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Proportion of asymptomatic infection among COVID-19 positive persons and their transmission potential: A systematic review and meta-analysis

  • Mercedes Yanes-Lane,

    Roles Conceptualization, Formal analysis, Investigation, Supervision, Writing – original draft

    Affiliation Research Institute, McGill University Health Centre, Montreal, Quebec, Canada

  • Nicholas Winters,

    Roles Data curation, Formal analysis, Investigation

    Affiliation Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Quebec, Canada

  • Federica Fregonese,

    Roles Data curation, Investigation, Writing – original draft

    Affiliation Research Institute, McGill University Health Centre, Montreal, Quebec, Canada

  • Mayara Bastos,

    Roles Formal analysis, Methodology

    Affiliation Research Institute, McGill University Health Centre, Montreal, Quebec, Canada

  • Sara Perlman-Arrow,

    Roles Data curation, Investigation

    Affiliation Research Institute, McGill University Health Centre, Montreal, Quebec, Canada

  • Jonathon R. Campbell ,

    Contributed equally to this work with: Jonathon R. Campbell, Dick Menzies

    Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

    Affiliations Research Institute, McGill University Health Centre, Montreal, Quebec, Canada, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Quebec, Canada, McGill International TB Centre, Montreal, Quebec, Canada

  • Dick Menzies

    Contributed equally to this work with: Jonathon R. Campbell, Dick Menzies

    Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

    Affiliations Research Institute, McGill University Health Centre, Montreal, Quebec, Canada, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Quebec, Canada, McGill International TB Centre, Montreal, Quebec, Canada, Division of Respiratory Medicine, Department of Medicine, McGill University, Quebec, Canada

Proportion of asymptomatic infection among COVID-19 positive persons and their transmission potential: A systematic review and meta-analysis

  • Mercedes Yanes-Lane, 
  • Nicholas Winters, 
  • Federica Fregonese, 
  • Mayara Bastos, 
  • Sara Perlman-Arrow, 
  • Jonathon R. Campbell, 
  • Dick Menzies



The study objective was to conduct a systematic review and meta-analysis on the proportion of asymptomatic infection among coronavirus disease 2019 (COVID-19) positive persons and their transmission potential.


We searched Embase, Medline, bioRxiv, and medRxiv up to 22 June 2020. We included cohorts or cross-sectional studies which systematically tested populations regardless of symptoms for COVID-19, or case series of any size reporting contact investigations of asymptomatic index patients. Two reviewers independently extracted data and assessed quality using pre-specified criteria. Only moderate/high quality studies were included. The main outcomes were proportion of asymptomatic infection among COVID-19 positive persons at testing and through follow-up, and secondary attack rate among close contacts of asymptomatic index patients. A qualitative synthesis was performed. Where appropriate, data were pooled using random effects meta-analysis to estimate proportions and 95% confidence intervals (95% CI).


Of 6,137 identified studies, 71 underwent quality assessment after full text review, and 28 were high/moderate quality and were included. In two general population studies, the proportion of asymptomatic COVID-19 infection at time of testing was 20% and 75%, respectively; among three studies in contacts it was 8.2% to 50%. In meta-analysis, the proportion (95% CI) of asymptomatic COVID-19 infection in obstetric patients was 95% (45% to 100%) of which 59% (49% to 68%) remained asymptomatic through follow-up; among nursing home residents, the proportion was 54% (42% to 65%) of which 28% (13% to 50%) remained asymptomatic through follow-up. Transmission studies were too heterogenous to meta-analyse. Among five transmission studies, 18 of 96 (18.8%) close contacts exposed to asymptomatic index patients were COVID-19 positive.


Despite study heterogeneity, the proportion of asymptomatic infection among COVID-19 positive persons appears high and transmission potential seems substantial. To further our understanding, high quality studies in representative general population samples are required.


Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread worldwide. Many countries implemented unprecedented measures to control SARS-CoV-2. National lockdowns, physical distancing, quarantine, and travel restrictions were widely implemented. For many countries these measures were successful in controlling the initial wave of the epidemic. However, the disease caused by SARS-CoV-2, coronavirus disease 2019 (COVID-19), can range from asymptomatic infection to severe pneumonia and death [14]. The possibility of transmission occurring within this wide presentation range has made sustained control of the disease difficult [5]. Indeed, several early instances of countries easing restrictions and reopening economies and schools have resulted in epidemic recrudescence [68].

