8/33 (24.2%) episodic symptoms, focal neurologic deficits and seizures, and 5/33 (15.2) with mild intellectual impairment [141]. Although the study number is small, the complete recovery rate in this study is substantially higher than large population studies in the PSR.
Also included are the first reports of the effectiveness of thalidomide use in children with base of brain TBM, presenting with blindness or loss of visual acuity, CN and focal nerve deficits, and other brain and spine complications of TBM. Without surgery, “satisfactory clinical results” with radiologic improvement of DLMs was observed in 4/4 patients in the first report and 37/38 in the expanded cohort [966].
Methotrexate is used as a glucocorticoid-sparing agent to diminish the long-term AE associated with prolonged steroid administration. Etanercept is a tumor-necrosis factor inhibitor which decreases proinflammatory cytokines and is most often used in autoimmune diseases. Thalidomide is an antiangiogenic drug currently used in multiple myeloma and transplant related graft vs host disease, classified as an immunomodulatory drug with a black box warning for fetal teratogenicity.
Base of brain and CN deficits.
There were 83 sources containing 815 patients with cranial nerve symptoms caused by DLMs, accounting for 6.4% (815/12721) of patients in the PSR. Studies spanned from 1924–2019. Patients without a CD diagnosis or who failed therapy for TBM, or other organisms received surgery. Most base of brain reports (34.4%) involved visual changes due to optochiasmatic arachnoiditis (OCA). Unexpectedly, 21.4% (60/280) cases were iatrogenic due to (now obsolete) muslin wrapping of aneurysms in the past. Due to the wide range of dates, changes in surgical and medical management, and development of MRI, a subset cohort of the most recent 20 years is planned.
Open and endoscopic lysis of adhesions.
There were 45 articles containing 1258 patients dated from 1924–2019 treated with open, microsurgical, and endoscopic lysis of adhesions, of which 972 (77.3%) were identified as having LMF. Most studies reported early improvement ± new symptoms. Neurologic reporting was incomplete in all studies and all time points. Multiple surgical approaches were taken. Patients who survived had differing post-operative rehabilitation. Relapse or death from complications of disability was high. Meaningful outcome or quality of life differences was not clear.
Thirteen included contemporary articles on endoscopic lysis of adhesions (6 cranial, 7 spinal) demonstrate increasing ability to navigate the SAS, fenestrate adhesions, and perforate arachnoid cysts since 1991. A recent publication on 10 patients with extensive cervical and thoracic adhesions treated with a multimodality approach concludes the approach is feasible, particularly in early disease prior to spinal cord damage [967]. Follow-up is short. None of the 3 neurosurgery authors would perform open surgical lysis of adhesions based on current data. Future developments in minimally invasive lysis of adhesions are promising.
Spinal cord stimulation (SCS).
Table 6 shows references for 10 articles on SCS, ranging from 1976–2016. Of the 175 total patients with SCS implanted, 72% (n = 126) of had documented LMF or arachnoiditis. Pre-implantation use of opioids, number of repeat procedures, and complications were not consistently reported. However, when reported, a small number of patients counted for the majority of the re-implantations in the studies. Follow up time ranged from 6 months to 10 years. Studies excluded patients thought to be psychologically inappropriate or demonstrating drug-habituation.
The overall response rate was 64.3% (81/126 DLM patients) of this carefully chosen group, with demonstration of reduction of pain and >7 patients with prior disability able to return to work at some level. In DLMs patients receiving SCS, 15.1% (n = 19) achieved complete resolution of pain, including several patients who had resolution of neurologic changes and ultimately returned to work. Another 49.2% (62 patients, >9 of whom were on pre-implantation opioids) achieved a significant partial response (pain decreased 50–99%). There was no change in 23.8% (30 patients, >2 on opioids), and worsening of symptoms in 10.3% (13 patients, >1 on opioids). There were >52 re-implantations, with 10.3% (13/126) patients accounting for all revisions. Additional complications included 11 device infections, 1 iatrogenic paraplegia, and 5 unrelated deaths.
Some vocal patients within the FB community vehemently oppose SCS, stating further instrumentation of the LM will worsen the disease process. This PSR showed worsening of pain or new neurologic deficits in only 13.3%. The included articles discuss “adequate psychiatric screening” and the role of concurrent opioid use in SCS outcome. “Appropriate” use of concurrent opioids was not correlated to lack of response in this PSR, though patients determined to demonstrate addictive behavior or psychologic “problems” (psychologic difficulties, drug habituation, issues of secondary gain) were excluded.
The patient-reported practice of mandatory weaning off opioids prior to implantation of an SCS in some surgical practices is a contentious topic in patient communities. This PSR was not designed to address this practice, however as with several prescription drugs (hypertensives, psychiatric drugs, steroids), slow tapering is required for endogenous systems to acclimate to withdrawal of exogenous drugs without rebound symptoms, some of which can be life threatening. Intractable neuropathic pain can be unbearable without adequate treatment. There is no evidence to support weaning psychologically fit patients off needed opioids for SCS to be successful. We recommend evidence-based or evidence-generating approaches to pain management prior to SCS. SCS technology has advanced significantly in the past several years and is an important component of managing intractable pain and some neurologic deficits from DLMs in appropriately chosen patients.
Rehabilitation.
After critical review and removal of poor studies, the remaining three studies had four patients using neuro-mobilization in LMF or LM ossificans. Two patients with LMF had measurable decreases in pain. Two patients with LM ossification were wheelchair bound, but after surgery and intensive rehabilitation were wheelchair free for at least the 4 years [724,852,853].
Neural flossing, as recommended by Mayo Clinic Spine Rehabilitation (author consultation), is not found in structured databases, but there are multiple online resources. We use and teach evidence-based mind-body techniques. The hypothesis is slowly mobilizing nerves and tissues also break fibrotic strands. This approach is best accomplished in the setting of a multi-disciplinary mind-body team. The American College of Physicians has published systematic review evidence indicating yoga, tai chi, meditation, acupuncture, and massage increased activity and decreased chronic pain [968]. We recommend patients try any or all of these, pick what works and exercise regularly with slow progression. Swimming is also great exercise. Patients may flare at first, but they should continue slowly through the flare.
Neuropathic pain (NPP).
The 2017 review above evaluated nonpharmacologic therapies for low back pain, was not specific to patients with LMF. However, the PPI team uses and endorses them for improving activity and decreasing disease distress.
There are several evidence-based guidelines for pharmacologic treatment of NPP, not included in this PSR. As discussed above, 64.3% (81/126) DLM patients has a response to SCS, with 15.1% CR, many stopping opioids and even returning to work. For patients not controlled on high doses of opioids or looking for symptom improvement, SCS is an important adjunct with newer modalities hopefully enhancing response.
Cordotomy and rhizotomy are generally used as a last resort for intractable pain. There were 7 articles with 33% (69/209) DLM patients. For areas below the cervical nerves, rhizotomy failure rate is high, up to 73% in patients. Cordectomy was used in those with intolerable and intractable LE pain and loss of function wishing to preserve UE function and improved quality of life. Of the 15 performed, 1 patient had continued pain and 3 worsening LE spasm. Most responders demonstrated improvement of LE motor and sensory function.
IT treatments of DLMs symptoms.
Both IT urokinase and hyaluronidase have been used to treat existing LMF. Urokinase was used in preterm infants with intraventricular hemorrhage to prevent hydrocephalus, showing those receiving low dose urokinase required fewer shunts [841]. Three studies showed IT hyaluronidase benefitted OCA, spinal LMF, and non-infective LMF [189,576,842]. Many early articles attempted IT treatment of TBM and chronic fungal infections with traditional systemic antifungal drugs (amphotericin B}, universally causing worsened LMF.
Successful CSF exchange after IT methotrexate overdoses and toxic leptomeningitis.
Two boys received IT methotrexate overdoses of 240 mg instead of 12 mg on the same day due to pharmacy error. Both developed severe acute leptomeningitis with seizures and mental status changes. Glucarpidase was not on site. Untreated, death or diffuse LMF with progressive leukoencephalopathy was predicted [291]. CSF exchange was performed 5 hours after overdose by removing fixed amounts of CSF via LP catheter, then replacing it with warmed normal saline. Treatment was successful in one boy but was incomplete in the other. Glucarpidase was administered IT 11 hours later. Only short-term memory loss in the child with incomplete exchange is reported at three years follow-up. Authors state if patients have an implanted ventricular Ommaya, the procedure can be performed as a ventriculolumbar perfusion for CSF drainage.
The report reviewed 8 previous publications with 13 patients receiving successful CSF exchanges, though none were identified by our searches, highlighting neurologic terminology inconsistencies which has obscured knowledge of this apparent life-saving procedure in toxic IT injections. It also highlights limitations of using only structured database searches to reach conclusions.
We include this report as there have been accidental IT overdoses of other drugs for which there is no antidote resulting in death or permanent severe disability. Knowing CSF exchange can be safely performed may provide a glimmer of hope to an otherwise dire situation.
Other interesting therapies for possible clinical trials.
The PSR returned one report on “cerebrolysin” (not available in the USA) widely used in a few countries [850]. According to the article “cerebrolysin is a peptide solution containing free amino acids biologically active peptides” including fibroblast growth factor, brain-derived neurotrophic factor, glial-derived neurotrophic factor, TGF beta, and insulin-like growth factor 1. Of the 3/6 patients who could have had DLMs (2 viral meningoencephalitis; 1 traumatic avulsion RUE), all 3 had “remarkable recovery with acceptable residuals.” Further study is needed.
Metformin animal studies and reviews were not eligible for inclusion in the PSR. However, one member of the PPI was placed on metformin during data extraction for the PSR. Within 72 hours, they experienced a severe flare of the exact NPP, sensory and motor loss experienced in areas that had regained function and been quiescent for years. We immediately performed a literature search. Instead of finding metformin caused neuroinflammation, the search returned 4 animal articles indicating metformin reduces brain damage due to ischemia, decreases NPP, has anti-neuroinflammation properties, and promotes NSC activation [969–972]. The very anxious PPI member agreed to a one month trial. Within 3–4 weeks the flare stopped. Their neurologist documented improvement in sensory dysesthesia and reflexes from the previous exam prior to the start of metformin, which has continued. News spread quickly to FB groups. Now metformin is currently widely used, ending our plan for a placebo-controlled trial. Recent large metformin studies have demonstrated metformin is inexpensive with a good safety profile in the majority of people, even without hyperglycemia [973].
Not in the PSR, a 2022 critical review of metformin discusses the potential benefits, postulating mechanisms in a variety of positive clinical trials. In vitro studies shows restoration of autophagy, and activation of NSC among other cellular events. Induced B12 deficiency due to malabsorption occurs in 6–30% of chronic users, indicating the need for monitoring and sublingual replacement, but metformin use is not associated with hypoglycemia in the euglycemic population [973]. Placebo-controlled clinical trials are needed to determine efficacy in DLMs.
Treatments without sufficient evidence.
We recommend against use of the 2018 Tennant cocktails of “neuro-steroids and neurohormones” due to lack of studies in humans and questioned safety of supplements [893]. Since those protocols were written, a number of advances in targeted drugs and the molecular pathways involved in LMF have been made with better safety profiles for clinical trials.
We also recommend against the use of neural stem cells (NSC) off a clinical trial. The PPI team personally is aware of hundreds of LMF patients who have had these therapies at least once, many repeatedly. Currently, only the financially fortunate have access. A well conducted clinical, trial if positive, could lead to insurance coverage and decreased disparities. Positive trials of NSC in DLMs have not been published and harm is documented [974]. Evidence exists of stem cell culture supernate having a significant, though temporary impact on neurology recovery in spinal cord injury patients [975]. We found no evidence NSC can induce recovery LM cells, which come from a different embryonic lineage.
Hundreds, if not thousands of DLMs patients have tried low dose naltrexone(LDN) based on Tennent protocols and multiple sclerosis websites. There is sufficient data of a high safety profile for LDN in patients not taking opioids. The theory is low doses bind opioid receptors on immune modulating cells causing activation as well as increasing response to opioids by upregulating receptors [976]. No data appeared in our PSR. There is insufficient evidence for any conclusion.
Curcumin, a known anti-neuro-inflammatory agent that impacts glial cells in did not show up in the PSR. A report in rat SAH models demonstrates high doses of curcumin ameliorated the post inflammatory response and subsequent LMF after induced SAH. This striking response deserves further investigation as SAH has devastating LMF consequences. At therapeutic doses in humans it does not provide the neuroprotective, anti-neuroinflammation, or antioxidant affects seen in preclinical studies [977]. Doses nearing the toxic range might be necessary due to poor absorption [978]. Serious liver toxicity has been noted. Newer formulations are entering clinical trials.
Brief molecular biology primer
Though not included in results syntheses, we prospectively included pre-clinical research for future directions and were surprised at the advances in LM composition and functions. Of >1000 reviews and bench research studies going back to 1832, we collected and reviewed pertinent original non-human studies published after 2010. With the discovery of a glymphatic system in the dura and LM in 2015 there has since been exponential growth in understanding CSF flow and its relationship to both CNS and peripheral organs [906].
Current understanding is the SAS CSF plays a critical role in the process of providing oxygen and nutrients to neurons and removal of metabolic waste, in addition to housing multiple macrophages and NSC. Publications document the critical role the glymphatics play in maintaining normal brain function through aging as well as in neuroinflammation, injury, and cancers. The evolving framework explains the clinical syndromes which involve inflammation or disruption of LM architecture, CSF flow, and neurovascular units. A recent molecular and cellular biology review confirms this from scientific and animal study points, discussing clinical scenarios [900].
Several articles discuss the importance of the LM stem cell niches in migrating to and repairing CNS damage. We were unable to find evidence NSC can regenerate the LM or SAS, but studies have shown use of NSC or NSC supernate improve symptoms, function, and pathologic appearance of spinal cord lesions given through different routes in animal models. Although SAH generally leads to LMF and serious disability, preliminary animal studies with NSC may produce options post SAH, but data are early [979].
Because hrBMP-2 is used extensively in spine surgeries, we attempted to elucidate the mechanism by which rhBMP-2 might cause DLMs. BMP-2 was first identified because of its role in bone formation but there are multiple BMPs which participate in a wide variety of metabolic pathways for multiple cell types. With the exception of BMP-1, all other BMPs are part of the transforming growth factor (TGF-β) superfamily of secreted growth factors essential for cellular communication [980,981]. The TGF-β family contains >30 growth factors, all involved in just two SMAD signaling pathways (SMAD2/3 or SMAD 1/5/8) [982].
The apparent cause of rhBMP-2 DLMs is initiation of the SAS inflammatory and fibrotic cascades. A 2016 review of the clinical and pre-clinical side effects of rhBMP-2 discusses the intense inflammatory responses in addition to radiculitis, ectopic bone, osteoclast activation and other complications by activation (IL(interleukin)-1β, IL-6, IL-10, IL-17, IL-18, tumor necrosis factor-α, potentiation of nuclear factor-kβ ligand, induction of RANKL, and dose-dependent induction of PPARγ expression) [983]. Animal studies with rhBMP-2 have demonstrated activation of members of TGF-β1 decrease the ability of NSC to repair CNS damage as well as increase LMF [908,984–986].
The complete BMP/ TGFβ pathways are beyond the scope of this paper. Indeed different BMP/ TGFβ ligands can assemble identical Type I or II receptors that do not result in the same signaling pathway [980]. While hrBMP-2 is implicated in causing fibrosis, BMP-7 appears to decrease TGF-β-associated tissue fibrosis and enhance recovery of cardiac, pulmonary, and renal fibrosis [984]. We are scratching the surface of these biologically potent molecules. We strongly encourage spine surgeons and interventionalists to become active in initiating and supporting clinical trials in what will become a new field of study—prevention of permanent damage to the SAS and LMs, perhaps starting with early use of immune modulators showing activity in TBM.
ICD 11 proposal for consistent naming convention
As we progress in targeted therapy, improving outcomes depends on utilizing accurate, consistent terminology and unique International Classification of Diseases (ICD) coding to establish databases for appropriate treatments, outcomes analysis, and eligibility for clinical trials. Going forward, it will be critical to classify and capture different phases and forms of DLMs. In the real world DLMs represents several different pathologies for which there currently is no ICD10 category or “parent” for "Diseases of the Leptomeninges.” The prognosis is not the same for all DLMs. Causes, symptoms, current and proposed future treatments are likely to be different.
We proposed to the WHO complex hierarchical system changes for ICD11, as shown in Fig 5 for creation of a new chapter to be named “Diseases of the meninges.” We will resubmit the proposal upon demonstration of increased medical awareness the need for these changes. Hopefully clinical trials will produce therapies that when used in the acute phases will prevent permanent LMF progression.
The current version of ICD 11 does not contain a section for meningeal diseases, although there are scattered places where this complication appears as a complication of a specific disease. As many disease entities cause the same pathologic changes and symptoms, progress in quantifying LMDs, clinical course and outcomes, and eligibility for clinical trials will only be possible with consistent coding. We have proposed the hierarchical system below, with “grandchildren” being brain, brainstem, and spinal involvement of the LM. The example “generation 4 and 5” in green and purple would be repeated for each of the 3 main grandchildren. This proposal will be resubmitted to WHO, with all input welcome.
Certainty of body of evidence
We are confident the study results represent overall certainty of evidence in our primary conclusions and recommendations and will not be changed by others repeating this SR using the same time frame and our published methodology. We are hopeful future SR with later dates will have different results because of prevention, global disease treatment equity, and medical innovation
Implications for practice and future research
Based upon the scientific rigor of this review, we make several suggestions. First is dissemination of the information in this report to the medical and patient communities, including enhanced patient education efforts. Table 9 contains some possibilities for future research, but there are likely unpublished therapeutic candidates to consider. We propose using ICD11 to clarify and unify terminology and disease differences. Prevention and treatment for acute disease should be a priority. Finally, we must do a better job training radiologist to recognize the presence of DLMs on MRI’s, and we must do better bringing the outcomes in N-OECD up to OECD standards, particularly in treatment of curable diseases.
Conclusion
We conclude:
- Clinically, the LM constitute an organ with functions critical to the development and maintenance of the underlying CNS, as well as transiting neurons that comprise the peripheral nervous system, confirming preclinical research findings.
- The SAS porosity and unique cellular components (NSC, macrophages, etc.) must be preserved for normal CSF flow and CNS function, and is the anatomic area involved in “arachnoiditis, chronic meningitis,” as well as the other leptomeningeal pathologies ± concomitant CNS pathology.
- A spectrum from acute injury to complete fibrotic destruction occurs, the course of which differs by defined causes and can be captured by proposed ICD 11 terminology since coding accuracy identifies patients for providing treatments and measuring best outcomes and quality of life in searchable databases.
Acknowledgments
We thank: the Mayo Clinic Library and librarians for donation of time and resources; the modified d-Delphi team, named with written permission (Subhash Patel MD, Tiina Säynäjoki MS (Chief Data Integrity Officer), Marlisa Griffith RN BSN, Tracy Kruzick MD, Sarah Fox MBBS, Robert West PhD, Allison Tucker RT, Jill Ackerman MD, Rich Allen MD); the numerous other patients contributing time searching resources in the early phases of the PSR; the experts contributing content to the paper, named with written permission [Christopher Cohen PhD for Fig 4 pictures; Francesco Fornai MD for Fig 4 pictorial; Dieter Hoelzer MD PhD, President European Hematology Association and Director Emeritus, Department of Medicine, University of Frankfurt, Germany (personal communication); Richard Larson MD. Director Hematologic Malignancy Clinical Research Program, The University of Chicago (personal communication)]; neurosurgeon Charles V. Burton MD for multiple contributions prior to his death in December 2020.
References
- 1.
Dangerous Medical Implants and Devices—Consumer Reports [Internet]. [cited 2021 Feb 20]. Available from: https://www.consumerreports.org/cro/magazine/2012/04/cr-investigates-dangerous-medical-devices/index.htm.
- 2.
arachnoiditis Archives [Internet]. NORD (National Organization for Rare Disorders). [cited 2021 Feb 1]. Available from: https://rarediseases.org/tag/arachnoiditis/.
- 3.
Arachnoiditis Information Page | National Institute of Neurological Disorders and Stroke [Internet]. [cited 2021 Feb 1]. Available from: https://www.ninds.nih.gov/Disorders/All-Disorders/Arachnoiditis-Information-Page.
- 4.
Arachnoiditis | Genetic and Rare Diseases Information Center (GARD)–an NCATS Program [Internet]. [cited 2021 Feb 1]. Available from: https://rarediseases.info.nih.gov/diseases/5839/arachnoiditis.
- 5. Burton CV. Lumbosacral arachnoiditis. Spine. 1978 Mar;3(1):24–30. pmid:148106
- 6. Fabbri A, Lai A, Grundy Q, Bero LA. The Influence of Industry Sponsorship on the Research Agenda: A Scoping Review. Am J Public Health [Internet]. 2018 Nov [cited 2021 Sep 30];108(11):e9–16. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187765/. pmid:30252531
- 7. Egilman AC, Kesselheim AS, Krumholz HM, Ross JS, Kim J, Kapczynski A. Confidentiality Orders and Public Interest in Drug and Medical Device Litigation. JAMA Intern Med [Internet]. 2020 Feb 1 [cited 2020 Mar 20];180(2):292–9. Available from: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2753427. pmid:31657836
- 8. Cohen IG, Bagley N. Private Rights and the Public Interest in Drug and Medical Device Litigation. JAMA Intern Med [Internet]. 2020 Feb 1 [cited 2020 Mar 20];180(2):299–300. Available from: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2753420. pmid:31657844
- 9. Aksamit AJ. Chronic Meningitis. N Engl J Med [Internet]. 2021 Sep 2 [cited 2021 Sep 3];385(10):930–6. Available from: https://doi.org/10.1056/NEJMra2032996. pmid:34469648
- 10.
Disability adjusted life years [Internet]. World Health Organization. [cited 2021 Apr 16]. Available from: https://www.who.int/data/maternal-newborn-child-adolescent-ageing/advisory-groups/gama/activities-of-gama.
- 11.
Welcome to Unpaywall | Unpaywall [Internet]. Our Research; [cited 2021 Feb 11]. Available from: http://unpaywall.org/welcome.
- 12.
Sweeping Review of Arachnoiditis-Official Protocol—arcsology.org [Internet]. [cited 2022 Jan 8]. Available from: https://arcsology.org/about-arcsology/review-of-arachnoiditis-official-protocol/.
- 13. Simmonds MC, Brown JVE, Heirs MK, Higgins JPT, Mannion RJ, Rodgers MA, et al. Safety and Effectiveness of Recombinant Human Bone Morphogenetic Protein-2 for Spinal Fusion. Ann Intern Med [Internet]. 2013 Jun 18 [cited 2020 May 28];158(12):877–89. Available from: https://www.acpjournals.org/doi/10.7326/0003-4819-158-12-201306180-00005.
- 14. Low J, Ross JS, Ritchie JD, Gross CP, Lehman R, Lin H, et al. Comparison of two independent systematic reviews of trials of recombinant human bone morphogenetic protein-2 (rhBMP-2): the Yale Open Data Access Medtronic Project. Syst Rev [Internet]. 2017 Feb 15 [cited 2020 Mar 1];6(1):28. Available from: pmid:28196521
- 15.
All 1,039 postsurgical complications after surgeries using Medtronic’s Infuse product [Internet]. Star Tribune. [cited 2021 Jan 25]. Available from: https://www.startribune.com/all-1-039-postsurgical-complications-after-surgeries-using-medtronic-s-infuse-product/502733321/.
- 16.
Zotero | About [Internet]. [cited 2021 Jan 30]. Available from: https://www.zotero.org/about/.
- 17.
Covidence systematic review software, Veritas Health Innovation, Melbourne, Australia. [Internet]. [cited 2021 Jan 30]. Available from: https://www.covidence.org/.
- 18.
OECD Member countries—Ratification of the Convention on the OECD [Internet]. [cited 2021 Jan 31]. Available from: https://www.oecd.org/about/document/list-oecd-member-countries.htm.
- 19. Blumstein . ARACHNOIDITIS (DIFFUSE PROLIFERATIVE LEPTOMENINGITIS). Ann Intern Med [Internet]. 1943 May 1 [cited 2019 May 4];18(5):809. Available from: https://doi.org/10.7326/0003-4819-18-5-809.
- 20. Greenfield JG. On froin’s syndrome, and its relation to allied conditionsin the cerebrospinal fluid. J Neurol Neurosurg Psychiatry. 1921;S1-2(6):105–41.
- 21. Dlouhy BJ, Dawson JD, Menezes AH. Intradural pathology and pathophysiology associated with Chiari I malformation in children and adults with and without syringomyelia. J Neurosurg Pediatr. 2017 Dec;20(6):526–41. pmid:29027876
- 22. Mackay RP. Chronic adhesive spinal arachnoiditis: A clinical and pathologic study. JAMA J Am Med Assoc. 1939;112(9):802–8.
- 23. Jackson C, Yang BW, Bi WL, Chiocca EA, Groff MW. Adult Tethered Cord Syndrome Following Chiari Decompression. World Neurosurg. 2018 Apr;112:205–8. pmid:29409774
- 24. Agamanolis DP, Hite SH, Platt MS, Boeckman CR. Arnold-Chiari malformation. Report of four cases with contamination of the central nervous system by amniotic contents. Surg Neurol. 1986;25(3):261–6. pmid:3945906
- 25. Paul KS, Lye RH, Strang FA, Dutton J. Arnold-Chiari malformation. Review of 71 cases. J Neurosurg. 1983 Feb;58(2):183–7. pmid:6848674
- 26. Belen D, Er U, Gurses L, Yigitkanli K. Delayed pseudomyelomeningocele: a rare complication after foramen magnum decompression for Chiari malformation. Surg Neurol. 2009 Mar;71(3):357–61. pmid:18207518
- 27. Klekamp J. Neurological deterioration after foramen magnum decompression for Chiari malformation Type I: Old or new pathology? Clinical article. J Neurosurg Pediatr. 2012 Dec;10(6):538–47.
- 28. Beck ES, Ramachandran PS, Khan LM, Sample HA, Zorn KC, O’Connell EM, et al. Clinicopathology conference: 41-year-old woman with chronic relapsing meningitis: Chronic Arachnoiditis Cause. Ann Neurol [Internet]. 2019 Feb [cited 2019 Apr 10];85(2):161–9. Available from: http://doi.wiley.com/10.1002/ana.25400.
- 29. Absinta M, Cortese ICM, Vuolo L, Nair G, de Alwis MP, Ohayon J, et al. Leptomeningeal gadolinium enhancement across the spectrum of chronic neuroinflammatory diseases. Neurology. 2017 Apr 11;88(15):1439–44. pmid:28283598
- 30. Anderson NE, Willoughby EW, Synek BJ. Leptomeningeal and brain biopsy in chronic meningitis. Aust N Z J Med. 1995 Dec;25(6):703–6. pmid:8770335
- 31. Castillo-Iglesias H, Mouly S, Ducros A, Sarfati C, Sulahian A, Bergmann JF. Late-onset eosinophilic chronic meningitis occurring 30 years after Taenia solium infestation in a white Caucasian woman. J Infect [Internet]. 2006;53(1):e35–38. Available from: https://www.ncbi.nlm.nih.gov/pubmed/16253336. pmid:16253336
- 32. Charleston AJ, Anderson NE, Willoughby EW. Idiopathic steroid responsive chronic lymphocytic meningitis—clinical features and long-term outcome in 17 patients. Aust N Z J Med. 1998 Dec;28(6):784–9. pmid:9972407
- 33. Giménez-Roldán S, Benito C, Martin M. Dementia paralytica: deterioration from communicating hydrocephalus. J Neurol Neurosurg Psychiatry. 1979 Jun;42(6):501–8. pmid:469557
- 34. Go T. Sequential MRI in chronic meningitis during adrenocorticotropic hormone treatment for West syndrome. Childs Nerv Syst ChNS Off J Int Soc Pediatr Neurosurg [Internet]. 2001;17(8):497–9. Available from: https://www.ncbi.nlm.nih.gov/pubmed/11508542. pmid:11508542
- 35. Hessler C, Kauffman CA, Chow FC. The Upside of Bias: A Case of Chronic Meningitis Due to Sporothrix Schenckii in an Immunocompetent Host. The Neurohospitalist [Internet]. 2017 Jan 1 [cited 2019 May 15];7(1):30–4. Available from: pmid:28042367
- 36. Hobhouse E. CHRONIC MENINGITIS AS A SEQUELA OF EPIDEMIC CEREBRO-SPINAL MENINGITIS. The Lancet. 1897;150(3871):1185–6.
- 37. Jinnah HA, Dixon A, Brat DJ, Hellmann DB. Chronic meningitis with cranial neuropathies in Wegener’s granulomatosis. Case report and review of the literature. Arthritis Rheum. 1997 Mar;40(3):573–7. pmid:9082947
- 38. Lidove O, Chauveheid MP, Benoist L, Alexandra JF, Klein I, Papo T. Chronic meningitis and thalamic involvement in a woman: Fabry disease expanding phenotype. J Neurol Neurosurg Psychiatry. 2007 Sep;78(9):1007. pmid:17702786
- 39. Lin WC, Chen PC, Wang HC, Tsai NW, Chou KH, Chen HL, et al. Diffusion tensor imaging study of white matter damage in chronic meningitis. PloS One. 2014;9(6):e98210. pmid:24892826
- 40. Moling O, Lass-Floerl C, Verweij PE, Porte M, Boiron P, Prugger M, et al. Case Reports. Chronic and acute Aspergillus meningitis. Mycoses [Internet]. 2002;45(11–12):504–11. Available from: https://www.ncbi.nlm.nih.gov/pubmed/12472730. pmid:12472730
- 41. Savage TR. Chronic Adhesive Spinal Meningitis Associated With Lumbar Naevus And Dimple. Br Med J [Internet]. 1950 [cited 2019 May 5];2(4681):709–11. Available from: https://www.jstor.org/stable/25358452. pmid:14772460
- 42. Scott D. Case of Monomania, Caused Apparently by Circumscribed Chronic Meningitis, with Remarks. Edinb Med Surg J. 1828 Jul 1;30(96):37–43. pmid:30332258
- 43. Shimada K, Matsui T, Kawakami M, Hayakawa H, Futami H, Michishita K, et al. Diffuse chronic leptomeningitis with seropositive rheumatoid arthritis: Report of a case successfully treated as rheumatoid leptomeningitis. Mod Rheumatol. 2009;19(5):556–62. pmid:19521743
- 44. Sköldenberg B, Stiernstedt G, Gårde A, Kolmodin G, Carlström A, Nord CE. Chronic meningitis caused by a penicillin-sensitive microorganism? Lancet Lond Engl. 1983 Jul 9;2(8341):75–8. pmid:6134962
- 45. Smith JE, Aksamit AJ. Outcome of chronic idiopathic meningitis. Mayo Clin Proc. 1994 Jun;69(6):548–56. pmid:8189760
- 46. Southey. ST. BARTHOLOMEW’S HOSPITAL. THREE CASES OF CHRONIC MENINGITIS, FOLLOWING INJURY TO THE SKULL. The Lancet. 1879;114(2937):871–2.
- 47. Stein SC, Corrado ML, Friedlander M, Farmer P. Chronic mycotic meningitis with spinal involvement (arachnoiditis): a report of five cases. Ann Neurol. 1982 May;11(5):519–24. pmid:7103428
- 48. Ueno T, Nishijima H, Kurotaki H, Kurose A, Tomiyama M. An unusual case of chronic meningitis due to histiocytic sarcoma of the central nervous system with meningeal dissemination. Neurol Sci. 2016 Nov;37(11):1875–7. pmid:27325388
- 49. Williams M. A CASE OF CHRONIC MENINGITIS LASTING FIFTEEN YEARS. The Lancet. 1925;206(5323):496–7.
- 50. Wilson MR, O’Donovan BD, Gelfand JM, Sample HA, Chow FC, Betjemann JP, et al. Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing. JAMA Neurol. 2018 Aug 1;75(8):947–55. pmid:29710329
- 51. Yanagimura F, Fukushima T, Sakamaki Y, Nakamura G, Maruyama H, Makino K. Fabry disease associated with chronic meningitis and cerebral infarction. Neurol Clin Neurosci [Internet]. 2015 [cited 2019 Apr 19];3(4):147–9. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/ncn3.168.
