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Herpes zoster in older adults in Ontario, 2002–2016: Investigating incidence and exploring equity

  • Sarah A. Buchan ,

    Roles Conceptualization, Methodology, Project administration, Writing – original draft, Writing – review & editing

    sarah.buchan@oahpp.ca

    Affiliations Health Protection, Public Health Ontario, Toronto, Ontario, Canada, Populations and Public Health, ICES, Toronto, Ontario, Canada, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada

  • Nick Daneman,

    Roles Conceptualization, Methodology, Writing – review & editing

    Affiliations Health Protection, Public Health Ontario, Toronto, Ontario, Canada, Populations and Public Health, ICES, Toronto, Ontario, Canada, Sunnybrook Research Institute, Toronto, Ontario, Canada, Division of Infectious Diseases, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada, Department of Medicine, University of Toronto, Toronto, Ontario, Canada, Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada

  • Jun Wang,

    Roles Conceptualization, Data curation, Formal analysis, Methodology

    Affiliations Health Protection, Public Health Ontario, Toronto, Ontario, Canada, Populations and Public Health, ICES, Toronto, Ontario, Canada

  • Sarah E. Wilson,

    Roles Conceptualization, Methodology, Writing – review & editing

    Affiliations Health Protection, Public Health Ontario, Toronto, Ontario, Canada, Populations and Public Health, ICES, Toronto, Ontario, Canada, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada

  • Gary Garber,

    Roles Conceptualization, Methodology, Writing – review & editing

    Affiliations Health Protection, Public Health Ontario, Toronto, Ontario, Canada, Department of Medicine, University of Toronto, Toronto, Ontario, Canada, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada

  • Anne E. Wormsbecker,

    Roles Conceptualization, Methodology, Writing – review & editing

    Affiliations Unity Health Toronto, Toronto, Ontario, Canada, Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

  • Tony Antoniou,

    Roles Conceptualization, Methodology, Writing – review & editing

    Affiliations Populations and Public Health, ICES, Toronto, Ontario, Canada, Unity Health Toronto, Toronto, Ontario, Canada, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Ontario, Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada

  • Shelley L. Deeks

    Roles Conceptualization, Methodology, Writing – review & editing

    Affiliations Health Protection, Public Health Ontario, Toronto, Ontario, Canada, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada

Abstract

Older adults are at increased risk of herpes zoster (HZ) and post-herpetic neuralgia (PHN) and HZ vaccines are available to help prevent infection. The objective of our study was to provide updated data on incidence of HZ and PHN related to clinical and demographic factors in older adults to inform immunization practices. We conducted a population-based, retrospective cohort study and included all cases of HZ seen in outpatient, emergency department, and hospital settings for adults aged 65 years and over between April 1, 2002 to August 31, 2016 in Ontario, Canada. We calculated the incidence of HZ and PHN, and estimated the proportion within each subgroup that developed PHN. We also assessed incidence by neighbourhood-level income quintile before and after the availability of vaccine for private purchase. The average annual incidence of HZ in any setting was 59.0 per 10,000 older adults, with higher incidence in outpatient as opposed to hospital settings. Incidence was higher in the oldest age groups, females, and those classified as immunocompromised or frail. Relative to the pre-vaccine era, the disparities in incidence of HZ by neighbourhood-level income increased, with higher rates of HZ and PHN seen in those residing in lower income quintiles. Additional prevention efforts should be targeted toward adults who are immunocompromised, frail, and those living in lower socioeconomic quintiles. Future work should assess the impact of the zoster vaccine program with a particular focus on equity in the publicly-funded era.

Introduction

Herpes zoster (HZ) is caused by reactivation of latent varicella zoster virus, related typically to a decline in cell mediated immunity [1]. The incidence of HZ and related complications increases with age, with steep inclines in those ≥50 years [2]. Several studies [35], have reported an increase in the incidence of HZ over the last two decades, related possibly to an aging population and/or an increase in the number of individuals living with underlying comorbidities. Immunocompromised individuals are at greater risk of HZ and its complications, including post herpetic neuralgia (PHN) [2, 6, 7], which can have significant impacts on quality of life [8, 9]. Additionally, older frail adults may also be at increased risk [10, 11]; however, this has not been well characterized.

In Canada, two HZ vaccines are currently available. In 2008, a live attenuated (LZV) vaccine was approved initially for those aged ≥65, however, its use is contraindicated in immunocompromised individuals. This vaccine was only available through private purchase from September 2009-September 2016, when it became part of the province of Ontario’s publicly funded immunization program for those aged 65–70 years. In October 2017, after the period of the current study, a recombinant subunit vaccine (RZV) was also authorized for use and has been preferentially recommended by Canada’s National Advisory Committee on Immunization for those ≥50 years without contraindications but it is currently available only for private purchase in Ontario [12].

