https://orcid.org/0000-0002-4843-1083
Figures
Abstract
Background
Kinetic data obtained during gait can be used to clarify the biomechanical pathogenesis of osteoarthritis of the lower extremity. This study aimed to investigate the difference in ankle varus moment between the varus angulation and medial translation types of medial ankle osteoarthritis, and to identify the radiographic measurements associated with ankle varus moment.
Methods
Twenty-four consecutive patients [mean age 65.8 (SD) 8.0 years; 9 men and 15 women] with medial ankle osteoarthritis were included. Fourteen and 10 patients had the varus angulation (tibiotalar tilt angle≥3 degrees) and medial translation (tibiotalar tilt angle<3 degrees) types, respectively. All patients underwent three-dimensional gait analysis, and the maximum varus moment of the ankle was recorded. Radiographic measurement included tibial plafond inclination, tibiotalar tilt angle, talar dome inclination, and lateral talo-first metatarsal angle. Comparison between the two types of medial ankle osteoarthritis and the relationship between the maximum ankle varus moment and radiographic measurements were analyzed.
Results
The mean tibial plafond inclination, tibiotalar tilt angle, talar dome inclination, lateral talo-first metatarsal angle, and maximum ankle varus moment were 6.4 degrees (SD 3.3 degrees), 5.0 degrees (SD 4.6 degrees), 11.4 degrees (SD 5.2 degrees), -6.5 degrees (SD 11.7 degrees), and 0.185 (SD 0.082) Nm/kg, respectively. The varus angulation type showed a greater maximum ankle varus moment than the medial translation type (p = .005). The lateral talo-first metatarsal angle was significantly associated with the maximum ankle varus moment (p = .041) in the multiple regression analysis.
Conclusion
The varus angulation type of medial ankle osteoarthritis is considered to be more imbalanced biomechanically than the medial displacement type. The lateral talo-first metatarsal angle, being significantly associated with the ankle varus moment, should be considered for correction during motion-preserving surgeries for medial ankle osteoarthritis to restore the biomechanical balance of the ankle.
Citation: Choi JH, Han HS, Park YJ, Koo S, Lee T, Lee KM (2021) Relationship between ankle varus moment during gait and radiographic measurements in patients with medial ankle osteoarthritis. PLoS ONE 16(6): e0253570. https://doi.org/10.1371/journal.pone.0253570
Editor: Hans-Peter Simmen, University Hospital Zurich, SWITZERLAND
Received: April 27, 2021; Accepted: June 5, 2021; Published: June 24, 2021
Copyright: © 2021 Choi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: All relevant data are within the paper.
Funding: This study was funded by Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science & ICT (NRF2017M3A9D8064200).
Competing interests: The authors have declared that no competing interests exist.
Introduction
Ankle osteoarthritis is a degenerative disease that results in pain and reduced range of motion of the weight-bearing joint, which causes general disability and a reduced quality of life [1]. The prevalence of ankle osteoarthritis has been reported to be 3.4% [2] and is expected to increase with the aging society. Understanding the pathomechanics of ankle arthritis with regard to daily life activities and gait is important because this should provide physicians with more diverse therapeutic approaches to this condition.
Several studies focused on the kinematic and spatiotemporal characteristics of ankle osteoarthritis during gait [3–5]. Decreases in walking speed, stride length, and ankle range of motion were observed in patients with ankle osteoarthritis [5]. Compensatory increases in hip flexion and extension moments were also reported due to decreased plantar flexion moment during the terminal stance in patients with ankle osteoarthritis [6]. However, the results of most of these studies focused on the resultant aspect of the biomechanics, not on the causative biomechanical factors.
The biomechanical pathogenesis of the ankle osteoarthritis is especially important for motion-preserving surgeries such as supramalleolar osteotomy and total ankle replacement arthroplasty because the restoration of biomechanical balance could affect surgical outcomes. A greater preoperative tibiotalar tilt angle (TT) (ankle varus incongruence) was associated with unfavorable outcomes following total ankle replacement arthroplasty or supramalleolar osteotomy [7–11]. However, the biomechanical etiology for these unfavorable outcomes has not been investigated.
Therefore, it has been hypothesized that patients with medial ankle osteoarthritis would have different biomechanics according to TT. Thus, this study aimed to investigate the different ankle varus moments between arthritic ankles with TT ≥3 degrees and those with TT <3 degrees, and to analyze the radiographic factors affecting the ankle varus moment.
Materials and methods
This prospective cohort study was approved by the institutional review board of Seoul National University Bundang Hospital (a tertiary referral medical center), and written informed consent was obtained from each participant.