- 52. Ackerman LL, Menezes AH. Spinal Congenital Dermal Sinuses: A 30-Year Experience. PEDIATRICS [Internet]. 2003 Sep 1 [cited 2019 Apr 8];112(3):641–7. Available from: http://pediatrics.aappublications.org/cgi/doi/10.1542/peds.112.3.641. pmid:12949296
- 53. Allenby PA, Gould NS, Thomas C. Congenital posthemorrhagic hydrocephalus: report of a case. Pediatr Pathol. 1985;4(3–4):303–8. pmid:3835553
- 54. Iskandar BJ, McLaughlin C, Oakes WJ. Split cord malformations in myelomeningocele patients. Br J Neurosurg. 2000 Jun;14(3):200–3. pmid:10912195
- 55. Jain F, Chaichana KL, McGirt MJ, Jallo GI. Neonatal anterior cervical arachnoid cyst: case report and review of the literature. Childs Nerv Syst ChNS Off J Int Soc Pediatr Neurosurg. 2008 Aug;24(8):965–70. pmid:18338174
- 56. Kurogi A, Morioka T, Murakami N, Nakanami N, Suzuki SO. Ruptured dermoid cyst of the conus medullaris in the myelomeningocele sac revealed at the initial repair surgery. Childs Nerv Syst. 2019; pmid:31776717
- 57. Sonnet MH, Joud A, Marchal JC, Klein O. Suprasellar arachnoid cyst after subdural haemorrhage in an infant. A case based update. Neurochirurgie. 2014 Apr;60(1–2):55–8. pmid:24656261
- 58. Steinlin M, Knecht B, Könü D, Martin E, Boltshauser E. Neonatal Escherichia coli meningitis: spinal adhesions as a late complication. Eur J Pediatr. 1999 Dec;158(12):968–70. pmid:10592071
- 59. Yun-Hai S, Nan B, Ping-Ping G, Bo Y, Cheng C. Is repair of the protruded meninges sufficient for treatment of meningocele? Childs Nerv Syst ChNS Off J Int Soc Pediatr Neurosurg. 2015 Nov;31(11):2135–40. pmid:26298824
- 60. Pasoglou V, Janin N, Tebache M, Tegos TJ, Born JD, Collignon L. Familial adhesive arachnoiditis associated with syringomyelia. AJNR Am J Neuroradiol. 2014 Jun;35(6):1232–6. pmid:24481329
- 61. Duke RJ, Hashimoto S. Familial spinal arachnoiditis—a new entity. Trans Am Neurol Assoc. 1973;98:98–102. pmid:4784982
- 62. Gray PE, Shadur B, Russell S, Mitchell R, Buckley M, Gallagher K, et al. Late-Onset Non-HLH Presentations of Growth Arrest, Inflammatory Arachnoiditis, and Severe Infectious Mononucleosis, in Siblings with Hypomorphic Defects in UNC13D. Front Immunol. 2017;8:944. pmid:28848550
- 63. Liu JKC, Turner RD, Luciano MG, Krishnaney AA. Circumferential intrathecal ossification in oculoleptomeningeal amyloidosis. J Clin Neurosci. 2015 Apr 1;22(4):769–71. pmid:25630425
- 64. Uyama E, Takahashi K, Owada M, Okamura R, Naito M, Tsuji S, et al. Hydrocephalus, corneal opacities, deafness, valvular heart disease, deformed toes and leptomeningeal fibrous thickening in adult siblings: a new syndrome associated with beta-glucocerebrosidase deficiency and a mosaic population of storage cells. Acta Neurol Scand. 1992 Oct;86(4):407–20. pmid:1333717
- 65. Lindstrom KM, Cousar JB, Lopes MBS. IgG4-related meningeal disease: clinico-pathological features and proposal for diagnostic criteria. Acta Neuropathol (Berl). 2010 Dec;120(6):765–76. pmid:20844883
- 66. Lam AH, de Silva M, Procopis P, Kan A. Primary amoebic (Naegleria) meningoencephalitis. J Comput Assist Tomogr. 1982 Jun;6(3):620–3. pmid:7096709
- 67. Singhal T, Bajpai A, Kalra V, Kabra SK, Samantaray JC, Satpathy G, et al. Successful treatment of Acanthamoeba meningitis with combination oral antimicrobials. Pediatr Infect Dis J [Internet]. 2001;20(6):623–7. Available from: https://www.ncbi.nlm.nih.gov/pubmed/11419508. pmid:11419508
- 68. Bensmail D, Peskine A, Denys P, Bernard L, Bussel B. Aseptic meningitis after intrathecal baclofen injection. Spinal Cord. 2006 May;44(5):330–3. pmid:16172626
- 69. Codipietro L, Maino P. Aseptic Arachnoiditis in a Patient Treated With Intrathecal Morphine Infusion: Symptom Resolution on Switch to Ziconotide: Aseptic Arachnoiditis with Intrathecal Morphine. Neuromodulation Technol Neural Interface [Internet]. 2015 Apr [cited 2019 Apr 19];18(3):217–20. Available from: http://doi.wiley.com/10.1111/ner.12201.
- 70. Kelley RE, Daroff RB, Sheremata WA, McCormick JR. Unusual effects of metrizamide lumbar myelography. Constellation of aseptic meningitis, arachnoiditis, communicating hydrocephalus, and Guillaine-Barre syndrome. Arch Neurol. 1980 Sep;37(9):588–9.
- 71. Rossetti AO, Meagher-Villemure K, Vingerhoets F, Maeder P, Bogousslavsky J. Eosinophilic aseptic arachnoiditis. A neurological complication in HIV-negative drug-addicts. J Neurol [Internet]. 2002;249(7):884–7. Available from: https://www.ncbi.nlm.nih.gov/pubmed/12140673 pmid:12140673
- 72. Nardone R, Alessandrini F, Tezzon F. Syringomyelia following Listeria meningoencephalitis: report of a case. Neurol Sci Off J Ital Neurol Soc Ital Soc Clin Neurophysiol [Internet]. 2003;24(1):40–3. Available from: https://www.ncbi.nlm.nih.gov/pubmed/12754657. pmid:12754657
- 73. Pfadenhauer K, Rossmanith T. Spinal manifestation of neurolisteriosis. J Neurol. 1995 Feb;242(3):153–6. pmid:7751858
- 74. de Gans J, van de Beek D. Dexamethasone in Adults with Bacterial Meningitis. N Engl J Med [Internet]. 2002 Nov 14 [cited 2019 May 21];347(20):1549–56. Available from: http://www.nejm.org/doi/abs/10.1056/NEJMoa021334. pmid:12432041
- 75. Gubian A, Rosahl SK. Encasement of the Cauda Equina After Early Childhood Meningitis: Case Report and Review of the Literature. World Neurosurg. 2016 Dec;96:612.e15-612.e20. pmid:27609449
- 76. Hollifield JW, Kaiser AB, McGee ZA. Gram-negative bacillary meningitis therapy. Polyradiculitis following intralumbar aminoglycoside administration. JAMA. 1976 Sep 13;236(11):1264–6. pmid:785039
- 77. Koksal A, Canyigit M, Kara T, Ulus A, Gokbayir H, Sarisahin M. Unusual presentation of an anterior sacral meningocele: magnetic resonance imaging, multidetector computed tomography, and fistulography findings of bacterial meningitis secondary to a rectothecal fistula. Jpn J Radiol. 2011 Aug;29(7):528–31. pmid:21882098
- 78. Kratzig T, Dreimann M, Mende KC, Konigs I, Westphal M, Eicker SO. Extensive Spinal Adhesive Arachnoiditis After Extradural Spinal Infection-Spinal Spinal Dura Mater Is No Barrier to Inflammation. World Neurosurg. 2018 Aug;116:e1194–203.
- 79. Rajpal S, Chanbusarakum K, Deshmukh PR. Upper cervical myelopathy due to arachnoiditis and spinal cord tethering from adjacent C-2 osteomyelitis. Case report and review of the literature. J Neurosurg Spine. 2007 Jan;6(1):64–7. pmid:17233294
- 80. Antinori S, Corbellino M, Meroni L, Resta F, Sollima S, Tonolini M, et al. Aspergillus meningitis: a rare clinical manifestation of central nervous system aspergillosis. Case report and review of 92 cases. J Infect. 2013 Mar;66(3):218–38. pmid:23178421
- 81. Bryan CS, DiSalvo AF, Huffman LJ, Kaplan W, Kaufman L. Communicating hydrocephalus caused by Aspergillus flavus. South Med J. 1980 Dec;73(12):1641–4. pmid:6777876
- 82. Van de Wyngaert FA, Sindic CJ, Rousseau JJ, Fernandes Xavier FG, Brucher JM, Laterre EC. Spinal arachnoiditis due to aspergillus meningitis in a previously healthy patient. J Neurol. 1986 Feb;233(1):41–3. pmid:3512781
- 83. Takahashi H, Sasaki A, Arai T, Tsukamoto Y, Sato O. Chromoblastomycosis in the cisterna magna and the spinal subarachnoid space. Case report. J Neurosurg. 1973 Apr;38(4):506–9. pmid:4696200
- 84. Crete RN, Gallmann W, Karis JP, Ross J. Spinal Coccidioidomycosis: MR Imaging Findings in 41 Patients. AJNR Am J Neuroradiol. 2018 Nov;39(11):2148–53. pmid:30287458
- 85. D’Assumpcao C, Heidari A, Johnson RH. Patient With a 42-Year History of Coccidioidal Meningitis. J Investig Med High Impact Case Rep [Internet]. 2018 Jan 1 [cited 2019 Apr 20];6:2324709618820047. Available from: pmid:30622991
- 86. Drake KW, Adam RD. Coccidioidal meningitis and brain abscesses: analysis of 71 cases at a referral center. Neurology. 2009 Nov 24;73(21):1780–6. pmid:19933980
- 87. Lammering JC, Iv M, Gupta N, Pandit R, Patel MR. Imaging spectrum of CNS coccidioidomycosis: prevalence and significance of concurrent brain and spinal disease. AJR Am J Roentgenol. 2013 Jun;200(6):1334–46. pmid:23701073
- 88. Mathisen G, Shelub A, Truong J, Wigen C. Coccidioidal meningitis: Clinical presentation and management in the fluconazole era. Medicine (Baltimore). 2010 Sep;89(5):251–84. pmid:20827104
- 89. Winston DJ, Kurtz TO, Fleischmann J, Morgan D, Batzdorf U, Stern WE. Successful treatment of spinal arachnoiditis due to coccidioidomycosis. Case report. J Neurosurg. 1983 Aug;59(2):328–31. pmid:6306182
- 90. Wrobel CJ, Meyer S, Johnson RH, Hesselink JR. MR findings in acute and chronic coccidioidomycosis meningitis. AJNR Am J Neuroradiol [Internet]. 1992 Aug;13(4):1241–5. Available from: http://www.ajnr.org/content/13/4/1241.short. pmid:1636543
- 91. Panackal AA, Komori M, Kosa P, Khan O, Hammoud DA, Rosen LB, et al. Spinal Arachnoiditis as a Complication of Cryptococcal Meningoencephalitis in Non-HIV Previously Healthy Adults. Clin Infect Dis Off Publ Infect Dis Soc Am. 2017 Feb 1;64(3):275–83. pmid:28011613
- 92. Agrawal A, Agrawal A, Agrawal C, Rohtagi A. An unusual spinal arachnoiditis. Clin Neurol Neurosurg. 2006 Dec;108(8):775–9. pmid:16257113
- 93. Merkler AE, Gaines N, Baradaran H, Schuetz AN, Lavi E, Simpson SA, et al. Direct Invasion of the Optic Nerves, Chiasm, and Tracts by Cryptococcus neoformans in an Immunocompetent Host. The Neurohospitalist. 2015 Oct;5(4):217–22. pmid:26425249
- 94. Murai H, Tokunaga H, Kubo I, Kawajiri M, Iwaki T, Taniwaki T, et al. Myeloradiculitis caused by Cryptococcus neoformans infection in a patient with ulcerative colitis: A neuropathological study. J Neurol Sci. 2006 Sep 25;247(2):236–8. pmid:16815466
- 95. Woodall WC, Bertorini TE, Bakhtian BJ, Gelfand MS. Spinal arachnoiditis with Cryptococcus neoformans in a nonimmunocompromised child. Pediatr Neurol [Internet]. 1990 Jun;6(3):206–8. Available from: https://www.sciencedirect.com/science/article/pii/0887899490900659. pmid:2360963
- 96. Malani AN, Kauffman CA, Latham R, Peglow S, Ledtke CS, Kerkering TM, et al. Long-term Outcomes of Patients With Fungal Infections Associated With Contaminated Methylprednisolone Injections. Open Forum Infect Dis. 2020 Jun;7(6):ofaa164. pmid:32528999
- 97. Rangel-Castilla L, Hwang SW, White AC, Zhang YJ. Neuroendoscopic diagnosis of central nervous system histoplasmosis with basilar arachnoiditis. World Neurosurg. 2012 Feb;77(2):399.E9-13. pmid:22120362
- 98. Tyler KL, Johnson ECB, Cantu DS, Haller BL. A 20-Year-Old Woman With Headache and Transient Numbness. The Neurohospitalist [Internet]. 2013 Apr [cited 2019 Apr 21];3(2):101–10. Available from: http://journals.sagepub.com/doi/10.1177/1941874412473118. pmid:23983894
- 99. Argersinger DP, Natkha VP, Shepard MJ, Thomas AA, Oler AJ, Williamson PR, et al. Intradural cauda equina Candida abscess presenting with hydrocephalus: Case report. J Neurosurg Spine. 2019;31(6):890–3. pmid:31470401
- 100. Ucar S. Subdural granuloma and arachnoiditis of melithococcical (undulant fever) origin. Acta Neurochir (Wien). 1950;1(2–3):321. pmid:24539100
- 101. Finsterer J, Capek J, Mamoli B. Misjudged Bannwarth’s syndrome culminating in laminectomy. Acta Neurochir (Wien). 1998;140(5):515–6. pmid:9728254
- 102. Finsterer J, Dauth J, Angel K, Markowicz M. Dysuria, Urinary Retention, and Inguinal Pain as Manifestation of Sacral Bannwarth Syndrome. Case Rep Med. 2015;2015:185917. pmid:26664404
- 103. Hindfelt B, Jeppsson PG, Nilsson B, Olsson JE, Ryberg B, Sörnäs R. Clinical and cerebrospinal fluid findings in lymphocytic meningo-radiculitis (Bannwarth’s syndrome). Acta Neurol Scand. 1982 Oct;66(4):444–53. pmid:7148387
- 104. Wulff CH, Hansen K, Strange P, Trojaborg W. Multiple mononeuritis and radiculitis with erythema, pain, elevated CSF protein and pleocytosis (Bannwarth’s syndrome). J Neurol Neurosurg Psychiatry [Internet]. 1983 Jun;46(6):485–90. Available from: https://jnnp.bmj.com/content/46/6/485.short. pmid:6875581
- 105. Abdullah AAN, Tallantyre E. HSV-2 radiculitis: An unusual presentation mere days after genital infection. Clin Neurol Neurosurg. 2019 Oct;185 (no pagination)(105429). pmid:31450189
- 106. Allorent J, Cozic C, Guimard T, Tanguy G, Cormier G. Sciatica with motor loss and hemi-cauda equina syndrome due to varicella-zoster virus meningoradiculitis. Jt Bone Spine Rev Rhum. 2013 Jul;80(4):436–7. pmid:23453474
- 107. Buonsenso D, Focarelli B, Valentini P, Onesimo R. IVIG treatment for VZV-related acute inflammatory polyneuropathy in a child. BMJ Case Rep [Internet]. 2012 Jul 19 [cited 2019 Apr 11];2012. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543348/. pmid:22814982
- 108. De La Blanchardiere A, Rozenberg F, Caumes E, Picard O, Lionnet F, Livartowski J, et al. Neurological complications of varicella-zoster virus infection in adults with human immunodeficiency virus infection. Scand J Infect Dis. 2000;32(3):263–9. pmid:10879596
- 109. Farkkila M, Koskiniemi M, Vaheri A. Clinical spectrum of neurological herpes simplex infection. Acta Neurol Scand. 1993 Apr;87(4):325–8. pmid:8389089
- 110. Karam C, Revuelta M, MacGowan D. Human herpesvirus 6 meningoradiculitis treated with intravenous immunoglobulin and valganciclovir. J Neurovirol. 2009;15(1):108–9. pmid:18821121
- 111. Majid A, Galetta SL, Sweeney CJ, Robinson C, Mahalingam R, Smith J, et al. Epstein-Barr virus myeloradiculitis and encephalomyeloradiculitis. Brain. 2002;125(1):159–65. pmid:11834601
- 112. McKendall RR, Sadiq SA, Calverley JR. Unusual manifestations of Epstein-Barr virus encephalomyelitis. Infection. 1990 Feb;18(1):33–5. pmid:2155877
- 113. Muhle P, Suntrup-Krueger S, Dziewas R, Warnecke T. Pharyngeal dysphagia due to Varicella zoster virus meningoradiculitis and full recovery: Case report and endoscopic findings. SAGE Open Med Case Rep. 2018;6(no pagination). pmid:29468067
- 114. Shields LBE, Alsorogi MS. Herpes Simplex Virus Type 2 Radiculomyelitis Disguised as Conversion Disorder. Case Rep Neurol [Internet]. 2019 Apr 16 [cited 2019 Dec 20];11(1):117–23. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739805/. pmid:31543792
- 115. Shimizu R, Ohwada C, Nagao Y, Togasaki E, Kawajiri C, Muto T, et al. The Successful Treatment of a Cord Blood Transplant Recipient with Varicella Zoster Virus Meningitis, Radiculitis and Myelitis with Foscarnet. Intern Med Tokyo Jpn. 2017;56(3):353–6.
- 116. Skripuletz T, Pars K, Schulte A, Schwenkenbecher P, Yildiz Ö, Ganzenmueller T, et al. Varicella zoster virus infections in neurological patients: a clinical study. BMC Infect Dis. 2018 25;18(1):238. pmid:29801466
- 117. Whalen AM, Mateo CM, Growdon AS, Miller AF. Sacral myeloradiculitis: An uncommon complication of genital herpes infection. Pediatrics. 2019;144 (1) (no pagination)(e20182631). pmid:31217310
- 118. Brunel A, Makinson A, De Champfleur NM, Thouvenot E, Le Moing V, Lefalher G, et al. HIV-related immune reconstitution cryptococcal meningoradiculitis: Corticosteroid response. Neurology. 2009 Nov;73(20):1705–7. pmid:19917995
- 119. Candy S, Chang G, Andronikou S. Acute myelopathy or cauda equina syndrome in HIV-positive adults in a tuberculosis endemic setting: MRI, clinical, and pathologic findings. AJNR Am J Neuroradiol. 2014 Aug;35(8):1634–41. pmid:24788128
- 120. Falcone EL, Adegbulugbe AA, Sheikh V, Imamichi H, Dewar RL, Hammoud DA, et al. Cerebrospinal fluid HIV-1 compartmentalization in a patient with AIDS and acute Varicella-Zoster virus meningomyeloradiculitis. Clin Infect Dis. 2013 Sep 1;57(5):e135–42. pmid:23728149
- 121. Ho DD, Rota TR, Schooley RT, Kaplan JC, Allan JD, Groopman JE, et al. Isolation of HTLV-III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome. N Engl J Med. 1985 Dec 12;313(24):1493–7. pmid:2999591
- 122. Johnston SR, Corbett EL, Foster O, Ash S, Cohen J. Raised intracranial pressure and visual complications in AIDS patients with cryptococcal meningitis. J Infect. 1992 Mar;24(2):185–9. pmid:1569310
- 123. Kongsiriwattanakul S, Suankratay C. Central Nervous System Infections in HIV-Infected Patients Hospitalized at King Chulalongkorn Memorial Hospital. 2011;94(5):8.
- 124. Prevett MC, Plant GT. Intracranial hypertension and HIV associated meningoradiculitis. J Neurol Neurosurg Psychiatry. 1997 Apr;62(4):407–9. pmid:9120463
- 125. Thurnher MM, Post MJ, Jinkins JR. MRI of infections and neoplasms of the spine and spinal cord in 55 patients with AIDS. Neuroradiology. 2000 Aug;42(8):551–63. pmid:10997560
- 126. Bhigjee AI, Kelbe C, Haribhai HC, Windsor IM, Hoffmann MH, Modi G, et al. Myelopathy associated with human T cell lymphotropic virus type I (HTLV-I) in natal, South Africa. A clinical and investigative study in 24 patients. Brain J Neurol. 1990 Oct;113 (Pt 5):1307–20.
- 127. Knudtzen FC, Andersen NS, Jensen TG, Skarphedinsson S. Characteristics and Clinical Outcome of Lyme Neuroborreliosis in a High Endemic Area, 1995–2014: A Retrospective Cohort Study in Denmark. Clin Infect Dis. 2017 Oct 16;65(9):1489–95. pmid:29048514
- 128. Dabiri I, Calvo N, Nauman F, Pahlavanzadeh M, Burakgazi AZ. Atypical presentation of Lyme neuroborreliosis related meningitis and radiculitis. Neurol Int [Internet]. 2019 Dec 2 [cited 2019 Dec 29];11(4). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908959/. pmid:31871602
- 129. Diaz MM, Wesley SF. Meningoradiculitis and transaminitis from neuroborreliosis: A case of variant Bannwarth syndrome. Clin Neurol Neurosurg. 2019 Nov;186 (no pagination)(105532). pmid:31574359
- 130. Dotevall L, Eliasson T, Hagberg L, Mannheimer C. Pain as presenting symptom in Lyme neuroborreliosis. Eur J Pain Lond Engl [Internet]. 2003;7(3):235–9. Available from: https://www.ncbi.nlm.nih.gov/pubmed/12725846.
- 131. Hattingen E, Weidauer S, Kieslich M, Boda V, Zanella FE. MR imaging in neuroborreliosis of the cervical spinal cord. Eur Radiol [Internet]. 2004;14(11):2072–5. Available from: https://www.ncbi.nlm.nih.gov/pubmed/15048581. pmid:15048581
- 132. Henningsson AJ, Malmvall BE, Ernerudh J, Matussek A, Forsberg P. Neuroborreliosis—an epidemiological, clinical and healthcare cost study from an endemic area in the south-east of Sweden. Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis. 2010 Aug;16(8):1245–51. pmid:19793326
- 133. Jassam YN, Thaler DE. Lyme meningo-radiculitis responsive to oral doxycycline therapy in the USA. Oxf Med Case Rep. 2014 Dec;2014(9):162–3. pmid:25988066
- 134. Krüger H, Reuss K, Pulz M, Rohrbach E, Pflughaupt KW, Martin R, et al. Meningoradiculitis and encephalomyelitis due to Borrelia burgdorferi: a follow-up study of 72 patients over 27 years. J Neurol. 1989;236(6):322–8. pmid:2795099
- 135. Li X, Kirschner A, Metrie M, Loeb M. Lyme neuroborreliosis presenting as spinal myoclonus. BMJ Case Rep. 2019 Dec 29;12(12). pmid:31888906
- 136. Miklossy J, Kuntzer T, Bogousslavsky J, Regli F, Janzer RC. Meningovascular form of neuroborreliosis: similarities between neuropathological findings in a case of Lyme disease and those occurring in tertiary neurosyphilis. Acta Neuropathol (Berl). 1990;80(5):568–72.
- 137. Oschmann P, Dorndorf W, Hornig C, Schäfer C, Wellensiek HJ, Pflughaupt KW. Stages and syndromes of neuroborreliosis. J Neurol. 1998 May;245(5):262–72. pmid:9617706
- 138. Reik L, Burgdorfer W, Donaldson JO. Neurologic abnormalities in Lyme disease without erythema chronicum migrans. Am J Med. 1986 Jul;81(1):73–8. pmid:3728556
- 139. Schwenkenbecher P, Pul R, Wurster U, Conzen J, Pars K, Hartmann H, et al. Common and uncommon neurological manifestations of neuroborreliosis leading to hospitalization. BMC Infect Dis. 2017 21;17(1):90. pmid:28109263
- 140. Stiernstedt GT, Sköldenberg BR, Vandvik B, Hederstedt B, Gårde A, Kolmodin G, et al. Chronic meningitis and Lyme disease in Sweden. Yale J Biol Med. 1984 Aug;57(4):491–7. pmid:6516451
- 141. Nash TE, O’Connell EM, Hammoud DA, Wetzler L, Ware JM, Mahanty S. Natural History of Treated Subarachnoid Neurocysticercosis. Am J Trop Med Hyg. 2019 Oct 21.;
- 142. Amelot A, Faillot T. Hydrocephalus and neurocysticercosis: cases illustrative of three distinct mechanisms. J Clin Neurol Seoul Korea. 2014 Oct;10(4):363–6. pmid:25324888
- 143. Arriada-Mendicoa N, Celis-Lopez MA, Higuera-Calleja J, Corona-Vazquez T. Imaging features of sellar cysticercosis. AJNR Am J Neuroradiol [Internet]. 2003;24(7):1386–9. Available from: https://www.ncbi.nlm.nih.gov/pubmed/12917134 pmid:12917134
- 144. Bussone G, La Mantia L, Frediani F, Lamperti E, Salmaggi A, Campi A, et al. Neurocysticercosis: clinical and therapeutic considerations. Review of Italian literature. Ital J Neurol Sci. 1986 Oct;7(5):525–9. pmid:3804707
- 145. Callacondo D, Garcia HH, Gonzales I, Escalante D, Nash TE, Gilman RH, et al. High frequency of spinal involvement in patients with basal subarachnoid neurocysticercosis. Neurology [Internet]. 2012 May 1 [cited 2019 Apr 10];78(18):1394–400. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345784/ pmid:22517102
- 146. Cantú C, Barinagarrementeria F. Cerebrovascular complications of neurocysticercosis. Clinical and neuroimaging spectrum. Arch Neurol. 1996 Mar;53(3):233–9. pmid:8651876
- 147. Cardenas G, Guevara-Silva E, Romero F, Ugalde Y, Bonnet C, Fleury A, et al. Spinal Taenia solium cysticercosis in Mexican and Indian patients: a comparison of 30-year experience in two neurological referral centers and review of literature. Eur Spine J Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sect Cerv Spine Res Soc. 2016 Apr;25(4):1073–81. pmid:26474877
- 148. Colli BO, Assirati JA Jr., Machado HR, Santos F dos, Takayanagui OM. Cysticercose of the central nervous system: II. Spinal cysticercose. Arq Neuropsiquiatr [Internet]. 1994 Jun [cited 2019 Apr 19];52(2):187–99. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1994000200007&lng=en&tlng=en.
- 149. Del Brutto OH, Del Brutto VJ. Changing pattern of neurocysticercosis in an urban endemic center (Guayaquil, Ecuador). J Neurol Sci. 2012 Apr 15;315(1–2):64–6. pmid:22177754
- 150. Edwards CM, Miranda A, Pezzo S. Intradural-extramedullary spinal cysticercosis without parenchymal involvement. Am J Case Rep. 2008;9:301–3.
- 151. Figueroa JJ, Davis LE, Magalhaes A. Extraparenchymal neurocysticercosis in Albuquerque, New Mexico. J Neuroimaging Off J Am Soc Neuroimaging. 2011 Jan;21(1):38–43. pmid:20002970
- 152. Gupta S, Singh PK, Gupta B, Singh V, Azam A. Isolated primary intradural extramedullar spinal neurocysticercosis: A case report and review of literature. Acta Neurol Taiwanica. 2009 Sep;18(3):187–92.
- 153. Jongwutiwes U, Yanagida T, Ito A, Kline SE. Isolated intradural-extramedullary spinal cysticercosis: A case report. J Travel Med. 2011 Aug;18(4):284–7. pmid:21722242
- 154. Kumar S, Sharma A, Sharma S, Sharma A. Racemose neurocysticercosis: A rare cause of chronic meningitis. Online J Health Allied Sci. 2014;13(1).
- 155. Leite CC, Jinkins JR, Escobar BE, Magalhães AC, Gomes GC, Dib G, et al. MR imaging of intramedullary and intradural-extramedullary spinal cysticercosis. AJR Am J Roentgenol. 1997 Dec;169(6):1713–7. pmid:9393195
- 156. Lobato RD, Lamas E, Portillo JM, Roger R, Esparza J, Rivas JJ, et al. Hydrocephalus in cerebral cysticercosis. Pathogenic and therapeutic considerations. J Neurosurg. 1981 Nov;55(5):786–93. pmid:7310501
- 157. Loyo M, Kleriga E, Estanol B. Fourth ventricular cysticercosis. Neurosurgery. 1980 Nov;7(5):456–8. pmid:7442989
- 158. Nash TE, Ware JM, Coyle CM, Mahanty S. Etanercept to control inflammation in the treatment of complicated neurocysticercosis. Am J Trop Med Hyg. 2019;100(3):609–16. pmid:30608049
- 159. Rubalcava MA, Sotelo J. Differences between ventricular and lumbar cerebrospinal fluid in hydrocephalus secondary to cysticercosis. Neurosurgery. 1995 Oct;37(4):668–71; discussion 671–672. pmid:8559294
- 160. Ruiz-Garcia M, Gonzalez-Astiazaran A, Rueda-Franco F. Neurocysticercosis in children. Clinical experience in 122 patients. Childs Nerv Syst. 1997 Dec;13(11–12):608–12. pmid:9454978
- 161. Shenoy SN, Raja A. Spinal neurenteric cyst. Report of 4 cases and review of the literature. Pediatr Neurosurg [Internet]. 2004 Dec;40(6):284–92. Available from: https://www.ncbi.nlm.nih.gov/pubmed/15821359. pmid:15821359
- 162. Sotelo J, Marin C. Hydrocephalus secondary to cysticercotic arachnoiditis. A long-term follow-up review of 92 cases. J Neurosurg. 1987 May;66(5):686–9. pmid:3572494
- 163. Soto-Hernandez JL, Gomez-Llata Andrade S, Rojas-Echeverri LA, Texeira F, Romero V. Subarachnoid hemorrhage secondary to a ruptured inflammatory aneurysm: a possible manifestation of neurocysticercosis: case report. Neurosurgery. 1996 Jan;38(1):197–9; discussion 199–200. pmid:8747971
- 164. Vecchio RFD, Pinzone MR, Nunnari G, Cacopardo B. Neurocysticercosis in a 23-year-old Chinese man. Am J Case Rep. 2014;15:31–4. pmid:24459541
- 165. Wei GZ, Li CJ, Meng JM, Ding MC. Cysticercosis of the central nervous system. A clinical study of 1,400 cases. Chin Med J (Engl). 1988 Jul;101(7):493–500. pmid:3147846
- 166. Ceran N, Turkoglu R, Erdem I, Inan A, Engin D, Tireli H, et al. Neurobrucellosis: clinical, diagnostic, therapeutic features and outcome. Unusual clinical presentations in an endemic region. Braz J Infect Dis. 2011 Feb;15(1):52–9. pmid:21412590
- 167. Kesav P, Vishnu VY, Khurana D. Fatal disseminated neurobrucellosis. QJM Int J Med [Internet]. 2014 Apr 1 [cited 2019 Apr 20];107(4):321–2. Available from: https://academic.oup.com/qjmed/article/107/4/321/1674445. pmid:23792705
- 168. Nashi S, Preethish-Kumar V, Maji S, Chandrashekar N, Polavarapu K, Kashinkunti C, et al. Case Report: Neurobrucellosis with Plastered Spinal Arachnoiditis: A Magnetic Resonance Imaging-Based Report. Am J Trop Med Hyg. 2018;98(3):800–2. pmid:29345223
- 169. Oueslati I, Berriche A, Ammari L, Abdelmalek R, Kanoun F, Kilani B, et al. Epidemiological and clinical characteristics of neurobrucellosis case patients in Tunisia. Med Mal Infect. 2016 May 1;46(3):123–30. pmid:26897309
- 170. Raina S, Sharma A, Sharma R, Bhardwaj A. Neurobrucellosis: A Case Report from Himachal Pradesh, India, and Review of the Literature. Case Rep Infect Dis. 2016;2016:2019535. pmid:27818809
- 171. Erdem H, Inan A, Guven E, Hargreaves S, Larsen L, Shehata G, et al. The burden and epidemiology of community-acquired central nervous system infections: a multinational study. Eur J Clin Microbiol Infect Dis. 2017 Sep 1;36(9):1595–611. pmid:28397100
- 172. Ganesan K, Diwan A, Shankar SK, Desai SB, Sainani GS, Katrak SM. Chikungunya encephalomyeloradiculitis: report of 2 cases with neuroimaging and 1 case with autopsy findings. AJNR Am J Neuroradiol. 2008;29(9):1636–7. pmid:18566010
- 173. Kono R, Miyamura K, Tajiri E, Robin Y, Girard P. Serological studies of radiculomyelitis occurring during the outbreak of acute hemorrhagic conjunctivitis in Senegal in 1970. Jpn J Med Sci Biol. 1976 Apr;29(2):91–4. pmid:184327
- 174. Phuapradit P, Roongwithu N, Limsukon P, Boongird P, Vejjajiva A. Radiculomyelitis complicating acute haemorrhagic conjunctivitis. A clinical study. J Neurol Sci. 1976 Jan;27(1):117–22. pmid:1249577
- 175. Wadia NH, Irani PF, Katrak SM. Lumbosacral radiculomyelitis associated with pandemic acute haemorrhagic conjunctivitis. The Lancet. 1973 Feb 17;1(7799):350–2. pmid:4121939
- 176. Kaiser R. Tick-borne encephalitis in southwestern Germany. Infection. 1996 Oct;24(5):398–9. pmid:8923056
- 177. Marjelund S, Jaaskelainen A, Tikkakoski T, Tuisku S, Vapalahti O. Gadolinium enhancement of cauda equina: A new MR imaging finding in the radiculitic form of tick-borne encephalitis. Am J Neuroradiol. 2006 May;27(5):995–7. pmid:16687530
- 178. Schuler M, Zimmermann H, Altpeter E, Heininger U. Epidemiology of tick-borne encephalitis in Switzerland, 2005 to 2011. Eurosurveillance. 2014;19(13). pmid:24721541
- 179. Avenel G, Goeb V, Abboud P, Ait-Abdesselam T, Vittecoq O. Atypical forms of syphilis: Two cases. Jt Bone Spine Rev Rhum. 2009 May;76(3):293–5. pmid:19289298
- 180. Bruetsch WL. Surgical treatment of syphilitic primary atrophy of the optic nerves (syphilitic optochiasmatic arachnoiditis) a clinicoanatomic study. Arch Dis Child Educ Pract. 1947 Dec;38(6):735–54. pmid:18919403
- 181. Hausman L. Syphilitic arachnoiditis of the optic chiasm. Arch Neurol Psychiatry. 1937;37(4):929–58.
- 182. Hausman L. The surgical treatment of syphilitic optic atrophy due to chiasmal arachnoiditis. Am J Ophthalmol. 1941;24(2):119–32.
- 183. Monticelli J, Bazzocchi G, Luzzati R. A Luetic Cauda Equina Meningoradiculitis Mimicking a Central Nervous System Lymphoma. Sex Transm Dis. 2016 Feb;43(2):122–4. pmid:26766528
- 184. Vail D. Syphilitic Opticochiasmatic Arachnoiditis. Trans Am Ophthalmol Soc. 1938;36:126–44. pmid:16693142
- 185. Marais S, Roos I, Mitha A, Mabusha SJ, Patel V, Bhigjee AI. Spinal Tuberculosis: Clinicoradiological Findings in 274 Patients. Clin Infect Dis Off Publ Infect Dis Soc Am. 2018 Jun 18;67(1):89–98. pmid:29340585
- 186. Singh AK, Malhotra HS, Garg RK, Jain A, Kumar N, Kohli N, et al. Paradoxical reaction in tuberculous meningitis: presentation, predictors and impact on prognosis. BMC Infect Dis. 2016 21;16:306. pmid:27329253
- 187. Abo YN, Curtis N, Butters C, Rozen TH, Marais BJ, Gwee A. SUCCESSFUL TREATMENT OF A SEVERE VISION-THREATENING PARADOXICAL TUBERCULOUS REACTION WITH INFLIXIMAB: FIRST PEDIATRIC USE. Pediatr Infect Dis J. 2020 Jan 13.; pmid:31939874
- 188. Amour M, Matuja SS, Chin JH. Medical management of acute loss of vision in tuberculous meningitis: A case report. J Clin Tuberc Mycobact Dis. 2020 May;19:100145. pmid:32021909
- 189. Gourie-Devi M, Satishchandra P. Hyaluronidase as an adjuvant in the management of tuberculous spinal arachnoiditis. J Neurol Sci. 1991 Mar;102(1):105–11. pmid:1856727
- 190. Aditya GS, Mahadevan A, Santosh V, Chickabasaviah YT, Ashwathnarayanarao CB, Krishna SS. Cysticercal chronic basal arachnoiditis with infarcts, mimicking tuberculous pathology in endemic areas. Neuropathol Off J Jpn Soc Neuropathol [Internet]. 2004;24(4):320–5. Available from: https://www.ncbi.nlm.nih.gov/pubmed/15641592. pmid:15641592
- 191. Ameli NO. Recurrent attacks of raised intracranial pressure in case of tuberculous arachnoiditis. Acta Med Iran. 1960 Aug;3:35–9. pmid:13860936
- 192. Andreula CF, Recchia-Luciani ANM. Isolated leptomeningeal spinal tuberculosis: Case report. Riv Neuroradiol. 1998;11(2):211–4.