The goal of this study was to update and expand our estimates of the burden of HZ and its complications in Ontario, Canada, to inform immunization practices. Specifically, our objectives were to quantify the incidence of medically-attended HZ and PHN in older adults and compare the incidence of HZ and PHN by socioeconomic status (SES) in the privately-funded era of LZV.

Methods

Study population, setting, and design

We conducted a retrospective population-based cohort study of Ontario residents aged ≥65 years between April 1, 2002-August 31, 2016. These individuals had universal access to physician services, hospital care, and prescription drug coverage. We selected the start date to align with the introduction of International Classification of Diseases version-10 (ICD-10) codes in Ontario and the end date to coincide with the introduction of the provincial publicly-funded HZ vaccination program for those aged 65–70 years. Our outcome was annual incidence (organized by April to March fiscal year [FY]) of HZ in outpatient, ambulatory, and hospital settings. We obtained ethics approval from Public Health Ontario’s Ethics Research Board.

Data sources and definitions

We used Ontario’s administrative health databases, which are securely linked using unique encoded identifiers and analyzed at ICES (www.ices.on.ca). Use of these databases is authorized under section 45 of Ontario’s Personal Health Information Protection Act, which does not require patient consent for health system evaluation and improvement. All data were fully anonymized before we accessed them.

Herpes zoster.

We included an individual’s first medically-attended HZ visit during the study period in any outpatient, emergency department (ED), or hospital setting. If an individual was seen in more than one setting in one day, they were classified based on hierarchy of care (i.e. hospital>ED>outpatient). We applied a look-back window to exclude any individuals with HZ in any setting within one year prior to their index date. We used the Ontario Health Insurance Plan database (i.e. physician billing) to identify individuals seeking outpatient care for HZ. We defined an outpatient visit as anyone with a diagnostic code of ‘herpes zoster, shingles’ (053) and a prescription for a HZ antiviral (i.e. acyclovir, famciclovir, valacyclovir) dispensed in the five days preceding or following the date of the physician encounter. We excluded individuals with a vaccination fee code (G538, G539) in the same visit to minimize the risk of including those who were vaccinated for HZ as opposed to receiving care for the condition. We used the Ontario Drug Benefit (ODB) database, representing all publicly-funded prescriptions for those ≥65 years who are covered under provincial insurance (all Ontario residents ≥65 are eligible for drug benefits), to identify prescriptions for acyclovir, valacyclovir, or famciclovir. We used the Canadian Institute for Health Information Discharge Abstract Database and the National Ambulatory Care Reporting System to identify hospital and ED visits respectively, combining these outcomes and categorizing them as hospital-attended HZ. We included visits related to HZ (ICD-10 code B02) in any of the 25 allowable diagnostic codes for hospital visits or 10 for ED visits and excluded any case with coexistent varicella (B01). We obtained relevant information on age and sex, as well as population denominators to calculate incidence using the Registered Persons Database, a registry of all Ontario residents with provincial health insurance.

Covariates.

Using the midpoint of our FY (October 1), we categorized all individuals ≥65 years in Ontario based on a variety of characteristics, including age, frailty status, and immunocompromised status; this allowed us to create annual population-based denominators for each characteristic. Details of our definition for immunocompromising condition have been described elsewhere [13]. Briefly, we included anyone with immune system disorders, HIV, transplant (hematopoietic stem cell transplantation or solid organ transplant), hematologic diseases, recent malignancy and/or ongoing chemotherapy or radiation treatment, and receiving immunosuppressive therapy using a variety of data sources at ICES. We used the Johns Hopkins Adjusted Clinical Groups (ACG) frailty indicator to define frailty [14]. This indicator was designed to identify frailty-defining diagnoses in administrative data and has been used in other studies at ICES [15, 16]. We used neighbourhood-income derived from the Canadian census to classify income quintiles based on residential postal code.

Outcomes.

We included an individual’s first case of medically-attended HZ in hospital, ED, or physician office. We also included acute complications (cutaneous, disseminated, ocular, and neurologic complications associated with HZ) using a window of 7 days before or 30 days after the initial HZ diagnosis in any setting [13]. Only individuals who did not present initially with a complication (i.e. only B02.9 in hospital/ED) and who did not have any acute complication during the follow up time were classified as HZ without complications. We looked separately at the development of PHN in individuals who had HZ, defining the window of PHN diagnosis as 90–365 days after the diagnosis of HZ. We restricted this analysis to individuals who had 365 days of follow-up (i.e. did not die or lose their provincial health insurance eligibility) after their HZ diagnosis date [7]. PHN was defined using a validated algorithm applied to Ontario data, comprising diagnostic codes and prescriptions for drugs used to treat PHN (S1 File) [7, 17]. The maximum follow up for PHN outcomes was March 31, 2017 due to data availability at the time of analysis.

