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COVID-19 vaccine hesitancy in underserved communities of North Carolina

  • Irene A. Doherty,

    Roles Data curation, Formal analysis, Software, Writing – original draft

    Affiliation Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC, United States of America

  • William Pilkington,

    Roles Data curation, Methodology, Project administration, Writing – review & editing

    Affiliation Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC, United States of America

  • Laurin Brown,

    Roles Data curation, Formal analysis, Software, Visualization, Writing – review & editing

    Affiliation Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC, United States of America

  • Victoria Billings,

    Roles Investigation, Methodology, Resources

    Affiliation Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC, United States of America

  • Undi Hoffler,

    Roles Data curation, Investigation, Methodology, Project administration

    Affiliation Division of Research and Sponsored Programs, North Carolina Central University, Durham, NC, United States of America

  • Lisa Paulin,

    Roles Investigation, Methodology, Project administration

    Affiliation Department of Mass Communication, North Carolina Central University, Durham, NC, United States of America

  • K. Sean Kimbro,

    Roles Data curation, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

    Affiliation Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC, United States of America

  • Brittany Baker,

    Roles Data curation, Investigation, Methodology, Resources, Supervision, Writing – review & editing

    Affiliation Department of Nursing, North Carolina Central University, Durham, NC, United States of America

  • Tianduo Zhang,

    Roles Data curation, Project administration, Software, Writing – review & editing

    Affiliation Department of Mass Communication, North Carolina Central University, Durham, NC, United States of America

  • Tracie Locklear,

    Roles Data curation, Investigation, Software, Validation, Writing – review & editing

    Affiliation Department of Pharmaceutical Sciences, North Carolina Central University, Durham, NC, United States of America

  • Seronda Robinson,

    Roles Data curation, Investigation, Methodology, Resources, Supervision

    Affiliation Department of Public Health Education, North Carolina Central University, Durham, NC, United States of America

  • Deepak Kumar

    Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

    Affiliations Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC, United States of America, Department of Pharmaceutical Sciences, North Carolina Central University, Durham, NC, United States of America



In the United States, underserved communities including Blacks and Latinx are disproportionately affected by COVID-19. This study sought to estimate the prevalence of COVID-19 vaccine hesitancy, describe attitudes related to vaccination, and identify correlates among historically marginalized populations across 9 counties in North Carolina.


We conducted a cross-sectional survey distributed at free COVID-19 testing events in underserved rural and urban communities from August 27 –December 15, 2020. Vaccine hesitancy was defined as the response of “no” or “don’t know/not sure” to whether the participant would get the COVID-19 vaccine as soon as it became available.


The sample comprised 948 participants including 27.7% Whites, 59.6% Blacks, 12.7% Latinx, and 63% female. 32% earned <$20K annually, 60% owned a computer and ~80% had internet access at home. The prevalence of vaccine hesitancy was 68.9% including 62.7%, 74%, and 59.5% among Whites, Blacks, and Latinx, respectively. Between September and December, the largest decline in vaccine hesitancy occurred among Whites (27.5 percentage points), followed by Latinx (17.6) and only 12.0 points among Blacks. 51.2% of respondents reported vaccine safety concerns, 23.7% wanted others to get vaccinated first, and 63.1% would trust health care providers about the COVID-19 vaccine. Factors associated with hesitancy in multivariable logistic regression included being female (OR = 1.90 95%CI [1.36, 2.64]), being Black (OR = 1.68 1.16, 2.45]), calendar month (OR = 0.76 [0.63, 0.92]), safety concerns (OR = 4.28 [3.06, 5.97]), and government distrust (OR = 3.57 [2.26, 5.63]).


This study engaged the community to directly reach underserved minority populations at highest risk of COVID-19 that permitted assessment of vaccine hesitancy (which was much higher than national estimates), driven in part by distrust, and safety concerns.


The COVID-19 pandemic in the United States has exacerbated deeply rooted socioeconomic and health disparities in historically marginalized populations [1, 2]. Since the coronavirus epidemic started in the US, it has become one of the leading cause of death [3, 4]. COVID-19 incidence is disproportionately higher among both Blacks and Hispanics. Racial minorities are more likely to become severely ill, and nearly three times as likely as Whites to die from COVID-19 [5].