- 193. Anuradha HK, Garg RK, Agarwal A, Sinha MK, Verma R, Singh MK, et al. Predictors of stroke in patients of tuberculous meningitis and its effect on the the outcome. QJM Mon J Assoc Physicians. 2010 Sep;103(9):671–8.
- 194. Blaivas AJ, Lardizabal A, Macdonald R. Two unusual sequelae of tuberculous meningitis despite treatment. South Med J [Internet]. 2005;98(10):1028–30. Available from: https://www.ncbi.nlm.nih.gov/pubmed/16295818. pmid:16295818
- 195. Canova G, Boaro A, Giordan E, Longatti P. Treatment of Posttubercular Syringomyelia Not Responsive to Antitubercular Therapy: Case Report and Review of Literature. J Neurol Surg Rep. 2017 Apr;78(2):e59–67. pmid:28428929
- 196. Chandra J, Sen S, Mandal Ravi RN, Bagga V, Sharma D. Tubercular spinal arachnoiditis with radiculomyelopathy. Indian J Pediatr. 1989 Oct;56(5):670–4. pmid:2632442
- 197. Chotmongkol V, Kitkuandee A, Limpawattana P. Tuberculous radiculomyelitis (arachnoiditis) associated with tuberculous meningitis. Southeast Asian J Trop Med Public Health [Internet]. 2005;36(3):722–4. Available from: https://www.ncbi.nlm.nih.gov/pubmed/16124445. pmid:16124445
- 198. Chotmongkol V, Panthavasit J, Tiamkao S, Jitpimolmard S. Tuberculous meningitis in adults: a four-year review during 1997–2000. Southeast Asian J Trop Med Public Health. 2003 Dec;34(4):869–71. pmid:15115102
- 199. Deiva K, Sothratanak S, Husson B, Chevret L, Landrieu P. Febrile Brain Stroke and Tuberculous Meningitis: Persisting Threat in Non-Endemic Countries. Neuropediatrics [Internet]. 2010 Dec [cited 2019 May 3];41(06):273–5. Available from: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0031-1273706. pmid:21445820
- 200. Dhawan SR, Chatterjee D, Radotra BD, Vaidya PC, Vyas S, Sankhyan N, et al. A Child with Tuberculous Meningitis Complicated by Cortical Venous and Cerebral Sino-Venous Thrombosis. Indian J Pediatr. 2019 Apr 10;86(4):371–8. pmid:30623313
- 201. Dhawan SR, Gupta A, Singhi P, Sankhyan N, Malhi P, Khandelwal N. Predictors of Neurological Outcome of Tuberculous Meningitis in Childhood: A Prospective Cohort Study From a Developing Country. J Child Neurol. 2016;31(14):1622–7. pmid:27655469
- 202. Elavarasi A, Dash D, Warrier AR, Jain D. Leptomeningeal leukaemia misdiagnosed as tubercular meningitis. BMJ Case Rep. 2019 Mar 5;12(3). pmid:30842137
- 203. Fehlings MG, Bernstein M. Syringomyelia as a complication of tuberculous meningitis. Can J Neurol Sci J Can Sci Neurol. 1992 Feb;19(1):84–7. pmid:1562914
- 204. Feng Y, Guo N, Huang F, Chen X, Sun Q, Liu J, et al. Radiculomyelitis due to atypical tuberculous infection: 4 cases report. J Neurol Neurosurg Psychiatry. 2011 May;82(5):585–7. pmid:20581415
- 205. Freilich D, Swash M. Diagnosis and management of tuberculous paraplegia with special reference to tuberculous radiculomyelitis. J Neurol Neurosurg Psychiatry. 1979 Jan;42(1):12–8. pmid:762581
- 206. Gimenez-Roldan S, Esteban A, Benito C. Communicating syringomyelia following cured tuberculous meningitis. J Neurol Sci. 1974 Oct;23(2):185–97. pmid:4547786
- 207. Gomez AJ, Ziegler DK. Myelopathy-arachnoiditis secondary to tuberculous meningitis. A case report and review of the literature. J Nerv Ment Dis. 1966 Jan;142(1):94–100. pmid:5931174
- 208. Gonzalez-Saldana N, Hernandez-Porras M, Macias-Parra M, Monroy-Colin VA, Acebo-Arcentales JJ, Juarez-Olguin H. Tuberculous meningitis: Symptoms, diagnosis and evaluation experienced in 532 patients in a pediatric hospital. Asian Pac J Trop Dis. 2016 Mar 1;6(3):208–11.
- 209. Goyal V, Elavarasi A, Abhishek Abhishek null, Shukla G, Behari M. Practice Trends in Treating Central Nervous System Tuberculosis and Outcomes at a Tertiary Care Hospital: A Cohort Study of 244 Cases. Ann Indian Acad Neurol. 2019 Mar;22(1):37–46. pmid:30692758
- 210. Gupta A, Garg RK, Singh MK, Verma R, Malhotra HS, Sankhwar SN, et al. Bladder dysfunction and urodynamic study in tuberculous meningitis. J Neurol Sci. 2013 Apr 15;327(1–2):46–54. pmid:23472924
- 211. Gupta R, Garg RK, Jain A, Malhotra HS, Verma R, Sharma PK. Spinal cord and spinal nerve root involvement (myeloradiculopathy) in tuberculous meningitis. Medicine (Baltimore). 2015 Jan;94(3):e404. pmid:25621686
- 212. Hernández-Albújar S, Arribas JR, Royo A, González-García JJ, Peña JM, Vázquez JJ. Tuberculous radiculomyelitis complicating tuberculous meningitis: case report and review. Clin Infect Dis Off Publ Infect Dis Soc Am. 2000 Jun;30(6):915–21. pmid:10854362
- 213. Hristea A, Constantinescu RVM, Exergian F, Arama V, Besleaga M, Tanasescu R. Paraplegia due to non-osseous spinal tuberculosis: report of three cases and review of the literature. Int J Infect Dis IJID Off Publ Int Soc Infect Dis. 2008 Jul;12(4):425–9. pmid:18321747
- 214. Hu W, Hudon M, Hui ACF, Chan YL, Kay R. Syrinx and tuberculoma formation in tuberculous arachnoiditis. Can J Neurol Sci. 2001;28(2):148–9. pmid:11383941
- 215. Huang LK, Lin CM, Chen CJ, Hu CJ. Diagnosis of Chronic Leptomeningitis by Using Meningeal Biopsy: A Case Report of Tuberculous Meningitis. Acta Neurol Taiwanica. 2017;26(3):5. pmid:29468622
- 216. John JF, Douglas RG. Tuberculous arachnoiditis. J Pediatr. 1975 Feb;86(2):235–7. pmid:1111686
- 217. Kaynar MY, Koçer N, Gençosmanoğlu BE, Hancı M. Syringomyelia—As a Late Complication of Tuberculous Meningitis. Acta Neurochir (Wien) [Internet]. 2000 Aug 30 [cited 2019 Apr 20];142(8):935–9. Available from: http://link.springer.com/10.1007/s007010070081. pmid:11086834
- 218. Konar SK, Rao KN, Mahadevan A, Devi BI. Tuberculous lumbar arachnoiditis mimicking conus cauda tumor: A case report and review of literature. J Neurosci Rural Pract [Internet]. 2011 [cited 2019 Apr 20];2(1):93–6. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123009/. pmid:21716842
- 219. Lee JS, Song GS, Son DW. Surgical Management of Syringomyelia Associated with Spinal Adhesive Arachnoiditis, a Late Complication of Tuberculous Meningitis: A Case Report. Korean J Neurotrauma. 2017 Apr;13(1):34–8. pmid:28512616
- 220. Liao PW, Chiang TR, Lee MC, Huang CH. Tuberculosis with meningitis, myeloradiculitis, arachnoiditis and hydrocephalus: a case report. Acta Neurol Taiwanica. 2010 Sep;19(3):189–93. pmid:20824539
- 221. Lifeso RM, Weaver P, Harder EH. Tuberculous spondylitis in adults. J Bone Joint Surg Am. 1985 Dec;67(9):1405–13. pmid:4077912
- 222. Lolekha R, Chokephaibulkit K, Vanprapar N, Phongsamart W, Chearskul S. Breakthrough neurological manifestation during appropriate antituberculous therapy of miliary tuberculosis. Southeast Asian J Trop Med Public Health [Internet]. 2003;34(3):634–5. Available from: https://www.ncbi.nlm.nih.gov/pubmed/15115142. pmid:15115142
- 223. Lolge S, Chawla A, Shah J, Patkar D, Seth M. MRI of spinal intradural arachnoid cyst formation following tuberculous meningitis. Br J Radiol [Internet]. 2004;77(920):681–4. Available from: https://www.ncbi.nlm.nih.gov/pubmed/15326049. pmid:15326049
- 224. Maheswari EU, Bhoopathy RM, Bhanu K, Anandan H. Clinical Spectrum of Central Nervous System Tuberculosis and the Efficacy of Revised National Tuberculosis Control Program in its Management. J Neurosci Rural Pract. 2019 Mar;10(1):71–7. pmid:30765974
- 225. Malhotra HS, Garg RK, Lalla R, Gupta A. Paradoxical extensive thoracolumbosacral arachnoiditis in a treated patient of tuberculous meningitis. BMJ Case Rep. 2012 Jul 9;2012.
- 226. Marais S, Meintjes G, Pepper DJ, Dodd LE, Schutz C, Ismail Z, et al. Frequency, Severity, and Prediction of Tuberculous Meningitis Immune Reconstitution Inflammatory Syndrome. Clin Infect Dis Off Publ Infect Dis Soc Am [Internet]. 2013 Feb 1 [cited 2019 May 11];56(3):450–60. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540040/.
- 227. Marais S, Roos I, Mitha A, Patel V, Bhigjee AI. Posttubercular syringomyelia in HIV-infected patients: A report of 10 cases and literature review. J Neurol Sci. 2018 Dec 15;395:54–61. pmid:30292964
- 228. Merkler AE, Reynolds AS, Gialdini G, Morris NA, Murthy SB, Thakur K, et al. Neurological Complications after Tuberculous Meningitis in a Multi-State Cohort in the United States. J Neurol Sci [Internet]. 2017 Apr 15 [cited 2020 Aug 6];375:460–3. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549847/. pmid:28320186
- 229. Moghtaderi A, Alavi Naini R. Tuberculous radiculomyelitis: review and presentation of five patients. Int J Tuberc Lung Dis Off J Int Union Tuberc Lung Dis [Internet]. 2003;7(12):1186–90. Available from: https://www.ncbi.nlm.nih.gov/pubmed/14677894. pmid:14677894
- 230. Moghtaderi A, Alavi-Naini R, Rahimi-Movaghar V. Tuberculous myelopathy: current aspects of neurologic sequels in the southeast of Iran. Acta Neurol Scand. 2006 Apr;113(4):267–72. pmid:16542167
- 231. Narayanan S, Prakash D, Subramaniam G. Bilateral primary optic neuropathy as the presenting manifestation of tuberculosis in an immunocompetent patient. IDCases [Internet]. 2019 Jul 11 [cited 2019 Dec 22];18. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656685/.
- 232. Nema N, Verma A, Singh K, Mehar V. Management of paradoxical response in pediatric tubercular meningitis with methylprednisolone. Middle East Afr J Ophthalmol. 2014 Jun;21(2):189–92. pmid:24791114
- 233. Nissenbaum M. Neurotrophic arthropathy of the shoulder secondary to tuberculous arachnoiditis: a case report. Clin Orthop. 1976 Aug;(118):169–72. pmid:954273
- 234. Ozkok A, Elcioglu OC, Akpinar TS, Kara E, Tufan F, Cagatay A. Tuberculous meningitis together with systemic brucellosis. J Infect Chemother. 2012 Jun;18(3):403–5. pmid:22033577
- 235. Pandit L, Agrawal A, Mudgal S, Achar P. Tuberculous spinal meningitis: A treatable cause of myeloradiculopathy. Infect Dis Clin Pract. 2009 Jul;17(4):281–2.
- 236. Pasco PM. Diagnostic features of tuberculous meningitis: a cross-sectional study. BMC Res Notes [Internet]. 2012 Dec [cited 2020 Jan 4];5(1):49. Available from: https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-5-49. pmid:22264254
- 237. Poon TL, Ho WS, Pang KY, Wong CK. Tuberculous meningitis with spinal tuberculous arachnoiditis. Hong Kong Med J Xianggang Yi Xue Za Zhi [Internet]. 2003;9(1):59–61. Available from: https://www.ncbi.nlm.nih.gov/pubmed/12547960. pmid:12547960
- 238. Pruthi N, Vora TK, Shukla DP. Craniovertebral Junction Arachnoiditis: An Unusual Sequelae to Tuberculous Meningitis. J Neurosci Rural Pract [Internet]. 2019 Oct [cited 2019 Dec 20];10(4):711–4. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906089/. pmid:31831994
- 239. Purkayastha S, Bodhey NK, Gupta AK, Kesavadas C. MRI features of tubercular spinal arachnoiditis: A case report. Riv Neuroradiol. 2005 Jun;18(3):386–9.
- 240. Ramachandran V, Barry J, Abughali N, Friedman NR, Staugaitis SM, Goldfarb J. Tuberculous radiculomyelitis presenting in a toddler with lower extremity weakness and seizure. Pediatr Infect Dis J. 2013 Aug;32(8):919–21. pmid:23624430
- 241. Sangani SV, Parikh S. Can sonographic measurement of optic nerve sheath diameter be used to detect raised intracranial pressure in patients with tuberculous meningitis? A prospective observational study. Indian J Radiol Imaging. 2015 Jun;25(2):173–6. pmid:25969641
- 242. Schoeman JF, Andronikou S, Stefan DC, Freeman N, van Toorn R. Tuberculous meningitis-related optic neuritis: recovery of vision with thalidomide in 4 consecutive cases. J Child Neurol. 2010 Jul;25(7):822–8. pmid:20519667
- 243. Sethi D, Gupta M, Sood S. Cauda equina syndrome after spinal anaesthesia in a patient with asymptomatic tubercular arachnoiditis. Indian J Anaesth. 2011 Jul;55(4):375–7. pmid:22013254
- 244. Sharma A, Goyal M, Mishra NK, Gupta V, Gaikwad SB. MR imaging of tubercular spinal arachnoiditis. AJR Am J Roentgenol. 1997 Mar;168(3):807–12. pmid:9057539
- 245. Sil K, Chatterjee S. Shunting in tuberculous meningitis: a neurosurgeon’s nightmare. Childs Nerv Syst ChNS Off J Int Soc Pediatr Neurosurg. 2008 Sep;24(9):1029–32. pmid:18437392
- 246. Silverman IE, Liu GT, Bilaniuk LT, Volpe NJ, Galetta SL. Tuberculous meningitis with blindness and perichiasmal involvement on MRI. Pediatr Neurol. 1995 Jan;12(1):65–7. pmid:7748365
- 247. Sinha MK, Garg RK, Hk A, Agarwal A, Singh MK, Verma R, et al. Vision impairment in tuberculous meningitis: predictors and prognosis. J Neurol Sci. 2010 Mar 15;290(1–2):27–32. pmid:20056252
- 248. Sivalingam J, Kumar A, Rajasekhar KV. Non-osseous tubercular lesions of spinal and paraspinal region-evaluation by MRI. J Clin Diagn Res. 2019 Feb 1;13(2):TC06–TC10.
- 249. Sridhar A, Bhandari JK, Lewis G, Ganesan S, Parepalli S, Abulhoul L. Tuberculous radiculomyelitis presenting as urinary retention in a child with Down’s syndrome. BMJ Case Rep. 2012 Apr 2;2012.
- 250. Srivastava T, Kochar DK. Asymptomatic spinal arachnoiditis in patients with tuberculous meningitis. Neuroradiology. 2003 Oct;45(10):727–9. pmid:14504848
- 251. Suresh TN, Mahadevan A, Santosh V, Shankar SK. Subarachnoid spread of germinoma mimicking tuberculous meningitis. Neurol India. 2004 Jun;52(2):251–3. pmid:15269485
- 252. Suryapraba AAA, Susilawathi NM, Niryana IW. Central Nervous System Tuberculoma Complicated with Spinal Arachnoiditis in Immunocompetent Patient. Open Access Maced J Med Sci [Internet]. 2019 Jun 30 [cited 2019 Dec 22];7(12):2002–5. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684426/. pmid:31406545
- 253. Synmon B, Das M, Kayal AK, Goswami M, Sarma J, Basumatary L, et al. Clinical and radiological spectrum of intracranial tuberculosis: A hospital based study in Northeast India. Indian J Tuberc. 2017 Apr;64(2):109–18. pmid:28410693
- 254. Tanriverdi T, Kizilkiliç O, Hanci M, Kaynar MY, Ünalan H, Oz B. Atypical intradural spinal tuberculosis: report of three cases. Spinal Cord [Internet]. 2003 Jul [cited 2019 Apr 21];41(7):403–9. Available from: http://www.nature.com/articles/3101463. pmid:12815372
- 255. Umerah B, Singarayar J. Tuberculous arachnoiditis. A case report from central Africa and a brief review of the disease. Med J Zambia. 1977 May;11(2):55–7.
- 256. Vaishnav B, Suthar N, Shaikh S, Tambile R. Clinical study of spinal tuberculosis presenting with neuro-deficits in Western India. Indian J Tuberc. 2019 Jan;66(1):81–6. pmid:30797289
- 257. Vassileva E, Klissurski M, Daskalov M. Transcranial doppler in tuberculous meningitis: A case study. Acta Clin Croat [Internet]. 2004 Jun;43(2):137–41. Available from: https://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=22116.
- 258. Well GTJ van, Paes BF, Terwee CB, Springer P, Roord JJ, Donald PR, et al. Twenty Years of Pediatric Tuberculous Meningitis: A Retrospective Cohort Study in the Western Cape of South Africa. Pediatrics [Internet]. 2009 Jan 1 [cited 2019 May 11];123(1):e1–8. Available from: https://pediatrics.aappublications.org/content/123/1/e1. pmid:19367678
- 259. Yuhl ET, Rand CW. Tuberculous opticochiasmatic arachnoiditis; report of a case. J Neurosurg. 1951 Jul;8(4):441–3. pmid:14851018
- 260. Cosan TE, Kabukcuoglu S, Arslantas A, Atasoy MA, Dogan N, Ozgunes I, et al. Spinal toxoplasmic arachnoiditis associated with osteoid formation: a rare presentation of toxoplasmosis. Spine [Internet]. 2001 Aug 1;26(15):1726–8. Available from: https://www.ncbi.nlm.nih.gov/pubmed/11474362. pmid:11474362
- 261. Ali M, Safriel Y, Sohi J, Llave A, Weathers S. West Nile Virus Infection: MR Imaging Findings in the Nervous System. Am J Neuroradiol [Internet]. 2005 Feb 1 [cited 2019 May 15];26(2):289–97. Available from: http://www.ajnr.org/content/26/2/289. pmid:15709126
- 262. Hwang J, Ryu HS, Kim H, Lee SA. The first reported case of West Nile encephalitis in Korea. J Korean Med Sci. 2015 Mar;30(3):343–5. pmid:25729260
- 263. Park M, Hui JS, Bartt RE. Acute anterior radiculitis associated with West Nile virus infection. J Neurol Neurosurg Psychiatry. 2003 Jun;74(6):823–5. pmid:12754368
- 264. Scholz S, Kaas B, Simpkins A, Lyons J, Venkatesan A, Probasco J. Brachial plexitis preceding encephalomyelitis in a patient with West Nile virus infection. BMJ Case Rep. 2013 Dec 5;2013.
- 265. Huang CT, Chang MY, Chang CJ, Hsieh CT, Huang JS. Sparganosis of the cauda equina: A rare case report and review of the literature. Neurol India. 2012 Feb;60(1):102–3. pmid:22406793
- 266. Maretić T, Perović M, Vince A, Lukas D, Dekumyoy P, Begovac J. Meningitis and radiculomyelitis caused by Angiostrongylus cantonensis. Emerg Infect Dis. 2009 Jun;15(6):996–8. pmid:19523323
- 267. McAuliffe L, Fortin Ensign S, Larson D, Bavaro M, Yetto J, Cathey M, et al. Severe CNS angiostrongyliasis in a young marine: a case report and literature review. Lancet Infect Dis. 2018 Nov 16.;
- 268. Noiphithak R, Doungprasert G. A case of disseminated central nervous system sparganosis. Surg Neurol Int. 2016;7(Suppl 39):S958–61. pmid:28031991
- 269. Park JH, Park YS, Kim JS, Roh SW. Sparganosis in the lumbar spine: report of two cases and review of the literature. J Korean Neurosurg Soc. 2011 Apr;49(4):241–4. pmid:21607186
- 270. Schmutzhard E, Boongird P, Vejjajiva A. Eosinophilic meningitis and radiculomyelitis in Thailand, caused by CNS invasion of Gnathostoma spinigerum and Angiostrongylus cantonensis. J Neurol Neurosurg Psychiatry. 1988 Jan;51(1):80–7. pmid:3351533
- 271. Suksathien R, Kunadison S, Wongfukiat O, Ingkasuthi K. Spinal Gnathostomiasis: A Case Report with Magnetic Resonance Imaging and Electrophysiological Findings. J Med Assoc Thail Chotmaihet Thangphaet. 2016 Dec;99(12):1367–71. pmid:29953176
- 272. Mehta R, Soares CN, Medialdea-Carrera R, Ellul M, da Silva MTT, Rosala-Hallas A, et al. The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series. PLoS Negl Trop Dis. 2018;12(2):e0006212. pmid:29432457
- 273. Beaufrère A, Bessières B, Bonnière M, Driessen M, Alfano C, Couderc T, et al. A clinical and histopathological study of malformations observed in fetuses infected by the Zika virus. Brain Pathol [Internet]. 2019 [cited 2019 Apr 10];29(1):114–25. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/bpa.12644. pmid:30020561
- 274. Aldrete JA, Brown TL. Intrathecal hematoma and arachnoiditis after prophylactic blood patch through a catheter. Anesth Analg. 1997 Jan;84(1):233–4. pmid:8989043
- 275. Aldrete JA, Vascello LA, Ghaly R, Tomlin D. Paraplegia in a patient with an intrathecal catheter and a spinal cord stimulator. Anesthesiology. 1994;81(6):1542–5. pmid:7992925
- 276. Avidan A, Gomori MJ, Davidson E. Nerve root inflammation demonstrated by magnetic resonance imaging in a patient with transient neurologic symptoms after intrathecal injection of lidocaine. Anesthesiology. 2002;97(1):257–8. pmid:12131127
- 277. Bhargava P, Wicken C, Smith MD, Strowd RE, Cortese I, Reich DS, et al. Trial of intrathecal rituximab in progressive multiple sclerosis patients with evidence of leptomeningeal contrast enhancement. Mult Scler Relat Disord. 2019 Feb 11;30:136–40. pmid:30771580
- 278. Devulder J. Hyperalgesia induced by high-dose intrathecal sufentanil in neuropathic pain. J Neurosurg Anesthesiol. 1997 Apr;9(2):146–8. pmid:9100184
- 279. Huang M, Dalm B, Simpson RK. Toxic Myelitis and Arachnoiditis After Intrathecal Delivery of Bupivacaine via an Implanted Drug Delivery System: Case Report and Review of the Literature. Cureus. 2018 Feb 27;10(2):e2240. pmid:29719742
- 280. Kochany JZ, Tran ND, Sarria JE. Increasing back and radicular pain 2 years following intrathecal pump implantation with review of arachnoiditis. Pain Med Malden Mass. 2013 Nov;14(11):1658–63. pmid:23889758
- 281. Kubota M, Shin M, Taniguchi M, Terao T, Nakauchi J, Takahashi H. Syringomyelia caused by intrathecal remnants of oil-based contrast medium. J Neurosurg Spine. 2008 Feb;8(2):169–73. pmid:18248289
- 282. Moens M, De Smedt A, Marien P, Brouns R. Intrathecal bupivacaine for arachnoiditis ossificans: a case report. Clin Neurol Neurosurg. 2013 Jul;115(7):1162–3. pmid:23040246
- 283. Paddison RM, Alpers BJ. Role of intrathecal detergents in pathogenesis of adhesive arachnoiditis. M Arch Neurol Psychiatry. 1954 Jan;71(1):87–100. pmid:13123573
- 284. Reisner LS, Hochman BN, Plumer MH. Persistent neurologic deficit and adhesive arachnoiditis following intrathecal 2-chloroprocaine injection. Anesth Analg. 1980 Jun;59(6):452–4. pmid:7189987
- 285. Rincon F, Mocco J, Komotar RJ, Khandji AG, McCormick PC, Olarte M. Chronic myelopathy due to a giant spinal arachnoid cyst: a complication of the intrathecal injection of phenol. Case report. J Neurosurg Spine. 2008 Apr;8(4):390–3. pmid:18377326
- 286. Stark AM, Barth H, Grabner JP, Mehdorn HM. Accidental intrathecal mercury application. Eur Spine J. 2004 May;13(3):241–3. pmid:14586664
- 287. Teodorczyk J, Szmuda T, Siemiński M, Lass P, Słoniewski P. Evaluation of usefulness of scintigraphic imaging in diagnosis of intrathecal drug delivery system malfunction—a preliminary report. Pol J Radiol. 2013 Jul;78(3):21–7. pmid:24115956
- 288. Tkaczuk H. Intrathecal prednisolone therapy in postoperative arachnoiditis following operation of herniated disc. Acta Orthop Scand. 1976 Aug;47(4):388–90. pmid:989244
- 289. Vivek V, Kavar B, Hogg M, Eisen DP, Butzkueven H. Aspergillus arachnoiditis post intrathecal baclofen pump insertion. J Clin Neurosci Off J Neurosurg Soc Australas. 2013 Aug;20(8):1159–60. pmid:23685108
- 290. Ward M, Mammis A, Barry MT, Heary RF. Novel Association Between Intrathecal Drug Administration and Arachnoiditis Ossificans. World Neurosurg. 2018 Jul;115:400–6. pmid:29747017
- 291. Wormdal OM, Flægstad T, Stokland T. Treatment of two cases on the same day of intrathecal methotrexate overdose using cerebrospinal fluid exchange and intrathecal instillation of carboxypeptidase-G2. Pediatr Hematol Oncol. 2018 Sep;35(5–6):350–4. pmid:30672361
- 292. Bassan R, Masciulli A, Intermesoli T, Audisio E, Rossi G, Pogliani EM, et al. Randomized trial of radiation-free central nervous system prophylaxis comparing intrathecal triple therapy with liposomal cytarabine in acute lymphoblastic leukemia. Haematologica [Internet]. 2015 Jun [cited 2019 Apr 6];100(6):786–93. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450624/. pmid:25749825
- 293. Bay A, Oner AF, Etlik O, Yilmaz C, Caksen H. Myelopathy due to intrathecal chemotherapy: report of six cases. J Pediatr Hematol Oncol [Internet]. 2005 May;27(5):270–2. Available from: https://www.ncbi.nlm.nih.gov/pubmed/15891563. pmid:15891563
- 294. Bradley AM, Buie LW, Kuykendal A, Voorhees PM. Successful use of intrathecal carboxypeptidase g2 for intrathecal methotrexate overdose: A case study and review of the literature. Clin Lymphoma Myeloma Leuk. 2013 Apr;13(2):166–70. pmid:23084403
- 295. Chamberlain MC, Glantz MJ. Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia [1]. Blood. 2007 Sep 1;110(5):1698.
- 296. Chamberlain MC, Johnston SK, Horn A, Glantz MJ. Recurrent lymphomatous meningitis treated with intra-CSF rituximab and liposomal ara-C. J Neurooncol. 2009;91(3):271–7. pmid:18820836
- 297. Denier C, Tertian G, Ribrag V, Lozeron P, Bilhou-Nabera C, Lazure T, et al. Multifocal deficits due to leukemic meningoradiculitis in chronic lymphocytic leukemia. J Neurol Sci. 2009 Feb 15;277(1–2):130–2. pmid:19100998
- 298. Duarte RF, Arnan M, Sanchez-Ortega I, de Llano MPQ, Abellan PF. Clinical experience using intrathecal liposomal cytarabine to manage neoplastic meningitis in three patients with acute promyelocytic leukemia. Leuk Res. 2011 Jul;35(7):e128–30. pmid:21501870
- 299. Dufourg MN, Landman-Parker J, Auclerc MF, Schmitt C, Perel Y, Michel G, et al. Age and high-dose methotrexate are associated to clinical acute encephalopathy in FRALLE 93 trial for acute lymphoblastic leukemia in children. Leukemia. 2007 Feb;21(2):238–47. pmid:17170721
- 300. Duttera MJ, Bleyer WA, Pomeroy TC, Leventhal CM, Leventhal BG. Irradiation, methotrexate toxicity, and the treatment of meningeal leukaemia. The Lancet. 1973 Sep 29;2(7831):703–7.
- 301. Gallego Perez-Larraya J, Palma JA, Carmona-Iragui M, Fernandez-Torron R, Irimia P, Rodriguez-Otero P, et al. Neurologic complications of intrathecal liposomal cytarabine administered prophylactically to patients with non-Hodgkin lymphoma. J Neurooncol. 2011 Jul;103(3):603–9. pmid:20953897
- 302. García-Recio M, Cladera A, Bento L, Dominguez J, Ruiz de Gracia S, Sartori F, et al. Analysis of the role of intratecal liposomal cytarabine in the prophylaxis and treatment of central nervous system lymphomatosis: The Balearic Lymphoma Group experience. PLoS ONE [Internet]. 2017 Jun 30 [cited 2019 Apr 6];12(6). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493300/. pmid:28665999
- 303. Glantz MJ, LaFollette S, Jaeckle KA, Shapiro W, Swinnen L, Rozental JR, et al. Randomized trial of a slow-release versus a standard formulation of cytarabine for the intrathecal treatment of lymphomatous meningitis. J Clin Oncol. 1999 Oct;17(10):3110–6. pmid:10506606
- 304. Hilgendorf I, Wolff D, Junghanss C, Kahl C, Leithaeuser M, Steiner B, et al. Neurological complications after intrathecal liposomal cytarabine application in patients after allogeneic haematopoietic stem cell transplantation. Ann Hematol. 2008 Dec;87(12):1009–12. pmid:18704421
- 305. Jabbour E, O’Brien S, Kantarjian H, Garcia-Manero G, Ferrajoli A, Ravandi F, et al. Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia. Blood. 2007 Apr 15;109(8):3214–8. pmid:17209054
- 306. Levinsen M, Harila-Saari A, Grell K, Jonsson OG, Taskinen M, Abrahamsson J, et al. Efficacy and Toxicity of Intrathecal Liposomal Cytarabine in First-line Therapy of Childhood Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2016;38(8):602–9. pmid:27571129
- 307. Pillon M, Di Tullio MT, Garaventa A, Cesaro S, Putti MC, Favre C, et al. Long-term results of the first Italian Association of Pediatric Hematology and Oncology protocol for the treatment of pediatric B-cell non-Hodgkin lymphoma (AIEOP LNH92). Cancer. 2004 Jul 15;101(2):385–94. pmid:15241838
- 308. Potter SLP, Berg S, Ingle AM, Krailo M, Adamson PC, Blaney SM. Phase 2 clinical trial of intrathecal topotecan in children with refractory leptomeningeal leukemia: a Children’s Oncology Group trial (P9962). Pediatr Blood Cancer. 2012 Mar;58(3):362–5. pmid:21910214
- 309. Salzer WL, Devidas M, Carroll WL, Winick N, Pullen J, Hunger SP, et al. Long-term results of the pediatric oncology group studies for childhood acute lymphoblastic leukemia 1984–2001: A report from the children’s oncology group. Leukemia. 2010 Feb;24(2):355–70. pmid:20016527
- 310. Sanchez-Gonzalez B, Llorente A, Sancho JM, Panizo C, Guinea JM, Cladera A, et al. A new modified prophylactic scheme against liposomal cytarabine-induced arachnoiditis in adult patients with lymphoma. Leuk Lymphoma. 2013 Apr;54(4):892–3. pmid:22988933
- 311. Segot A, Raffoux E, Lengline E, Thieblemont C, Dombret H, Boissel N, et al. Liposomal cytarabine in prophylaxis or curative treatment of central nervous system involvement in Burkitt leukemia/lymphoma. Ann Hematol. 2015 Nov;94(11):1859–63. pmid:26280395
- 312. Seif AE, Reilly AF, Rheingold SR. Intrathecal liposomal cytarabine in relapsed or refractory infant and pediatric leukemias: The children s hospital of philadelphia experience and review of the literature. J Pediatr Hematol Oncol. 2010 Nov;32(8):e349–52. pmid:20962675
- 313. Sommer C, Lackner H, Benesch M, Sovinz P, Schwinger W, Moser A, et al. Neuroophthalmological side effects following intrathecal administration of liposomal cytarabine for central nervous system prophylaxis in three adolescents with acute myeloid leukaemia. Ann Hematol. 2008 Nov;87(11):887–90. pmid:18575860
- 314. Suematsu M, Imamura T, Chiyonobu T, Osone S, Hosoi H. Lumbosacral polyradiculopathy after intrathecal chemotherapy in pediatric acute lymphoblastic leukemia. Int J Hematol. 2018 May 1;107(5):499–501. pmid:29470812
- 315. Valentin A, Troppan K, Pfeilstocker M, Nosslinger T, Linkesch W, Neumeister P. Safety and tolerability of intrathecal liposomal cytarabine as central nervous system prophylaxis in patients with acute lymphoblastic leukemia. Leuk Lymphoma. 2014 Aug;55(8):1739–42. pmid:24138308
- 316. Bernardi RJ, Bomgaars L, Fox E, Balis FM, Egorin MJ, Lagattuta TF, et al. Phase I clinical trial of intrathecal gemcitabine in patients with neoplastic meningitis. Cancer Chemother Pharmacol. 2008 Jul;62(2):355–61. pmid:17909804
- 317. Blaney SM, Heideman R, Berg S, Adamson P, Gillespie A, Geyer JR, et al. Phase I Clinical Trial of Intrathecal Topotecan in Patients With Neoplastic Meningitis. J Clin Oncol [Internet]. 2003 Jan 1 [cited 2019 Apr 11];21(1):143–7. Available from: https://ascopubs.org/doi/full/10.1200/JCO.2003.04.053. pmid:12506183
- 318. Blaney SM, Tagen M, Onar-Thomas A, Berg SL, Gururangan S, Scorsone K, et al. A Phase 1 Pharmacokinetic Optimal Dosing Study of Intraventricular Topotecan for Children with Neoplastic Meningitis: A Pediatric Brain Tumor Consortium Study. Pediatr Blood Cancer [Internet]. 2013 Apr [cited 2019 Apr 11];60(4):627–32. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573253/. pmid:23002039
- 319. Bomgaars L, Geyer JR, Franklin J, Dahl G, Park J, Winick NJ, et al. Phase I trial of intrathecal liposomal cytarabine in children with neoplastic meningitis. J Clin Oncol Off J Am Soc Clin Oncol [Internet]. 2004 Oct 1;22(19):3916–21. Available from: https://www.ncbi.nlm.nih.gov/pubmed/15459213. pmid:15459213
- 320. Butto A, Al-Holou WN, Junck L, Sagher O, Fletcher JJ. Fulminant chemical ventriculomeningitis following intrathecal liposomal cytarabine administration. J Clin Neurosci. 2011 Oct;18(10):1417–8. pmid:21764318
- 321. Chamberlain MC. A phase II trial of intra-cerebrospinal fluid alpha interferon in the treatment of neoplastic meningitis. Cancer [Internet]. 2002 May 15;94(10):2675–80. Available from: https://www.ncbi.nlm.nih.gov/pubmed/12173336. pmid:12173336
- 322. Chamberlain MC, Tsao-Wei DD, Groshen S. Phase II trial of intracerebrospinal fluid etoposide in the treatment of neoplastic meningitis. Cancer. 2006 May 1;106(9):2021–7. pmid:16583432
- 323. Fathallah-Shaykh HM, Zimmerman C, Morgan H, Rushing E, Schold SC, Unwin DH. Response of primary leptomeningeal melanoma to intrathecal recombinant interleukin-2. A case report. Cancer. 1996 Apr 15;77(8):1544–50. pmid:8608541
- 324. Hung PC, Chang YC, Hsieh MY, Wu CT. Primary intracranial meningeal melanoma mimicking chronic meningitis: A case report. Pediatr Neonatol. 2019 Oct;60(5):589–91. pmid:30497968
- 325. Jaeckle KA, Phuphanich S, Bent MJ, Aiken R, Batchelor T, Campbell T, et al. Intrathecal treatment of neoplastic meningitis due to breast cancer with a slow-release formulation of cytarabine. Br J Cancer. 2001 Jan;84(2):157–63. pmid:11161370
- 326. Jaeckle KA, Batchelor T, O’Day SJ, Phuphanich S, New P, Lesser G, et al. An open label trial of sustained-release cytarabine (DepoCyt) for the intrathecal treatment of solid tumor neoplastic meningitis. J Neurooncol [Internet]. 2002;57(3):231–9. Available from: https://www.ncbi.nlm.nih.gov/pubmed/12125986. pmid:12125986
- 327. Kaif M, Neyaz A, Shukla S, Husain N. Fulminant leptomeningeal carcinomatosis from a malignant melanoma arising in a cerebellopontine epidermoid cyst: A rare case with diagnostic pointers. Neuropathol Off J Jpn Soc Neuropathol. 2018;38(5):503–9.