Statistical analysis

We calculated the annual incidence of HZ per 10,000 older adults (i.e. 65 years and older) in Ontario by age group, sex, income quintile, frailty status, immunocompromised status, as well as age group stratified by frailty status. We calculated these incidences overall as well as by setting, providing separate results for outpatient as well as hospital-attended (hospital or ED) settings. We also calculated the incidence of HZ with or without acute complications. In our restricted cohort of individuals who had 365 days of follow-up, we calculated the percentage of HZ cases who developed PHN. In a sensitivity analysis, we repeated our analysis in those with 180 days follow-up to determine the proportion that developed PHN. We compared the incidence of HZ and PHN by income quintile in the periods before and after vaccine availability through private purchase (i.e., before and after September 1, 2009). We used negative binomial regression to derive relative risks (RR) and 95% confidence intervals (CI), adjusting for age, sex, and year.

Results

Between April 1, 2002-August 31, 2016, there were 162,507 incident cases of HZ among older adults; 107,592 (66.2%) of these cases were seen in outpatient settings, 48,193 (29.7%) in the ED, and 6,722 (4.1%) in hospital. A higher proportion of the HZ cases were female (60.7%). Compared to outpatient settings, a higher proportion of adults classified as frail, immunocompromised, or ≥80 years were seen in hospital/ED (Table 1).

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Table 1. Characteristics of herpes zoster cases by study setting.

https://doi.org/10.1371/journal.pone.0246086.t001

The average annual incidence of HZ in any setting was 59.0 per 10,000 older adults, with higher incidence in outpatient as opposed to hospital settings (Table 2). Average annual population denominators during the study period are provided in S1 Table. Incidence was higher in females and increased with age. The incidence of HZ in immunocompromised adults was twice that of those who were immunocompetent (106.5 vs 54.3 per 10,000) and was also higher in those classified as frail, with some variation by frailty within age groups. For instance, the relative impact of frailty was higher in hospital, and in adults aged 65–69 as compared to those aged ≥80, where the incidence did not differ by frailty. Overall, we observed similar incidence in frail adults aged 65–69 as not frail adults aged 70–79. We also observed similar overall incidence by income quintile, but there was a gradient in hospital-attended HZ, with higher incidence in lower income quintiles. These patterns persisted when exploring incidence of HZ with no complications, as well as with any acute complication and PHN (Table 3).

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Table 2. Annual incidence of herpes zoster per 10,000 by setting and overall, 2002–2016.

https://doi.org/10.1371/journal.pone.0246086.t002

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Table 3. Average annual incidence of herpes zoster complicationsa per 10,000, 2002–2016.

https://doi.org/10.1371/journal.pone.0246086.t003

The majority (n = 153,371; 94.4%) of those with HZ were eligible for our PHN analysis (i.e. had 365 days of follow-up). Overall, 21,727 (14.2%) of this restricted cohort developed PHN within 90–365 days after initial HZ diagnosis (Table 4). The pattern of individuals developing PHN was similar to our overall HZ analysis, with a higher proportion of frail, immunocompromised, and adults ≥80 years developing PHN. We observed a higher proportion of frail adults 65–69 who developed PHN relative to those in the same age group who were not frail (21.3% vs 11.2%); however, as age increased, the difference in proportions developing PHN by frailty status decreased. We found similar results in a sensitivity analysis using a 180-day follow-up period.

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Table 4. Number and proportion who developed post herpetic neuralgiaa (between 90–365 days after herpes zoster diagnosis) across study period.

https://doi.org/10.1371/journal.pone.0246086.t004

We explored equity in disease burden by estimating incidence of HZ and PHN by income quintile in two time periods–before and after the availability of LZV in Ontario (Table 5), during which time vaccine was available for private purchase. Prior to licensure, annual incidence of HZ in higher income quintiles was equal to or higher as compared to the lowest income quintile. When the vaccine became available for private purchase, the incidence of HZ was equal to or lower in the higher quintiles as compared to the lowest income quintile, and there was a significant reduction when comparing the highest income quintile to the lowest income quintile (RR = 0.96 [95% CI 0.94–0.98]). When we repeated the analysis with PHN as our outcome, we found a lower risk of PHN in the pre-vaccine era in those in the highest income quintile compared to the lowest quintile (RR = 0.78 [95% CI 0.73–0.83]) with an even greater difference following private availability of vaccine (RR = 0.68 [95% CI 0.64–0.73]).