As more jurisdictions move towards lifting restrictions, public health strategies addressing the spectrum of COVID-19 will be necessary to maintain epidemic control. Persons with asymptomatic COVID-19 infection present a unique challenge as they lack characteristics that might indicate they are infected. Virological studies [9, 10] indicate asymptomatic persons shed similar quantities of virus to symptomatic persons and observational studies have found that younger patients are less likely to present with severe forms of the disease [11, 12]. However, the proportion of infections that are asymptomatic and their infectiousness is still uncertain. Therefore, improving our understanding of the role of persons with asymptomatic COVID-19 infection in the epidemic will be crucial to informing public health strategies.

We conducted a systematic review and meta-analysis to critically evaluate the literature on the proportion of asymptomatic infection among COVID-19 positive persons and their transmission potential.


This systematic review adheres to the PRISMA guidelines and our protocol was prospectively registered with PROSPERO (CRD42020181543) [13]. As our scientific understanding of COVID-19 evolved in the process of conducting this review and more data became available, we submitted protocol amendments to our initial strategy for data synthesis. These were submitted to PROSPERO.

Search strategy and selection criteria

We conducted a systematic review of peer-reviewed or pre-print articles up to June 22, 2020. We designed a search strategy in MEDLINE and EMBASE to identify studies reporting the proportion of persons with asymptomatic COVID-19 infection and/or the number of close contacts of asymptomatic persons who were diagnosed with COVID-19. The complete search strategy was as follows: exp Asymptomatic Diseases/ OR (asymptomatic or "no symptoms").ti,ab,kw. OR (presymptomatic or Pre-Symptomatic).ti,ab,kw OR (symptomatic).ti,ab,kw AND ("Wuhan Coronavirus" or "novel coronavirus" or SARS-CoV-2 or COVID-19 or 2019-nCoV).ti,ab,kw. In addition, we searched the compendium on COVID-19 and SARS-CoV-2 from MedRxiv and BioRxiv for pre-print articles. All titles, abstracts, and full texts were independently assessed by two reviewers (NW, MYL) without language restriction. These same reviewers also searched reference lists of articles and systematic reviews identified in the search for additional studies.

We included studies for quality assessment that: systematically tested individuals for COVID-19 regardless of symptoms; were cross-sectional or cohort (prospective or retrospective) studies that reported the proportion of COVID-19 positive persons who were asymptomatic at time of testing and/or proportion of COVID-19 positive persons that were asymptomatic at time of testing who later developed symptoms; were case series describing contact or outbreak investigations of asymptomatic index patients and; included ≥25 participants tested for COVID-19 (except in case series describing transmission, which could be any size). Studies were excluded if authors used extrapolated data, based outcomes on modelling, did not define the criteria for SARS-CoV-2 testing, or did not define the population eligible for testing.

Data extraction and quality assessment

Data from all studies eligible for quality assessment were extracted into a pre-defined extraction form (see S1 File for form) by one of three reviewers (MYL, NW, or SPA) and independently verified by a second reviewer. Disagreements were resolved by consensus with two other reviewers (FF and JRC). If multiple studies reported on the same or overlapping cohorts of participants, information was extracted from each individual study to complement the available information. We defined asymptomatic COVID-19 positive persons as those who did not present any symptoms (or any new symptoms, if pre-existing chronic conditions) at the time of SARS-CoV-2 diagnosis. Pre-symptomatic COVID-19 positive persons were those who were asymptomatic at the time of initial SARS-CoV-2 testing but developed symptoms during study follow-up. Two independent reviewers (MYL, SPA) assessed the quality of each study; any disagreements were resolved by consensus with a third reviewer (JRC). The quality of included studies was evaluated using adapted criteria from the Newcastle-Ottawa scale for cohort studies, and from the Joanna Briggs Institute Prevalence Critical Appraisal Tool for cross-sectional [14, 15]. The quality of included studies was assessed in the domains of selection bias, reporting bias and detection bias (depending on follow-up and outcome measures). We developed our own quality assessment tool for case series exclusively reporting on asymptomatic transmission as we could not identify a validated tool. Our quality assessment tool assessed the domains of reporting bias, detection bias (for contact identification and diagnosis), and misclassification bias (for direction of transmission from the index patient). Signalling questions and domains were selected based on epidemiological knowledge. All studies were classified as low, moderate, or high quality based on presence of bias in each, following grading scales developed a priori (see S2 File for detail on quality assessment tools and grading scales).