- 328. Nygaard R, Kivivuori SM. Treatment for recurrent medulloblastoma with intrathecal liposomal cytarabine and systemic metronomic combination therapy. Anticancer Drugs. 2012 Mar;23(3):342–6. pmid:22156796
- 329. Pan Z, Yang G, Cui J, Li W, Li Y, Gao P, et al. A pilot phase 1 study of intrathecal pemetrexed for refractory leptomeningeal metastases from non-small-cell lung cancer. Front Oncol. 2019;9 (AUG) (no pagination)(838). pmid:31544065
- 330. Pardo-Moreno J, Fernandez C, Arroyo R, Ruiz-Ocana C, Alaez C, Cuadrado ML. Safety of intra-cerebrospinal fluid chemotherapy in onco-haematological patients: a retrospective analysis of 627 interventions. J Neurooncol. 2015 Sep 5;125(2):351–8. pmid:26342710
- 331. Park MJ. Durable Response of Leptomeningeal Metastasis of Breast Cancer to Salvage Intrathecal Etoposide After Methotrexate: A Case Report and Literature Review. Am J Case Rep. 2015 Aug 10;16:524–7. pmid:26258900
- 332. Thomas DA, Jabbour E, Kantarjian H, O’Brien S. Neurologic toxicity of intrathecal liposomal cytarabine when used for CNS prophylaxis in conjunction with the hyper-CVAD regimen [2]. Blood. 2007 Sep 1;110(5):1698–9.
- 333. Benesch M, Siegler N, Hoff K von, Lassay L, Kropshofer G, Müller H, et al. Safety and toxicity of intrathecal liposomal cytarabine (Depocyte) in children and adolescents with recurrent or refractory brain tumors: a multi-institutional retrospective study. Anticancer Drugs [Internet]. 2009 Oct;20(9):794–9. Available from: Safety and toxicity of intrathecal liposomal cytarabine (Depocyte) in children and adolescents with recurrent or refractory brain tumors: a multi-institutional retrospective study. pmid:19617818
- 334. Blaney SM, Boyett J, Friedman H, Gajjar A, Geyer R, Horowtiz M, et al. Phase I clinical trial of mafosfamide in infants and children aged 3 years or younger with newly diagnosed embryonal tumors: A Pediatric Brain Tumor Consortium Study (PBTC-001). J Clin Oncol. 2005;23(3):525–31. pmid:15659498
- 335. Blaney SM, Kocak M, Gajjar A, Chintagumpala M, Merchant T, Kieran M, et al. Pilot study of systemic and intrathecal mafosfamide followed by conformal radiation for infants with intracranial central nervous system tumors: A pediatric brain tumor consortium study (PBTC-001). J Neurooncol. 2012 Sep;109(3):565–71. pmid:22790443
- 336. Bruggers CS, Friedman HS, Phillips PC, Wiener MD, Hockenberger B, Oakes WJ, et al. Leptomeningeal dissemination of optic pathway gliomas in three children. Am J Ophthalmol. 1991;111(6):719–23. pmid:2039043
- 337. Caroli E, Acqui M, Roperto R, Ferrante L, D’Andrea G. Spinal en plaque meningiomas: a contemporary experience. Neurosurgery. 2004 Dec;55(6):1275–9; discussion 1279. pmid:15574209
- 338. D’Haene N, Coen N, Neugroschl C, Balériaux D, Salmon I. Leptomeningeal dissemination of low-grade intramedullary gliomas: about one case and review. Clin Neurol Neurosurg. 2009 May;111(4):390–4. pmid:19128871
- 339. Gururangan S, Petros WP, Poussaint TY, Hancock ML, Phillips PC, Friedman HS, et al. Phase I trial of intrathecal spartaject busulfan in children with neoplastic meningitis: a Pediatric Brain Tumor Consortium Study (PBTC-004). Clin Cancer Res Off J Am Assoc Cancer Res. 2006 Mar 1;12(5):1540–6. pmid:16533779
- 340. Holtzman RN, Brisson PM, Pearl RE, Gruber ML. Lobular capillary hemangioma of the cauda equina. Case report. J Neurosurg. 1999 Apr;90(2 Suppl):239–41. pmid:10199255
- 341. Jabeen SA, Chowdary AH, Kandadai RM, Uppin MS, Meena AK, Borgohain R, et al. Primary diffuse leptomeningeal gliomatosis: An autopsy case report. Ann Indian Acad Neurol. 2014 Apr;17(2):227–30. pmid:25024582
- 342. Kastenbauer S, Danek A, Klein W, Yousry TA, Bise K, Reifenberger G, et al. Primary diffuse leptomeningeal gliomatosis: Unusual MRI with non-enhancing nodular lesions on the cerebellar surface and spinal leptomeningeal enhancement. J Neurol Neurosurg Psychiatry. 2000 Sep;69(3):385–8. pmid:10945815
- 343. Keith T, Llewellyn R, Harvie M, Roncaroli F, Weatherall MW. A report of the natural history of leptomeningeal gliomatosis. J Clin Neurosci. 2011 Apr;18(4):582–5. pmid:21316246
- 344. Kim SH, Jun DC, Park JS, Heo JH, Kim SM, Kim J, et al. Primary diffuse leptomeningeal gliomatosis: report of a case presenting with chronic meningitis. J Clin Neurol Seoul Korea. 2006 Sep;2(3):202–5. pmid:20396508
- 345. Ko MW, Turkeltaub PE, Lee EB, Gonatas NK, Volpe NJ, Moster ML, et al. Primary diffuse leptomeningeal gliomatosis mimicking a chronic inflammatory meningitis. J Neurol Sci. 2009 Mar 15;278(1–2):127–31. pmid:19135216
- 346. Partap S, Murphy PA, Vogel H, Barnes PD, Edwards MSB, Fisher PG. Liposomal cytarabine for central nervous system embryonal tumors in children and young adults. J Neurooncol. 2011 Jul;103(3):561–6. pmid:20859651
- 347. Pence DM, Kim TH, Levitt SH. Aneurysm, arachnoiditis and intrathecal Au (gold). Int J Radiat Oncol Biol Phys. 1990 May;18(5):1001–4. pmid:2347709
- 348. Shuangshoti S, Shuangshoti S. Primary diffuse leptomeningeal glioblastoma multiforme of brainstem and spinal cord clinically mimicking meningitis: case report and review of literature. J Med Assoc Thai. 1996 Jun;79(6):403–8. pmid:8855617
- 349. Wheen LC, Anderson NE, Baker PCH, Singh VK, Synek BJL. Leptomeningeal infiltration as the presenting manifestation of a malignant glioma. J Clin Neurosci Off J Neurosurg Soc Australas. 2006 Feb;13(2):298–301. pmid:16431108
- 350. Odin M, Runstrom G. Iodized Oils as an AID to the Diagnosis of Lesions of Tihe Spinal Cord and a Contribution to the Knowledge of Adhesive Circumscribed Meningitis. Acta Radiol [Internet]. 1928 Jan [cited 2019 May 13];9(sup7):1–85. Available from: http://www.tandfonline.com/doi/full/10.3109/00016922809136774.
- 351. Ahlgren P. Long term side effects after myelography with watersoluble contrast media: Conturex, Conray Meglumin 282 and Dimer-X. Neuroradiology. 1973 Dec;6(4):206–11. pmid:4772444
- 352. Ahlgren P. Amipaque myelography without late adhesive arachnoid changes. Neuroradiology. 1978 Feb 17;14(5):231–3. pmid:634468
- 353. Barry JF, Harwood-Nash DC, Fitz CR, Byrd SE, Boldt DW. Metrizamide in pediatric myelography. Radiology. 1977 Aug;124(2):409–18. pmid:877281
- 354. Bidstrup P. A case of chronic adhesive arachnoiditis after lumbar myelography with methiodal-sodium. Neuroradiology. 1972 Mar;3(3):157–9. pmid:4363898
- 355. de Villiers PD. Myelography with a water-soluble contrast medium: a revision of technique and a review of results. South Afr Med J Suid-Afr Tydskr Vir Geneeskd. 1977;52(19):751–60. pmid:601652
- 356. Deep NL, Patel AC, Hoxworth JM, Barrs DM. Pantopaque contrast mimicking intracanalicular vestibular schwannoma. The Laryngoscope. 2017;127(8):1916–9. pmid:27726152
- 357. Freilich D. Cauda equina lesion due to thorotrast. Aust N Z J Med. 1983 Jun;13(3):283–4. pmid:6314961
- 358. Gnanalingham KK, Joshi SM, Sabin I. Thoracic arachnoiditis, arachnoid cyst and syrinx formation secondary to myelography with Myodil, 30 years previously. Eur Spine J Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sect Cerv Spine Res Soc. 2006 Oct;15 Suppl 5:661–3. pmid:16944225
- 359. Gopalakrishnan CV, Mishra A, Thomas B. Iophendylate myelography induced thoracic arachnoiditis, arachnoid cyst and syrinx, four decades later. Br J Neurosurg [Internet]. 2010 Dec [cited 2020 Sep 10];24(6):711–3. Available from: http://www.tandfonline.com/doi/full/10.3109/02688697.2010.522746. pmid:20979434
- 360. Gupta SR, Naheedy MH, O’Hara RJ, Rubino FA. Hydrocephalus following iophendylate injection myelography with spontaneous resolution: case report and review. Comput Radiol Off J Comput Tomogr Soc. 1985 Dec;9(6):359–64. pmid:3841504
- 361. Halaburt H, Lester J. Leptomeningeal changes following lumbar myelography with water-soluble contrast media (meglumine iothalamate and methiodal sodium). Neuroradiology. 1973 Apr;5(2):70–6. pmid:4363536
- 362. Hansen EB, Fahrenkrug A, Praestholm J. Late meningeal effects of myelographic contrast media with special reference to metrizamide. Br J Radiol. 1978 May;51(605):321–7. pmid:638401
- 363. Hurteau EF, Baird WC, Sinclair E. Arachnoiditis following the use of iodized oil. J Bone Jt Surg—Am Vol. 1954 Apr;36(A:2):393–400. pmid:13152150
- 364. Hwang SW, Bhadelia RA, Wu J. Thoracic spinal iophendylate-induced arachnoiditis mimicking an intramedullary spinal cord neoplasm. Case report. J Neurosurg Spine. 2008 Mar;8(3):292–4. pmid:18312083
- 365. Irstam L. Lumbar myelography with amipaque. Spine. 1978 Mar;3(1):70–82. pmid:205957
- 366. Irstam L, Rosencrantz M. Water-soluble contrast media and adhesive arachnoiditis. I. Reinvestigation of nonoperated cases. Acta Radiol Diagn (Stockh). 1973 Sep;14(5):497–506. pmid:4357889
- 367. Irstam L, Rosencrantz M. Water-soluble contrast media and adhesive arachnoiditis. II. Reinvestigation of operated cases. Acta Radiol Diagn (Stockh). 1974 Jan;15(1):1–15. pmid:4362555
- 368. Jellinek E. Myodil arachnoiditis: Iatrongenic and forensic illness. Pract Neurol. 2002;2(4):237–9.
- 369. Jensen TS, Hein O. Intraspinal arachnoiditis and hydrocephalus after lumbar myelography using methylglucamine iocarmate. J Neurol Neurosurg Psychiatry. 1978 Feb;41(2):108–12. pmid:305466
- 370. Kaplan AW, Teng SS, Koo AH. CT recognition of thorotrast-induced intracranial and lumbar arachnoiditis. AJNR Am J Neuroradiol. 1984 Jun;5(3):323–5. pmid:6426285
- 371. Krishnamoorthy T, Thomas B. Unknown case. Spine. 2006 Jun 15;31(14):1633–4. pmid:16778701
- 372. Kriss TC, Kriss VM. Symptomatic spinal intradural arachnoid cyst development after lumbar myelography. Case report and review of the literature. Spine. 1997 Mar 1;22(5):568–72. pmid:9076891
- 373. Laitt R, Jackson A, Isherwood I. Patterns of chronic adhesive arachnoiditis following Myodil myelography: the significance of spinal canal stenosis and previous surgery. Br J Radiol. 1996 Aug;69(824):693–8. pmid:8949669
- 374. Lee SK, Kim DH, Kim SH, Lim DJ. Asymptomatic thoracic Pantopaque cyst mimicking an intradural extramedullary lipoma on MR images. Eur Spine J. 2013 May;22 Suppl 3:S321–8. pmid:22610440
- 375. Liliequist B, Lundstrom B. Lumbar myelography and arachnoiditis. Neuroradiology. 1974;7(2):91–4. pmid:4368879
- 376. Ljass FM. Radioisotope myelography with 133Xe. Neuroradiology. 1974;7(1):29–35. pmid:4407647
- 377. Long RW, Rachmaninoff N. Spinal adhesive arachnoiditis with cyst formation: injection of cyst during myelography. J Neurosurg. 1967 Jul;27(1):73–6. pmid:6028873
- 378. On TCE ricks, Baaren H van. LATE MENINGEAL REACTION TO ETHYL IODOPHENYLUNDECYLATE USED IN MYELOGRAPHY: REPORT OF A CASE THAT TERMINATED FATALLY. J Am Med Assoc [Internet]. 1953 Oct 17 [cited 2019 May 18];153(7):636–9. Available from: https://jamanetwork.com/journals/jama/fullarticle/288657. pmid:13084436
- 379. Pandya PM, Keogh AJ. Case report: arachnoiditis following intracranial “Thorotrast”. Clin Radiol. 1992 Feb;45(2):141–3.
- 380. Quiles M, Marchisello PJ, Tsairis P. Lumbar adhesive arachnoiditis. Etiologic and pathologic aspects. Spine. 1978 Mar;3(1):45–50. pmid:644392
- 381. Shah J, Patkar D, Parmar H, Prasad S, Varma R. Arachnoiditis associated with arachnoid cyst formation and cord tethering following myelography: magnetic resonance features. Australas Radiol. 2001 May;45(2):236–9. pmid:11380373
- 382. Skalpe IO. Adhesive arachnoiditis following lumbar radiculography with water-soluble contrast agents. A clinical report with special reference to metrizamide. Radiology. 1976 Dec;121(3 Pt. 1):647–51. pmid:185649
- 383. Skalpe IO, Sortland O. Adhesive arachnoiditis in patients with spinal block. Neuroradiology. 1982;22(5):243–5. pmid:7063116
- 384. Slatis P, Autio E, Suolanen J, Norrback S. Hyperosmolality of the cerebrospinal fluid as a cause of adhesive arachnoiditis in lumbar myelography. Acta Radiol Diagn (Stockh). 1974 Nov;15(6):619–29. pmid:4463698
- 385. Clarke GR, Plewes JL, Jacobson I. Sciatica caused by sacral-nerve-root cysts. The Lancet. 1970 Nov 28;2(7683):1135–6. pmid:4097936
- 386. Roeder MB, Bazan C, Jinkins JR. Ruptured spinal dermoid cyst with chemical arachnoiditis and disseminated intracranial lipid droplets. Neuroradiology. 1995 Feb;37(2):146–7. pmid:7761002
- 387. Boisseau W, Touat M, Berzero G, Savatovsky J, Marabelle A, Touitou V, et al. Safety of treatment with nivolumab after ipilimumab-related meningoradiculitis and bilateral optic neuropathy. Eur J Cancer [Internet]. 2017 Sep 1 [cited 2019 Apr 11];83:28–31. Available from: https://www.ejcancer.com/article/S0959-8049(17)31000-6/abstract. pmid:28710954
- 388. Lacour M, Grangeon L, Flament J, Duval-Modeste AB, Zarea A, Guillaume M, et al. Ipilimumab-induced severe meningoradiculitis. J Clin Neurosci. 2019 Apr;62:246–7. pmid:30598268
- 389. Zimmer L, Goldinger SM, Hofmann L, Loquai C, Ugurel S, Thomas I, et al. Neurological, respiratory, musculoskeletal, cardiac and ocular side-effects of anti-PD-1 therapy. Eur J Cancer Oxf Engl 1990. 2016;60:210–25. pmid:27084345
- 390. Gurbuz MS, Erdogan B, Yuksel MO, Somay H. Postlumbar puncture arachnoiditis mimicking epidural abscess. BMJ Case Rep. 2013 Nov 6;2013. pmid:24197809
- 391. Etchepare F, Roche B, Rozenberg S, Dion E, Bourgeois P, Fautrel B. Post-lumbar puncture arachnoiditis. The need for directed questioning. Jt Bone Spine Rev Rhum. 2005 Mar;72(2):180–2. pmid:15797502
- 392. Diaz FG, Yock DH, Rockswold GL. Spinal subarachnoid hematoma after lumbar puncture producing acute thoracic myelopathy: case report. Neurosurgery. 1978;3(3):404–6. pmid:154073
- 393. Auroy Y, Benhamou D, Bargues L, Ecoffey C, Falissard B, Mercier F, et al. Major Complications of Regional Anesthesia in France: The SOS Regional Anesthesia Hotline Service. Anesthesiology [Internet]. 2002 Nov [cited 2019 May 3];97(5):1274–80. Available from: https://insights.ovid.com/crossref?an=00000542-200211000-00034. pmid:12411815
- 394. Abraham AA, Shetty R, Ninan M. Late complications of spinal anaesthesia—A prospective study of 5000 cases. J Anaesthesiol Clin Pharmacol. 2010;26(1):39–44.
- 395. Al Maach N, Vogels OJM, Bollen TL, Wessels PH. Arachnoiditis and communicating hydrocephalus as a complication of epidural blood patch. J Neurol. 2010 Apr;257(4):672–3. pmid:20033201
- 396. Aldrete JA, Godinez-Cubillo N, Ramirez-Bermejo A, Ghaly RF. Cauda equina syndrome and arachnoiditis from an epidural dose of chloroprocaine injected subdural: Farewell to a local anesthetic. Rev Mex Anestesiol. 2010 Dec;33(4):220–4.
- 397. Aldrete JA, Reza-Medina M, Daud O, Lalin-Iglesias S, Chiodetti G, Guevara U, et al. Exacerbation of preexisting neurological deficits by neuraxial anesthesia: report of 7 cases. J Clin Anesth [Internet]. 2005;17(4):304–13. Available from: https://www.ncbi.nlm.nih.gov/pubmed/15950859. pmid:15950859
- 398. Anitescu M, DaSilva AN, Frim DM. Intrapleural migration of a spinal catheter in a patient with arachnoiditis and extensive epidural scarring after tethered cord release: a case report and review of literature. Neuromodulation J Int Neuromodulation Soc. 2012 Jun;15(3):200–3; discussion 203.
- 399. Aromaa U, Lahdensuu M, Cozanitis DA. Severe complications associated with epidural and spinal anaesthesias in Finland 1987–1993 A study based on patient insurance claims. Acta Anaesthesiol Scand [Internet]. 1997 [cited 2019 May 14];41(4):445–52. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1399-6576.1997.tb04722.x.
- 400. Auroy Y, Narchi P, Messiah A, Litt L, Rouvier B, Samii K. Serious Complications Related to Regional AnesthesiaResults of a Prospective Survey in France. Anesthesiol J Am Soc Anesthesiol [Internet]. 1997 Sep 1 [cited 2019 May 15];87(3):479–86. Available from: http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1948141. pmid:9316950
- 401. Benoist M, Ficat C, Baraf P, Cauchoix J. Postoperative lumbar epiduro-arachnoiditis. Diagnostic and therapeutic aspects. Spine. 1980 Oct;5(5):432–6. pmid:6450453
- 402. Boiardi A, Sghirlanzoni A, La Mantia L, Bussone G, Lombardi B, Girotti F. Diffuse arachnoiditis following epidural analgesia. J Neurol. 1983;230(4):253–7. pmid:6198485
- 403. Carlsward C, Darvish B, Tunelli J, Irestedt L. Chronic adhesive arachnoiditis after repeat epidural blood patch. Int J Obstet Anesth. 2015 Aug;24(3):280–3. pmid:26119259
- 404. Chattopadhyay I, Jha AK, Banerjee SS, Basu S. Post-procedure adhesive arachnoiditis following obstetric spinal anaesthesia. Indian J Anaesth [Internet]. 2016 May 1 [cited 2019 Apr 18];60(5):372. Available from: http://www.ijaweb.org/article.asp?issn=0019-5049;year=2016;volume=60;issue=5;spage=372;epage=374;aulast=Chattopadhyay;type=0. pmid:27212734
- 405. Chen X, Xu Z, Lin R, Liu Z. Persistent cauda equina syndrome after cesarean section under combined spinal-epidural anesthesia: a case report. J Clin Anesth. 2015 Sep;27(6):520–3. pmid:26111666
- 406. Chiapparini L, Sghirlanzoni A, Pareyson D, Savoiardo M. Imaging and outcome in severe complications of lumbar epidural anaesthesia: report of 16 cases. Neuroradiology. 2000 Aug;42(8):564–71. pmid:10997561
- 407. Cohn J, Moaveni D, Sznol J, Ranasinghe J. Complications of 761 short-term intrathecal macrocatheters in obstetric patients: a retrospective review of cases over a 12-year period. Int J Obstet Anesth. 2016 Feb;25:30–6. pmid:26421698
- 408. Cook TM, Counsell D, Wildsmith J a. W, Royal College of Anaesthetists Third National Audit Project. Major complications of central neuraxial block: report on the Third National Audit Project of the Royal College of Anaesthetists. Br J Anaesth. 2009 Feb;102(2):179–90. pmid:19139027
- 409. Creaney M, Mac Colgáin S. Antisepsis for neuraxial procedures in Irish obstetric units and its possible impact on patient safety. A survey of national practice and associated complications. Int J Obstet Anesth. 2019 Dec 12.; pmid:31917052
- 410. Hachisuka K, Ogata H, Kohshi K. Post-operative paraplegia with spinal myoclonus possibly caused by epidural anaesthesia: case report. Paraplegia. 1991 Feb;29(2):131–6. pmid:2023778
- 411. Haisa T, Todo T, Mitsui I, Kondo T. Lumbar adhesive arachnoiditis following attempted epidural anesthesia—case report. Neurol Med Chir (Tokyo). 1995 Feb;35(2):107–9. pmid:7753309
- 412. Hardjasudarma M, Davis DR. Neuroimaging of arachnoiditis induced by spinal anesthesia. South Med J. 1993 Nov;86(11):1293–6. pmid:8235790
- 413. Iga K, Murakoshi T, Kato A, Kato K, Terada S, Konno H, et al. Repeat epidural blood patch at the level of unintentional dural puncture and its neurologic complications: a case report. JA Clin Rep. 2019 Dec 1;5 (1) (no pagination)(14). pmid:32025902
- 414. Jain M, Srivastava U, Saxena S, Singh AK, Kumar A. Cauda equina syndrome following an uneventful spinal anaesthesia. Indian J Anaesth. 2010 Feb;54(1):68–9. pmid:20532079
- 415. Kennedy F, Somberg HM, Goldberg BR. Arachnoiditis and paralysis following spinal anesthesia. JAMA J Am Med Assoc. 1945;129(10):664–7.
- 416. Killeen T, Kamat A, Walsh D, Parker A, Aliashkevich A. Severe adhesive arachnoiditis resulting in progressive paraplegia following obstetric spinal anaesthesia: a case report and review. Anaesthesia [Internet]. 2012 [cited 2018 Dec 19];67(12):1386–94. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/anae.12017. pmid:23061983
- 417. Loo CC, Irestedt L. Cauda equina syndrome after spinal anaesthesia with hyperbaric 5% lignocaine: A review of six cases of cauda equina syndrome reported to the Swedish Pharmaceutical Insurance 1993–1997. Acta Anaesthesiol Scand. 1999;43(4):371–9. pmid:10225068
- 418. Martin R, Louy C, Babu V, Jiang Y, Far A, Schievink W. A two-level large-volume epidural blood patch protocol for spontaneous intracranial hypotension: retrospective analysis of risk and benefit. Reg Anesth Pain Med. 2019 Sep 20.; pmid:31541008
- 419. Merino-Urrutia W, Villagrán-Schmidt M, Ulloa-Vásquez P, Carrasco-Moyano R, Uribe A, Stoicea N, et al. Cauda equina syndrome following an uneventful spinal anesthesia in a patient undergoing drainage of the Bartholin abscess: A case report. Medicine (Baltimore). 2018 May;97(19):e0693. pmid:29742719
- 420. Na EH, Han SJ, Kim MH. Delayed occurrence of spinal arachnoiditis following a caudal block. J Spinal Cord Med [Internet]. 2011 Nov [cited 2019 Apr 8];34(6):616–9. Available from: http://www.tandfonline.com/doi/full/10.1179/2045772311Y.0000000035. pmid:22330119
- 421. Netravathi M, Taly AB, Sinha S, Bindu PS, Goel G. Accidental spinal cord injury during spinal anesthesia: A report. Ann Indian Acad Neurol. 2010 Dec;13(4):297–8. pmid:21264140
- 422. Pitkänen MT, Aromaa U, Cozanitis DA, Förster JG. Serious complications associated with spinal and epidural anaesthesia in Finland from 2000 to 2009. Acta Anaesthesiol Scand. 2013 May;57(5):553–64. pmid:23305109
- 423. Reynolds F. Damage to the conus medullaris following spinal anaesthesia. Anaesthesia [Internet]. 2001 [cited 2019 May 14];56(3):238–47. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2044.2001.01422-2.x. pmid:11251431
- 424. Riley CA, Spiegel JE. Complications following large-volume epidural blood patches for postdural puncture headache. Lumbar subdural hematoma and arachnoiditis: initial cause or final effect? J Clin Anesth [Internet]. 2009 Aug 1 [cited 2018 Dec 19];21(5):355–9. Available from: http://www.sciencedirect.com/science/article/pii/S0952818009001433. pmid:19700281
- 425. Roy-Gash F, Engrand N, Lecarpentier E, Bonnet MP. Intrathecal hematoma and arachnoiditis mimicking bacterial meningitis after an epidural blood patch. Int J Obstet Anesth. 2017 Nov;32:77–81. pmid:28689621
- 426. Sarifakioglu AB, Yemisci OU, Yalbuzdag SA, Ciftkaya PO, Cosar NS. Cauda equina syndrome after cesarean section. Am J Phys Med Rehabil. 2013 Feb;92(2):179–82. pmid:23044703
- 427. Schell RM, Brauer FS, Cole DJ, Applegate RL. Persistent sacral nerve root deficits after continuous spinal anaesthesia. Can J Anaesth [Internet]. 1991 Oct [cited 2019 May 28];38(7):908–11. Available from: http://link.springer.com/10.1007/BF03036972 pmid:1742828
- 428. Sghirlanzoni A, Marazzi R, Pareyson D, Olivieri A, Bracchi M. Epidural anaesthesia and spinal arachnoiditis. Anaesthesia [Internet]. 1989 Apr;44(4):317–21. Available from: https://www.ncbi.nlm.nih.gov/pubmed/2719203. pmid:2719203
- 429. Shields LBE, Iyer VG, Zhang YP, Shields CB. Acute cauda equina syndrome following orthopedic procedures as a result of epidural anesthesia. Surg Neurol Int. 2018;9:81. pmid:29721359
- 430. Sklar EM, Quencer RM, Green BA, Montalvo BM, Post MJ. Complications of epidural anesthesia: MR appearance of abnormalities. Radiology. 1991 Nov;181(2):549–54. pmid:1924803
- 431. Tarkkila P, Huhtala J, Tuominen M. Transient radicular irritation after spinal anaesthesia with hyperbaric 5% lignocaine. Br J Anaesth [Internet]. 1995 Mar 1 [cited 2019 May 14];74(3):328–9. Available from: http://www.sciencedirect.com/science/article/pii/S0007091217407057. pmid:7718381
- 432. Abhinav K, Bradley M, Aquilina K, Patel NK. Spinal arachnoiditis and cyst formation with subarachnoid haemorrhage. Br J Neurosurg. 2012 Aug;26(4):574–5. pmid:22299598
- 433. Augustijn P, Vanneste J, Davies G. Chronic spinal arachnoiditis following intracranial subarachnoid haemorrhage. Clin Neurol Neurosurg. 1989;91(4):347–50. pmid:2555097
- 434. Babson SG. Spontaneous subarachnoid hemorrhage in infants and its relation to hydrocephalus. J Pediatr. 1944;25(1):68–73.
- 435. Basaran R, Kaksi M, Efendioglu M, Onoz M, Balkuv E, Kaner T. Spinal arachnoid cyst associated with arachnoiditis following subarachnoid haemorrhage in adult patients: A case report and literature review. Br J Neurosurg. 2015 Apr;29(2):285–9. pmid:25365662
- 436. Cronqvist S, Greitz D, Maeder P. Spread of blood in cerebrospinal fluid following craniotomy simulates spinal metastases. Neuroradiology. 1993;35(8):592–5. pmid:8278039
- 437. Cronqvist S. Encephalographic Changes following Subarachnoid Haemorrhage. Br J Radiol [Internet]. 1967 Jan 1 [cited 2019 Apr 19];40(469):38–42. Available from: https://www.birpublications.org/doi/abs/10.1259/0007-1285-40-469-38. pmid:5297179
- 438. Dossani RH, Patra DP, Sun H, Nanda A, Cuellar H. Delayed Spinal Arachnoiditis Following Aneurysmal Subarachnoid Hemorrhage: A Case Report. Cureus. 2018 Jan 6;10(1):e2031. pmid:29535904
- 439. Eneling J, Bostrom S, Rossitti S. Subarachnoid hemorrhage-associated arachnoiditis and syringomyelia. Clin Neuroradiol. 2012 Jun;22(2):169–73. pmid:21687960
- 440. Fong YW, Huang CT. Brown-Sequard syndrome following intracranial subarachnoid hemorrhage-induced spinal arachnoid cyst. Interdiscip Neurosurg Adv Tech Case Manag. 2017 Dec;10:119–21.