In November 2020, Moderna and Pfizer-BioNTech released their findings from randomized trials of COVID-19 vaccines, showing a remarkable 90–95% efficacy [6, 7]. The Food and Drug Administration (FDA) issued Emergency Use Authorizations (EUA) for the Pfizer-BioNTech vaccine on December 10, 2020 [8] and the Moderna vaccine on December 18, 2020 [9]. The Advisory Committee on Immunization Practices (ACIP) updated recommendations for allocating initial supplies with tiered distribution to groups at highest risk first (e.g., health care workers, nursing home residents, and the elderly) [10, 11]. Since that time, the vaccine has been distributed throughout the United States. The population effectiveness [12] to reach herd immunity thresholds for COVID-19 requires an estimated 70% of the population to be vaccinated [13, 14]. To promote vaccine uptake and access requires resources, strategies and structural intervention in multiple sectors [15]. Vaccine hesitancy is defined as a “delay in acceptance or refusal of vaccination despite availability of vaccination services [16].” The decision to accept, delay, or refuse vaccination is complex depending heavily on the context, place, and the specific vaccine. It is paramount that we understand COVID-19 vaccine hesitancy in historically marginalized populations (HMPs) where underlying trust issues directly impact vaccine decisions.

Since early in the pandemic, several studies have used commercial panels, address lists, or random telephone surveys, representative of the US population to estimate vaccine hesitancy [1729]. The advantage of panel studies is that a large sample can be enrolled within a very short time (weeks or days), but participation often requires internet access. Two studies conducted during May and June, 2020 drawing from different panels, each estimated that 31% of the US population had vaccine hesitancy [23, 27]. Others from approximately the same period reported rates as low as 11% to 25% [20, 21, 26]. These studies consistently reported higher levels of vaccine hesitancy among female and Black respondents, but it decreased with increasing age. Other indicators of low socioeconomic status (e.g., education and income) were also frequently associated with vaccine hesitancy. Serial polls and studies from the Pew Research Center and others show that vaccine hesitancy declined when the FDA issued EUAs for the two COVID-19 vaccines [3032]. Although these studies provide important national estimates of vaccine hesitancy for the overall population and within subpopulations, online surveys do not capture the variants associated with social context, particularly for rural communities with low and intermittent internet connectivity [33].

In response to the COVID-19 public health emergency, North Carolina Central University (NCCU), a historically black college and university (HBCU), established the Advanced Center for COVID-19 Related Disparities (ACCORD). ACCORD aims to facilitate COVID-19 testing, multidisciplinary research, and messaging directed at historically marginalized populations in several North Carolina counties. A key component of the ACCORD efforts is working in close collaboration with community partners. Unlike online incentivized panels, the ACCORD study investigated vaccine hesitancy in targeted predominately rural and urban communities with entrenched, persistent, socioeconomic and health inequalities. The ACCORD strategy was to enroll a purposive sample at COVID-19 testing events hosted by NCCU. This targeted engagement with communities permitted directly assessing the prevalence and identifying correlates of vaccine hesitancy and whether it changed over time.

Materials and methods

North Carolina has 100 counties that vary widely with respect to population density, rurality and urbanicity, race/ethnicity, and socioeconomic and health indicators. As an HBCU, NCCU has fostered trusting and collaborative relationships with Black underserved communities for decades. Building on these partnerships, ACCORD facilitated COVID-19 testing and surveying programs in nine counties that represent economically-distressed and Health Research Services Administration (HRSA)-designated medically-underserved areas. ACCORD identified local residents as community facilitators and leveraged existing health resources such as public health departments in each county to garner community support for COVID-19 testing events. ACCORD hosted 32 testing events at locations carefully selected by community facilitators to provide access in otherwise COVID-19 testing deserts. Testing events occurred between August 27, 2020 and December 15, 2020.

ACCORD COVID-19 testing events took place in the parking lots of churches, schools, and similar venues that accommodated drive-through testing. ACCORD partnered with health departments and other service providers to collect nasal swabs for PCR tests. Eligibility criteria to participate in the survey included at least 18 years of age, English or Spanish comprehension, and providing informed consent. NCCU students, faculty and staff greeted individuals in their cars and explained that the university was conducting a survey to better understand the experiences and thoughts about COVID-19 in their community. If they agreed, they received the consent form and survey on a sanitized clipboard with a new ink pen that had never been used (to keep). (Initially, participants were offered sanitized tablets to enter their responses electronically but this was discontinued for a variety of reasons.) All volunteers had their temperatures recorded upon arrival, wore masks at all times, sanitized their hands frequently, and used sanitized clipboards and tablets. Survey participants received a variety of NCCU-branded items (e.g., T-shirts, string bags, and cups) and their names were entered into a monthly raffle for gift cards. The Institutional Review Board at NCCU approved the study.