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Table 5. Incidence of herpes zoster by income quintile, before and after availability of vaccine through private purchase in those ≥65 yearsa.

https://doi.org/10.1371/journal.pone.0246086.t005

Discussion

Over the course of our study period, we observed more than 160,000 incident cases of medically-attended HZ in adults aged ≥65 years. We found higher incidences of HZ in older age groups, females, lower income quintiles, and those who were classified as immunocompromised or frail.

Consistent with published research, the majority of HZ cases were seen as outpatients and a higher proportion of cases were in older adults and females [3, 4, 18, 19]. Our reported incidence was also comparable to other studies, although there are important differences to consider when making comparisons in terms of age groups, setting (inpatient, outpatient), timeframe (including with respect to vaccine availability), and outcome definition. In a systematic review of global incidence, Kawai et al. estimated a rate of 6–8 per 1,000 PY at age 60 and 8–12 per 1,000 PY at age 80 [20]. In several Canadian provinces, incidence of HZ has been reported across a variety of ages and time frames [35, 21, 22]. The incidence in our study was lower than that of other studies, including those in Ontario, likely due to our criterion of including an antiviral prescription within five days of an outpatient visit [5, 23]. In British Columbia, Marra et al. reported a decreased incidence in sensitivity analyses restricted to those with an antiviral prescription [3], and we therefore may have underestimated burden.

Across our study period we estimated that 14.2% of older adults diagnosed with HZ developed PHN. A recent systematic review noted the percentage reporting PHN ranged from 5–30%; however, these studies differed in their age groups, study design, years included, and importantly, definition of PHN [20]. Our estimate aligned with several estimates reported in the review among adults >50 years [2427], although the authors noted that estimates of PHN were often lower when using administrative databases relative to other studies. We adapted an algorithm validated for use in administrative data to identify PHN which has been used in the United Kingdom (UK) [7, 17]. Similar to this study, we found higher risk of PHN in females, immunocompromised adults, and adults living in lower income neighborhoods [7]. Of note, we found that a high proportion of frail adults aged 65–69 developed PHN, which may be impacted by our criteria that those in the PHN analyses had 365 days follow-up. However, the finding remained even after we relaxed the criterion for PHN to 180 days of follow-up.

Clinical factors

We estimated the incidence of HZ, acute complications, and PHN in several subgroups, aligning with an increasingly promoted life-course approach to vaccination, in which circumstances beyond age are necessary considerations in making vaccination decisions and in which vaccination to prevent disease is seen as a component in promoting healthy ageing [28, 29]. We found that the incidence of HZ in immunocompromised adults across all settings was twice that of those who were immunocompetent. This is in line with other published estimates but lower than in our previous published work which was limited to hospital-attended HZ [30, 31]; in this publication, we had hypothesized that there may be a greater difference when limited to more severe disease. We have now provided estimates for all medically attended HZ in those ≥65 years by immunocompromised status, which has important implications given that the vaccines available to prevent HZ have different contraindications.

We are not aware of any studies that have provided an estimate of risk of HZ and PHN in adults by frailty status, although it has been suggested that frail older adults may be disproportionately affected [9, 10]. Other research has examined the development of frailty following HZ infection (finding no effect) [32, 33], whereas we assessed the incidence of HZ within cohorts stratified by frailty status and found a higher incidence compared to older adults who are not frail. While aging correlates with frailty, the concept of frailty is distinct and may serve as a better proxy to immunosenescence [34, 35]. This has implications for vaccine promotion given the increase in susceptibility to infectious diseases as the immune response weakens and a goal to target vaccines to those most at risk, beyond considering age alone, but also may have implications for immune response to vaccine [10, 11, 29]. We compared the incidence of HZ and PHN by frailty within age groups in order to better understand the relative contribution of each factor. For both outcomes, we observed a higher incidence in frail older adults within each age group, but that the relative impact of frailty decreased with increasing age. For example, the incidence of PHN in frail 65–69 year old adults was almost twice that of non-frail adults of the same age group. Conversely, in those ≥80 years, the incidence of PHN was equal by frailty status. As Russell et al. noted, the effect of comorbidity was more pronounced in younger ages [4].