There were three primary outcome measures: 1) the proportion of asymptomatic COVID-19 infection among persons testing positive for COVID-19; 2) the proportion of COVID-19 infection that remains asymptomatic throughout study follow-up; and 3) the secondary COVID-19 attack rate among close contacts (both household and non-household) of asymptomatic index patients.

Data analysis

Because of significant bias concerns, we excluded all low-quality studies from data synthesis and analysis. For all included studies, a qualitative synthesis was performed describing each of the primary outcome measures among different populations included in the studies. To facilitate synthesis, we used the following population categories: general population, contacts, and other populations (this includes healthcare workers in settings other than nursing homes, obstetric patients presenting to hospitals, liver transplant patients presenting to hospitals, persons in congregate settings, patients and staff in nursing homes, and public facing workers). Crude proportions of asymptomatic infection at COVID-19 initial testing, and of COVID-19 infection that remained asymptomatic throughout follow-up, were calculated using n/N based on data availability within each study.

Where at least three studies were conducted in the same population and we judged studies were sufficiently homogenous based on study design and inclusion criteria, we conducted meta-analysis. For overlapping cohorts of participants, the study with the longest study duration or the most complete information on participants was included in the meta-analysis. All meta-analyses were performed with package meta and metaprop function (version 4.12.0) in R (version 3.6.0). For each primary outcome measure, we logit transformed individual study outcomes and applied random-effects meta-analysis using generalized linear mixed models for each as well as for the overall proportion; pooled and individual study proportions were then back-transformed. For all meta-analyses, heterogeneity was quantified using the I2 statistic. In order to determine the proportion of truly asymptomatic individuals (i.e. those who do not develop symptoms at any time during follow up) the total number of COVID-19 infected persons that remain asymptomatic through follow up was used as numerator, and the total number of COVID-19 infections was used as denominator. For studies on transmission, meta-analysis was not performed. For individual transmission studies, we calculated the proportion of contacts traced and tested who were positive for COVID-19 and corresponding exact confidence intervals using the Clopper-Pearson method [16] and report the secondary attack rate overall.

Patient and public involvement

Patients were not involved in the development of the research question or its outcome measures, conduct of the research, or preparation of the manuscript.


We identified 6,137 studies in our search and 282 studies entered full text assessment. Of these, 71 studies were included in quality assessment and 28 (39.4%) were high or moderate quality and ultimately included in this review (Fig 1).

Fig 1. PRISMA flow diagram of identified and included studies with reasons for exclusion at the full text stage.

Among the 43 low quality studies excluded, 28 were studies on proportion of asymptomatic infection [1744] and 15 were transmission studies [4559]. Among the studies on proportion of asymptomatic infection excluded, potential selection bias (21/28; 75%) and detection bias (16/28; 57.1%) were the most common concerns, while for the transmission studies excluded, detection bias (15/15; 100%) and reporting bias (14/15; 93.3%) were the most common concerns (S1 Table). Primary outcome measures extracted from excluded studies are summarized in S2S4 Tables.

From the 28 high or moderate quality studies included, 24 reported on the proportion of asymptomatic COVID-19 infection at initial testing and/or the proportion of COVID-19 infections remaining asymptomatic throughout follow-up [9, 6081] and five reported on transmission of COVID-19 from asymptomatic or pre-symptomatic index patients (one study reported both) [8286].

Proportion of asymptomatic COVID-19 infection at initial testing & proportion asymptomatic throughout follow-up

Overall, 22 unique cohorts of participants described in 24 studies (15 cohorts, 7 cross sectional) reported the proportion of asymptomatic infection at initial testing and/or the proportion of COVID-19 infections remaining asymptomatic throughout follow-up; study characteristics are summarized in Table 1. Study cohorts were from the USA (n = 10) [6, 9, 6062, 66, 69, 73, 75, 78, 80, 81], Europe (n = 8) [63, 67, 68, 70, 72, 74, 76, 77], and Asia (n = 4) [65, 70, 79, 84]. Definition of asymptomatic infection was variable among studies, ranging from absence of symptoms in the previous 14 days to only absence of symptoms at time of testing. All studies used reverse transcriptase polymerase chain reaction (RT-PCR) on pharyngeal swabs to diagnose COVID-19. Two cohorts reported on general population samples, three cohorts reported on COVID-19 contacts, and the remaining 17 cohorts reported on other populations, most commonly obstetric patients presenting to hospitals (n = 5) [60, 69, 71, 78, 80, 81] and residents/staff in nursing homes (n = 5) [9, 6264, 73, 75].