- 441. Ginanneschi F, Palma L, Rossi A. Arachnoid cyst and arachnoiditis following idiopathic spinal subarachnoid haemorrhage. Br J Neurosurg. 2008 Aug;22(4):578–9. pmid:18661312
- 442. Go T, Tsutsui T, Iida Y, Fukutake K, Fukano R, Ishigaki K, et al. A Case of Spontaneous Spinal Subdural Hematoma Complicated by Cranial Subarachnoid Hemorrhage and Spinal Adhesive Arachnoiditis. Case Rep Orthop. 2019;2019:7384701. pmid:31001442
- 443. Ishizaka S, Hayashi K, Otsuka M, Fukuda S, Tsunoda K, Ushijima R, et al. Syringomyelia and arachnoid cysts associated with spinal arachnoiditis following subarachnoid hemorrhage. Neurol Med Chir (Tokyo). 2012;52(9):686–90. pmid:23006888
- 444. Kok AJ, Verhagen WI, Bartels RH, van Dijk R, Prick MJ. Spinal arachnoiditis following subarachnoid haemorrhage: report of two cases and review of the literature. Acta Neurochir (Wien). 2000;142(7):795–8; discussion 798–799. pmid:10955674
- 445. Lo BM, Quinn SM. Gross xanthochromia on lumbar puncture may not represent an acute subarachnoid hemorrhage. Am J Emerg Med. 2009 Jun;27(5):621–3. pmid:19497470
- 446. Motohashi O, Suzuki M, Shida N, Umezawa K, Ohtoh T, Sakurai Y, et al. Subarachnoid haemorrhage induced proliferation of leptomeningeal cells and deposition of extracellular matrices in the arachnoid granulations and subarachnoid space. Immunhistochemical study. Acta Neurochir (Wien). 1995;136(1–2):88–91. pmid:8748833
- 447. Nakanishi K, Uchiyama T, Nakano N, Fukawa N, Yamada K, Yabuuchi T, et al. Spinal syringomyelia following subarachnoid hemorrhage. J Clin Neurosci Off J Neurosurg Soc Australas. 2012 Apr;19(4):594–7. pmid:22285478
- 448. Oppo V, Cossu G, Secci S, Melis M. Widening the spectrum of secondary headache: intracranial hypotension following a non-aneurysmal subarachnoid hemorrhage. Neurol Sci Off J Ital Neurol Soc Ital Soc Clin Neurophysiol. 2019 Mar 7; pmid:30847675
- 449. Rahmathulla G, Kamian K. Compressive Cervicothoracic Adhesive Arachnoiditis following Aneurysmal Subarachnoid Hemorrhage: A Case Report and Literature Review. J Neurol Surg Rep. 2014 Aug;75(1):e56–61. pmid:25083391
- 450. Sajant J, Heikkinen E, Majamaa K. Rapid induction of meningeal collagen synthesis in the cerebral cisternal and ventricular compartments after subarachnoid hemorrhage. Acta Neurochir (Wien). 2001 Aug;143(8):821–6. pmid:11678403
- 451. Scott EW, Cazenave CR, Virapongse C. Spinal subarachnoid hematoma complicating lumbar puncture: diagnosis and management. Neurosurgery. 1989 Aug;25(2):287–92; discussion 292–293. pmid:2770992
- 452. Silva N, Januel AC, Sabatier J, Demonet JF, Tall P, Cognard C. Delayed Medullar Syndrome after Aneurysmal Subarachnoid Haemorrhage. A Case report of Cystic Arachnoiditis! Interv Neuroradiol J Peritherapeutic Neuroradiol Surg Proced Relat Neurosci. 2007 Jun;13(2):201–4. pmid:20566150
- 453. Sobel D, Li FC, Norman D, Newton TH. Cisternal enhancement after subarachnoid hemorrhage. AJNR Am J Neuroradiol. 1981 Dec;2(6):549–52. pmid:6797280
- 454. Son S, Lee SG, Park CW. Solitary ruptured aneurysm of the spinal artery of adamkiewicz with subarachnoid hemorrhage. J Korean Neurosurg Soc. 2013 Jul;54(1):50–3. pmid:24044082
- 455. StenströM N. Arachnoiditis haemorrhagica together with porencephalia. Acta Med Scand. 1922;56(1):591–600.
- 456. Swarna SS, McKean D, Belci M. Cervicothoracic arachnoiditis-a rare complication of aneurysmal intracranial subarachnoid haemorrhage. Spinal Cord Ser Cases. 2018;4:57. pmid:29977608
- 457. Thines L, Khalil C, Fichten A, Lejeune JP. Spinal arachnoid cyst related to a nonaneurysmal perimesencephalic subarachnoid hemorrhage: case report. Neurosurgery. 2005 Oct;57(4):E817. pmid:17152671
- 458. Tjandra JJ, Varma TR, Weeks RD. Spinal arachnoiditis following subarachnoid haemorrhage. Aust N Z J Surg. 1989 Jan;59(1):84–7. pmid:2913997
- 459. Todeschi J, Chibbaro S, Gubian A, Pop R, Proust F, Cebula H. Spinal adhesive arachnoiditis following the rupture of an Adamkiewicz aneurysm: Literature review and a case illustration. Neurochirurgie. 2018 Jun;64(3):177–82. pmid:29433818
- 460. Tumialán LM, Cawley CM, Barrow DL. Arachnoid cyst with associated arachnoiditis developing after subarachnoid hemorrhage. Case report. J Neurosurg. 2005 Dec;103(6):1088–91. pmid:16381198
- 461. Weiner LA, Richardson AC, Tewelde SZ. Spontaneous Intracranial and Lumbar Subdural Hematoma Presenting as Vaginal Pain. J Emerg Med. 2019 Feb 8; pmid:30745198
- 462. Yost MD, Rabinstein AA. Spontaneous Spinal Subarachnoid Hemorrhage: Presentation and Outcome. J Stroke Cerebrovasc Dis Off J Natl Stroke Assoc. 2018 Oct;27(10):2792–6. pmid:30064869
- 463. Bahr AL, Krumholz A, Kristt D, Hodges FJ. Neuroradiological manifestations of intracranial sarcoidosis. Radiology. 1978 Jun;127(3):713–7. pmid:663162
- 464. HOSSEINI H, TOURBAH A, HOSSEINI H, TOURBAH A. Sarcoid related optochiasmatic arachnoiditis: favourable outcome confirmed with MRI. J Neurol Neurosurg Psychiatry [Internet]. 1999 Nov [cited 2019 Feb 1];67(5):690. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1736651/. pmid:10519885
- 465. Leonhard SE, Fritz D, Eftimov F, van der Kooi AJ, van de Beek D, Brouwer MC. Neurosarcoidosis in a Tertiary Referral Center: A Cross-Sectional Cohort Study. Medicine (Baltimore). 2016 Apr;95(14):e3277. pmid:27057889
- 466. Nikhar NK, Shah JR, Tselis AC, Lewis RA. Primary neurosarcoidosis: A diagnostic and therapeutic challenge. Neurologist. 2000 Mar;6(2):126–33.
- 467. Riancho-Zarrabeitia L, Delgado-Alvarado M, Riancho J, Oterino A, Sedano MJ, Rueda-Gotor J, et al. Anti-TNF-alpha therapy in the management of severe neurosarcoidosis: A report of five cases from a single centre and literature review. Clin Exp Rheumatol. 2014;32(2):275–84.
- 468. Sollberger M, Fluri F, Baumann T, Sonnet S, Tamm M, Steck AJ, et al. Successful treatment of steroid-refractory neurosarcoidosis with infliximab [5]. J Neurol. 2004 Jun;251(6):760–1.
- 469. Ueno T, Desaki R, Kon T, Haga R, Nunomura JI, Murakami K, et al. Clinical diagnostic utility of contrast-enhanced three-dimensional fluid-attenuated inversion recovery for selection of brain biopsy sites in neurosarcoidosis: A case report. Clin Neurol Neurosurg. 2018;173:101–4. pmid:30107352
- 470. Zuber M, Defer G, Cesaro P, Degos JD. Efficacy of cyclophosphamide in sarcoid radiculomyelitis. J Neurol Neurosurg Psychiatry. 1992 Feb;55(2):166–7. pmid:1538228
- 471. Aslam F, Parsons A, Grill M, Goodman B. Rheumatoid meningitis: Meningeal biopsy is not essential for diagnosis. Arthritis Rheumatol. 2018 Sep;70 (Supplement 9):524.
- 472. Bilgen IG, Yunten N, Ustun EE, Oksel F, Gumusdis G. Adhesive arachnoiditis causing cauda equina syndrome in ankylosing spondylitis: CT and MRI demonstration of dural calcification and a dorsal dural diverticulum. Neuroradiology [Internet]. 1999 Jul;41(7):508–11. Available from: https://www.ncbi.nlm.nih.gov/pubmed/30447665. pmid:10450845
- 473. Byrne E, McNeill P, Gilford E, Wright C. Intradural cyst with compression of the cauda equina in ankylosing spondylitis. Surg Neurol. 1985 Feb;23(2):162–4. pmid:3966210
- 474. Charlesworth CH, Savy LE, Stevens J, Twomey B, Mitchell R. MRI demonstration of arachnoiditis in cauda equina syndrome of ankylosing spondylitis. Neuroradiology. 1996 Jul;38(5):462–5. pmid:8837094
- 475. Cianfoni A, Falcone C, Faustini F, Lauriola L, Imbesi S, Della Marca G, et al. Rheumatoid leptomeningitis: magnetic resonance imaging and pathologic findings—a case report. J Neuroimaging Off J Am Soc Neuroimaging. 2010 Apr;20(2):192–4. pmid:19309435
- 476. Fan YK, Cheng SJ, Huang JK. MRI appearance of lumbosacral spine in a patient with ankylosing spondylitis and cauda equina syndrome. Chin J Radiol. 2004 Aug;29(4):217–21.
- 477. GORDON AL, YUDELL A. Cauda Equina Lesion Associated with Rheumatoid Spondylitis. Ann Intern Med [Internet]. 1973 huhtikuu [cited 2019 Feb 25];78(4):555–7. Available from: https://dx.doi.org/10.7326/0003-4819-78-4-555. pmid:4694040
- 478. Grosman H, Gray R, St Louis EL. CT of long-standing ankylosing spondylitis with cauda equina syndrome. AJNR Am J Neuroradiol. 1983 Oct;4(5):1077–80. pmid:6414268
- 479. Khan MU, Devlin JAJ, Fraser A. Adhesive arachnoiditis in mixed connective tissue disease: a rare neurological manifestation. BMJ Case Rep. 2016 Dec 16;2016. pmid:27986694
- 480. Lan HHC, Chen DY, Chen CCC, Lan JL, Hsieh CW. Combination of transverse myelitis and arachnoiditis in cauda equina syndrome of long-standing ankylosing spondylitis: MRI features and its role in clinical management. Clin Rheumatol. 2007 Nov;26(11):1963–7. pmid:17332972
- 481. Levin A, Kasem S, Mader R, Naparstek Y, Friedman G, Ben-Yehuda A. Wegener granulomatosis with back pain, periaortitis, and dural inflammation developing while receiving monthly cyclophosphamide. J Clin Rheumatol Pract Rep Rheum Musculoskelet Dis. 2006 Dec;12(6):294–7.
- 482. Matthews WB. The neurological complications of ankylosing spondylitis. J Neurol Sci [Internet]. 1968 May 1 [cited 2019 May 23];6(3):561–73. Available from: http://www.sciencedirect.com/science/article/pii/0022510X6890035X. pmid:4303835
- 483. Mitchell MJ, Sartoris DJ, Moody D, Resnick D. Cauda equina syndrome complicating ankylosing spondylitis. Radiology. 1990 May;175(2):521–5. pmid:2326476
- 484. Scarrow AM, Segal R, Medsger TA, Wasko MC. Communicating hydrocephalus secondary to diffuse meningeal spread of Wegener’s granulomatosis: case report and literature review. Neurosurgery. 1998 Dec;43(6):1470–3. pmid:9848863
- 485. Singanamalla B, Saini AG, Sidana V, Saini L, Sankhyan N, Singh P. Progressive quadriparesis and inflammation: A common disease, a rare presentation. Indian J Tuberc. 2019; pmid:32825861
- 486. Soeur M, Monseu G, Baleriaux-Waha D, Duchateau M, Williame E, Pasteels JL. Cauda equina syndrome in ankylosing spondylitis. Anatomical, diagnostic, and therapeutic considerations. Acta Neurochir (Wien). 1981;55(3–4):303–15. pmid:7234535
- 487. Tang C, Moser FG, Reveille J, Bruckel J, Weisman MH. Cauda equina syndrome in ankylosing spondylitis: Challenges in diagnosis, management, and pathogenesis. J Rheumatol. 2019 Dec 1;46(12):1582–8. pmid:30936280
- 488. Van Hoydonck M, de Vlam K, Westhovens R, Luyten FP, Lories RJ. Destructive dural ectasia of dorsal and lumbar spine with cauda equina syndrome in a patient with ankylosing spondylitis. Open Rheumatol J. 2010 Aug 26;4:31–4. pmid:21331306
- 489. Ransford AO, Harries BJ. Localised arachnoiditis complicating lumbar disc lesions. J Bone Jt Surg—Br Vol. 1972 Nov;54(4):656–65. pmid:4264363
- 490. Buchman A, Wright RB, Wichter MD, Whisler WW, Bosch A. Hemorrhagic complications after the lumbar injection of chymopapain. Neurosurgery. 1985 Feb;16(2):222–4. pmid:3883224
- 491. Eisenberg E, Goldman R, Schlag-Eisenberg D, Grinfeld A. Adhesive arachnoiditis following lumbar epidural steroid injections: a report of two cases and review of the literature. J Pain Res. 2019;12:513–8. pmid:30774420
- 492. Manchikanti L, Malla Y, Wargo BW, Cash KA, Pampati V, Fellows B. A prospective evaluation of complications of 10,000 fluoroscopically directed epidural injections. Pain Physician [Internet]. 2012 Apr;15(2):131–40. Available from: https://www.ncbi.nlm.nih.gov/pubmed/22430650. pmid:22430650
- 493. Manchikanti L, Singh V, Falco FJE, Cash KA, Pampati V. Evaluation of the effectiveness of lumbar interlaminar epidural injections in managing chronic pain of lumbar disc herniation or radiculitis: a randomized, double-blind, controlled trial. Pain Physician. 2010 Aug;13(4):343–55. pmid:20648203
- 494. McLain RF, Fry M, Hecht ST. Transient paralysis associated with epidural steroid injection. J Spinal Disord. 1997 Oct;10(5):441–4. pmid:9355063
- 495. Mohamed Iqbal I, Morris R, Hersch M. Adhesive arachnoiditis following inadvertent epidural injection of 2% chlorhexidine in 70% alcohol-partial recovery over the ensuing eight years. Anaesth Intensive Care. 2018 Nov;46(6):572–4. pmid:30447665
- 496. Nanjayan SK, Swamy GN, Yallappa S, Bommireddy R. Arachnoiditis following caudal epidural injections for the lumbo-sacral radicular pain. Asian Spine J. 2013 Dec;7(4):355–8. pmid:24353855
- 497. North RB, Cutchis PN, Epstein JA, Long DM. Spinal cord compression complicating subarachnoid infusion of morphine: Case report and laboratory experience. Neurosurgery. 1991;29(5):778–84. pmid:1961414
- 498. Rauck R, Deer T, Rosen S, Padda G, Barsa J, Dunbar E, et al. Long-term follow-up of a novel implantable programmable infusion pump. Neuromodulation. 2013 Apr;16(2):163–7. pmid:23057877
- 499. Smith L, Brown JE. Treatment of lumbar intervertebral disc lesions by direct injection of chymopapain. J Bone Jt Surg—Br Vol. 1967 Aug;49(3):502–19. pmid:4227024
- 500. Watts C, Hutchison G, Stern J, Clark K. Comparison of intervertebral disc disease treatment by chymopapain injection and open surgery. J Neurosurg. 1975 Apr;42(4):397–400. pmid:1123657
- 501. Dardashti S, Chang EY, Kim RB, Alsharif KI, Hata JT, Perret DM. False positive radiographical evidence of pump catheter migration into the spinal cord. Pain Physician. 2013 Oct;16(5):E627–630. pmid:24077212
- 502. Elias WJ, Simmons NE, Kaptain GJ, Chadduck JB, Whitehill R. Complications of posterior lumbar interbody fusion when using a titanium threaded cage device. J Neurosurg. 2000 Jul;93(1 Suppl):45–52. pmid:10879757
- 503. Sherman B, Crowell T. Corrosion of Harrington rod in idiopathic scoliosis: long-term effects. Eur Spine J Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sect Cerv Spine Res Soc. 2018 Jul;27(Suppl 3):298–302.
- 504. Yashiro K, Homma T, Hokari Y, Katsumi Y, Okumura H, Hirano A. The Steffee variable screw placement system using different methods of bone grafting. Spine. 1991 Nov;16(11):1329–34. pmid:1750008
- 505. Chang MS, Chang YH, Revella J, Crandall DG. Outcomes of lumbar spinal fusion in patients older than 75. Spine J. 2012 Sep;1):120S.
- 506. Formica M, Zanirato A, Cavagnaro L, Basso M, Divano S, Felli L, et al. Extreme lateral interbody fusion in spinal revision surgery: clinical results and complications. Eur Spine J. 2017;26(Suppl 4):464–70. pmid:28488095
- 507. Hsu CJ, Chou WY, Chang WN, Wong CY. Clinical follow up after instrumentation-augmented lumbar spinal surgery in patients with unsatisfactory outcomes. J Neurosurg Spine. 2006 Oct;5(4):281–6. pmid:17048763
- 508. Rihn JA, Patel R, Makda J, Hong J, Anderson DG, Vaccaro AR, et al. Complications associated with single-level transforaminal lumbar interbody fusion. Spine J Off J North Am Spine Soc. 2009 Aug;9(8):623–9.
- 509. lu Yan D, xing Pei F, Li J, long Soo C. Comparative study of PILF and TLIF treatment in adult degenerative spondylolisthesis. Eur Spine J [Internet]. 2008 Oct [cited 2019 Apr 19];17(10):1311–6. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556474/. pmid:18685873
- 510. Khan TR, Pearce KR, McAnany SJ, Peters CM, Gupta MC, Zebala LP. Comparison of transforaminal lumbar interbody fusion outcomes in patients receiving rhBMP-2 versus autograft. Spine J Off J North Am Spine Soc. 2018;18(3):439–46. pmid:28822825
- 511. Baron EM, Mejía DM, Drazin D, Anand N. Postoperative Cyst Associated with Bone Morphogenetic Protein Use in Posterior and Transforaminal Lumbar Interbody Fusion Managed Conservatively: Report of Two Cases. Cureus. 2016 Feb 7;8(2):e485. pmid:27014519
- 512. Esmail N, Buser Z, Cohen JR, Brodke DS, Meisel HJ, Park JB, et al. Postoperative Complications Associated With rhBMP2 Use in Posterior/Posterolateral Lumbar Fusion. Glob Spine J [Internet]. 2018 Apr [cited 2019 Jan 1];8(2):142–8. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898669/ pmid:29662744
- 513. Litrico S, Langlais T, Pennes F, Gennari A, Paquis P. Lumbar interbody fusion with utilization of recombinant human bone morphogenetic protein: a retrospective real-life study about 277 patients. Neurosurg Rev. 2018 Jan;41(1):189–96. pmid:28281191
- 514. Mesfin A, Buchowski JM, Zebala LP, Bakhsh WR, Aronson AB, Fogelson JL, et al. High-dose rhBMP-2 for adults: major and minor complications: a study of 502 spine cases. J Bone Joint Surg Am. 2013 Sep 4;95(17):1546–53. pmid:24005194
- 515. Mindea SA, Shih P, Song JK. Recombinant human bone morphogenetic protein-2-induced radiculitis in elective minimally invasive transforaminal lumbar interbody fusions: a series review. Spine. 2009 Jun 15;34(14):1480–4; discussion 1485. pmid:19525840
- 516. Nourian AA, Harrington J, Pulido PA, McCauley JC, Bruffey JD, Eastlack RK. Fusion Rates of Lateral Lumbar Interbody Fusion Using Recombinant Human Bone Morphogenetic Protein-2. Glob Spine J. 2019 Jun 1;9(4):398–402. pmid:31218198
- 517. Rihn JA, Makda J, Hong J, Patel R, Hilibrand AS, Anderson DG, et al. The use of RhBMP-2 in single-level transforaminal lumbar interbody fusion: a clinical and radiographic analysis. Eur Spine J Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sect Cerv Spine Res Soc. 2009 Nov;18(11):1629–36. pmid:19475434
- 518. Singh K, Nandyala SV, Marquez-Lara A, Cha TD, Khan SN, Fineberg SJ, et al. Clinical sequelae after rhBMP-2 use in a minimally invasive transforaminal lumbar interbody fusion. Spine J Off J North Am Spine Soc. 2013 Sep;13(9):1118–25.
- 519. Hallman B ICIJ. The Implant Files: a global investigation into medical devices: 2018 report. ICIJ [Internet]. [cited 2020 Feb 24]; Available from: https://www.icij.org/investigations/implant-files/.
- 520. Auld AW. Chronic spinal arachnoiditis. A postoperative syndrome that may signal its onset. Spine. 1978 Mar;3(1):88–91. pmid:644396
- 521. Benner B, Ehni G. Spinal arachnoiditis. The postoperative variety in particular. Spine. 1978 Mar;3(1):40–4. pmid:644391
- 522. li Chen S, li Zhang G, wei Zhang H, Lei T, chen Hu C. Arachnoid adhesion caused by SURGICEL after operation for ventral spinal schwannoma. Chin Med J (Engl) [Internet]. 2010 Nov [cited 2020 Jan 9];123(21):3167. Available from: https://journals.lww.com/cmj/Fulltext/2010/11010/Arachnoid_adhesion_caused_by_SURGICEL_after.42.aspx.
- 523. Cheng J, Wang H, Zheng W, Li C, Wang J, Zhang Z, et al. Reoperation after lumbar disc surgery in two hundred and seven patients. Int Orthop [Internet]. 2013 Aug [cited 2019 Apr 19];37(8):1511–7. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728382/. pmid:23695881
- 524. Cybulski GR, Stone JL, Kant R. Outcome of laminectomy for civilian gunshot injuries of the terminal spinal cord and cauda equina: review of 88 cases. Neurosurgery. 1989 Mar;24(3):392–7. pmid:2927613
- 525. Davidoff LM, Gass H, Grossman J. Postoperative spinal adhesive arachnoiditis and recurrent spinal cord tumor. J Neurosurg. 1947 Sep;4(5):451–64. pmid:20260246
- 526. Dosoglu M, Is M, Aytekin H, Gezen F, Karatas A. Unexpected perioperative complication of aneurysm surgery: Armored arachnoiditis case report. Noropsikiyatri Arsivi. 2011;48(3):207–10.
- 527. Endriga DT, Dimar JR, Carreon LY. Communicating hydrocephalus, a long-term complication of dural tear during lumbar spine surgery. Eur Spine J. 2016 May 1;25(Supplement 1):157–61. pmid:26521076
- 528. Fitt GJ, Stevens JM. Postoperative arachnoiditis diagnosed by high resolution fast spin-echo MRI of the lumbar spine. Neuroradiology. 1995 Feb;37(2):139–45. pmid:7761001
- 529. Hayashi K, Nagano J, Hattori S. Adhesive arachnoiditis after percutaneous fibrin glue treatment of a sacral meningeal cyst. J Neurosurg Spine. 2014 Jun;20(6):763–6. pmid:24702510
- 530. Jaime Torres-Corzo MD*, Juan Sa´nchez-Rodr ıguez MD*, Dominic Cervantes MD*, Roberto Rodr ıguez-Della , Vecchia MD*, Fernando Muruato-Araiza, et al. Endoscopic Transventricular Transaqueductal Magendie and Luschka Foraminoplasty for Hydrocephalus. Neurosurgery. 2014 Apr;74(4):436. pmid:24378828
- 531. Kayaoglu CR, Calikoğlu C, Binler S. Re-operation after lumbar disc surgery: results in 85 cases. J Int Med Res. 2003 Aug;31(4):318–23. pmid:12964508
- 532. Kim RC, Talbert WM, Choe W, Choi BH. Massive Craniospinal Collagen Deposition after Persistent Postoperative Intraventricular Bleeding. Neurosurgery [Internet]. 1989 May 1 [cited 2019 Apr 20];24(5):771–5. Available from: https://academic.oup.com/neurosurgery/article/24/5/771/2754902. pmid:2716989
- 533. Koerts G, Rooijakkers H, Abu-Serieh B, Cosnard G, Raftopoulos C. Postoperative spinal adhesive arachnoiditis presenting with hydrocephalus and cauda equina syndrome. Clin Neurol Neurosurg. 2008 Feb;110(2):171–5. pmid:17950992
- 534. Lukas A, van der Weide M, Boogerd W, Prevoo W, Zuurmond WWA, Sanders M. Adhesive arachnoiditis following percutaneous cervical cordotomy—may we still use lipiodol? J Pain Symptom Manage. 2008 Nov;36(5):e1–4. pmid:18823752
- 535. Marano PJ, Stone SSD, Mugamba J, Ssenyonga P, Warf EB, Warf BC. Reopening of an obstructed third ventriculostomy: long-term success and factors affecting outcome in 215 infants. J Neurosurg Pediatr. 2015 Apr;15(4):399–405. pmid:25658247
- 536. Matsui H, Tsuji H, Kanamori M, Kawaguchi Y, Yudoh K, Futatsuya R. Laminectomy-induced arachnoradiculitis: a postoperative serial MRI study. Neuroradiology. 1995 Nov;37(8):660–6. pmid:8748902
- 537. Nikodinovska VV, Szeimies U, Stabler A. Adhesive arachnoiditis in post operative lumbar sine. Neuroradiology. 2014 Sep;1):202.
- 538. Ostling LR, Bierbrauer KS, Kuntz C. Outcome, reoperation, and complications in 99 consecutive children operated for tight or fatty filum. World Neurosurg. 2012 Jan;77(1):187–91. pmid:22154150
- 539. Ozgen S, Naderi S, Ozek MM, Pamir MN. Findings and outcome of revision lumbar disc surgery. J Spinal Disord. 1999 Aug;12(4):287–92. pmid:10451043
- 540. Peretta P, Cinalli G, Spennato P, Ragazzi P, Ruggiero C, Aliberti F, et al. Long-term results of a second endoscopic third ventriculostomy in children: retrospective analysis of 40 cases. Neurosurgery. 2009 Sep;65(3):539–47; discussion 547. pmid:19687699
- 541. Razak MA, Ong KP, Hyzan Y. The surgical outcome of degenerative lumbar spinal stenosis. Med J Malaysia. 1998 Sep;53 Suppl A:12–21. pmid:10968178
- 542. Sinigaglia R, Bundy A, Costantini S, Nena U, Finocchiaro F, Monterumici DAF. Comparison of single-level L4-L5 versus L5-S1 lumbar disc replacement: Results and prognostic factors. Eur Spine J. 2009 Jun;18(SUPPL. 1):S52–63. pmid:19404688
- 543. Smolik EA, Nash FP. Lumbar spinal arachnoiditis: a complication of the intervertebral disc operation. Ann Surg. 1951 Apr;133(4):490–5. pmid:14819986
- 544. Teng MMH, Cheng H, Ho DMT, Chang CY. Intraspinal leakage of bone cement after vertebroplasty: a report of 3 cases. AJNR Am J Neuroradiol. 2006 Jan;27(1):224–9. pmid:16418389
- 545. Wagner W, Koch D. Mechanisms of failure after endoscopic third ventriculostomy in young infants. J Neurosurg. 2005 Jul;103(1 Suppl):43–9. pmid:16122004
- 546. Wang JC, Bohlman HH, Riew KD. Dural tears secondary to operations on the lumbar spine. Management and results after a two-year-minimum follow-up of eighty-eight patients. J Bone Joint Surg Am. 1998 Dec;80(12):1728–32. pmid:9875930
- 547. Yasui K, Kotani Y, Takeda Y, Minami A. Migration of intracranial hemostatic clip into the lumbar spinal canal causing sacral radiculopathy: a case report. Spine [Internet]. 2003 Dec 15;28(24):E511–514. Available from: https://www.ncbi.nlm.nih.gov/pubmed/14673377. pmid:14673377
- 548. Coffin CM, Weill A, Miaux Y, Srour A, Cognard C, Dubard T, et al. Posttraumatic spinal subarachnoid cyst. Eur Radiol. 1996;6(4):523–5. pmid:8798036
- 549. Fobe JL, Nishikuni K, Gianni MA. Evolving magnetic resonance spinal cord trauma in child: from hemorrhage to intradural arachnoid cyst. Spinal Cord. 1998 Dec;36(12):864–6. pmid:9881737
- 550. Hao X, Junwen W, Jiaqing L, Ran L, Zhuo Z, Yimin H, et al. High fibrosis indices in cerebrospinal fluid of patients with shunt-dependent post-traumatic chronic hydrocephalus. Transl Neurosci. 2016;7(1):92–7. pmid:28123828
- 551. Klekamp J. Treatment of posttraumatic syringomyelia: Clinical article. J Neurosurg Spine. 2012 Sep;17(3):199–211.
- 552. Kumaran SP, Gupta K, Maddali A, Viswamitra S. Post traumatic arachnoiditis ossificans. J Emerg Trauma Shock. 2012 Jul;5(3):250–2. pmid:22988405
- 553. Lee TT, Arias JM, Andrus HL, Quencer RM, Falcone SF, Green BA. Progressive posttraumatic myelomalacic myelopathy: treatment with untethering and expansive duraplasty. J Neurosurg. 1997 Apr;86(4):624–8. pmid:9120625
- 554. MacDonald RL, Findlay JM, Tator CH. Microcystic spinal cord degeneration causing posttraumatic myelopathy. Report of two cases. J Neurosurg. 1988 Mar;68(3):466–71. pmid:3343618
- 555. Osborne DR, Vavoulis G, Nashold BS, Dubois PJ, Drayer BP, Heinz ER. Late sequelae of spinal cord trauma. Myelographic and surgical correlation. J Neurosurg. 1982 Jul;57(1):18–23. pmid:7086496
- 556. Ramamurthi B, Ramamurthi R, Narayanan R. Late laminectomy in traumatic paraplegia. Surg Neurol. 1983 Nov;20(5):414–6. pmid:6635932
- 557. Ramli N, Merican AM, Lim A, Kumar G. Post-traumatic arachnoiditis: an unusual cause of Brown-Sequard syndrome. Eur Radiol [Internet]. 2001;11(10):2011–4. Available from: https://www.ncbi.nlm.nih.gov/pubmed/11702136. pmid:11702136
- 558. Williams B. Post-traumatic syringomyelia, an update. Paraplegia. 1990 Jun;28(5):296–313. pmid:2235038
- 559. Yaskin HE, Alpers BJ. Foster Kennedy syndrome with post-traumatic arachnoiditis of optic chiasm and base of frontal lobes. Arch Dis Child Educ Pract. 1945 Dec;34:399–401. pmid:21012366
- 560. Moura da Silva LF, Buffon VA, Coelho Neto M, Ramina R. Non-schwannomatosis lesions of the internal acoustic meatus-a diagnostic challenge and management: a series report of nine cases. Neurosurg Rev. 2015 Oct;38(4):641–8. pmid:25957055
- 561. Novy S, Jensen KM. Filling defects and nonfilling of the internal auditory canal in posterior fossa fossa myelography. Am J Roentgenol Radium Ther Nucl Med [Internet]. 1975;124(2):265–70. Available from: https://www.ncbi.nlm.nih.gov/pubmed/1079696.
- 562. Tator CH. Acoustic Neuromas: Management of 204 Cases. Can J Neurol Sci J Can Sci Neurol [Internet]. 1985 Nov [cited 2019 Apr 21];12(S4):353–7. Available from: http://www.journals.cambridge.org/abstract_S0317167100035526. pmid:4084877
- 563. Wilner HI, Kashef R. Unilateral arachnoidal cysts and adhesions involving the eighth nerve. Am J Roentgenol Radium Ther Nucl Med. 1972 May;115(1):126–32. pmid:4537195
- 564. Wright RE, Turner JS. Positive angle myelograms without acoustic neuroma. Laryngoscope. 1973 May;83(5):733–46. pmid:4702472
- 565. Adeloye A, Ogan O, Olumide AA. Arachnoiditis presenting as a cerebello-pontine angle tumour. J Laryngol Otol. 1978 Oct;92(10):911–3. pmid:309500
- 566. Dunkser SB, McCreary HS. Leptomeningeal cyst of the posterior fossa. Case report. J Neurosurg. 1971 May;34(5):687–92.
- 567. Ebina K, Suzuki S, Iwabuchi T. Clinical study of chronic arachnoiditis in the posterior fossa. Acta Neurochir (Wien). 1976;33(1–2):69–81. pmid:1274708
- 568. Ekuma M, Goto T, Hanaoka Y, Kanaya K, Horiuchi T, Hongo K, et al. Unilateral isolated hypoglossal nerve palsy due to pathologically adherent PICA fusiform aneurysm-A case report. Surg Neurol Int. 2017;8 (1) (no pagination)(114). pmid:28680733
- 569. Hald E. Arachnoiditis of the cerebellopontines cistern. Acta Otolaryngol (Stockh). 1947 Aug;35(4):377–89. pmid:18898428
- 570. Horrax G. GENERALIZED CISTERNAL ARACHNOIDITIS SIMULATING CEREBELLAR TUMOR: ITS SURGICAL TREATMENT AND END-RESULTS. Arch Surg [Internet]. 1924 Jul 1 [cited 2019 May 5];9(1):95–112. Available from: https://jamanetwork.com/journals/jamasurgery/fullarticle/536893.
- 571. Raimondo N, Vigorelli E. Ocular symptomatology of arachnoiditis of the posterior fossa. Associated with occlusive hydrocephalus. Am J Ophthalmol. 1963 Mar;55:521–6. pmid:13990504
- 572. Rongxun Z. Chronic arachnoiditis in the posterior fossa: a study of 82 cases. J Neurol Neurosurg Psychiatry [Internet]. 1982 Jul [cited 2019 Jan 6];45(7):598–602. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC491474/. pmid:6981688
- 573. Sun L, Emich S, Fu W, Chen Z, Hao W, Ling F, et al. Retrocerebellar arachnoid cyst resulting in syringomyelia in a patient without tonsillar herniation: successful surgical treatment with reconstruction of CSF flow in the foramen magnum region. Neurosurg Rev. 2016 Apr;39(2):341–6; discussion 347. pmid:26728365
- 574. Thompson RK. Cystic cerebellar arachnoiditis. J Neurosurg. 1946 Nov;3(6):461–7. pmid:20279142
- 575. Shirao T, Ichiki H, Uchiyama K, Okuma Y, Takezako K, Sakamoto A. Clinical Survey of 153 Consecutive Cases of Cerebral Arachnoiditis; The Effect of Combinaiton of Spinal Tap with Instillation of Air and Steroid Hormon for Ophthalmologic Symptoms. Neurol Med Chir (Tokyo). 1966;8.
- 576. Gourie-Devi M, Satish P. Hyaluronidase as an adjuvant in the treatment of cranial arachnoiditis (hydrocephalus and optochiasmatic arachnoiditis) complicating tuberculous meningitis. Acta Neurol Scand. 1980 Dec;62(6):368–81. pmid:7468156
- 577. Anupriya A, Sunithi M, Maya T, Goel M, Alexander M, Aaron S, et al. Tuberculous optochiasmatic arachnoiditis. Neurol India. 2010 Oct;58(5):732–5. pmid:21045497
- 578. Arle JE, Abrahams JM, Zager EL, Taylor C, Galetta SL. Pupil-sparing third nerve palsy with preoperative improvement from a posterior communicating artery aneurysm. Surg Neurol. 2002 Jun;57(6):423–6; discussion 426–427. pmid:12176209
- 579. Bell RA, Robertson DM, Rosen DA, Kerr AW. Optochiasmatic arachnoiditis in multiple sclerosis. Arch Ophthalmol. 1975 Mar;93(3):191–3. pmid:1138685
- 580. Brain WR. Arachnoiditis following Acute Mastoiditis, and Leading to Obesity. J R Soc Med. 1930;23(4):527.