Socio-economic factors

In addition to clinical factors, we were interested in exploring disease incidence by SES in an effort to understand equity [36]. There is conflicting evidence regarding SES (i.e. income, deprivation) and HZ incidence, with some reporting no association, some reporting an increased risk in more deprived individuals and others reporting an inverse association [2, 3739]. In comparison to lower income quintiles, we found similar or greater risk of HZ in higher income quintiles in the pre-vaccine era, but equal or lower risk of HZ in higher income quintiles in the private purchase era. We observed a larger effect when we repeated this analysis with PHN as an outcome. The risk of PHN was significantly lower in the pre-vaccine era in the highest income quintile, but the magnitude of difference between highest and lowest quintiles increased in the private-vaccine era.

There are several reasons for why we may have observed this effect in the two eras. First, only LZV was available in Canada during the study period and its short-term efficacy against PHN has been shown to be higher than efficacy against HZ incidence [25, 38]; as such, the reduced incidence of PHN in particular may suggest that those in the highest income quintile were more likely to purchase vaccine out of pocket. Second, our capture of PHN included a combination of diagnostic codes and prescription data, with prescriptions being limited to those covered by the provincial drug plan. If those in a higher income quintile were being treated with medication not on the formulary, they would not have been identified with PHN and this could lead to a discrepancy in PHN capture between income quintiles. However, other studies have previously reported higher incidence of PHN in low SES prior to the availability of a vaccine [7], and given that we observed a further reduction in PHN in the private vaccine era, these results suggest PHN is lower in those with higher SES. Last, the likelihood of developing PHN may have been impacted by timely access to antivirals or supplemental therapies [40, 41], which could be influenced by SES. Although our PHN analyses were restricted to those with HZ and the majority of individuals were included using criteria that included an antiviral prescription (i.e., outpatients), we did not have data on other medications prescribed or those not publicly-funded.

We are unaware of other studies that have used this approach to identify and understand disparities. In Australia and the UK, HZ vaccine is publicly-funded for older adults. In Canada, Ontario is currently the only province to publicly fund HZ vaccination and does so using LZV for those 65–70 years; however, this program started after our study period [42]. While not comparing disease incidence directly by SES, several studies have reported discrepancies in vaccine uptake by sociodemographic characteristics. In Alberta, Liu et al. estimated vaccine uptake in those ≥60 years for the first four years following LZV licensure and found the odds of vaccination were 57% higher in those in the highest quintile relative to the lowest (OR = 1.57 [95% CI 1.45–1.69]) [43]. In the UK, Ward et al. estimated coverage in 2014–15 as 8.2% lower in the most deprived compared to the least deprived [44]. Also in the UK, Jain et al. reported a lower odds of vaccination in the most deprived compared to the least deprived (OR = 0.69 [95% CI 0.64–0.75]) [45]. Of note, both the UK studies were conducted in an era of public funding, indicating issues related to access may persist beyond cost alone.

Limitations and strengths

There are several limitations worth noting. First, our study was restricted to those who were ≥65 years. We were concerned that outpatient visits for HZ vaccination could be misclassified in our data as cases of HZ and we therefore added the criteria for an antiviral prescription in conjunction with a coded HZ visit in order to define a case of HZ. However, these prescription data are only available in Ontario for those ≥65 years and we were thus unable to explore incidence in younger age groups. We were also unable to assess those who received prescriptions related to HZ or PHN through private insurance (i.e., prescriptions not be covered by ODB). Further, due to the lack of HZ vaccine-specific billing codes, we could not identify whether an individual had received HZ vaccine. We also did not account for the introduction of varicella vaccine in our analyses, which is a hypothesized contributor to the changing epidemiology of HZ in adults given the reduction in opportunities for adults to be “boosted” due to lower immunosurveillance [46]; however, results supporting this hypothesis have been conflicting [4, 5, 4750]. There also may be issues due to misclassification in our data. These include: missing some adults aged 65 who were on prior immunosuppressive therapy because the drug data is only available for those ≥65 years; misclassifying annual immunocompromising status as we defined it based on October 1 each year; and misclassifying ongoing PHN or recurrent zoster as a new case as our washout period was limited to one year.

Our study provides updated burden of disease data for adults ≥65 years in Ontario, and may be a helpful basis for evaluating future immunization programs. We estimated population-based incidence overall and in groups at increased risk of HZ during adulthood in an effort to apply a life-course approach to immunization that incorporates not just age group as an important component of immunization programs but also recognizes that providing protection should take into account other circumstances, such as frailty and immunocompromised [28, 29]. We also provided data on complications, including PHN, which may reduce quality of life and the impacts of which should be taken into consideration when discussing immunization as it relates to healthy ageing.