Table 1. Characteristics of studies reporting proportion of asymptomatic infection among persons positive for COVID-19, by study population (i.e. contacts, general population, and other populations).

No studies were blinded for participants or assessors.

The proportion of asymptomatic COVID-19 infection by population group are reported in Table 2. Among the populations, the median (range) number of people tested for COVID-19 was 118 (34 to 8,437) and the median (range) prevalence of COVID-19 was 8.7% (0.3% to 49%). Of those testing positive for COVID-19, the proportion of asymptomatic infection at initial testing among them ranged from 20% to 75% in the general population (n = 2); 8.2% to 50% in contacts (n = 3); 21.4% to 100% in healthcare workers in settings other than nursing homes (n = 3); 45% to 100% in obstetric patients presenting to hospitals (n = 5); 42.9% to 66.7% among nursing home residents (n = 5); 0% to 50% among nursing home staff (n = 3 studies); and 51% to 87.8% in congregate settings (n = 2). Other populations in which only one study assessed proportion of asymptomatic infection at initial testing included liver transplant patients presenting to hospitals (100%) and public facing workers (76.2%). Within each population group, the proportion of asymptomatic infection did not appear to vary significantly with the number of people tested or the number of people who were COVID-19 positive.

Table 2. Population characteristics, COVID-19 prevalence, and proportion of asymptomatic infection among COVID-19 positive persons at time of testing.

The proportion of COVID-19 positive persons remaining asymptomatic throughout follow-up is described in Table 3. For all but one study, which had follow-up time defined by time in hospital [81], follow-up for symptom development occurred for a minimum of 7 days. Among the general population, one study [67] found that 39.7% remained asymptomatic in the first round of testing and 62.5% in the second round. Among one study [84] in contacts, 4.1% of infections remained asymptomatic. For studies in healthcare workers in settings other than nursing homes, infections remained asymptomatic in 12.2% to 14.3% (n = 2). Among obstetric patients presenting to hospitals, 45% to 100% of infections remained asymptomatic (n = 3), while for residents of nursing homes, 4.3% to 48.1% of infections remained asymptomatic (n = 4). Time to symptom onset was variable and was not reported in five studies. When reported, most studies reported symptoms developing within the first week.

Table 3. Studies reporting the proportion of asymptomatic infections among COVID-19 positive persons at the end of follow-up, and time to symptom onset among those developing symptoms.

Data was sufficient (i.e., minimum three studies) and study designs and inclusion criteria homogenous enough for meta-analysis in three populations: obstetric patients presenting to hospitals, nursing home residents, and nursing home staff (Table 4). Among obstetric patients presenting to hospitals, the pooled proportion of asymptomatic COVID-19 infection at initial testing in five studies was 95.1% (95% CI: 45.1% to 99.8%; I2 = 92%), and the proportion of infections remaining asymptomatic throughout follow-up in three studies was 58.8% (95% CI: 48.8% to 68.1%; I2 = 0%). For nursing home residents, the pooled proportion of asymptomatic infection at initial testing in five studies was 53.6% (95% CI: 42.0% to 64.7%; I2 = 40%), and the proportion of infections remaining asymptomatic throughout follow-up was 27.9% (95% CI: 13.0% to 49.8%; I2 = 84%). Among nursing home staff, data was only available to estimate the proportion of asymptomatic infection at initial testing and in four studies this was 46.9% (95% CI: 30.6% to 63.0%; I2 = 0%).

Table 4. Pooled estimates of the proportion of asymptomatic infection at initial testing for COVID-19 and proportion asymptomatic at the end of follow-up.