Participants
Twenty-four consecutive patients aged >50 years, who were diagnosed with medial ankle osteoarthritis on radiographic examination, were enrolled between September 2019 and February 2020. The exclusion criteria were as follows: 1) neuromuscular disease, 2) previous trauma history, 3) infection, 4) tumor, 5) previous foot or ankle surgery, 6) congenital anomaly, 7) inability to walk for any other reason, and 8) any other condition that could change the anatomy of the lower extremity other than ankle osteoarthritis.
Radiographic examination and measurements
The radiographs were captured using a UT 2000 X-ray machine (Philips Research, Eindhoven, the Netherlands) according to our protocol as follows: the weight-bearing AP view of the ankles was obtained with the horizontal beam centered between the ankle joints at the joint level. The patients were positioned on a 5-cm block, with the film cassette behind the heels. The weight-bearing lateral view of the foot and ankle was captured separately for each foot in the standing position with the beam focusing on the lateral malleolus. The patients were placed in the standing position and the cassette was positioned between both feet. All radiographic images were digitally acquired using a picture archiving and communication system (PACS; Infinitt, Seoul, South Korea), and radiographic measurements were performed using the PACS software.
Four radiographic indices were selected and measured as follows: tibial plafond inclination (TPI) [12], TT [13], talar-dome inclination (TDI) [14], and lateral talo-first metatarsal angle (LTMA) [15]. In the AP view, TPI was measured between the tibial plafond and the horizontal line parallel to the floor [12]. TT was the angle between the tibial plafond and the talar dome [13]. TDI was the angle between the talar dome and the horizontal line (Fig 1A) [14]. In the lateral view, LTMA was measured between the longitudinal axis of the talus and that of the first metatarsal bone (Fig 1B) [15].
A: The ankle in AP view. TPI is the angle between the tibial plafond (a) and the floor (c). TT is measured between the tibial plafond (a) and the talar dome (b). TDI is the angle between the talar dome (b) and the floor (c). B: The foot and ankle in lateral view. LTMA is the angle between the longitudinal axis of the talus (d) and that of the first metatarsal (e).
To determine interobserver reliability, two orthopedic surgeons with experiences of 5 and 3 years, respectively, performed radiographic measurements for 15 randomly selected patients without the knowledge of the patients’ clinical information after consensus was established for measurement. After reliability testing, one surgeon with an experience of 5 years performed radiographic measurements for all the patients.
Three-dimensional gait analysis
Three-dimensional gait analysis was conducted using a motion analysis system (Motion Analysis Corporation, Santa Rosa, California, USA) equipped with 10 cameras and two force plates. Photo-reflective skin markers were placed according to the Helen Hayes Marker set [16] by a single operator with an experience of 9 years. All participants were instructed to walk barefooted along a 9-m long track at a self-selected comfortable speed. Three gait trials were selected and averaged to define a gait cycle using the kinematic and kinetic gait variables retrieved for each participant. Of these, the maximum ankle varus moment normalized by body size was retrieved and recorded (Fig 2). Spatiotemporal gait parameters including cadence, step length, and walking velocity were also collected.
Classification of medial ankle osteoarthritis
Medial ankle osteoarthritis was divided into the varus angulation and medial translation types according to the primary area of joint space narrowing. The tibial plafond and the talar dome tilted with the upper joint space narrowed between the medial talar dome and the medial tibial plafond in the varus angulation type. The medial gutter was primarily narrowed in the medial translation type where the tibial plafond and talar dome were near parallel (Fig 3). Quantitatively, medial ankle osteoarthritis with TT≥3 degrees was classified as the varus angulation type and that with TT<3 degrees as the medial translation type [17].
A: The varus angulation type was defined as TT ≥ 3 degrees. B: The medial translation type was defined as TT < 3 degrees.
Statistical analysis
The results of the descriptive statistical analysis are presented as the average, standard deviation (SD), and proportion. Data normality was confirmed with the Kolmogorov-Smirnov test. Comparison of means between the two types of medial ankle arthritis was performed using the Student t-test or Mann-Whitney U-test as appropriate. Comparison of proportions between the two groups was performed using the chi-square test or Fisher exact test (when the cell data were less than 5). The correlation between the variables was analyzed using Pearson’s correlation. Multiple regression analysis was performed to examine the radiographic measurements contributing to the maximum ankle varus moment after univariate analysis; variables with p ≤ .1 in the univariate analysis were included in multiple regression analysis. Goodness of fit is presented using adjusted R2 values.
For the interobserver reliability test, the target value of intraclass correlation coefficients (ICCs) for radiographic measurements was 0.9, with a 95% confidence interval (CI) of 0.2. The sample size was calculated, using Bonnett’s approximation (ref), as 15 patients for two observers.
All statistical analyses were performed using SPSS version 20.0 (IBM Corp., Armonk, NY, USA), and statistical significance was defined as p < .05.