Conclusions

Our results suggest that additional prevention efforts should be targeted toward adults who are immunocompromised, frail, and those living in lower income neighbourhoods. Future work should assess the impact of the HZ vaccine program with a particular focus on equity in the publicly-funded era.

Supporting information

S1 File. Post Herpetic Neuralgia (PHN) definition.

https://doi.org/10.1371/journal.pone.0246086.s001

(DOCX)

S1 Table. Average annual population in Ontario aged ≥65 years by characteristic, 2002–2016.

https://doi.org/10.1371/journal.pone.0246086.s002

(DOCX)

Acknowledgments

We would like to thank Dr. Harriet Forbes for sharing information related to identifying PHN diagnoses in administrative data.

References

  1. 1. McElhaney JE, Verschoor C, Pawelec G. Zoster Vaccination in Older Adults: Efficacy and Public Health Implications. J Gerontol A Biol Sci Med Sci 2019 Jul 12;74(8):1239–1243. pmid:30945744
  2. 2. Kawai K, Yawn BP. Risk Factors for Herpes Zoster: A Systematic Review and Meta-analysis. Mayo Clin Proc 2017 Dec;92(12):1806–1821. pmid:29202939
  3. 3. Marra F, Chong M, Najafzadeh M. Increasing incidence associated with herpes zoster infection in British Columbia, Canada. BMC Infect Dis 2016 Oct 20;16(1):589. pmid:27765026
  4. 4. Russell ML, Dover DC, Simmonds KA, Svenson LW. Shingles in Alberta: before and after publicly funded varicella vaccination. Vaccine 2014 Oct 29;32(47):6319–6324. pmid:24099868
  5. 5. Tanuseputro P, Zagorski B, Chan KJ, Kwong JC. Population-based incidence of herpes zoster after introduction of a publicly funded varicella vaccination program. Vaccine 2011 Nov 3;29(47):8580–8584. pmid:21939721
  6. 6. Marra F, Lo E, Kalashnikov V, Richardson K. Risk of Herpes Zoster in Individuals on Biologics, Disease-Modifying Antirheumatic Drugs, and/or Corticosteroids for Autoimmune Diseases: A Systematic Review and Meta-Analysis. Open Forum Infect Dis 2016 Sep 28;3(4):ofw205. pmid:27942537
  7. 7. Forbes HJ, Bhaskaran K, Thomas SL, Smeeth L, Clayton T, Mansfield K, et al. Quantification of risk factors for postherpetic neuralgia in herpes zoster patients: A cohort study. Neurology 2016 Jul 5;87(1):94–102. pmid:27287218
  8. 8. Drolet M, Brisson M, Schmader KE, Levin MJ, Johnson R, Oxman MN, et al. The impact of herpes zoster and postherpetic neuralgia on health-related quality of life: a prospective study. CMAJ 2010 Nov 9;182(16):1731–1736. pmid:20921251
  9. 9. McElhaney JE. Herpes zoster: a common disease that can have a devastating impact on patients’ quality of life. Expert Rev Vaccines 2010 Mar;9(3 Suppl):27–30. pmid:20192715
  10. 10. Zorzoli E, Pica F, Masetti G, Franco E, Volpi A, Gabutti G. Herpes zoster in frail elderly patients: prevalence, impact, management, and preventive strategies. Aging Clin Exp Res 2018 Jul;30(7):693–702. pmid:29721782
  11. 11. Caruso C, Buffa S, Candore G, Colonna-Romano G, Dunn-Walters D, Kipling D, et al. Mechanisms of immunosenescence. Immun Ageing 2009 Jul 22;6:10. pmid:19624841
  12. 12. The National Advisory Committee on Immunization (NACI). Updated Recommendations on the Use of Herpes Zoster Vaccines. Ottawa, ON: Public Health Agency of Canada; 2018.
  13. 13. Buchan SA, Daneman N, Wang J, Garber G, Wormsbecker AE, Wilson SE, et al. Incidence of hospitalizations and emergency department visits for herpes zoster in immunocompromised and immunocompetent adults in Ontario, Canada, 2002–2016. Clin Infect Dis 2019
  14. 14. John Hopkins Bloomberg School of Public Health. The Johns Hopkins Adjusted Clinical Groups Technical Reference Guide. Version 9.0 ed. Baltimore, MD: The Johns Hopkins University; 2009.
  15. 15. Tran DTT, Tu JV, Dupuis JY, Bader Eddeen A, Sun LY. Association of frailty and long-term survival in patients undergoing coronary artery bypass grafting. J Am Heart Assoc 2018 Jul 20;7(15):e009882. pmid:30030214