Transmission potential among asymptomatic index patients

Transmission from asymptomatic individuals was assessed in six high or moderate quality studies (4 case series and 1 cohort) [57, 8286]. The majority of studies were conducted in China (4/5; 80%) [82, 83, 85, 86], and one study was in South Korea [84]. Study characteristics are reported in S4 Table. Two studies’ (40%) contact investigations were exclusively in household contacts, while the remaining three studies’ (60%) contact investigations included other close contacts (e.g., work contacts, social contacts). Each of the five included studies reported on index patients who ended up being pre-symptomatic but were asymptomatic during contact, while one study also reported on index patients who remained asymptomatic throughout infection. Data on time to testing among contacts and time to symptom onset are provided in S5 Table. Overall, the five studies included 13 index patients who had 96 contacts traced and tested, with 18 (18.8%) being positive for COVID-19.

Secondary attack rates ranged from 0% to 80% among the studies (Table 5). For index patients who were pre-symptomatic, 18 of 92 (19.6%) contacts who were exposed while index patients were asymptomatic tested positive for COVID-19. In the one study that also reported on index patients who remained asymptomatic throughout infection, none of the four exposed contacts tested positive for COVID-19.

Table 5. Pooled estimates of secondary attack rates, only high and moderate quality studies.


In this systematic review and meta-analysis, we found that the proportion of asymptomatic infections at initial testing for COVID-19 appears high in many populations and such persons may have substantial transmission potential. Given the variability in study designs and settings and the scarcity of high-quality studies for different populations, pooled estimates could only be calculated for few populations. These included obstetric patients and residents and staff of nursing homes, population groups with unique characteristics that may not be generalizable to the general population. Therefore, caution must be applied when trying to estimate a precise number for the proportion of COVID-19 infections asymptomatic at initial testing and the overall proportion of infections that will remain asymptomatic.

Most studies included in this systematic review reported on relatively small cohorts of people (<100) who were COVID-19 positive, which may limit the precision of estimates. In a study that tested almost all residents of a municipality during the initial wave of the epidemic in Italy [67], approximately half of all participants with COVID-19 were asymptomatic at testing and by the end of follow-up approximately 40% remained asymptomatic. This is similar to the proportion of infections that were asymptomatic estimated by seroprevalence surveys. Surveys performed in both Italy [87] and Spain [88] estimated that approximately one-third of seropositive participants had previous asymptomatic infections, although such classifications could be affected by symptom-recall bias.

Few thorough case-series were identified reporting transmission from asymptomatic persons and among the five studies included, most traced and tested limited contacts and only one included index patients who were asymptomatic throughout infection. While it is understandable that in the first months of the pandemic any case-series are of great interest, there is a limited value to the evidence this type of research presents. In order to provide a higher level of evidence, future COVID-19 research should focus on using cohort study designs that include: systematic screening, clear reporting of participant selection criteria, ascertainment of time of exposure, time from exposure to diagnosis, adequate follow-up time after diagnosis, assessment of time to symptom onset, and time to RT-PCR negativity. Additionally, new phone applications for contact tracing coupled with systematic surveillance surveys could work to identify persons while they are asymptomatic and trace their close contacts to provide more evidence on their role in transmission.

Given heterogeneity between studies, we could not systematically compare proportions of asymptomatic infection in different age categories or by sex. Although a high proportion of persons with asymptomatic COVID-19 infection was estimated in meta-analysis for studies with younger populations (e.g., obstetric patients), it was also high in older age groups (e.g., nursing home residents). However, in these younger populations it appeared fewer people developed symptoms compared to older groups, during similar follow up times. This is in line with reports of higher disease severity among older persons, but must be confirmed in population studies [89].

From included studies, we could conclude that the proportion of asymptomatic infection at initial testing for COVID-19 is not negligible in any population, similar to findings of a narrative review on the topic [90], and likely has an important role in viral transmission. While larger included studies suggest 40–50% of persons asymptomatic at testing did develop symptoms during follow-up, the lag time between diagnosis and symptom onset indicates that if untested, people may unknowingly spread the disease for up to two weeks before a diagnosis based on symptom screening.

The transmission studies in our review documented substantial transmission—like that seen in a large study in South Korea [91]—but data was not available to compare secondary attack rates between pre-symptomatic and asymptomatic index patients. It is likely that transmission from index patients who remained asymptomatic throughout infection may not be detected or reported due the nature of the asymptomatic infection. Therefore, secondary attack rates estimated from these studies may not be truly representative of real-world attack rates, but when combined with other studies on viral shedding [92, 93], provide evidence that asymptomatic persons can readily transmit SARS-CoV-2. In addition, studies have identified high viral loads in asymptomatic persons for up to 9 days, and in pre-symptomatic persons for up to 6 days prior to symptoms [9, 10]. These viral loads are like those found in symptomatic persons [9, 10, 94, 95]. Together, these findings suggest that exclusively carrying out symptom-based testing will not be sufficient to eliminate transmission and will likely miss a large proportion of SARS-CoV-2 infections.