- 581. Brochert A, Reynolds T, Baker R. MRI in a case of muslin-induced granuloma. Neuroradiology [Internet]. 2003 Feb;45(2):82–4. Available from: https://www.ncbi.nlm.nih.gov/pubmed/12592488 pmid:12592488
- 582. Cant JS, Harrison MI. Chiasmatic arachnoiditis with growth failure. Am J Ophthalmol. 1968 Mar;65(3):432–4. pmid:5640546
- 583. Carreras EM, Lyons CJ, Cochrane DD. Delayed visual loss from optochiasmatic arachnoiditis after resection of craniopharyngioma. J Neurosurg Pediatr. 2014 May;13(5):520–4. pmid:24606404
- 584. Cox M, Sedora-Roman NI, Choudhri O. Muslin Granuloma Mimicking Parenchymal Hematoma in Patient with Seizures 30 Years After Aneurysm Wrapping. World Neurosurg. 2018 Dec;120:129–30. pmid:30189309
- 585. Coyle JT. Chiasmatic arachnoiditis. A case report and review. Am J Ophthalmol. 1969 Aug;68(2):345–9. pmid:5306335
- 586. Craig WM, Lillie WI. CHIASMAL SYNDROME PRODUCED BY CHRONIC LOCAL ARACHNOIDITIS: REPORT OF EIGHT CASES. Arch Ophthalmol [Internet]. 1931 Apr 1 [cited 2019 Apr 21];5(4):558–74. Available from: https://jamanetwork.com/journals/jamaophthalmology/fullarticle/609011.
- 587. Dickmann GH, Cramer FK, Kaplan AD. Opto-chiasmatic arachnoiditis; surgical treatment and results. J Neurosurg. 1951 Jul;8(4):355–9. pmid:14851009
- 588. Ewelt C, Stalder S, Steiger HJ, Brandt GH, Heilbronner R. Impact of cordectomy as a treatment option for posttraumatic and non-posttraumatic syringomyelia with tethered cord syndrome and myelopathy. J Neurosurg Spine. 2010 Aug;13(2):193–9. pmid:20672954
- 589. Feldman AW. Optic atrophy with arachnoiditis. Am J Ophthalmol. 1947 Aug;30(8):1027. pmid:20344417
- 590. Felsberg GJ, Tien RD, Haplea S, Osumi AK. Muslin-induced optic arachnoiditis (“gauzoma”): findings on CT and MR. J Comput Assist Tomogr. 1993 Jun;17(3):485–7. pmid:8491918
- 591. Fujimura M, Nishijima M, Umezawa K, Hayashi T, Mino Y, Sakuraba T, et al. Optochiasmal arachnoiditis following cotton wrapping of anterior communicating artery aneurysm treated by surgical removal of granuloma. J Clin Neurosci Off J Neurosurg Soc Australas [Internet]. 2003;10(2):254–7. Available from: https://www.ncbi.nlm.nih.gov/pubmed/12637066. pmid:12637066
- 592. Gibbs DC. Chiasmal arachnoiditis. Br J Ophthalmol. 1959 Jan;43(1):52–6. pmid:13618533
- 593. Goldsmith AJ. Chiasmal Arachnoiditis. Proc R Soc Med. 1943 Feb;36(4):163–8. pmid:19992601
- 594. Gupta SR, Biller J, Frenkel M, Yarzagaray L, Fine M. Foster-Kennedy syndrome due to optochiasmatic arachnoiditis. Surg Neurol. 1983 Sep;20(3):216–20. pmid:6879420
- 595. Iraci G, Galligioni F, Gerosa M, Secchi AG, Fiore D, Zampieri P, et al. Opto-chiasmatic arachnoiditis: a review of traditional neuroradiological diagnosis (82 cases, 1951–1976). Acta Neurochir (Wien). 1979;48(3–4):151–76. pmid:384755
- 596. Kravitz D. ARACHNOIDITIS. Arch Ophthalmol [Internet]. 1947 Feb 1 [cited 2019 Jun 17];37(2):199–210. Available from: https://jamanetwork.com/journals/jamaophthalmology/fullarticle/619299. pmid:20287735
- 597. Lee KF. Ischemic chiasma syndrome. AJNR Am J Neuroradiol. 1983 Jun;4(3):777–80. pmid:6410855
- 598. Lemoine AN. Optic Tract Lesion, Probably the Result of Opticochiasmal Arachnoiditis Due to Infected Sphenoid Sinuses. Trans Am Ophthalmol Soc. 1938;36:145–56. pmid:16693143
- 599. Marcus AO, Demakas JJ, Ross HA, Duick DS, Crowell RM. Optochiasmatic arachnoiditis with treatment by surgical lysis of adhesions, corticosteroids, and cyclophosphamide: report of a case. Neurosurgery. 1986 Jul;19(1):101–3. pmid:3748328
- 600. Maruki C, Nakano H, Shimoji T, Maeda M, Ishii S. Loss of vision due to cryptococcal optochiasmatic arachnoiditis and optocurative surgical exploration—case report. Neurol Med Chir (Tokyo). 1988 Jul;28(7):695–7. pmid:2462180
- 601. McClard CK, Prospero Ponce CM, Vickers A, Lee AG. Case Report: Late Sequela of a Muslinoma Involving the Optic Chiasm. Neuro-Ophthalmol Aeolus Press. 2018 Dec;42(6):385–90. pmid:30524491
- 602. McFadzean RM, Hadley DM, McIlwaine GG. Optochiasmal arachnoiditis following muslin wrapping of ruptured anterior communicating artery aneurysms. J Neurosurg. 1991 Sep;75(3):393–6. pmid:1869940
- 603. Navarro IM, Peralta VH, Leon JA, Varela EA, Cabrera JM. Tuberculous optochiasmatic arachnoiditis. Neurosurgery. 1981 Dec;9(6):654–60. pmid:7322330
- 604. Oliver M, Beller AJ, Behar A. Chiasmal arachnoiditis as a manifestation of generalized arachnoiditis in systemic vascular disease. Clinico-pathological report of two cases. Br J Ophthalmol. 1968 Mar;52(3):227–35. pmid:4384625
- 605. Ouma J. Visual deterioration 1(1/2) years after wrapping an un-clippable anterior communicating artery aneurysm: report of a case and review of the literature regarding opto-chiasmatic arachnoiditis. Afr J Psychiatry. 2007 Aug;10(3):164–6. pmid:19588037
- 606. Prabhu SS, Keogh AJ, Parekh HC, Perera S. Optochiasmal arachnoiditis induced by muslin wrapping of intracranial aneurysms. A report of two cases and a review of the literature. Br J Neurosurg. 1994;8(4):471–6. pmid:7811414
- 607. Raiford MB. Optochiasmatic arachnoiditis. Coll PHYSICIANS Phila Sect Ophthalmol. 1949 Sep;32:157–8.
- 608. Ramina R, Arruda WO, Prestes AC, Parolim MK. Severe optochiasmatic arachnoiditis after rupture of an internal carotid artery aneurysm. Arq Neuropsiquiatr. 1989 Jun;47(2):192–6. pmid:2597011
- 609. Scott RM, Sonntag VK, Wilcox LM, Adelman LS, Rockel TH. Visual loss from optochiasmatic arachnoiditis after tuberculous meningitis. Case report. J Neurosurg. 1977 Apr;46(4):524–6. pmid:845636
- 610. Sinha MK, Garg RK, Anuradha HK, Agarwal A, Parihar A, Mandhani PA. Paradoxical vision loss associated with optochiasmatic tuberculoma in tuberculous meningitis: a report of 8 patients. J Infect. 2010 Jun;60(6):458–66. pmid:20346972
- 611. Tai MLS, Viswanathan S, Rahmat K, Chong HT, Goh WZ, Yeow EKM, et al. Tuberculous optochiasmatic arachnoiditis and optochiasmatic tuberculoma in Malaysia. Neurol Asia. 2018 Dec;23(4):319–25.
- 612. Taravati P, Lee AG, Bhatti MT, Lewis SB. That’s a wrap. Surv Ophthalmol. 2006 Aug;51(4):434–44. pmid:16818086
- 613. Yoon MA, Kim E, Kwon B, Kim JE, Kang HS, Park JH, et al. Muslinoma and muslin-induced foreign body inflammatory reactions after surgical clipping and wrapping for intracranial aneurysms: imaging findings and clinical features. J Neurosurg. 2010;112(3):640–7. pmid:20192671
- 614. Yu-Wai-Man P, Neoh C. Delayed Optochiasmal Arachnoiditis following Intervention for a Subarachnoid Haemorrhage. Ophthalmol Int [Internet]. 2013 [cited 2019 Apr 19];8(3):85–6. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340544/ pmid:25729408
- 615. Cervera-Martinez C, Martinez-Manrique JJ, Revuelta-Gutierrez R. Surgical management of familial trigeminal neuralgia with different inheritance patterns: A case report. Front Neurol. 2018;9(MAY):316. pmid:29867726
- 616. Chen GQ, Wang XS, Wang L, Zheng JP. Arterial compression of nerve is the primary cause of trigeminal neuralgia. Neurol Sci Off J Ital Neurol Soc Ital Soc Clin Neurophysiol. 2014 Jan;35(1):61–6. pmid:23963805
- 617. Chen JCT. Microvascular decompression for trigeminal neuralgia in patients with and without prior stereotactic radiosurgery. World Neurosurg. 2012 Jul;78(1–2):149–54. pmid:22120253
- 618. Cheng J, Liu W, Hui X, Lei D, Zhang H. Microvascular decompression for trigeminal neuralgia in patients with failed gamma knife surgery: Analysis of efficacy and safety. Clin Neurol Neurosurg. 2017 Oct;161:88–92. pmid:28865322
- 619. Dumot C, Brinzeu A, Berthiller J, Sindou M. Trigeminal neuralgia due to venous neurovascular conflicts: outcome after microvascular decompression in a series of 55 consecutive patients. Acta Neurochir (Wien). 2017;159(2):237–49. pmid:27817008
- 620. Grigoryan YA, Onopchenko CV. Persistent trigeminal neuralgia after removal of contralateral posterior cranial fossa tumor. Report of two cases. Surg Neurol. 1999 Jul;52(1):56–60; discussion 60–61. pmid:10390175
- 621. Hsu HT, Huang CJ, Huang KF, Lee MH, Chen HH. Role of the blood vessel and arachnoid as conflicting structures during microvascular decompression for treating typical trigeminal neuralgia. Formos J Surg. 2016;49(4):142–8.
- 622. Huang H, Wang Z, Ma Y, Li Y, Wang L, Wang G, et al. Analysis of magnetic resonance tomographic angiography false negatives in trigeminal neuralgia before microvascular decompression. Oral Radiol. 2017;33(1):45–50.
- 623. Ishikawa M, Soma N, Kojima A, Naritaka H. Straightening the trigeminal nerve axis by complete dissection of arachnoidal adhesion and its neuroendoscopic confirmation for trigeminal neuralgia without neurovascular compression. Interdiscip Neurosurg Adv Tech Case Manag. 2017 Dec;10:126–9.
- 624. Khan SA, Khan B, Khan AA, Afridi EAK, Mehmood S, Muhammad G, et al. MICROVASCULAR DECOMPRESSION FOR TRIGEMINAL NEURALGIA. J Ayub Med Coll Abbottabad JAMC. 2015 Sep;27(3):539–42. pmid:26721002
- 625. Lopez-Elizalde R, Reyes-Velasco E, Campero A, Ajler P, Cornelio-Freer KC, Godinez-Rubi M. Minimally invasive asterional approach for microvascular decompression in trigeminal neuralgia. Gac Med Mex. 2019;155(Supplement 1):S56–63. pmid:31638613
- 626. Mazzucchi E, Brinzeu A, Sindou M. Arachnoiditis as an outcome factor for microvascular decompression in classical trigeminal neuralgia. Acta Neurochir (Wien). 2019 Aug;161(8):1589–98. pmid:31240582
- 627. Rappaport ZH, Gomori JM. Recurrent trigeminal cistern glycerol injections for tic douloureux. Acta Neurochir (Wien). 1988;90(1–2):31–4. pmid:2449803
- 628. Sekula RF, Frederickson AM, Jannetta PJ, Bhatia S, Quigley MR. Microvascular decompression after failed Gamma Knife surgery for trigeminal neuralgia: a safe and effective rescue therapy? J Neurosurg. 2010 Jul;113(1):45–52. pmid:20136393
- 629. Sindou M, Leston J, Decullier E, Chapuis F. Microvascular decompression for primary trigeminal neuralgia: long-term effectiveness and prognostic factors in a series of 362 consecutive patients with clear-cut neurovascular conflicts who underwent pure decompression. J Neurosurg. 2007 Dec;107(6):1144–53. pmid:18077952
- 630. Ugwuanyi UCPC, Kitchen ND. The operative findings in re-do microvascular decompression for recurrent trigeminal neuralgia. Br J Neurosurg. 2010 Feb;24(1):26–30. pmid:20158349
- 631. Enzmann DR, Norman D, Mani J, Newton TH. Computed tomography of granulomatous basal arachnoiditis. Radiology. 1976 Aug;120(2):341–4. pmid:778909
- 632. Byrd SE, Cohn ML, Biggers SL, Huntington CT, Locke GE, Charles MF. The radiographic evaluation of the symptomatic postoperative lumbar spine patient. Spine. 1985 Sep;10(7):652–61. pmid:2933827
- 633. Donaldson I, Gibson R. Spinal cord atrophy associated with arachnoiditis as demonstrated by computed tomography. Neuroradiology. 1982;24(2):101–5. pmid:7177369
- 634. Herkowitz HN, Garfin SR, Bell GR, Bumphrey F, Rothman RH. The use of computerized tomography in evaluating non-visualized vertebral levels caudad to a complete block on a lumbar myelogram. A review of thirty-two cases. J Bone Joint Surg Am. 1987 Feb;69(2):218–24. pmid:3805082
- 635. Leonardi M, Biasizzo E, Fabris G, Penco T, Bertolissi D. CT evaluation of the lumbosacral spine. AJNR Am J Neuroradiol. 1983 Jun;4(3):846–7. pmid:6410869
- 636. Teplick JG, Haskin ME. Intravenous contrast-enhanced CT of the postoperative lumbar spine: improved identification of recurrent disk herniation, scar, arachnoiditis, and diskitis. AJR Am J Roentgenol. 1984 Oct;143(4):845–55. pmid:6332496
- 637. Rockswold GL, Bradley WE, Timm GW, Chou SN. Electrophysiological technique for evaluating lesions of the conus medullaris and cauda equina. J Neurosurg. 1976 Sep;45(3):321–6. pmid:985854
- 638. Swash M, Snooks SJ. Slowed motor conduction in lumbosacral nerve roots in cauda equina lesions: a new diagnostic technique. J Neurol Neurosurg Psychiatry. 1986 Jul;49(7):808–16. pmid:3018168
- 639. Kawauchi Y, Yone K, Sakou T. Myeloscopic observation of adhesive arachnoiditis in patients with lumbar spinal canal stenosis. Spinal Cord [Internet]. 1996 Jul [cited 2019 Apr 20];34(7):403–10. Available from: http://www.nature.com/articles/sc199672. pmid:8963995
- 640. Peek RD, Thomas JCJ, Wiltse LL. Diagnosis of lumbar arachnoiditis by myeloscopy. Spine. 1993 Nov;18(15):2286–9. pmid:8278848
- 641. Tobita T, Okamoto M, Tomita M, Yamakura T, Fujihara H, Baba H, et al. Diagnosis of spinal disease with ultrafine flexible fiberscopes in patients with chronic pain. Spine. 2003 Sep 1;28(17):2006–12. pmid:12973149
- 642. Selinsky H. Disseminated spinal arachnoiditis: Its diagnosis and treatment with roentgen rays. Arch Neurol Psychiatry. 1936;35(6):1262–79.
- 643. Delamarter RB, Ross JS, Masaryk TJ, Modic MT, Bohlman HH. Diagnosis of lumbar arachnoiditis by magnetic resonance imaging. Spine. 1990 Apr;15(4):304–10. pmid:2353276
- 644. Anderson TL, Morris JM, Wald JT, Kotsenas AL. Imaging Appearance of Advanced Chronic Adhesive Arachnoiditis: A Retrospective Review. AJR Am J Roentgenol. 2017 Sep;209(3):648–55. pmid:28639826
- 645. Aldrete JA, Avidan A, Davidson E, Gomori M. Nerve root “irritation” or inflammation diagnosed by magnetic resonance imaging [2] (multiple letters). Anesthesiology. 2003 May 1;98(5):1294.
- 646. Bruining K, Weiss K, Zeifer B, Comfort C, Kaplan JG. Arachnoiditis in the Cauda Equina Syndrome of Longstanding Ankylosing Spondylitis. J Neuroimaging. 1993 Jan 1;3(1):55–7.
- 647. Burke JW, Podrasky AE, Bradley WG. Meninges: benign postoperative enhancement on MR images. Radiology. 1990 Jan;174(1):99–102. pmid:2294579
- 648. Cavanagh S, Stevens J, Johnson JR. High-resolution MRI in the investigation of recurrent pain after lumbar discectomy. J Bone Joint Surg Br. 1993 Jul;75(4):524–8. pmid:8331103
- 649. Chang HS, Nagai A, Oya S, Matsui T. Dorsal spinal arachnoid web diagnosed with the quantitative measurement of cerebrospinal fluid flow on magnetic resonance imaging: Report of 2 cases. J Neurosurg Spine. 2014 Feb;20(2):227–33.
- 650. Dhagat PK, Jain M, Singh SN, Arora S, Leelakanth K. Failed Back Surgery Syndrome: Evaluation with Magnetic Resonance Imaging. J Clin Diagn Res JCDR. 2017 May;11(5):TC06–9. pmid:28658870
- 651. Dong A, Zuo C, Zhang P, Lu J, Bai Y. MRI and FDG PET/CT findings in 3 cases of spinal infectious arachnoiditis. Clin Nucl Med. 2014 Oct;39(10):900–3. pmid:24321827
- 652. Erdem H, Senbayrak S, Meriç K, Batirel A, Karahocagil MK, Hasbun R, et al. Cranial imaging findings in neurobrucellosis: results of Istanbul-3 study. Infection. 2016 Oct;44(5):623–31. pmid:27138335
- 653. Fan YF, Chong VF. MRI findings in failed back surgery syndrome. Med J Malaysia. 1995 Mar;50(1):76–81. pmid:7752981
- 654. Floeth F, Herdmann J. Chronic dura erosion and intradural lumbar disc herniation: CT and MR imaging and intraoperative photographs of a transdural sequestrectomy. Eur Spine J Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sect Cerv Spine Res Soc. 2012 Jun;21 Suppl 4:S453–457. pmid:22109565
- 655. Gottschalk A, Schmitz B, Mauer UM, Bornstedt A, Steinhoff S, Danz B, et al. Dynamic visualization of arachnoid adhesions in a patient with idiopathic syringomyelia using high-resolution cine magnetic resonance imaging at 3T. J Magn Reson Imaging JMRI. 2010 Jul;32(1):218–22. pmid:20575079
- 656. Frizzell B, Kaplan P, Dussault R, Sevick R. Arachnoiditis ossificans: MR imaging features in five patients. AJR Am J Roentgenol [Internet]. 2001;177(2):461–4. Available from: https://www.ncbi.nlm.nih.gov/pubmed/11461883 pmid:11461883
- 657. Grane P, Lindqvist M. Evaluation of the post-operative lumbar spine with MR imaging. The role of contrast enhancement and thickening in nerve roots. Acta Radiol Stockh Swed 1987. 1997 Nov;38(6):1035–42. pmid:9394665
- 658. McIntyre HD. A suggested treatment of spinal block caused by spinal adhesive arachnoiditis by means of repeated spinal air injection. J Nerv Ment Dis. 1942;96(6):668–79.
- 659. Dale AJ, Love JG. Thorium dioxide myelopathy. JAMA J Am Med Assoc. 1967 Feb 27;199(9):606–9. pmid:6071250
- 660. Dullerud R, Morland TJ. Adhesive arachnoiditis after lumbar radiculography with Dimer-X and Depo-Medrol. Radiology. 1976 Apr;119(1):153–5. pmid:1257435
- 661. Jacobsen HH, Lester J. A myelographic manifestation of diffuse spinal leptomeningeal melanomatosis. Neuroradiology. 1970;1(1):30–1.
- 662. Jorgensen J, Hansen PH, Steenskov V, Ovesen N. A clinical and radiological study of chronic lower spinal arachnoiditis. Neuroradiology. 1975 Aug 7;9(3):139–44. pmid:1161142
- 663. Meyer MW, Powell HC, Wagner M, Niwayama G. Thorotrast induced adhesive arachnoiditis associated with meningioma and schwannoma. Hum Pathol. 1978 May;9(3):366–70. pmid:306957
- 664. Mulvey RB. An unusual myelographic pattern of arachnoiditis. Radiology. 1960 Nov;75:778–81. pmid:13726765
- 665. Smith RW, Loeser JD. A myelographic variant in lumbar arachnoiditis. J Neurosurg. 1972 Apr;36(4):441–6. pmid:5013614
- 666. Yamaguchi S, Hida K, Takeda M, Mitsuhara T, Morishige M, Yamada N, et al. Visualization of regional cerebrospinal fluid flow with a dye injection technique in focal arachnoid pathologies. J Neurosurg Spine. 2015 May;22(5):554–7. pmid:25679234
- 667. Wilson MR, Naccache SN, Samayoa E, Biagtan M, Bashir H, Yu G, et al. Actionable Diagnosis of Neuroleptospirosis by Next-Generation Sequencing. http://dx.doi.org/101056/NEJMoa1401268 [Internet]. 2014 Jun 18 [cited 2019 May 15]; Available from: https://www.nejm.org/doi/10.1056/NEJMoa1401268. pmid:24896819
- 668. Alkan O, Yildirim T, Kizilkilic O, Albayram S, Altinkaya N. Pseudoarachnoiditis in spontaneous intracranial hypotension. Balk Med J. 2011;28(1):107–10.
- 669. Beauchesne P, Pialat J, Duthel R, Barral FG, Clavreul G, Schmitt T, et al. Aggressive treatment with complete remission in primary diffuse leptomeningeal gliomatosis—a case report. J Neurooncol. 1998 Apr;37(2):161–7. pmid:9524095
- 670. Bose B, Myers DL, Osterholm JL. Arachnoiditis presenting as a cervical cord neoplasm: two case reports. Neurosurgery. 1983 Jan;12(1):120–2. pmid:6828217
- 671. Christensen E. CHRONIC ADHESIVE SPINAL ARACHNOIDITIS. Acta Psychiatr Scand. 1942;17(1):23–38.
- 672. Cinalli G, Sainte-Rose C, Lellouch-Tubiana A, Sebag G, Renier D, Pierre-Kahn A. Hydrocephalus associated with intramedullary low-grade gliomas. J Neurosurg [Internet]. 1995 Sep [cited 2019 Apr 19];83(3):480–5. Available from: https://thejns.org/view/journals/j-neurosurg/83/3/article-p480.xml
- 673. Cutler EC, Zollinger R. Case studies in chronic arachnoiditis. JAMA J Am Med Assoc. 1933;100(13):1022–5.
- 674. Dietrich PY, Aapro MS, Rieder A, Pizzolato GP. Primary diffuse leptomeningeal gliomatosis (PDLG): a neoplastic cause of chronic meningitis. J Neurooncol. 1993 Mar;15(3):275–83. pmid:8360714
- 675. Epstein F, Allen J. Segmental arachnoiditis after posterior fossa operation: differentiation from metastatic tumor deposit. Neurosurgery. 1981 Aug;9(2):183–4. pmid:7266819
- 676. idris et al. Fibromyalgia and arachnoiditis presented as an acute spinal disorder. Surg Neurol Int [Internet]. 2014 Oct [cited 2019 Apr 23]; Available from: http://surgicalneurologyint.com/surgicalint-articles/fibromyalgia-and-arachnoiditis-presented-as-an-acute-spinal-disorder/ pmid:25396073
- 677. Keet PC. The lumbar disc and its imitators. South Afr Med J Suid-Afr Tydskr Vir Geneeskd. 1975 Jul 12;49(29):1169–76. pmid:1154172
- 678. Kim KS, Ho SU, Weinberg PE, Lee C. Spinal leptomeningeal infiltration by systemic cancer: myelographic features. AJR Am J Roentgenol. 1982 Aug;139(2):361–5. pmid:6979894
- 679. Marshall GG. Cerebral pseudotumors or chronic arachnoiditis. Report of three cases. Am J Ophthalmol. 1933;16(9):799–802.
- 680. Nishio A, Ohata K, Takami T, Nishikawa M, Hara M. Atypical spinal dural arteriovenous fistula with supply from the lateral sacral artery. J Clin Neurosci Off J Neurosurg Soc Australas. 2007 Jan;14(1):65–8. pmid:17092723
- 681. Paramore CG. Dorsal arachnoid web with spinal cord compression: variant of an arachnoid cyst? Report of two cases. J Neurosurg. 2000 Oct;93(2 Suppl):287–90. pmid:11012061
- 682. Shinde SV, Monipanda K. Craniospinal dissemination of clival chondroid chordoma. J Postgrad Med. 2005 Sep;51(3):220–2. pmid:16333198
- 683. Stookey B. Adhesive spinal arachnoiditis simulating spinal cord tumor. Arch Neurol Psychiatry. 1927;17(2):151–78.
- 684. Vloeberghs M, Herregodts P, Stadnik T, Goossens A, D’Haens J. Spinal arachnoiditis mimicking a spinal cord tumor: a case report and review of the literature. Surg Neurol. 1992 Mar;37(3):211–5. pmid:1536026
- 685. Hoppenstein R. A new approach to the failed, failed back syndrome. Spine. 1980 Aug;5(4):371–9. pmid:6450450
- 686. Mooij JJ. Spinal arachnoiditis: disease or coincidence? Acta Neurochir (Wien). 1980;53(3–4):151–60. pmid:7424611
- 687. Barker LF, Ford FR. Chronic Arachnoiditis Obliterating the Spinal Subarachnoid Space. JAMA J Am Med Assoc. 1937;109(10):785–6.
- 688. Chan RC, Thompson GB, Bratty PJ. Symptomatic anterior spinal arachnoid diverticulum. Neurosurgery. 1985 May;16(5):663–5. pmid:3923384
- 689. de Mattos JP, André C, Couto BA. Recurrent spinal adhesive arachnoiditis. A case report. Arq Neuropsiquiatr. 1988 Mar;46(1):65–8. pmid:3408384
- 690. French JD. Recurrent arachnoiditis in the dorsal spinal region. Arch Neurol Psychiatry Chic. 1947 Aug;58(2):200–6. pmid:20263997
- 691. Grahame R, Clark B, Watson M, Polkey C. Toward a rational therapeutic strategy for arachnoiditis. A possible role for d-penicillamine. Spine. 1991 Feb;16(2):172–5. pmid:2011771
- 692. Hulbert NG. Various manifestations of non-specific arachnoiditis of indefinite aetiology. Postgrad Med J. 1944;20(221):108–11. pmid:21313365
- 693. Jenik F, Tekle-Haimanot R, Hamory BH. Non-traumatic adhesive arachnoiditis as a cause of spinal cord syndromes. Investigation on 507 patients. Spinal Cord [Internet]. 1981 Jun [cited 2018 Dec 27];19(3):140–54. Available from: https://www.nature.com/articles/sc198131
- 694. Morimoto O. A neurogenic factor affecting development of gastric and duodenal ulcers; on the chronic arachnoiditis. Folia Psychiatr Neurol Jpn. 1958 Apr;12(1):50–64. pmid:13609724
- 695. Murphy KR, Han JL, Yang S, Hussaini SMQ, Elsamadicy AA, Parente B, et al. Prevalence of Specific Types of Pain Diagnoses in a Sample of United States Adults. Pain Physician. 2017;20(2):E257–68. pmid:28158163
- 696. Paisley WJ, Ouvrier RA, Johnston I, Jones RF, Sofer-Schreiber M, de Silva M. Chronic spinal arachnoiditis in childhood. Dev Med Child Neurol. 1982 Dec;24(6):798–807. pmid:7152142
- 697. Shaw MD, Russell JA, Grossart KW. The changing pattern of spinal arachnoiditis. J Neurol Neurosurg Psychiatry. 1978 Feb;41(2):97–107. pmid:632824
- 698. Wadia NH, Dastur DK. Spinal meningitides with radiculo-myelopathy. 1. Clinical and radiological features. J Neurol Sci. 1969 Apr;8(2):239–60. pmid:5805757
- 699. Abduljabbar T, Williams B. Listeria monocytogenes meningitis complicated by symptomatic spinal subarachnoid cysts. Br J Neurosurg. 1996;10(3):317–9. pmid:8799548
- 700. Fortuna A, Mercuri S. Intradural spinal cysts. Acta Neurochir (Wien). 1983;68(3–4):289–314. pmid:6880882
- 701. Hung-Kai Weng R, Chang MC, Feng SW, Wang ST, Liu CL, Chen TH. Progressive growth of arachnoid cysts with cauda equina syndrome after lumbar spine surgery. J Chin Med Assoc. 2013 Sep;76(9):527–31. pmid:23806807
- 702. Kashcheev A, Arestov SO, Gushcha AO. Flexible endoscopy in surgical treatment of spinal adhesive arachnoiditis and arachnoid cysts. Zh Vopr Neirokhir Im N N Burdenko. 2013;77(5):44–54; discussion 54–5. pmid:24564085
- 703. Klekamp J. A New Classification for Pathologies of Spinal Meninges-Part 2: Primary and Secondary Intradural Arachnoid Cysts. Neurosurgery. 2017 Aug 1;81(2):217–29. pmid:28327950
- 704. Maenhoudt W, Rasschaert R, Bontinck H, Pinson H, Van Roost D, Hallaert G. Postarachnoiditis Anterior Spinal Arachnoid Cyst Formation with Compressive Myelopathy: Report of 2 Cases. World Neurosurg. 2018 Oct;118:59–62. pmid:30017769
- 705. Nath PC, Mishra SS, Deo RC, Satapathy MC. Intradural Spinal Arachnoid Cyst: A Long-Term Postlaminectomy Complication: A Case Report and Review of the Literature. World Neurosurg. 2016 Jan;85:367.e1-4. pmid:26428320
- 706. Tseng SH, Lin SM. Surgical treatment of thoracic arachnoiditis with multiple subarachnoid cysts caused by epidural anesthesia. Clin Neurol Neurosurg. 1997 Dec;99(4):256–8. pmid:9491300
- 707. Buxton N, Jaspan T, White B. Arachnoid telangiectasia causing meningeal fibrosis and secondary syringomyelia. Br J Neurosurg. 2001 Feb;15(1):54–7. pmid:11303664
- 708. Chalif D, Duchen LW, Marshall J, Hayward R. Progressive leptomeningeal fibrosis: a clinico-pathological case report. J Neurol Neurosurg Psychiatry. 1983 Mar;46(3):261–5. pmid:6842233
- 709. Cooper RG, Mitchell WS, Illingworth KJ, Forbes WS, Gillespie JE, Jayson MI. The role of epidural fibrosis and defective fibrinolysis in the persistence of postlaminectomy back pain. Spine. 1991 Sep;16(9):1044–8. pmid:1835160
- 710. De La Porte C, Siegfried J. Lumbosacral Spinal Fibrosis (Spinal Arachnoiditis): Its Diagnosis and Treatment by Spinal Cord Stimulation. Spine [Internet]. 1983 Sep [cited 2019 Apr 20];8(6):593. Available from: https://journals.lww.com/spinejournal/Abstract/1983/09000/Lumbosacral_Spinal_Fibrosis__Spinal.5.aspx.
- 711. Destian S, Heier LA, Zimmerman RD, Morgello S, Deck MD. Differentiation between meningeal fibrosis and chronic subdural hematoma after ventricular shunting: value of enhanced CT and MR scans. Am J Neuroradiol. 1989;10(5):1021–6. pmid:2505514
- 712. Etus V, Kurtkaya O, Koc K, Ciftci E, Sav A, Ceylan S. Multisegmental spinal leptomeningeal fibrosis in Riedel thyroiditis: Case illustration. J Neurosurg Spine [Internet]. 2003 Apr 1 [cited 2019 Apr 5];98(3):299–299. Available from: https://thejns.org/view/journals/j-neurosurg-spine/98/3/article-p299.xml.