  16. 16. Gruneir A, Fung K, Fischer HD, Bronskill SE, Panjwani D, Bell CM, et al. Care setting and 30-day hospital readmissions among older adults: a population-based cohort study. CMAJ 2018 Sep 24;190(38):E1124–E1133. pmid:30249758
  17. 17. Klompas M, Kulldorff M, Vilk Y, Bialek SR, Harpaz R. Herpes zoster and postherpetic neuralgia surveillance using structured electronic data. Mayo Clin Proc 2011 Dec;86(12):1146–1153. pmid:21997577
  18. 18. Sato K, Adachi K, Nakamura H, Asano K, Watanabe A, Adachi R, et al. Burden of herpes zoster and postherpetic neuralgia in Japanese adults 60 years of age or older: Results from an observational, prospective, physician practice-based cohort study. J Dermatol 2017 Apr;44(4):414–422. pmid:27917531
  19. 19. Schmidt SA, Kahlert J, Vestergaard M, Schonheyder HC, Sorensen HT. Hospital-based herpes zoster diagnoses in Denmark: rate, patient characteristics, and all-cause mortality. BMC Infect Dis 2016 Mar 1;16:99. pmid:26932311
  20. 20. Kawai K, Gebremeskel BG, Acosta CJ. Systematic review of incidence and complications of herpes zoster: towards a global perspective. BMJ Open 2014 Jun 10;4(6):e004833. pmid:24916088
  21. 21. Letellier MC, Amini R, Gilca V, Trudeau G, Sauvageau C. Herpes Zoster Burden in Canadian Provinces: A Narrative Review and Comparison with Quebec Provincial Data. Can J Infect Dis Med Microbiol 2018 Oct 21;2018:3285327. pmid:30420904
  22. 22. Drolet M, Zhou Z, Sauvageau C, DeWals P, Gilca V, Amini R, et al. Effectiveness and cost-effectiveness of vaccination against herpes zoster in Canada: a modelling study. CMAJ 2019 Aug 26;191(34):E932–E939. pmid:31451524
  23. 23. Antoniou T, Zheng H, Singh S, Juurlink DN, Mamdani MM, Gomes T. Statins and the risk of herpes zoster: a population-based cohort study. Clin Infect Dis 2014 Feb;58(3):350–356. pmid:24235264
  24. 24. Gauthier A, Breuer J, Carrington D, Martin M, Remy V. Epidemiology and cost of herpes zoster and post-herpetic neuralgia in the United Kingdom. Epidemiol Infect 2009 Jan;137(1):38–47. pmid:18466661
  25. 25. Oxman MN, Levin MJ, Johnson GR, Schmader KE, Straus SE, Gelb LD, et al. A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N Engl J Med 2005 Jun 2;352(22):2271–2284. pmid:15930418
  26. 26. Stein AN, Britt H, Harrison C, Conway EL, Cunningham A, Macintyre CR. Herpes zoster burden of illness and health care resource utilisation in the Australian population aged 50 years and older. Vaccine 2009 Jan 22;27(4):520–529. pmid:19027048
  27. 27. Lukas K, Edte A, Bertrand I. The impact of herpes zoster and post-herpetic neuralgia on quality of life: patient-reported outcomes in six European countries. Z Gesundh Wiss 2012 Aug;20(4):441–451. pmid:22822293
  28. 28. Philip RK, Attwell K, Breuer T, Di Pasquale A, Lopalco PL. Life-course immunization as a gateway to health. Expert Rev Vaccines 2018 Oct;17(10):851–864. pmid:30350731
  29. 29. Tate J, Aguado T, Belie J, Holt D, Karafillakis E, Larson HJ, et al. The life-course approach to vaccination: Harnessing the benefits of vaccination throughout life. Vaccine 2019 Oct 16;37(44):6581–6583. pmid:31558327
  30. 30. Hillebrand K, Bricout H, Schulze-Rath R, Schink T, Garbe E. Incidence of herpes zoster and its complications in Germany, 2005–2009. J Infect 2015 Feb;70(2):178–186. pmid:25230396
  31. 31. Schroder C, Enders D, Schink T, Riedel O. Incidence of herpes zoster amongst adults varies by severity of immunosuppression. J Infect 2017 Sep;75(3):207–215. pmid:28676411
  32. 32. Wang GC, Han C, Detrick B, Casolaro V, Levine DM, Fried LP, et al. Herpesvirus Infections and Risk of Frailty and Mortality in Older Women: Women’s Health and Aging Studies. J Am Geriatr Soc 2016 May;64(5):998–1005. pmid:27131018