Rapid identification of COVID-19 positive persons, isolation, and contact tracing are essential for detection and prevention of secondary cases. In the absence of symptoms, strategies must be proactive. Testing of high-risk populations such as healthcare workers, workers in long-term care facilities, public facing workers, and people in congregated settings should be conducted at frequencies informed by circulating COVID-19 prevalence to identify asymptomatic infections and interrupt transmission chains. This testing would be facilitated by development and distribution of inexpensive, point of care tests for COVID-19. In symptomatic persons diagnosed with COVID-19, contact tracing should be extended to several days prior to symptom onset (i.e., up to 6 days based on viral shedding) [9, 58] to ensure persons exposed to index patients while they were asymptomatic are identified. Finally, current non-pharmaceutical measures, such as frequent handwashing, physical distancing, and use of facemasks should be continued as they limit exposure to persons who are infected but asymptomatic.

Strengths and limitations

This systematic review and meta-analysis provides a detailed synthesis of the current and growing literature on the role of asymptomatic persons with COVID-19. We were able to include evidence from several populations and risk groups, which can be used to inform public health practice. By only including studies that tested populations systematically, without pre-selecting symptomatic or asymptomatic populations, we tried to limit the potential for selection bias and thus increase the accuracy of our estimates. We excluded studies assessed to be of low quality, as these did not include information on the population tested, methods for ascertaining the presence of symptoms or definition of asymptomatic, which we deemed to be important for reducing bias. By including studies that had rigorous methodologies as well as complete reporting, we were able to provide more accurate estimates, however, considerations need to be taken regarding the generalizability of results.

This study is not without its limitations. Since studies were highly heterogeneous—in terms of design, follow up time, definition of asymptomatic, setting and population included—we could not carry out meta-analyses for many populations. Studies also differed in terms of when they were conducted in relation to epidemic stage; however, by only including studies with systematic screening, this should overcome potential biases. We could not identify high-quality studies in children and so this important population was not included in this review. Another important limitation is the fact that no tools were identified to evaluate the quality of transmission studies, and although we created a tool for this purpose, it is not validated. It is possible there is publication bias towards case-series documenting transmission from asymptomatic and pre-symptomatic individuals, given that studies in which transmission from asymptomatic individuals was not documented are not available. This may cause us to overestimate the true secondary attack rate from these types of infections. We attempted to mitigate this risk by applying strict criteria for inclusion, which necessitated clear reporting of the contact investigation, number of contacts traced, number of contacts tested, and time of transmission.

Conclusion and policy implications

Among the populations evaluated, many COVID-19 infections were asymptomatic and transmission in the asymptomatic period was documented in numerous studies. Additional, unbiased research would further help inform the role that asymptomatic infections are playing in the pandemic. Proactive steps should be taken to develop public health strategies aimed to identify and mitigate transmission from asymptomatic individuals. Systematic testing of high-risk populations should be performed regardless of symptoms. This should be augmented with thorough tracing and testing of all contacts in addition to existing non-pharmaceutical interventions. Given the large proportion of COVID-19 infections that are asymptomatic, such multifaceted strategies will be essential to prevent recrudescence as countries ease restrictions and reopen economies and schools.

Supporting information

S2 File. Criterial for quality assessment in included studies.


S1 Table. Quality assessment of all included studies.


S2 Table. Low quality studies reporting population characteristics, COVID-19 prevalence, and proportion of asymptomatic infection among COVID-19 positive persons at time of testing.


S3 Table. Low quality studies reporting proportion of asymptomatic infections among COVID-19 positive persons through follow-up, and time to symptom onset among those developing symptoms in follow-up.


S4 Table. Transmissibility of infection for asymptomatic and pre-symptomatic patients: From studies on contact investigations.


S5 Table. Transmission from asymptomatic/pre-symptomatic index patients to contacts and time to symptoms development in positive contacts (high and moderate quality studies).

All index patients were asymptomatic when they were in contact with others.



We thank Zhiyi Lan for his help translating and his valuable insights.


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