To reduce respondent burden, participants received one of three survey questionnaires that each assessed different topics related to COVID-19 in greater depth. The different surveys assessed psychosocial stress, barriers to COVID-19 testing, contact tracing acceptability, and electronic media use. Each version included a set of core questions. Each survey was clearly marked with a version number (i.e., 1, 2, 3) to ensure that they were evenly distributed. All three versions assessed COVID-19 vaccine hesitancy and one version had additional questions about trusted sources for information about the vaccine.

Vaccine hesitancy was assessed (across all three questionnaire versions) with the question “Scientists are working on a COVID-19 vaccine. Would you get vaccinated against COVID-19 as quickly as possible when the vaccine becomes available?” Response choices included yes, no, and don’t know/not sure. To explore features of vaccine hesitancy, regardless of participants’ responses, the survey then asked, “Which of the reasons below would stop you or delay you from getting vaccinated against COVID-19 as soon as the vaccine becomes available?” Participants could choose multiple responses including: 1) Don’t believe that vaccines work; 2) Have concerns about vaccine safety; 3) Do not trust the government about the vaccine; 4) Do not trust the medical system; and 5) Want others to get the vaccine first.

The outcome used for regression analysis—vaccine hesitancy—combined the responses no, and don’t know/not sure. Participants who skipped or declined to answer the question were excluded. This analysis also assessed temporal trends for vaccine hesitancy over the data collection period by segmenting the events into three time periods: August-September, October, and November-December. The month number during which the event occurred was treated as a continuous variable in regression models.


All analyses were conducted using Stata Ver 15 (College Station, TX). The analysis generated descriptive statistics and tabular analysis with Chi Square or Fisher’s exacts tests, estimated the prevalence of vaccine hesitancy, quantified reasons to delay or not get vaccinated, and changes over time. Respondents who skipped or declined to answer question(s) were excluded from most analyses. Logistic regression models were used to identify correlates associated with vaccine hesitancy. We selected variables for the adjusted regression model on the basis of previous studies and whether the number of observations was too small for any single variable to generate meaningful findings. A variable with a small cell size can artificially inflate effect estimates. Also, the multivariable model includes variables for questions that were in each of the three survey versions to maximize sample size.

As a sensitivity analysis, we used general linear models (glm) with a poisson distribution, log link function, and robust standard errors. The effect estimates were somewhat attenuated, but consistent with the logistic regression and do not change interpretation (S1 Table).


We recruited a purposive sample of 1,004 participants from 34 testing events held at times and places accessible to this otherwise unreachable population. Recruitment of participants varied between 50%-95% of people who sought testing. Most participants (94%) reported their race/ethnicity and remained in the analysis. The majority of participants were Black (59.1%), followed by Whites (26.6%) and Hispanics (14.4%) (Table 1). Females comprised 63.9% of the sample. The median age for Blacks was 57 years and significantly older than Whites (45 years) and Hispanics (37 years).

Table 1. Characteristics of ACCORD study respondents by race/ethnicity ACCORD study, August-December 2020.

Overall, 15.6%, 38.2%, and 13.1% of respondents reported difficulty paying for food, monthly bills and medical care or prescriptions, respectively (Table 1). Whites reported the lowest prevalence of poor socioeconomic markers and Hispanics were markedly poorer than both Blacks and Whites. Half of Hispanics (51%) reported an annual income of <$20K (compared to 23% and 30.8% of Whites and Blacks, respectively), 40% did not complete high school, 37.9% lived in mobile homes, and only 28.9% had health insurance. Hispanics were less likely to trust health care providers for information about COVID-19 testing (32.1%) as compared to 45.2% and 42.9% of Whites and Blacks, respectively.

Disparities with respect to technology and access to the internet were evident among all survey participants. Approximately 39% of respondents did not own a computer. Only 69.3% of Hispanics owned a mobile phone as compared 88.2% of Whites and 80.5% of Blacks. Although internet access in the home was nearly universal among Whites (92.4%), significantly fewer Blacks (80.1%) and Hispanics (78.7%) reported internet access.