- 713. Hoyland JA, Freemont AJ, Denton J, Thomas AM, McMillan JJ, Jayson MI. Retained surgical swab debris in post-laminectomy arachnoiditis and peridural fibrosis. J Bone Joint Surg Br. 1988 Aug;70(4):659–62. pmid:3403620
- 714. Netsky MG. Diffuse Meningiomatosis, Arachnoidal Fibrosis, and Syringomyelia. AMA Arch Neurol Psychiatry [Internet]. 1957 Dec 1 [cited 2019 Apr 5];78(6):553–61. Available from: https://jamanetwork.com/journals/archneurpsyc/fullarticle/652532. pmid:13478213
- 715. Probst C. Microsurgical cordotomy in 20 patients with epi-/intradural fibrosis following operation for lumbar disc herniation. Acta Neurochir (Wien). 1990;107(1–2):30–6. pmid:2096605
- 716. Sajanti J, Majamaa K. Detection of meningeal fibrosis after subarachnoid haemorrhage by assaying procollagen propeptides in cerebrospinal fluid. J Neurol Neurosurg Psychiatry. 1999 Aug;67(2):185–8. pmid:10406986
- 717. Couto da Silva JM, Couto da Silva JMJ, Antonio Aldrete J. Body temperature and diaphoresis disturbances in a patient with arachnoiditis. Anesth Analg [Internet]. 2001;93(6):1578–9, table of contents. Available from: https://www.ncbi.nlm.nih.gov/pubmed/11726448. pmid:11726448
- 718. McKenzie T. Nocturnal enuresis as a late complication of meningitis. Br Med J. 1971 Dec 11;4(5788):662–3. pmid:5134564
- 719. Maurice-Williams RS, Marsh HT. Priapism as a feature of claudication of the cauda equina. Surg Neurol. 1985 Jun;23(6):626–8. pmid:3992466
- 720. Bilello JA, Tennant FS. Patterns of chronic inflammation in extensively treated patients with arachnoiditis and chronic intractable pain. Postgrad Med. 2017;129(1):87–91. pmid:27929717
- 721. Kasapas K, Varthalitis D, Georgakoulias N, Orphanidis G. Hydrocephalus due to Membranous Obstruction of Magendie’s Foramen. J Korean Neurosurg Soc. 2015 Jan;57(1):68–71. pmid:25674349
- 722. Sgouros S, Malluci C, Walsh AR, Hockley AD. Long-term complications of hydrocephalus. Pediatr Neurosurg. 1995;23(3):127–32. pmid:8751293
- 723. Turnbull IM, Shulman R, Woodhurst WB. Thalamic stimulation for neuropathic pain. J Neurosurg. 1980;52(4):486–93. pmid:6966326
- 724. Shiraishi T, Crock HV, Reynolds A. Spinal arachnoiditis ossificans. Observations on its investigation and treatment. Eur Spine J Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sect Cerv Spine Res Soc. 1995;4(1):60–3. pmid:7749911
- 725. Bagley JH, Owens TR, Grunch BH, Moreno JR, Bagley CA. Arachnoiditis ossificans of the thoracic spine. J Clin Neurosci Off J Neurosurg Soc Australas. 2014 Mar;21(3):386–9. pmid:24291474
- 726. Bakhsh WR, Mesfin A, Bridwell KH. Arachnoiditis ossificans after revision adolescent idiopathic scoliosis surgery: a 22-year follow-up and review. Spine. 2013 Aug 15;38(18):E1166–1170. pmid:23722605
- 727. Chan CC, Lau PY, Sun LK, Lo SS. Arachnoiditis ossificans. Hong Kong Med J Xianggang Yi Xue Za Zhi. 2009 Apr;15(2):146–8. pmid:19342743
- 728. Domenicucci M, Ramieri A, Passacantilli E, Russo N, Trasimeni G, Delfini R. Spinal arachnoiditis ossificans: report of three cases. Neurosurgery [Internet]. 2004;55(4):985. Available from: https://www.ncbi.nlm.nih.gov/pubmed/15934184. pmid:15934184
- 729. El Asri AC, El Mostarchid B, Akhaddar A, Baallal H, Dao I, Naama O, et al. Arachnoiditis ossificans of the cauda equina. Br J Neurosurg. 2012 Aug;26(4):547–8. pmid:22239274
- 730. Faure A, Khalfallah M, Perrouin-Verbe B, Caillon F, Deschamps C, Bord E, et al. Arachnoiditis ossificans of the cauda equina. Case report and review of the literature. J Neurosurg. 2002 Sep;97(2 Suppl):239–43. pmid:12296687
- 731. Hasturk AE, Coven I, Ozdemir O, Erinanc H, Bal A. Arachnoiditis ossificans in a patient with ankylosing spondylitis, syringomyelia, and a history of spinal surgery. J Back Musculoskelet Rehabil. 2013;26(4):479–82. pmid:23948833
- 732. Ibrahim GM, Kamali-Nejad T, Fehlings MG. Arachnoiditis ossificans associated with syringomyelia: An unusual cause of myelopathy. Evid-Based Spine-Care J. 2010 Aug;1(2):46–51. pmid:23637667
- 733. Jaspan T, Preston BJ, Mulholland RC, Webb JK. The CT appearances of arachnoiditis ossificans. Spine. 1990 Feb;15(2):148–51. pmid:2326711
- 734. Jokovic M, Grujicic D, Bascarevic V, Sokic D, Ristic AJ. Thoracal arachnoiditis ossificans associated with multifocal motor neuropathy: a case report. Br J Neurosurg. 2019.;
- 735. Joo KB, Lee S, Kang CN, Kim TH. Arachnoid ossificans of thoracolumbosacral spine in the advanced ankylosing spondylitis: a case report. Rheumatol Int. 2013 Jun;33(6):1623–5. pmid:22198660
- 736. Kahler RJ, Knuckey NW, Davis S. Arachnoiditis ossificans and syringomyelia: a unique case report. J Clin Neurosci Off J Neurosurg Soc Australas. 2000 Jan;7(1):66–8. pmid:10847657
- 737. Kasai Y, Sudo T, Sakakibara T, Akeda K, Sudo A. A Case of Lumbosacral Arachnoiditis Ossificans. NMC Case Rep J. 2016 Jan;3(1):5–8. pmid:28663987
- 738. Kitagawa H, Kanamori M, Tatezaki S, Itoh T, Tsuji H. Multiple spinal ossified arachnoiditis. A case report. Spine. 1990 Nov;15(11):1236–8. pmid:2125149
- 739. Kriaa S, Hafsa C, Zbidi M, Laifi A, Golli M, Gannouni A. Arachnoiditis ossificans of the lumbar spine: a case report. Jt Bone Spine Rev Rhum. 2006 Dec;73(6):765–7. pmid:16928463
- 740. Kumari M, Bhardwaj M, Choudhary A. A rare cause of progressive neuropathy: Arachnoiditis ossificans. Indian J Pathol Microbiol. 2019 Mar;62(1):114–6. pmid:30706872
- 741. Liu LD, Zhao S, Liu WG, Zhang SK. Arachnoiditis ossificans after spinal surgery. Orthopedics. 2015 May;38(5):e437–442. pmid:25970374
- 742. Lynch C, Moraes GP. Spinal arachnoiditis ossificans: case report. Neurosurgery. 1983 Mar;12(3):321–4. pmid:6843804
- 743. Manabe Y, Shiro Y, Warita H, Hayashi T, Nakashima H, Abe K. Fluctuating monoplegia due to venous insufficiency by spinal arachnoiditis ossificans. J Neurol Sci. 2000 Sep 15;178(2):163–6. pmid:11018709
- 744. Maulucci CM, Ghobrial GM, Oppenlander ME, Flanders AE, Vaccaro AR, Harrop JS. Arachnoiditis ossificans: clinical series and review of the literature. Clin Neurol Neurosurg. 2014 Sep;124:16–20. pmid:24999276
- 745. McCullough GA. Arachnoid calcification producing spinal cord compression. J Neurol Neurosurg Psychiatry [Internet]. 1975 Nov [cited 2019 May 26];38(11):1059–62. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC492156/. pmid:1206414
- 746. Mello LR, Bernardes CI, Feltrin Y, Rodacki MA. Thoracic spine arachnoid ossification with and without cord cavitation: Report of three cases. J Neurosurg. 2001;94(1 SUPPL.):115–20.
- 747. Miles J, Bhandari YS. Ossifying spinal arachnoiditis. Neurochirurgia (Stuttg). 1971 Sep;14(5):184–8. pmid:4999304
- 748. Nainkin L. Arachnoiditis ossificans. Report of a case. Spine. 1978 Mar;3(1):83–6. pmid:644395
- 749. Ng P, Lorentz I, Soo YS. Arachnoiditis ossificans of the cauda equina demonstrated on computed tomography scanogram. A case report. Spine. 1996 Nov 1;21(21):2504–7. pmid:8923640
- 750. Nizzoli V, Testa C. A case of calcification in the spinal arachnoid giving rise to spinal cord compression. J Neurol Sci [Internet]. 1968 Sep 1 [cited 2019 May 26];7(2):381–4. Available from: https://www.jns-journal.com/article/0022-510X(68)90156-1/abstract. pmid:5707084
- 751. Papavlasopoulos F, Stranjalis G, Kouyialis AT, Korfias S, Sakas D. Arachnoiditis ossificans with progressive syringomyelia and spinal arachnoid cyst. J Clin Neurosci Off J Neurosurg Soc Australas. 2007 Jun;14(6):572–6. pmid:17368029
- 752. Puusepp L. Surgical intervention in four cases of myelitis compression caused by osseous deposits in the arachnoidea of the spinal cord (arachnoiditis ossificans). J Nerv Ment Dis. 1931;73(1):1–19.
- 753. Scalia G, Certo F, Maione M, Barbagallo GMV. Spinal Arachnoiditis Ossificans: Report of Quadruple-Triggered Case. World Neurosurg [Internet]. 2019 Mar [cited 2019 May 4];123:1–6. Available from: http://europepmc.org/abstract/med/30521955. pmid:30521955
- 754. Singh H, Meyer SA, Jannapureddy MR, Weiss N. Arachnoiditis ossificans. World Neurosurg. 2011 Nov;76(5):478.e12-14. pmid:22152583
- 755. Steel CJ, Abrames EL, O’Brien WT. Arachnoiditis Ossificans—A Rare Cause of Progressive Myelopathy. Open Neuroimaging J. 2015;9:13–20.
- 756. Tetsworth KD, Ferguson RL. Arachnoiditis ossificans of the cauda equina. A case report. Spine. 1986 Sep;11(7):765–6. pmid:3024330
- 757. Toribatake Y, Baba H, Maezawa Y, Umeda S, Tomita K. Symptomatic arachnoiditis ossificans of the thoracic spine. Case report. Paraplegia. 1995 Apr;33(4):224–7. pmid:7609981
- 758. Varughese G. Lumbosacral intradural periradicular ossification: Case report. J Neurosurg [Internet]. 1978 Jul 1 [cited 2021 Mar 27];49(1):132–7. Available from: https://thejns.org/view/journals/j-neurosurg/49/1/article-p132.xml.
- 759. Wang C, Chen Z, Song D, Xuan T. Arachnoiditis ossificans associated with syringomyelia: a case report. Br J Neurosurg. 2017 Nov 2;1–3. pmid:29092643
- 760. Wang L, Wang YP. Arachnoiditis ossificans of lumbosacral spine: a case report and literature review. Chin Med Sci J. 2014 Jun;29(2):125–7. pmid:24998238
- 761. Wang S, Ahuja CS, Das S. Arachnoiditis Ossificans: a Rare Etiology of Oil-Based Spinal Myelography and Review of Literature. World Neurosurg. 2019 Mar 9;09:09.
- 762. Whittle IR, Dorsch NW, Segelov JN. Symptomatic arachnoiditis ossificans. Report of two cases. Acta Neurochir (Wien). 1982;65(3–4):207–16. pmid:7180598
- 763. Wise BL, Smith M. Spinal arachnoiditis ossificans. Oper Treat Course—On Nov 13 1962 Thoracolumbar Laminectomy Was Performed Gen Anesth Excision Lamina T-10–2 Dura Was Opened Spinal Cord Roots Were Found Be Involv Dense Adhes Arachnoiditis Ext Length Incision Posteriorly Several Bony Plaques Were Encased Scarred Arachnoid Some These Plaques Small Amount Adhes Arachnoidal Tissue Were Removed. 1965 Oct;13(4):391–4.
- 764. Agarwal N, Hansberry DR, Goldstein IM. Tethered Cord as a Complication of Chronic Cerebral Spinal Fluid Diversion. Int J Spine Surg. 2017;11:26. pmid:29372130
- 765. Lee JH, Jeon I, Kim SW. Intradural Extramedullary Capillary Hemangioma In the Upper Thoracic Spine with Simultaneous Extensive Arachnoiditis. Korean J Spine. 2017 Jun;14(2):57–60. pmid:28704911
- 766. O’Connor M, Brighouse D, Glynn CJ. Unusual complications of the treatment of chronic spinal arachnoiditis. Clin J Pain. 1990 Sep;6(3):240–2. pmid:2135019
- 767. de Goede CGEL, Jardine PE, Eunson P, Renowden S, Sharples P, Newton RW. Severe progressive late onset myelopathy and arachnoiditis following neonatal meningitis. Eur J Paediatr Neurol EJPN Off J Eur Paediatr Neurol Soc. 2006 Jan;10(1):31–6. pmid:16540357
- 768. Wolfgang GL. Neurotrophic arthropathy of the shoulder—a complication of progressive adhesive arachnoiditis. A case report. Clin Orthop [Internet]. 1972 Sep;87:217–21. Available from: https://journals.lww.com/clinorthop/Citation/1972/09000/Neurotrophic_Arthropathy_of_the_Shoulder_A.27.aspx.
- 769. Woods WW, Franklin RG. Progressive adhesive arachnoiditis following spinal anesthesia. Calif Med [Internet]. 1951 Sep;75(3):196–8. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1521038/. pmid:14870035
- 770. Aghakhani N, Baussart B, David P, Lacroix C, Benoudiba F, Tadie M, et al. Surgical Treatment of Posttraumatic Syringomyelia. Neurosurgery. 2010 Jun;66(6):1120–7; discussion 1127. pmid:20495426
- 771. Aghakhani N, Parker F, David P, Morar S, Lacroix C, Benoudiba F, et al. Long-term follow-up of Chiari-related syringomyelia in adults: analysis of 157 surgically treated cases. Neurosurgery. 2009 Feb;64(2):308–15; discussion 315. pmid:19190458
- 772. Aldrete JA, Ferrari H. Myelopathy with Syringomyelia following Thoracic Epidural Anaesthesia. Anaesth Intensive Care [Internet]. 2004 Feb 1 [cited 2019 May 14];32(1):100–3. Available from: https://doi.org/10.1177/0310057X0403200116. pmid:15058129
- 773. Appleby A, Bradley WG, Foster JB, Hankinson J, Hudgson P. Syringomyelia due to chronic arachnoiditis at the foramen magnum. J Neurol Sci. 1969 Jun;8(3):451–64. pmid:5807283
- 774. Barbaro NM, Wilson CB, Gutin PH, Edwards MS. Surgical treatment of syringomyelia. Favorable results with syringoperitoneal shunting. J Neurosurg. 1984 Sep;61(3):531–8. pmid:6747690
- 775. Ben Nsir A, Boubaker A, Jemel H. Syringomyelia following surgery for a spontaneous spinal subdural hematoma in a 13-year-old girl with congenital von Willebrand disease: case report and literature review. Childs Nerv Syst [Internet]. 2016 Apr [cited 2019 Apr 10];32(4):727–31. Available from: http://link.springer.com/10.1007/s00381-015-2875-3. pmid:26277360
- 776. Brammah TB, Jayson MI. Syringomyelia as a complication of spinal arachnoiditis. Spine. 1994 Nov 15;19(22):2603–5. pmid:7855688
- 777. Brodbelt AR, Stoodley MA. Syringomyelia and the arachnoid web. Acta Neurochir (Wien). 2003 Aug;145(8):707–11; discussion 711. pmid:14520553
- 778. Caplan LR, Norohna AB, Amico LL. Syringomyelia and arachnoiditis. J Neurol Neurosurg Psychiatry [Internet]. 1990 Feb 1 [cited 2019 Apr 10];53(2):106–13. Available from: http://jnnp.bmj.com/cgi/doi/10.1136/jnnp.53.2.106. pmid:2313296
- 779. Chang HS, Joko M, Matsuo N, Kim SD, Nakagawa H. Subarachnoid pressure-dependent change in syrinx size in a patient with syringomyelia associated with adhesive arachnoiditis. Case report. J Neurosurg Spine [Internet]. 2005;2(2):209–14. Available from: https://www.ncbi.nlm.nih.gov/pubmed/15739536. pmid:15739536
- 780. Ciappetta P, D’Urso PI, Delvecchio C, Colamaria A, De Giorgi G. Cervicothoracic postarachnoiditic hydrosyringomyelia secondary to pedicular hook dislocation: case report. Surg Neurol. 2009 Apr;71(4):500–3; discussion 503. pmid:18207536
- 781. da Silva JAG, Holanda MM de A. Basilar impression, Chiari malformation and syringomyelia: a retrospective study of 53 surgically treated patients. Arq Neuropsiquiatr. 2003 Jun;61(2B):368–75. pmid:12894269
- 782. Davidoff CL, Liu S, Wong JHY, Koustais S, Rogers JM, Stoodley MA. Treatment of Syringomyelia in Patients with Arachnoiditis at the Craniocervical Junction. World Neurosurg. 2017 Nov;107:565–73. pmid:28842236
- 783. Davidson KA, Rogers JM, Stoodley MA. Syrinx to Subarachnoid Shunting for Syringomyelia. World Neurosurg. 2018 Feb;110:e53–9. pmid:29017977
- 784. Ellenbogen RG, Armonda RA, Shaw DW, Winn HR. Toward a rational treatment of Chiari I malformation and syringomyelia. Neurosurg Focus. 2000 Mar 15;8(3):E6. pmid:16676929
- 785. Fischer EG, Welch K, Shillito J. Syringomyelia following lumboureteral shunting for communicating hydrocephalus. Report of three cases. J Neurosurg [Internet]. 1977 Jul;47(1):96–100. Available from: https://www.ncbi.nlm.nih.gov/pubmed/864509. pmid:864509
- 786. Haimoto S, Nishimura Y, Ginsberg HJ. Surgical treatment of a thoracic ventral intradural arachnoid cyst associated with syringomyelia: case report. J Neurosurg Spine. 2018 Nov 1;1–5. pmid:30497153
- 787. Hirai T, Kato T, Kawabata S, Enomoto M, Tomizawa S, Yoshii T, et al. Adhesive arachnoiditis with extensive syringomyelia and giant arachnoid cyst after spinal and epidural anesthesia: a case report. Spine. 2012 Feb 1;37(3):E195–198. pmid:21738091
- 788. Huang H, Li Y, Xu K, Li Y, Qu L, Yu J. Foramen magnum arachnoid cyst induces compression of the spinal cord and syringomyelia: case report and literature review. Int J Med Sci. 2011;8(4):345–50. pmid:21647327
- 789. Iwatsuki K, Yoshimine T, Ohnishi YI, Ninomiya K, Moriwaki T, Ohkawa T. Syringomyelia associated with spinal arachnoiditis treated by partial arachnoid dissection and syrinx-far distal subarachnoid shunt. Clin Med Insights Case Rep. 2014;7:107–10. pmid:25232285
- 790. Kakar A, Madan VS, Prakash V. Syringomyelia—a complication of meningitis–case report. Spinal Cord [Internet]. 1997 Sep [cited 2019 Apr 19];35(9):629–31. Available from: http://www.nature.com/articles/3100420. pmid:9300973
- 791. Klekamp J. Treatment of syringomyelia related to nontraumatic arachnoid pathologies of the spinal canal. Neurosurgery. 2013 Mar;72(3):376–89. pmid:23208064
- 792. Klekamp J, Batzdorf U, Samii M, Bothe HW. Treatment of syringomyelia associated with arachnoid scarring caused by arachnoiditis or trauma. J Neurosurg. 1997 Feb;86(2):233–40. pmid:9010425
- 793. Klekamp J, Iaconetta G, Batzdorf U, Samii M. Syringomyelia associated with foramen magnum arachnoiditis. J Neurosurg [Internet]. 2002;97(3 Suppl):317–22. Available from: https://www.ncbi.nlm.nih.gov/pubmed/12408385. pmid:12408385
- 794. Koyanagi I, Iwasaki Y, Hida K, Houkin K. Clinical features and pathomechanisms of syringomyelia associated with spinal arachnoiditis. Surg Neurol. 2005 Apr;63(4):350–5; discussion 355–356. pmid:15808720
- 795. Lubin AJ. Adhesive spinal arachnoiditis as a cause of intramedullary cavitation: Comparison with syringomyelia. Arch Neurol Psychiatry. 1940;44(2):409–20.
- 796. Milhorat TH, Capocelli AL, Anzil AP, Kotzen RM, Milhorat RH. Pathological basis of spinal cord cavitation in syringomyelia: analysis of 105 autopsy cases. J Neurosurg. 1995 May;82(5):802–12. pmid:7714606
- 797. Milhorat TH, Johnson RW, Milhorat RH, Capocelli AL, Pevsner PH. Clinicopathological correlations in syringomyelia using axial magnetic resonance imaging. Neurosurgery. 1995 Aug;37(2):206–13. pmid:7477770
- 798. Naftel RP, Tubbs RS, Menendez JY, Wellons JC, Pollack IF, Oakes WJ. Worsening or development of syringomyelia following Chiari I decompression: case report. J Neurosurg Pediatr. 2013 Oct;12(4):351–6. pmid:23931767
- 799. Nagai M, Sakuma R, Aoki M, Abe K, Itoyama Y. Familial spinal arachnoiditis with secondary syringomyelia: clinical studies and MRI findings. J Neurol Sci. 2000 Aug 1;177(1):60–4. pmid:10967183
- 800. Nagpal RD, Gokhale SD, Parikh VR. Ossification of spinal arachnoid with unrelated syringomyelia. Case report. J Neurosurg [Internet]. 1975;42(2):222–5. Available from: https://www.ncbi.nlm.nih.gov/pubmed/803555. pmid:803555
- 801. Naito K, Yamagata T, Ohata K, Takami T. Safety and Efficacy of Syringoperitoneal Shunting with a Programmable Shunt Valve for Syringomyelia Associated with Extensive Spinal Adhesive Arachnoiditis: Technical Note. World Neurosurg. 2019 Dec;132:14–20. pmid:31465850
- 802. Nelson J. Intramedullary cavitation resulting from adhesive spinal arachnoiditis. Arch Neurol Psychiatry. 1943;50(1):1–7.
- 803. Ohata K, Gotoh T, Matsusaka Y, Morino M, Tsuyuguchi N, Sheikh B, et al. Surgical management of syringomyelia associated with spinal adhesive arachnoiditis. J Clin Neurosci Off J Neurosurg Soc Australas. 2001 Jan;8(1):40–2. pmid:11148076
- 804. Oluigbo CO, Thacker K, Flint G. The role of lumboperitoneal shunts in the treatment of syringomyelia. J Neurosurg Spine. 2010 Jul;13(1):133–8. pmid:20594028
- 805. Padovani R, Cavallo M, Gaist G. Surgical treatment of syringomyelia: favorable results with syringosubarachnoid shunting. Surg Neurol. 1989 Sep;32(3):173–80. pmid:2475914
- 806. Phanthumchinda K, Kaoropthum S. Syringomyelia associated with post-meningitic spinal arachnoiditis due to Candida tropicalis. Postgrad Med J. 1991 Aug;67(790):767–9. pmid:1754530
- 807. Pillay PK, Awad IA, Little JR, Hahn JF. Surgical management of syringomyelia: a five year experience in the era of magnetic resonance imaging. Neurol Res. 1991 Mar;13(1):3–9. pmid:1675444
- 808. Porensky P, Muro K, Ganju A. Nontraumatic cervicothoracic syrinx as a cause of progressive neurologic dysfunction. J Spinal Cord Med. 2007;30(3):276–81. pmid:17684895
- 809. Rahme R, Koussa S, Samaha E. C1 arch regeneration, tight cisterna magna, and cervical syringomyelia following foramen magnum surgery. Spontaneous Bone Regrowth Arachnoid Scarring May Lead Dev Cerv Syr Several Years Foramen Magnum Surg Neurosurgeons Should Be Aware This Rare Complicat Whose Manag Similar Chiari Malform Namely Craniocervical Decompression Establ Pat Foramen Magendie. 2009 Jul;72(1):83–5; discussion 85–86.
- 810. Schaan M, Jaksche H. Comparison of different operative modalities in post-traumatic syringomyelia: preliminary report. Eur Spine J Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sect Cerv Spine Res Soc. 2001 Apr;10(2):135–40. pmid:11345635
- 811. Shu W, Li Y, Tao W, Hu Y. Spinal cord stimulation combined with microsurgical DREZotomy for pain due to syringomyelia. Br J Neurosurg. 2016 Oct;30(5):585–7. pmid:27080749
- 812. Siddiqi F, Hammond R, Lee D, Duggal N. Spontaneous chronic spinal subdural hematoma associated with spinal arachnoiditis and syringomyelia. J Clin Neurosci Off J Neurosurg Soc Australas [Internet]. 2005;12(8):949–53. Available from: https://www.ncbi.nlm.nih.gov/pubmed/16326275. pmid:16326275
- 813. Simmons JD, Norman D, Newton TH. Preoperative demonstration of postinflammatory syringomyelia. AJNR Am J Neuroradiol. 1983 Jun;4(3):625–8. pmid:6410816
- 814. Slavin KV, Nixon RR, Nesbit GM, Burchiel KJ. Extensive arachnoid ossification with associated syringomyelia presenting as thoracic myelopathy. Case report and review of the literature. J Neurosurg. 1999 Oct;91(SUPPL. 2):223–9. pmid:10505510
- 815. Sridharan A, Heilman CB. Transverse dorsal arachnoid web and syringomyelia: case report. Neurosurgery. 2009 Jul;65(1):E216–217; discussion E217. pmid:19574806
- 816. Talacchi A, Meneghelli P, Borghesi I, Locatelli F. Surgical management of syringomyelia unrelated to Chiari malformation or spinal cord injury. Eur Spine J Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sect Cerv Spine Res Soc. 2016 Jun;25(6):1836–46. pmid:26441259
- 817. Tator CH, Briceno C. Treatment of Syringomyelia with a Syringosubarachnoid Shunt. Can J Neurol Sci J Can Sci Neurol [Internet]. 1988 Feb [cited 2019 Apr 21];15(01):48–57. Available from: http://www.journals.cambridge.org/abstract_S0317167100027190. pmid:3345462
- 818. Thrush DC, Foster JB. An analysis of nystagmus in 100 consecutive patients with communicating syringomyelia. J Neurol Sci. 1973 Dec;20(4):381–6. pmid:4772396
- 819. Vernet O, Farmer JP, Montes JL. Comparison of syringopleural and syringosubarachnoid shunting in the treatment of syringomyelia in children. J Neurosurg. 1996 Apr;84(4):624–8. pmid:8613854
- 820. Wilson DA, Fusco DJ, Rekate HL. Terminal ventriculostomy as an adjuvant treatment of complex syringomyelia: a case report and review of the literature. Acta Neurochir (Wien). 2011 Jul;153(7):1449–53; discussion 1453. pmid:21523358
- 821. Wisoff JH, Epstein F. Management of hydromyelia. Neurosurgery. 1989 Oct;25(4):562–71. pmid:2797394
- 822. Possover M, Baekelandt J, Kaufmann A, Chiantera V. Laparoscopic endopelvic sacral implantation of a Brindley controller for recovery of bladder function in a paralyzed patient. Spinal Cord. 2008 Jan;46(1):70–3. pmid:17420771
- 823. Loeser JD. Dorsal rhizotomy for the relief of chronic pain. J Neurosurg. 1972 Jun;36(6):745–50. pmid:5030402
- 824. Sindou MP, Blondet E, Emery E, Mertens P. Microsurgical lesioning in the dorsal root entry zone for pain due to brachial plexus avulsion: a prospective series of 55 patients. J Neurosurg [Internet]. 2005;102(6):1018–28. Available from: https://www.ncbi.nlm.nih.gov/pubmed/16028760. pmid:16028760
- 825. Albrektsson B. Sacral rhizotomy in cases of ano-coccygeal pain. A follow-up of 24 cases. Acta Orthop Scand. 1981;52(2):187–90. pmid:7246096
- 826. Durward QJ, Rice GP, Ball MJ, Gilbert JJ, Kaufmann JC. Selective spinal cordectomy: clinicopathological correlation. J Neurosurg. 1982 Mar;56(3):359–67. pmid:6948922
- 827. Echols DH. Sensory rhizotomy following operation for ruptured intevertebral disc. A review of 62 cases. J Neurosurg. 1969 Sep;31(3):335–8. pmid:5258253
- 828. Ea HK, Lioté F, Lot G, Bardin T. Cauda equina syndrome in ankylosing spondylitis: successful treatment with lumboperitoneal shunting. Spine. 2010 Nov 15;35(24):E1423–1429. pmid:21030893
- 829. Tan DCH, Vaughan KA, Koeck H. Endoscopic-Assisted Spinal Arachnoiditis Adhesiolysis and Placement of a Spinal Cysto-Subarachnoid Shunt. World Neurosurg. 2019 Nov;131:43–6. pmid:31362104
- 830. Kushner J, Alexander E, Davis CH, Kelly DL. Kyphoscoliosis following lumbar subarachnoid shunts. J Neurosurg. 1971 Jun;34(6):783–91. pmid:5561023
- 831. Kawasaki T, Hukuda S, Katsuura A, Inoue K, Chano T. Lumboperitoneal shunt for cauda equina syndrome in ankylosing spondylitis. J Spinal Disord. 1996 Feb;9(1):72–5. pmid:8727460
- 832. Hoffman HJ, Hendrick EB, Humphreys RP. New lumboperitoneal shunt for communicating hydrocephalus; technical note. J Neurosurg. 1976 Feb;44(2):258–61. pmid:1245865
- 833. Mitsuyama T, Asamoto S, Kawamata T. Novel surgical management of spinal adhesive arachnoiditis by arachnoid microdissection and ventriculo-subarachnoid shunting. J Clin Neurosci Off J Neurosurg Soc Australas. 2011 Dec;18(12):1702–4. pmid:22019435
- 834. McIvor J, Krajbich JI, Hoffman H. Othopaedic complications of lumboperitoneal shunts. J Pediatr Orthop. 1988;8(6):687–9.
- 835. Bech RA, Waldemar G, Gjerris F, Klinken L, Juhler M. Shunting effects in patients with idiopathic normal pressure hydrocephalus; correlation with cerebral and leptomeningeal biopsy findings. Acta Neurochir (Wien). 1999;141(6):633–9. pmid:10929729
- 836. Bakare AA, Weyhenmeyer J, Lee A. Subarachnoid-to-Subarachnoid Shunt for Correction of Nonfunctioning Baclofen Pump in a Severe Case of Chronic Debilitating Post-Spinal Cord Injury Spasticity. World Neurosurg. 2018;110:26–9. pmid:29101071
- 837. Suzuki M, Davis C, Symon L, Gentili F. Syringoperitoneal shunt for treatment of cord cavitation. J Neurol Neurosurg Psychiatry. 1985 Jul;48(7):620–7. pmid:4031906
- 838. Milhorat TH, Johnson WD, Miller JI. Syrinx shunt to posterior fossa cisterns (syringocisternostomy) for bypassing obstructions of upper cervical theca. J Neurosurg. 1992 Dec;77(6):871–4. pmid:1432128
- 839. Sotelo J. Update: The new ventriculoperitoneal shunt at the Institute of Neurology of Mexico. Surg Neurol. 1996;46(1):19–20. pmid:8677480
- 840. Tang LM. Ventriculoperitoneal shunt in cryptococcal meningitis with hydrocephalus. Surg Neurol. 1990 May;33(5):314–9. pmid:2330532
- 841. Hudgins RJ, Boydston WR, Hudgins PA, Morris R, Adler SM, Gilreath CL. Intrathecal urokinase as a treatment for intraventricular hemorrhage in the preterm infant. Pediatr Neurosurg. 1997 Jun;26(6):281–7. pmid:9485155
- 842. Gourie-Devi M, Satish P. Intrathecal hyaluronidase treatment of chronic spinal arachnoiditis of noninfective etiology. Surg Neurol. 1984 Sep;22(3):231–4. pmid:6547785
- 843. Schuchard M, Krames ES, Lanning R. Intraspinal analgesia for nonmalignant pain: a retrospective analysis for efficacy, safety and feasability in 50 patients. Neuromodulation J Int Neuromodulation Soc. 1998 Jan;1(1):46–56. pmid:22150885
- 844. Hassenbusch SJ, Stanton-Hicks MD, Soukup J, Covington EC, Boland MB. Sufentanil citrate and morphine/bupivacaine as alternative agents in chronic epidural infusions for intractable non-cancer pain. Neurosurgery. 1991 Jul;29(1):76–81; discussion 81–2. pmid:1831248
- 845. Cevizci R, Dilci A, Tekin AM, Bayazıt Y. Recovery of Tinnitus and Sensorineural Hearing Loss Due to Lysis of Arachnoid Adhesions in the Posterior Cranial Fossa: Is There a Novel Etiology in Neurotological Disorders? J Int Adv Otol. 2017 Aug;13(2):295–7. pmid:28816700
- 846. Johnston JD, Matheny JB. Microscopic lysis of lumbar adhesive arachnoiditis. Spine. 1978 Mar;3(1):36–9. pmid:644390
- 847. Manchikanti L, Pampati V, Bakhit CE, Pakanati RR. Non-endoscopic and endoscopic adhesiolysis in post-lumbar laminectomy syndrome: a one-year outcome study and cost effectiveness analysis. Pain Physician. 1999 Oct;2(3):52–8. pmid:16906216
- 848. Torres-Corzo JG, Islas-Aguilar MA, Cervantes DS, Chalita-Williams JC. The Role of Flexible Neuroendoscopy in Spinal Neurocysticercosis: Technical Note and Report of 3 Cases. World Neurosurg. 2019 Oct;130:77–83. pmid:31279105
- 849. Wilkinson HA, Schuman N. Results of surgical lysis of lumbar adhesive arachnoiditis. Neurosurgery. 1979 May;4(5):401–9. pmid:460567
- 850. Hamed SA. Cerebrolysin as a nerve growth factor for treatment of acquired peripheral nervous system diseases. Neural Regen Res. 2011 Jun;6(18):1415–20.
- 851. Feder BH, Smith JL. Roentgen therapy in chronic spinal arachnoiditis. Radiology. 1962 Feb;78:192–8. pmid:13891940
- 852. Cornelson SM, Johnnie ED, Kettner NW. Neural Mobilization in a 54-Year-Old Woman With Postoperative Spinal Adhesive Arachnoiditis. J Chiropr Med. 2018 Dec;17(4):283–8. pmid:30846922
- 853. Panicker JN, Menon L, Anandkumar A, Sundaram KR, Fowler CJ. Lower urinary tract symptoms following neurological illness may be influenced by multiple factors: Observations from a neurorehabilitation service in a developing country. Neurourol Urodyn. 2010 Mar;29(3):378–81. pmid:19475575
- 854. Ghaly RF, Lissounov A, Tverdohleb T, Kohanchi D, Candido KD, Knezevic NN. Spinal neuromodulation as a novel surgical option for failed back surgery syndrome following rhBMP exuberant bony growth in instrumented lumbar fusion: A case report and literature review. Surg Neurol Int. 2016;7(Suppl 25):S668–74. pmid:27843683
- 855. Richardson RR, Siqueira EB, Cerullo LJ. Spinal epidural neurostimulation for treatment of acute and chronic intractable pain: initial and long term results. Neurosurgery. 1979 Sep;5(3):344–8. pmid:315523
- 856. North RB, Ewend MG, Lawton MT, Piantadosi S. Spinal cord stimulation for chronic, intractable pain: superiority of “multi-channel” devices. Pain. 1991 Feb;44(2):119–30. pmid:2052378
- 857. Taub A, Collins WF, Venes J. Partial, reversible, functional spinal cord transection. A complication of dorsal column stimulation for the relief of pain. Arch Neurol. 1974 Jan;30(1):107–8. pmid:4808491
- 858. Meilman PW, Leibrock LG, Leong FT. Outcome of implanted spinal cord stimulation in the treatment of chronic pain: arachnoiditis versus single nerve root injury and mononeuropathy. Brief clinical clinical note. Clin J Pain. 1989 Jun;5(2):189–93.