Results
Twenty-four subjects (9 men, 15 women) with medial ankle osteoarthritis were included in the data analysis. The mean age of the subjects was 65.8 (SD 8.0) years. The mean BMI was 27.3 (SD 4.2) kg/m2. There were 17 right and 7 left arthritic ankles. The mean TT was 5.0 degrees (SD 4.6 degrees) and the mean maximum ankle varus moment was 0.185 (SD 0.082) Nm/kg (Table 1).
All radiographic measurements showed excellent interobserver reliability. LTMA showed the highest interobserver reliability (ICC 0.965; 95% CI, 0.900 to 0.988), followed by TT (ICC 0.958; 95% CI, 0.881 to 0.986), TPI (ICC 0.922; 95% CI, 0.789 to 0.973), and TDI (ICC 0.911; 95% CI, 0.763 to 0.969).
There were no significant differences in age, sex, BMI, and walking velocity between the varus angulation and medial translation types. TT (p < .001), LTMA (p = .001), and maximum ankle varus moment (p = .005) showed significant differences between the two types (Table 2).
TT was significantly correlated with TDI (r = .636, p = .001) and LTMA (r = .623, p = .001). TDI showed a significant correlation with LTMA (r = .481, p = .017). The maximum ankle varus moment was significantly correlated with LTMA (r = .437, p = .033) (Table 3).
Linear regression analysis showed that LTMA was the only significant radiographic measurement associated with the maximum ankle varus moment (p = .041). The explanatory power of the regression model was 25.5% (Table 4).
Discussion
The results of this study showed that the two types of medial ankle osteoarthritis had different biomechanical characteristics. Patients with a greater TT (ankle varus incongruence) showed a greater maximum ankle varus moment during gait, and LTMA (the amount of medial foot arch) was significantly associated with the maximum ankle varus moment in patients with medial ankle osteoarthritis.
The maximum ankle varus moment was significantly different between the two types of medial ankle osteoarthritis. The varus angulation type had greater varus incongruence, as shown by TT, and a greater maximum ankle varus moment during gait than the medial translation type. This implies that the varus angulation type would have greater biomechanical imbalance than the medial translation type. This has been clinically reflected in previous studies that reported unfavorable surgical outcomes following supramalleolar osteotomy or total ankle arthroplasty for ankle osteoarthritis in cases with increased TT [8–11, 18].
Increased TT represents greater varus incongruence at the ankle joint. Increase in the lateral joint space of the ankle could be caused by lateral ligament insufficiency, strong inverter or weak everter muscles, and primary hindfoot varus deformity or secondary hindfoot varus due to an increased medial foot arch (metatarsus primus equinus) [19]. Therefore, patients with medial ankle osteoarthritis with increased TT require thorough examination for these concomitant pathologies, including radiographic and physical examinations such as muscle power, ankle stress tests, and the Coleman block test [18]. The more complex nature of the varus angulation type of medial ankle osteoarthritis is considered to contribute to the greater biomechanical imbalance as shown by the increased ankle varus moment and unfavorable surgical outcome.
Our study showed the significant correlation between LTMA and the maximum ankle varus moment. Although TPI did not show a significant correlation with the maximum ankle varus moment, there was a tendency for positive correlation, which could be investigated in future studies with larger sample sizes. This supports the biomechanical basis for supramalleolar osteotomy for medial ankle osteoarthritis because supramalleolar osteotomy directly decreases TPI. Furthermore, for those with a larger TT and greater ankle varus moment, an increased LTMA might need to be corrected with metatarsal osteotomy and/or Dwyer osteotomy [20]. Future clinical studies should investigate biomechanical restoration following those corrective osteotomies.
There are some limitations to be addressed in this study. First, the number of cases was small. Although the important findings were statistically significant, they should be generalized with caution. Second, the compound ankle and hindfoot motion could not discriminate the motions of the ankle and subtalar joints with the Helen-Hayes marker set. Detailed kinematics and kinetics of the ankle and subtalar joints need to be investigated in a future study. Third, the ankle moment obtained from the gait analysis could not discriminate between active and passive moments. The incorporation of EMG data into the gait analysis should help identify pathologic active moment by muscle action and passive moment by abnormal bone or joint alignment.
In conclusion, the varus angulation type of medial ankle osteoarthritis showed a greater maximum ankle varus moment than the medial translation type, suggesting that the former could be associated with more severe biomechanical imbalance than the latter. Our study results showed that LTMA was significantly associated with ankle varus moment, suggesting that LTMA needs to be considered for correction at the time of motion-preserving surgeries for medial ankle osteoarthritis.