  33. 33. Araujo Carvalho AC, Tavares Mendes ML, Santos VS, Tanajura DM, Prado Nunes MA, Martins-Filho PRS. Association between human herpes virus seropositivity and frailty in the elderly: A systematic review and meta-analysis. Ageing Res Rev 2018 Dec;48:145–152. pmid:30391341
  34. 34. Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet 2013 Mar 2;381(9868):752–762. pmid:23395245
  35. 35. Chen X, Mao G, Leng SX. Frailty syndrome: an overview. Clin Interv Aging 2014 Mar 19;9:433–441. pmid:24672230
  36. 36. Boyce T, Gudorf A, de Kat C, Muscat M, Butler R, Habersaat KB. Towards equity in immunisation. Euro Surveill 2019 Jan;24(2):1800204. pmid:30646979
  37. 37. Esteban-Vasallo MD, Dominguez-Berjon MF, Gil-Prieto R, Astray-Mochales J, Gil de Miguel A. Sociodemographic characteristics and chronic medical conditions as risk factors for herpes zoster: a population-based study from primary care in Madrid (Spain). Hum Vaccin Immunother 2014;10(6):1650–1660. pmid:24805130
  38. 38. Langan SM, Smeeth L, Margolis DJ, Thomas SL. Herpes zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in an older US population: a cohort study. PLoS Med 2013;10(4):e1001420. pmid:23585738
  39. 39. Turner NM, MacRae J, Nowlan ML, McBain L, Stubbe MH, Dowell A. Quantifying the incidence and burden of herpes zoster in New Zealand general practice: a retrospective cohort study using a natural language processing software inference algorithm. BMJ Open 2018 May 31;8(5):e021241. pmid:29858420
  40. 40. Chen N, Li Q, Yang J, Zhou M, Zhou D, He L. Antiviral treatment for preventing postherpetic neuralgia. Cochrane Database Syst Rev 2014 Feb 6;2(Art. No.: CD006866.). pmid:24500927
  41. 41. Xing XF, Zhou ZF, Zhang FJ, Yan M. The Effect of Early Use of Supplemental Therapy on Preventing Postherpetic Neuralgia: A Systematic Review and Meta-analysis. Pain Physician 2017 Sep;20(6):471–486. pmid:28934778
  42. 42. Ontario Ministry of Health and Long Term Care. Publicly Funded Shingles (Herpes Zoster) Immunization Program: Information for Health Care Providers. 2016.
  43. 43. Liu XC, Simmonds KA, Russell ML, Svenson LW. Herpes zoster vaccine (HZV): utilization and coverage 2009–2013, Alberta, Canada. BMC Public Health 2014 Oct 23;14:1098. pmid:25342438
  44. 44. Ward C, Byrne L, White JM, Amirthalingam G, Tiley K, Edelstein M. Sociodemographic predictors of variation in coverage of the national shingles vaccination programme in England, 2014/15. Vaccine 2017;35(18):2372–2378. pmid:28363324
  45. 45. Jain A, van Hoek AJ, Walker JL, Forbes HJ, Langan SM, Root A, et al. Inequalities in zoster disease burden: a population-based cohort study to identify social determinants using linked data from the U.K. Clinical Practice Research Datalink. Br J Dermatol 2018 Jun;178(6):1324–1330. pmid:29388189
  46. 46. Hope-Simpson RE. The Nature of Herpes Zoster: a Long-Term Study and a New Hypothesis. Proc R Soc Med 1965 Jan;58:9–20. pmid:14267505
  47. 47. Humes EA, Weinberger DM, Kudish KS, Hadler JL. Trends in hospitalizations with primary varicella and herpes zoster during the prevaricella and initial postvaricella and herpes zoster vaccine eras, Connecticut, 1994–2012. Open Forum Infect Dis 2015 Jan 28;2(1):2795–804.
  48. 48. Reynolds MA, Chaves SS, Harpaz R, Lopez AS, Seward JF. The impact of the varicella vaccination program on herpes zoster epidemiology in the United States: a review. J Infect Dis 2008 Mar 1;197(Suppl 2):S224–S227. pmid:18419401
  49. 49. Wolfson LJ, Daniels VJ, Altland A, Black W, Huang W, Ou W. The Impact of Varicella Vaccination on the Incidence of Varicella and Herpes Zoster in the United States: Updated Evidence From Observational Databases, 1991–2016. Clin Infect Dis 2019. Apr 24.
  50. 50. Harpaz R, van Hoek AJ. Point-Counterpoint: The Hope-Simpson Hypothesis and Its Implications Regarding an Effect of Routine Varicella Vaccination on Herpes Zoster Incidence. J Infect Dis 2018 Sep 22;218(suppl_2):S57–S62. pmid:30247602