Vaccine hesitancy

Indicators of vaccine hesitancy varied by race/ethnicity (Table 2); only 23.4% of Blacks as compared to 36.1% of Whites and 32.6% Hispanics reported affirmatively that they would get vaccinated as soon as possible. Comparable proportions across all groups (35–36%) were unsure or did not know if they would get the vaccine as soon as possible and 89 respondents (9%) skipped the question. Notably, 10% of Blacks and 18.5% of Hispanics did not answer the question. Excluding participants who skipped the question and combining the responses no and don’t know classifies 69% of respondents as vaccine hesitant including 62.7%, 74%, and 59.5% of Whites, Blacks, and Hispanics, respectively (Table 2).

Table 2. Prevalence and features of vaccine hesitancy stratified by race, ACCORD study, North Carolina August–November 2020.

The most common reason for not- or delaying- getting vaccinated was safety concerns (50.3%). (Table 2). Only 17% of Hispanics wanted others to receive the vaccine first, as compared to 22.6% of Whites and 25.7% of Blacks. Significantly more Blacks (28.6%) mistrusted the government (as compared to 17.9% and 13.3% of Whites and Hispanics, respectively). Among the subset of respondents (n = 311) who received additional questions, trusted sources for information about the vaccine diverged significantly for Hispanics. Only 36.5% of Hispanics trust health care providers for information on COVID-19 as opposed to 70.7% and 67.4% of Whites and Blacks, respectively.

Fig 1 presents the distributions of reasons to prevent or delay vaccination stratified by participants’ responses to getting the vaccine as soon as possible. These results reveal important subtleties. Although 28.1% of respondents reported that they would indeed get the vaccine (Table 2), they nevertheless reported they had safety concerns (30.7%) (Fig 1). Respondents who reported they would not get vaccinated were more likely to report that vaccines don’t work (14.7%) and government mistrust (43%). It is important to note that between 24–26% of participants, independent of their vaccine hesitancy (or lack of) wanted others to get the vaccine first (p-value = 0.769).

Fig 1. Distribution of reasons to prevent or delay vaccination stratified by participants’ response to getting vaccinated as soon as it became available.

Fig 2 displays patterns of temporal changes over three intervals of vaccine hesitancy and stratified by race/ethnicity. The prevalence of hesitancy declined over the course of data collection for full sample and each racial/ethnic groups. The prevalence of hesitancy among Whites declined by 27.5 percentage points from a high of 69.2% during September to 41.7% during November-December (p-value = 0.01). While vaccine hesitancy also significantly declined among Blacks, the prevalence was very high during the first interval (78.4%) and declined by only 12 percentage points (66.4%) during November-December. It was not statistically significant for Hispanics because testing events in Hispanic neighborhoods started about one month (October 2020) after data collection started.

Fig 2. Distribution of vaccine hesitancy over time stratified by race/ethnicity and calendar time.

Logistic regression

Table 3 presents the bivariate associations with vaccine hesitancy. Although ownership of mobile phones (OR = 2.12, 95%CI [1.31, 3.43]) and computers (OR = 1.46, 95%CI [1.00, 2.13]), were associated with hesitancy, they were not included in the adjusted model because the questions were asked to 64% of participants (n = 607). While older adults (age ≥65) were less likely to report vaccine hesitancy (OR = 0.70 95%CI [0.50,0.98], Table 3), age was not in the multivariable model because it was highly correlated with race/ethnicity. In the multivariable model (Table 4), Blacks were 1.68(1.16, 2.45) times as likely Whites and females were 1.90 (1.36, 2.64) times as likely as males to report vaccine hesitancy, as well as participants who expressed safety concerns (OR = 4.28 [3.06, 5.97]), government distrust (OR = 3.57 [2.26, 5.63]), or wanting others to get vaccinated first (OR = 1.44, [0.98, 2.11], marginally significant p = 0.062). Hesitancy also persisted to significantly decline over time with each passing month (OR = 0.76 [0.63, 0.92]).

Table 3. Bivariate logistic regression—vaccine hesitancy, ACCORD study, NC August-December 2020.

Table 4. Multivariable logistic regression–vaccine hesitancy ACCORD study, NC August-December 2020.


The ACCORD study enrolled over 1000 participants attending COVID-19 testing events in targeted communities with high racial/ethnic minorities that suffer from health disparities and economic inequalities. The pandemic has intensified historically valid distrust of the government, medical establishment, and probably academic researchers. Our success in conducting this study emanates from the innate trust embedded in the definition of an HBCU, in addition to enlisting local residents as community facilitators who looked like participants, and our on-the-ground approach.