References
- 1. Saltzman CL, Zimmerman MB, O’Rourke M, Brown TD, Buckwalter JA, Johnston R. Impact of comorbidities on the measurement of health in patients with ankle osteoarthritis. J Bone Joint Surg Am. 2006;88(11):2366–72. pmid:17079392
- 2. Murray C, Marshall M, Rathod T, Bowen CJ, Menz HB, Roddy E. Population prevalence and distribution of ankle pain and symptomatic radiographic ankle osteoarthritis in community dwelling older adults: A systematic review and cross-sectional study. PLoS One. 2018;13(4):e0193662. pmid:29708977
- 3. Deleu PA, Besse JL, Naaim A, Leemrijse T, Birch I, Devos Bevernage B, et al. Change in gait biomechanics after total ankle replacement and ankle arthrodesis: a systematic review and meta-analysis. Clin Biomech (Bristol, Avon). 2020;73:213–25. pmid:32044672
- 4. Queen R. Directing clinical care using lower extremity biomechanics in patients with ankle osteoarthritis and ankle arthroplasty. J Orthop Res. 2017;35(11):2345–55. pmid:28543369
- 5. Valderrabano V, Nigg BM, von Tscharner V, Stefanyshyn DJ, Goepfert B, Hintermann B. Gait analysis in ankle osteoarthritis and total ankle replacement. Clin Biomech (Bristol, Avon). 2007;22(8):894–904. pmid:17604886
- 6. Schmitt D, Vap A, Queen RM. Effect of end-stage hip, knee, and ankle osteoarthritis on walking mechanics. Gait Posture. 2015;42(3):373–9. pmid:26213184
- 7. Coetzee JC, Castro MD. Accurate measurement of ankle range of motion after total ankle arthroplasty. Clin Orthop Relat Res. 2004(424):27–31. pmid:15241140
- 8. Doets HC, Brand R, Nelissen RG. Total ankle arthroplasty in inflammatory joint disease with use of two mobile-bearing designs. J Bone Joint Surg Am. 2006;88(6):1272–84. pmid:16757761
- 9. Haskell A, Mann RA. Ankle arthroplasty with preoperative coronal plane deformity: short-term results. Clin Orthop Relat Res. 2004(424):98–103. pmid:15241149
- 10. Lee WC, Moon JS, Lee K, Byun WJ, Lee SH. Indications for supramalleolar osteotomy in patients with ankle osteoarthritis and varus deformity. J Bone Joint Surg Am. 2011;93(13):1243–8. pmid:21776578
- 11. Wood PL, Sutton C, Mishra V, Suneja R. A randomised, controlled trial of two mobile-bearing total ankle replacements. J Bone Joint Surg Br. 2009;91(1):69–74. pmid:19092007
- 12. Xie K, Jiang X, Han X, Ai S, Qu X, Yan M. Association Between Knee Malalignment and Ankle Degeneration in Patients With End-Stage Knee Osteoarthritis. J Arthroplasty. 2018;33(12):3694–8 e1. pmid:30197215
- 13. Barg A, Saltzman CL. Joint-Preserving Procedures in Patients with Varus Deformity: Role of Supramalleolar Osteotomies. Foot Ankle Clin. 2019;24(2):239–64. pmid:31036267
- 14. Lee OS, Lee SH, Lee YS. Does Coronal Knee and Ankle Alignment Affect Recurrence of the Varus Deformity after High Tibial Osteotomy? Knee Surg Relat Res. 2018;30(4):311–8. pmid:30466251
- 15. Haraguchi N, Ota K, Tsunoda N, Seike K, Kanetake Y, Tsutaya A. Weight-bearing-line analysis in supramalleolar osteotomy for varus-type osteoarthritis of the ankle. J Bone Joint Surg Am. 2015;97(4):333–9. pmid:25695986
- 16. Szczerbik E, Kalinowska M. The influence of knee marker placement error on evaluation of gait kinematic parameters. Acta Bioeng Biomech. 2011;13(3):43–6. pmid:22098124
- 17. Kobayashi H, Kageyama Y, Shido Y. Treatment of Varus Ankle Osteoarthritis and Instability With a Novel Mortise-Plasty Osteotomy Procedure. J Foot Ankle Surg. 2016;55(1):60–7. pmid:26190784
- 18. Coleman SS, Chesnut WJ. A simple test for hindfoot flexibility in the cavovarus foot. Clin Orthop Relat Res. 1977(123):60–2. pmid:852192
- 19. Krahenbuhl N, Weinberg MW. Anatomy and Biomechanics of Cavovarus Deformity. Foot Ankle Clin. 2019;24(2):173–81. pmid:31036262
- 20. Maskill MP, Maskill JD, Pomeroy GC. Surgical management and treatment algorithm for the subtle cavovarus foot. Foot Ankle Int. 2010;31(12):1057–63. pmid:21189205