- 859. Wester K. Dorsal column stimulation in pain treatment. Acta Neurol Scand. 1987 Feb;75(2):151–5. pmid:3495091
- 860. Ahn NU, Ahn UM, Nallamshetty L, Springer BD, Buchowski JM, Funches L, et al. Cauda equina syndrome in ankylosing spondylitis (the CES-AS syndrome): Meta-analysis of outcomes after medical and surgical treatments. J Spinal Disord. 2001;14(5):427–33. pmid:11586143
- 861. Chacko AG, Daniel RT, Chacko G, Babu KS. Pial and arachnoid welding for restoration of normal cord anatomy after excision of intramedullary spinal cord tumors. J Clin Neurosci [Internet]. 2007 Aug [cited 2020 Jan 9];14(8):764–9. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0967586806006588. pmid:17532219
- 862. Dolan RA. Spinal adhesive arachnoiditis. Surg Neurol. 1993 Jun;39(6):479–84. pmid:8516746
- 863. Elkington JSC. Meningitis serosa circumscripta spinalis (spinal arachnoiditis). Brain. 1936;59(2):181–203.
- 864. Epstein JA, Epstein BS, Lavine LS, Rosenthal AD, Decker RE, Carras R. Obliterative arachnoiditis complicating lumbar spinal stenosis. J Neurosurg. 1978 Feb;48(2):252–8. pmid:624974
- 865. Fraioli B, Esposito V, Ferrante L, Trubiani L, Lunardi P. Microsurgical treatment of glossopharyngeal neuralgia: case reports. Neurosurgery. 1989 Oct;25(4):630–2. pmid:2797399
- 866. Hart GM. Circumscribed serous spinal arachnoiditis simulating protruded lumbar intervertebral disc. Ann Surg. 1958 Aug;148(2):266–70. pmid:13571903
- 867. Ishikawa Y, Miyakoshi N, Hongo M, Kasukawa Y, Shimada Y. Surgical treatment for thoracosacral concomitant spinal epidural and subdural abscess: a case report. Eur Orthop Traumatol. 2014;5(4):383–6.
- 868. Kashcheev A, Arestov S, Gushcha A. THECALOSCOPY: A NOVEL METHOD IN SPINE SURGERY. Coluna/Columna [Internet]. 2017 Sep [cited 2019 Apr 20];16(3):213–9. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512017000300213&lng=en&tlng=en.
- 869. Long DM. Chronic adhesive spinal arachnoiditis: Pathogenesis, prognosis, and treatment. Neurosurg Q. 1992;2(4):296–319.
- 870. Mauer UM, Gottschalk A, Kunz U, Schulz C. Arachnoscopy: a special application of spinal intradural endoscopy. Neurosurg Focus. 2011 Apr;30(4):E7. pmid:21456934
- 871. Maxmauer U, Danz B, Gottschalk A, Kunz U. Endoscope-assisted surgery of spinal intradural adhesions in the presence of cerebrospinal fluid flow obstruction. Spine. 2011 May 20;36(12):E773–779. pmid:21289584
- 872. Miyazaki M, Yoshiiwa T, Ishihara T, Kaku N, Kawano M, Tsumura H. Symptomatic spinal cord kinking due to focal adhesive arachnoiditis, with ossification of the ligamentum flavum: a case report. Spine. 2014 Apr 15;39(8):E538–541. pmid:24480938
- 873. O’Shaughnessy BA, Koski TR, Ondra SL. Reversal of neurologic deterioration after vertebral column resection by spinal cord untethering and duraplasty. Spine. 2008 Jan 15;33(2):E50–54. pmid:18197091
- 874. Reis AJ. New surgical approach for late complications from spinal cord injury. BMC Surg. 2006 Oct 23;6:12. pmid:17059598
- 875. Roca J, Moreta D, Ubierna MT, Cáceres E, Gómez JC. The results of surgical treatment of lumbar arachnoiditis. Int Orthop. 1993;17(2):77–81. pmid:8500936
- 876. Sanchez Rodriguez JJ, Torres-Corzo J, Cervantes DS, Rodriguez-DellaVecchia R, Gordillo-Moscoso A, Vinas-Rios JM, et al. Influence of the State of the Subarachnoid Space of the Cranial Base in Hydrocephalus Resolution after Endoscopy. J Neurol Surg Part Cent Eur Neurosurg. 2017 May;78(3):255–9. pmid:27684061
- 877. Shikata J, Yamamuro T, Iida H, Sugimoto M. Surgical treatment for symptomatic spinal adhesive arachnoiditis. Spine. 1989 Aug;14(8):870–5. pmid:2781399
- 878. Shimoji K, Fujioka H, Onodera M, Hokari T, Fukuda S, Fujiwara N, et al. Observation of spinal canal and cisternae with the newly developed small-diameter, flexible fiberscopes. Anesthesiology. 1991 Aug;75(2):341–4. pmid:1859021
- 879. Shimoji K, Ogura M, Gamou S, Yunokawa S, Sakamoto H, Fukuda S, et al. A new approach for observing cerebral cisterns and ventricles via a percutaneous lumbosacral route by using fine, flexible fiberscopes. J Neurosurg. 2009 Feb;110(2):376–81. pmid:19245290
- 880. Tachibana T, Moriyama T, Maruo K, Inoue S, Arizumi F, Yoshiya S. Subarachnoid-subarachnoid bypass for spinal adhesive arachnoiditis. J Neurosurg Spine. 2014 Nov;21(5):817–20. pmid:25170651
- 881. Taguchi Y, Suzuki R, Okada M, Sekino H. Spinal arachnoid cyst developing after surgical treatment of a ruptured vertebral artery aneurysm: a possible complication of topical use of fibrin glue. Case report. J Neurosurg. 1996 Mar;84(3):526–9. pmid:8609570
- 882. Torres-Corzo J, Sánchez-Rodríguez J, Cervantes D, Rodríguez-Della Vecchia R, Muruato-Araiza F, Hwang SW, et al. Endoscopic Transventricular Transaqueductal Magendie and Luschka Foraminoplasty for Hydrocephalus. Neurosurgery [Internet]. 2014 Apr 1 [cited 2019 Apr 19];74(4):426–36. Available from: https://academic.oup.com/neurosurgery/article/74/4/426/2557448. pmid:24378828
- 883. Torres-Corzo J, Vinas-Rios JM, Sanchez-Aguilar M, Vecchia RRD, Chalita-Williams JC, Rangel-Castilla L. Transventricular neuroendoscopic exploration and biopsy of the basal cisterns in patients with Basal meningitis and hydrocephalus. World Neurosurg. 2012 Jun;77(5–6):762–71. pmid:22120299
- 884. Torres-Corzo J, Vinas-Rios JM, Viana Rojas JA, Cervantes D, Sánchez-Aguilar M, Chalita-Williams JC, et al. Endoscopic transventricular exploration with biopsy of the basal cisterns and the role of endoscopic third ventriculostomy in patients suffering with basal cistern meningitis and consecutive hydrocephalus. Neurol Res. 2016 Jul;38(7):593–9. pmid:27236905
- 885. Vaughan D, Bolger C, O’Brien DF. An interesting case of primary spinal arachnoiditis. Br J Neurosurg. 2012 Aug;26(4):555–7. pmid:22369357
- 886. Warnke JP, Koppert H, Bensch-Schreiter B, Dzelzitis J, Tschabitscher M. Thecaloscopy part III: first clinical application. Minim Invasive Neurosurg MIN. 2003;46(2):94–9. pmid:12761680
- 887. Warnke JP, Mourgela S. Endoscopic treatment of lumbar arachnoiditis. Minim Invasive Neurosurg MIN. 2007 Feb;50(1):1–6. pmid:17546535
- 888. Weiss RM, Sweeney L, Dreyfuss M. Circumscribed adhesive spinal arachnoiditis. J Neurosurg. 1962 May;19:435–8. pmid:14005895
- 889. Wilkinson HA, Davidson KM, Davidson RI. Bilateral anterior cingulotomy for chronic noncancer pain. Neurosurgery. 1999 Nov;45(5):1129–34; discussion 1134–1136. pmid:10549929
- 890. Yone K, Sakou T, Kawauchi Y. The effect of Lipo prostaglandin E1 on cauda equina blood flow in patients with lumbar spinal canal stenosis: myeloscopic observation. Spinal Cord. 1999 Apr;37(4):269–74. pmid:10338347
- 891. Young WW. A case of adhesive spinal arachnoiditis simulating spinal cord tumor. J Nerv Ment Dis. 1928;68(1):11–6.
- 892. Zhi M, Lu XJ, Wang Q, Li B. Application of neuroendoscopy in the surgical treatment of complicated hemifacial spasm. Neurosci Riyadh Saudi Arab. 2017 Jan;22(1):25–30. pmid:28064327
- 893.
Bulletin-14-AA-is-a-Tumor-or-Mass-4-20.pdf [Internet]. [cited 2020 May 7]. Available from: http://arachnoiditishope.com/pages/wp-content/uploads/2020/04/Bulletin-14-AA-is-a-Tumor-or-Mass-4-20.pdf.
- 894.
Malan T. Stem Cell Therapy for Arachnoiditis | Stem Cell Treatment [Internet]. Center For Regenerative Cell Medicine. Dr. Todd Malan; 2017 [cited 2021 Jan 24]. Available from: https://www.mystemcelltherapy.com/stem-cell-treatments/arachnoiditis/.
- 895. Sebastian AS, Wanderman NR, Currier BL, Pichelmann MA, Treder VM, Fogelson JL, et al. Prospective Evaluation of Radiculitis following Bone Morphogenetic Protein-2 Use for Transforaminal Interbody Arthrodesis in Spine Surgery. Asian Spine J. 2019;15:15. pmid:30866616
- 896. Alobaidaan R, Cohen JR, Lord EL, Buser Z, Yoon ST, Youssef JA, et al. Complication Rates in Posterior Lumbar Interbody Fusion (PLIF) Surgery With Human Bone Morphogenetic Protein 2: Medicare Population. Glob Spine J. 2017 Dec;7(8):770–3. pmid:29238641
- 897. Vincentelli AF, Szadkowski M, Vardon D, Litrico S, Fuentes S, Steib JP, et al. rhBMP-2 (Recombinant Human Bone Morphogenetic Protein-2) in real world spine surgery. A phase IV, National, multicentre, retrospective study collecting data from patient medical files in French spinal centres. Orthop Traumatol Surg Res. 2019 Oct;105(6):1157–63. pmid:31324520
- 898. Guyer DW, Wiltse LL, Eskay ML, Guyer BH. The long-range prognosis of arachnoiditis. Spine. 1989 Dec;14(12):1332–41. pmid:2617363
- 899. Lewis C. Physiotherapy and spinal nerve root adhesion: a caution. Physiother Res Int J Res Clin Phys Ther. 2004;9(4):164–73. pmid:15790254
- 900. Derk J, Jones HE, Como C, Pawlikowski B, Siegenthaler JA. Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease. Front Cell Neurosci [Internet]. 2021 Jul 1 [cited 2021 Jul 25];15:703944. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281977/. pmid:34276313
- 901. Dasgupta K, Jeong J. Developmental Biology of the Meninges. Genes N Y N 2000 [Internet]. 2019 May [cited 2021 Apr 14];57(5):e23288. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520190/. pmid:30801905
- 902. Cohen C. University at Buffalo Neuroscience Slide Atlas [Internet]. Atlas of Neuroscience. [cited 2022 Jun 19]. Available from: https://ubneuro-ccohan.webapps.buffalo.edu/atlascss.html.
- 903. Nakagomi T, Matsuyama T. Leptomeninges: a novel stem cell niche with neurogenic potential. Stem Cell Investig [Internet]. 2017 Mar 31 [cited 2021 Apr 14];4(3). Available from: https://sci.amegroups.com/article/view/14214. pmid:28447037
- 904. Sakka L, Gabrillargues J, Coll G. Anatomy of the Spinal Meninges. Oper Neurosurg [Internet]. 2016 Jun 1 [cited 2021 Apr 14];12(2):168–88. Available from: https://academic.oup.com/ons/article/12/2/168/2281566. pmid:29506096
- 905. Saboori P, Sadegh A. Histology and Morphology of the Brain Subarachnoid Trabeculae. Anat Res Int [Internet]. 2015 [cited 2018 Dec 31];2015. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458278/. pmid:26090230
- 906. Natale G, Limanaqi F, Busceti CL, Mastroiacovo F, Nicoletti F, Puglisi-Allegra S, et al. Glymphatic System as a Gateway to Connect Neurodegeneration From Periphery to CNS. Front Neurosci [Internet]. 2021 [cited 2021 Apr 14];15. Available from: https://www.frontiersin.org/articles/10.3389/fnins.2021.639140/full. pmid:33633540
- 907. Mastorakos P, McGavern D. The anatomy and immunology of vasculature in the central nervous system. Sci Immunol [Internet]. 2019 Jul 12 [cited 2021 Apr 14];4(37). Available from: https://immunology.sciencemag.org/content/4/37/eaav0492 pmid:31300479
- 908. Zhan C, Xiao G, Zhang X, Chen X, Zhang Z, Liu J. Decreased MiR-30a promotes TGF-β1-mediated arachnoid fibrosis in post-hemorrhagic hydrocephalus. Transl Neurosci [Internet]. 2020 May 26 [cited 2021 Jan 3];11(1):60–74. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711221/. pmid:33335750
- 909. Kwiecien JM, Dabrowski W, Dąbrowska-Bouta B, Sulkowski G, Oakden W, Kwiecien-Delaney CJ, et al. Prolonged inflammation leads to ongoing damage after spinal cord injury. Nógrádi A, editor. PLOS ONE [Internet]. 2020 Mar 19 [cited 2020 Mar 20];15(3):e0226584. Available from: https://dx.plos.org/10.1371/journal.pone.0226584. pmid:32191733
- 910.
National Vital Statistics Reports Volume 70, Number 2, March 23 Births: Final Data for 2019. 2019;51.
- 911. Rosero EB, Joshi GP. Nationwide incidence of serious complications of epidural analgesia in the United States. Acta Anaesthesiol Scand. 2016 Jul;60(6):810–20. pmid:26876878
- 912. Kerezoudis P, Alvi MA, Freedman BA, Nassr A, Bydon M. Utilization Trends of Recombinant Human Bone Morphogenetic Protein in the United States. Spine [Internet]. 2021 Jul 1 [cited 2021 Oct 13];46(13):874–81. Available from: https://journals.lww.com/spinejournal/Abstract/2021/07010/Utilization_Trends_of_Recombinant_Human_Bone.11.aspx. pmid:33395021
- 913.
sample-8230547.pdf [Internet]. [cited 2021 Oct 13]. Available from: https://www.marketresearch.com/product/sample-8230547.pdf.
- 914.
Most Common Operations in Hospital Inpatient Stays—HCUP Fast Stats [Internet]. [cited 2021 Oct 13]. Available from: https://www.hcup-us.ahrq.gov/faststats/NationalProceduresServlet.
- 915.
Low Back and Neck Pain [Internet]. BMUS: The Burden of Musculoskeletal Diseases in the United States. [cited 2021 Oct 13]. Available from: https://www.boneandjointburden.org/fourth-edition/iia0/low-back-and-neck-pain
- 916. Manchikanti L, Pampati V, Hirsch JA. Retrospective cohort study of usage patterns of epidural injections for spinal pain in the US fee-for-service Medicare population from 2000 to 2014. BMJ Open [Internet]. 2016 Dec 12 [cited 2021 Apr 3];6(12). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5168679/. pmid:27965254
- 917.
Statistics Information—The Miami Project to Cure Paralysis [Internet]. The Miami Project. [cited 2021 Aug 14]. Available from: https://www.themiamiproject.org/resources/statistics/.
- 918.
Spinal cord injury [Internet]. [cited 2021 Aug 14]. Available from: https://www.who.int/news-room/fact-sheets/detail/spinal-cord-injury.
- 919. Etminan N, Chang HS, Hackenberg K, de Rooij NK, Vergouwen MDI, Rinkel GJE, et al. Worldwide Incidence of Aneurysmal Subarachnoid Hemorrhage According to Region, Time Period, Blood Pressure, and Smoking Prevalence in the Population. JAMA Neurol [Internet]. 2019 May [cited 2021 Mar 30];76(5):588–97. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515606/.
- 920.
World Health Statistics [Internet]. [cited 2021 Mar 25]. Available from: https://www.who.int/data/maternal-newborn-child-adolescent-ageing/advisory-groups/gama/activities-of-gama.
- 921. CDC. CDC Data & Statistics [Internet]. Centers for Disease Control and Prevention. 2020 [cited 2021 Apr 1]. Available from: https://www.cdc.gov/datastatistics/index.html.
- 922.
GHO [Internet]. [cited 2021 Mar 29]. Available from: https://www.who.int/data/gho.
- 923. Charalambous LT, Premji A, Tybout C, Hunt A, Cutshaw D, Elsamadicy AA, et al. Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States. J Med Microbiol [Internet]. 2018 Feb [cited 2021 Mar 30];67(2):215–27. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557145/. pmid:29244019
- 924.
Meningococcal Disease: Technical and Clinical Information | CDC [Internet]. 2021 [cited 2021 Aug 13]. Available from: https://www.cdc.gov/meningococcal/clinical-info.html.
- 925.
Neurotropism of SARS-CoV 2: Mechanisms and manifestations. [cited 2022 Jan 8]; Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141641/.
- 926. Sarubbo F. Neurological consequences of COVID-19 and brain related pathogenic mechanisms: A new challenge for neuroscience. 2022;12.
- 927. Talotta R, Bahrami S, Laska MJ. Sequence complementarity between human noncoding RNAs and SARS-CoV-2 genes: What are the implications for human health? Biochim Biophys Acta Mol Basis Dis. 2021 Oct 15;166291. pmid:34662705
- 928. Generoso JS, Barichello de Quevedo JL, Cattani M, Lodetti BF, Sousa L, Collodel A, et al. Neurobiology of COVID-19: how can the virus affect the brain? Rev Bras Psiquiatr Sao Paulo Braz 1999. 2021 Feb 10.; pmid:33605367
- 929. Lewis A, Jain R, Frontera J, Placantonakis DG, Galetta S, Balcer L, et al. COVID‐19 associated brain/spinal cord lesions and leptomeningeal enhancement: A meta‐analysis of the relationship to CSF SARS‐CoV‐2. J Neuroimaging [Internet]. 2021 Jun 8 [cited 2021 Oct 20]; Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242764/. pmid:34105198
- 930. Finsterer J, Scorza FA. Infectious and immune-mediated central nervous system disease in 48 COVID-19 patients. J Clin Neurosci Off J Neurosurg Soc Australas. 2021 Aug;90:140–3. pmid:34275539
- 931. Abdel Hafez SMN. Can Covid-19 attack our nervous system? J Chem Neuroanat [Internet]. 2021 Nov [cited 2021 Oct 20];117:102006. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312049/. pmid:34324964
- 932. Hong CM, Tosun C, Kurland DB, Gerzanich V, Schreibman D, Simard JM. Biomarkers as outcome predictors in subarachnoid hemorrhage–a systematic review. Biomarkers [Internet]. 2014 Mar [cited 2019 Jun 2];19(2):95–108. Available from: http://www.tandfonline.com/doi/full/10.3109/1354750X.2014.881418. pmid:24499240
- 933. Cherian S, Whitelaw A, Thoresen M, Love S. The pathogenesis of neonatal post-hemorrhagic hydrocephalus. Brain Pathol Zurich Switz [Internet]. 2004;14(3):305–11. Available from: https://www.ncbi.nlm.nih.gov/pubmed/15446586. pmid:15446586
- 934. Neal JM, Kopp SL, Pasternak JJ, Lanier WL, Rathmell JP. Anatomy and Pathophysiology of Spinal Cord Injury Associated With Regional Anesthesia and Pain Medicine: 2015 Update. Reg Anesth Pain Med. 2015 Oct;40(5):506–25. pmid:26263076
- 935.
Toxicities associated with checkpoint inhibitor immunotherapy—UpToDate [Internet]. [cited 2021 Sep 19]. Available from: https://www.uptodate.com/contents/toxicities-associated-with-checkpoint-inhibitor-immunotherapy.
- 936.
What is adhesive Arachnoiditis [Internet]. [cited 2021 Sep 19]. Available from: http://www.myodilaction.info/What_is_AA.html
- 937. Villani LA, Digre KB, Cortez MM, Bokat C, Rassner UA, Ozudogru SN. Arachnoiditis, a complication of epidural blood patch for the treatment of low-pressure headache: A case report and systematic review. Headache. 2021 Feb 13.; pmid:33583044
- 938. Regional Anesthesia and The Patient with Preexisting Neuropathy [Internet]. Anesthesia Experts. 2019 [cited 2021 Sep 20]. Available from: http://anesthesiaexperts.com/uncategorized/regional-anesthesia-patient-preexisting-neuropathy/.
- 939. Helm Ii S, Harmon PC, Noe C, Calodney AK, Abd-Elsayed A, Knezevic NN, et al. Transforaminal Epidural Steroid Injections: A Systematic Review and Meta-Analysis of Efficacy and Safety. Pain Physician. 2021 Jan;24(S1):S209–32. pmid:33492919
- 940. Mikhael MA, Ciric IS, Kudrna JC, Hindo WA. Recognition of lumbar disc disease with magnetic resonance imaging. Comput Radiol. 1985 Aug;9(4):213–22. pmid:2998699
- 941. Parenti V, Huda F, Richardson PK, Brown D, Aulakh M, Taheri MR. Lumbar arachnoiditis: Does imaging associate with clinical features? Clin Neurol Neurosurg [Internet]. 2020 Feb 3 [cited 2020 Feb 9];105717. Available from: http://www.sciencedirect.com/science/article/pii/S0303846720300603. pmid:32062307
- 942. El Homsi M, Gharzeddine K, Cuevas J, Arevalo-Perez J, Rebeiz K, Khoury NJ, et al. MRI Findings of Arachnoiditis, Revisited. Is Classification Possible? J Magn Reson Imaging JMRI. 2021 Feb 28.; pmid:33644967
- 943. Tsuchida R, Sumitani M, Azuma K, Abe H, Hozumi J, Inoue R, et al. A Novel Technique Using Magnetic Resonance Imaging in the Supine and Prone Positions for Diagnosing Lumbar Adhesive Arachnoiditis: A Preliminary Study. Pain Pract Off J World Inst Pain. 2019 Jul 20.; pmid:31325409
- 944. Li Z, Chen YA, Chow D, Talbott J, Glastonbury C, Shah V. Practical applications of CISS MRI in spine imaging. Eur J Radiol Open. 2019;6:231–42. pmid:31304197
- 945. Ineichen BV, Tsagkas C, Absinta M, Reich DS. Leptomeningeal enhancement in multiple sclerosis and other neurological diseases: A systematic review and Meta-Analysis. NeuroImage Clin [Internet]. 2022 Jan 1 [cited 2022 Jan 16];33:102939. Available from: https://www.sciencedirect.com/science/article/pii/S2213158222000043 pmid:35026625
- 946. Samlaska C. There is No Such Thing as Adhesive Arachnoiditis Syndrome [Internet]. Available from: https://www.youtube.com/watch?v=oIGCF4PVp1I.
- 947.
CDC. Disability and Health Related Conditions | CDC [Internet]. Centers for Disease Control and Prevention. 2019 [cited 2021 Oct 17]. Available from: https://www.cdc.gov/ncbddd/disabilityandhealth/relatedconditions.html.
- 948.
Global health estimates: Leading causes of DALYs [Internet]. [cited 2021 Apr 20]. Available from: https://www.who.int/data/maternal-newborn-child-adolescent-ageing/advisory-groups/gama/activities-of-gama.
- 949.
Adhesive Arachnoiditis:A Continuing Challenge [Internet]. [cited 2022 Jan 13]. Available from: https://www.practicalpainmanagement.com/pain/spine/adhesive-arachnoiditisa-continuing-challenge.
- 950. Elbasiouny SM, Moroz D, Bakr MM, Mushahwar VK. Management of Spasticity After Spinal Cord Injury: Current Techniques and Future Directions. Neurorehabil Neural Repair [Internet]. 2010 Jan [cited 2021 Oct 19];24(1):23–33. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860542/. pmid:19723923
- 951.
Spasticity: Symptoms & Treatment [Internet]. Cleveland Clinic. [cited 2021 Oct 19]. Available from: https://my.clevelandclinic.org/health/diseases/14346-spasticity.
- 952.
Spasticity and Spinal Cord Injury | Model Systems Knowledge Translation Center (MSKTC) [Internet]. [cited 2021 Oct 19]. Available from: https://msktc.org/sci/factsheets/Spasticity.
- 953.
Spasticity [Internet]. Reeve Foundation. [cited 2021 Oct 19]. Available from: https://www.christopherreeve.org/living-with-paralysis/health/secondary-conditions/spasticity.
- 954.
Spasticity–Causes, Symptoms and Treatments [Internet]. [cited 2021 Oct 19]. Available from: https://www.aans.org/.
- 955. Alexander M, Courtois F, Elliott S, Tepper M. Improving Sexual Satisfaction in Persons with Spinal Cord Injuries: Collective Wisdom. Top Spinal Cord Inj Rehabil [Internet]. 2017 [cited 2021 Oct 3];23(1):57–70. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340510/. pmid:29339878
- 956. Englewood CH 3425 SCS, Line 1-800-247-0257 C 80113 U s a ML 303 789 8000 NA. Sexual Function for Women After Spinal Cord Injury [Internet]. Craig Hospital. [cited 2021 Oct 6]. Available from: https://craighospital.org/resources/sexual-function-for-women-after-spinal-cord-injury.
- 957. Englewood CH 3425 SCS, Line 1-800-247-0257 C 80113 U s a ML 303 789 8000 NA. Sexual Function for Men After Spinal Cord Injury [Internet]. Craig Hospital. [cited 2021 Oct 6]. Available from: https://craighospital.org/resources/sexual-function-for-men-after-spinal-cord-injury.
- 958. Previnaire JG, Soler JM, Alexander MS, Courtois F, Elliott S, McLain A. Prediction of sexual function following spinal cord injury: a case series. Spinal Cord Ser Cases [Internet]. 2017 Dec 13 [cited 2021 Oct 6];3(1):1–7. Available from: https://www.nature.com/articles/s41394-017-0023-x. pmid:29423300
- 959. Klekamp J. A New Classification for Pathologies of Spinal Meninges-Part 2: Primary and Secondary Intradural Arachnoid Cysts. Neurosurgery. 2017 Aug 1;81(2):217–29. pmid:28327950
- 960. Gardner A, Gardner E, Morley T. Cauda equina syndrome: a review of the current clinical and medico-legal position. Eur Spine J [Internet]. 2011 May [cited 2021 Oct 19];20(5):690–7. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082683/. pmid:21193933
- 961. Petrasic JR, Chhabra A, Scott KM. Impact of MR Neurography in Patients with Chronic Cauda Equina Syndrome Presenting as Chronic Pelvic Pain and Dysfunction. Am J Neuroradiol [Internet]. 2017 Feb 1 [cited 2021 Oct 19];38(2):418–22. Available from: http://www.ajnr.org/content/38/2/418. pmid:28059708
- 962.
Acute vs Gradual Onsets of Cauda Equina Syndrome | CES Attorney Lisa levine [Internet]. Lisa S. Levine, P.A. 2018 [cited 2021 Oct 19]. Available from: https://www.floridainjuryclaim.com/blog/acute-vs-gradual-onsets-of-cauda-equina-syndrome/.
- 963. Barker TP, Steele N, Swamy G, Cook A, Rai A, Crawford R, et al. Long-term core outcomes in cauda equina syndrome. Bone Jt J [Internet]. 2021 Sep 1 [cited 2021 Oct 19];103-B(9):1464–71. Available from: https://online.boneandjoint.org.uk/doi/abs/10.1302/0301-620X.103B9.BJJ-2021-0094.R1.
- 964. Weiss TC. Cauda Equina Syndrome: Causes, Symptoms and Treatment [Internet]. Disabled World. 2015 [cited 2021 Oct 19]. Available from: https://www.disabled-world.com/disability/types/spinal/backpain/ces.php.
- 965. Korse NS, Veldman AB, Peul WC, Vleggeert-Lankamp CLA. The long term outcome of micturition, defecation and sexual function after spinal surgery for cauda equina syndrome. PLOS ONE [Internet]. 2017 Apr 19 [cited 2021 Oct 19];12(4):e0175987. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0175987. pmid:28423044
- 966. van Toorn R, Solomons RS, Seddon JA, Schoeman JF. Thalidomide use for complicated central nervous system tuberculosis in children: insights from an observational cohort. Clin Infect Dis Off Publ Infect Dis Soc Am. 2020 Dec 6.;
- 967. Mastorakos P, Pomeraniec IJ, Bryant JP, Chittiboina P, Heiss JD. Flexible thecoscopy for extensive spinal arachnoiditis. J Neurosurg Spine. 2021 Oct 1;1–11. pmid:34598155
- 968. Chou R, Deyo R, Friedly J, Skelly A, Hashimoto R, Weimer M, et al. Nonpharmacologic Therapies for Low Back Pain: A Systematic Review for an American College of Physicians Clinical Practice Guideline. Ann Intern Med [Internet]. 2017 Apr 4 [cited 2021 Oct 20];166(7):493–505. Available from: https://www.acpjournals.org/doi/10.7326/m16-2459 pmid:28192793
- 969. Yuan R, Wang Y, Li Q, Zhen F, Li X, Lai Q, et al. Metformin reduces neuronal damage and promotes neuroblast proliferation and differentiation in a cerebral ischemia/reperfusion rat model. Neuroreport. 2019 Feb 6;30(3):232–40. pmid:30614910
- 970. Weng W, Yao C, Poonit K, Zhou X, Sun C, Zhang F, et al. Metformin relieves neuropathic pain after spinal nerve ligation via autophagy flux stimulation. J Cell Mol Med [Internet]. 2019 [cited 2019 Apr 5];23(2):1313–24. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14033 pmid:30451370
- 971. Afshari K, Dehdashtian A, Haddadi NS, Haj-Mirzaian A, Iranmehr A, Ebrahimi MA, et al. Anti-inflammatory effects of Metformin improve the neuropathic pain and locomotor activity in spinal cord injured rats: introduction of an alternative therapy. Spinal Cord [Internet]. 2018 Nov [cited 2019 Jun 23];56(11):1032. Available from: https://www.nature.com/articles/s41393-018-0168-x pmid:29959433
- 972. Ahn MJ, Cho GW. Metformin promotes neuronal differentiation and neurite outgrowth through AMPK activation in human bone marrow-mesenchymal stem cells. Biotechnol Appl Biochem. 2017 Nov;64(6):836–42. pmid:28791738
- 973.
Frontiers | A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan | Endocrinology [Internet]. [cited 2022 Jan 14]. Available from: https://www.frontiersin.org/articles/10.3389/fendo.2021.718942/full.
- 974. Madhavan AA, Summerfield D, Hunt CH, Kim DK, Krecke KN, Raghunathan A, et al. Polyclonal lymphocytic infiltrate with arachnoiditis resulting from intrathecal stem cell transplantation. Neuroradiol J. 2020 Feb 3;1971400920902451. pmid:32013747
- 975. Ji WC, Li M, Jiang WT, Ma X, Li J. Protective effect of brain-derived neurotrophic factor and neurotrophin-3 overexpression by adipose-derived stem cells combined with silk fibroin/chitosan scaffold in spinal cord injury. Neurol Res. 2020 Mar 9;1–11. pmid:32149594
- 976. Toljan K, Vrooman B. Low-Dose Naltrexone (LDN)—Review of Therapeutic Utilization. Med Sci [Internet]. 2018 Sep 21 [cited 2021 Nov 22];6(4):82. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313374/. pmid:30248938
- 977. Gao Y, Zhuang Z, Lu Y, Tao T, Zhou Y, Liu G, et al. Curcumin Mitigates Neuro-Inflammation by Modulating Microglia Polarization Through Inhibiting TLR4 Axis Signaling Pathway Following Experimental Subarachnoid Hemorrhage. Front Neurosci [Internet]. 2019 Nov 15 [cited 2020 Jan 6];13. Available from: https://www9incbi.nlm.nih.gov/pmc/articles/PMC6872970/. pmid:31803007
- 978. Concetta Scuto M, Mancuso C, Tomasello B, Laura Ontario M, Cavallaro A, Frasca F, et al. Curcumin, Hormesis and the Nervous System. Nutrients [Internet]. 2019 Oct 10 [cited 2020 Jan 16];11(10). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835324/.
- 979. Song Z, Zhang JH. Recent Advances in Stem Cell Research in Subarachnoid Hemorrhage. Stem Cells Dev [Internet]. 2019 Nov 21 [cited 2021 Apr 14];29(4):178–86. Available from: https://www.liebertpub.com/doi/full/10.1089/scd.2019.0219. pmid:31752600
- 980. Nickel J, Mueller TD. Specification of BMP Signaling. Cells [Internet]. 2019 Dec 5 [cited 2020 Feb 22];8(12). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953019/. pmid:31817503
- 981. Katagiri T, Watabe T. Bone Morphogenetic Proteins. Cold Spring Harb Perspect Biol [Internet]. 2016 Jun [cited 2020 Feb 21];8(6):a021899. Available from: http://cshperspectives.cshlp.org/lookup/doi/10.1101/cshperspect.a021899. pmid:27252362
- 982. Nickel J, Mueller TD. Specification of BMP Signaling. Cells [Internet]. 2019 Dec 5 [cited 2020 Feb 22];8(12). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953019/. pmid:31817503
- 983. James AW, LaChaud G, Shen J, Asatrian G, Nguyen V, Zhang X, et al. A Review of the Clinical Side Effects of Bone Morphogenetic Protein-2. Tissue Eng Part B Rev [Internet]. 2016 Aug 1 [cited 2018 Dec 16];22(4):284–97. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964756/. pmid:26857241
- 984. Lowery JW, Rosen V. Bone Morphogenetic Protein–Based Therapeutic Approaches. Cold Spring Harb Perspect Biol [Internet]. 2018 Apr 1 [cited 2019 Apr 6];10(4):a022327. Available from: http://cshperspectives.cshlp.org/content/10/4/a022327. pmid:28389444
- 985. Dmitriev AE, Castner S, Lehman RA, Ling GSF, Symes AJ. Alterations in recovery from spinal cord injury in rats treated with recombinant human bone morphogenetic protein-2 for posterolateral arthrodesis. J Bone Joint Surg Am. 2011 Aug 17;93(16):1488–99. pmid:22204004
- 986. Dmitriev AE, Farhang S, Lehman RA, Ling GSF, Symes AJ. Bone morphogenetic protein-2 used in spinal fusion with spinal cord injury penetrates intrathecally and elicits a functional signaling cascade. Spine J Off J North Am Spine Soc. 2010 Jan;10(1):16–25. pmid:19914878