One other study in the US (to date) mirrors our methods [34]. Researchers at the University of California Berkeley have collaborated with Latino farmworker communities for decades. They recruited 1115 farmworkers receiving free COVID-19 tests at clinics and other community events during July–November 2020. Half (52%) of participants reported they would be extremely likely to get vaccinated and 32% were unsure. Most vaccine-hesitant participants reported worry about side effects (~65%). While this study and the ACCORD study reached different marginalized populations, they share similar concerns. Both studies suggest that working within communities where trust is earned is essential for addressing vaccination and the many needs that the COVID-19 pandemic has created or made worse.

Unlike numerous online panel studies [1728, 35] representative of the US population with internet access and email addresses, we captured vast differences in COVID-19 vaccine hesitancy among historically marginalized populations living in areas that lack technology and reliable internet service [33]. Furthermore, the target population has experienced disproportionally higher rates of COVID-19 infections and deaths. Obtaining nationally representative samples of the US, using rigorous sampling methodology to estimate vaccine hesitancy (or other health conditions) informs national public health policy. We assert such approaches do not translate to the devastation of the pandemic in the communities with the greatest needs.

The estimated prevalence of vaccine hesitancy in national studies ranged between ~11% to 35% whereas in the ACCORD study, it ranged between 42% to 79% depending on the race/ethnicity and data collection interval window. Online surveys tended to skip the questions about reasons not to vaccinate. Such questions were administered to all respondents in our paper survey. It revealed that people who would get the vaccine as soon as possible, nonetheless, had safety concerns and wanted others to get the vaccine first (Fig 2). This finding suggests that seeing others’ reactions to the vaccine is a universal concern for 25% of the population.

Repeated polls report that vaccine hesitancy has dropped over time (yet remains higher among Blacks) [25, 31]. Surveys of health care workers reported more hesitancy (than the public) at the beginning of the pandemic, but as the results from clinical trials were released, hesitancy diminished precipitously [36, 37]. Despite these promising trends, vaccine hesitancy may persist among historically marginalized populations unless substantial resources, funding, messaging, public health activities, and access to vaccination programs are deployed and evaluated.

Intervention research scientists often engage Black pastors and church leaders to promote healthy behaviors [38, 39]. Our findings show that fewer than 10% of respondents sought the advice of the faith leaders for COVID-19 vaccine information. The importance and influence of faith leaders, however, cannot be undermined, ignored, or diminished. Although, the majority of White and Black respondents (62.5%) placed their trust in their health care providers, efforts must be made to collectively utilize community and faith leaders and health providers of color [24] to deliver accurate and reliable information about the vaccine [15]. The findings also demonstrate the need for additional tailored interventions for Hispanics and their health providers to build trust. Misinformation may change attitudes and the appearance of any side effects from the first shot may deter people from receiving their second shot and any booster vaccinations. Providing transparent information about vaccine development, potential side effects, and answering related questions will help ameliorate vaccine hesitancy.

There are limitations of the ACCORD survey. The data originate from a purposive sample recruited from COVID-19 testing events of people who agreed to take the extra time to complete the survey. Although the study design could not determine detailed information about the extent that participants reflect the experiences of others in their communities, the high prevalence of distrust reported is evidence that we reached an otherwise unreachable population.

Logistical constraints prevented collecting COVID-19 test results from participants. That said, not collecting testing results likely increased participation and preserved community trust.


Our target population lived in extremely rural settings and disenfranchised urban neighborhoods. ACCORD’s structure within a large HBCU coupled with endorsement by community trusted facilitators enabled us to reach people where they live, work, and worship. Although vaccine hesitancy continues to plummet in the US as vaccine provision increases, it remains a priority to continue to directly monitor hesitancy in the communities disproportionately affected by COVID-19 –on the ground where needed most.

Supporting information

S1 Table. Multivariable sensitivity analysis.

IRR = Incidence Rate Ratio.



We acknowledge community/health partners and NCCU students, faculty and staff who volunteered at the many COVID testing sites organized by NCCU ACCORD. We gratefully acknowledge NIMHD grants U54MD012392 and R01MD012767. NCCU ACCORD is the result of support from the University of North Carolina Board of Governors’ Historically Minority Serving Institutions (HMSI) Committee with CARES funding thru the North Carolina Policy Collaboratory at the University of North Carolina at Chapel Hill.


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