20 Feb 2019: Li Y, Appius A, Pattipaka T, Feyereislova A, Cassidy A, et al. (2019) Correction: Real-world management of patients with epidermal growth factor receptor (EGFR) mutation-positive non-small-cell lung cancer in the USA. PLOS ONE 14(2): e0212831. https://doi.org/10.1371/journal.pone.0212831 View correction
Randomized phase III trials have established the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors as first-line treatment for EGFR mutation-positive advanced non–small-cell lung cancer (EGFR Mut+ NSCLC). This retrospective cohort study examined the management patterns and outcomes of patients with EGFR Mut+ NSCLC in a real-world setting.
Materials and methods
Data were extracted from the US Flatiron Electronic Health Record-derived database. Adult patients with stage IIIB/IV EGFR Mut+ NSCLC (exon 19 deletion or exon 21 L858R mutation) who had received first-line systemic therapy between 2011 and 2016 were included. Demographic and clinical characteristics were analyzed. Outcomes evaluated were time to next treatment (a surrogate for progression-free survival) and overall survival.
Of the 22,258 patients with advanced NSCLC in the database, 961 met the inclusion criteria. Median age was 69.0 years (range: 61–78) and the majority were female (68.0%), with stage IV (93.9%), non-squamous cell carcinoma (97.4%). EGFR tyrosine kinase inhibitors were the most widely prescribed first-line therapy (72.8%). The likelihood of receiving an EGFR tyrosine kinase inhibitor or chemotherapy was unaffected by the type of medical insurance patients had. Patients treated with an EGFR tyrosine kinase inhibitor had significantly longer time to next treatment than those given other first-line systemic therapies (p < 0.0001). There were no significant differences in overall survival according to treatment type.
Citation: Li Y, Appius A, Pattipaka T, Feyereislova A, Cassidy A, Ganti AK (2019) Real-world management of patients with epidermal growth factor receptor (EGFR) mutation-positive non–small-cell lung cancer in the USA. PLoS ONE 14(1): e0209709. https://doi.org/10.1371/journal.pone.0209709
Editor: Jung Weon Lee, Seoul National University College of Pharmacy, REPUBLIC OF KOREA
Received: September 26, 2018; Accepted: December 9, 2018; Published: January 4, 2019
Copyright: © 2019 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: Flatiron Health is willing to share data according to PLOS ONE policies; but is subject to the requirements of the Health Insurance Portability and Accountability Act of 1996 (HIPAA) including appropriate de-identification. Practically speaking, in order to share select data and data elements in adherence with the PLOS ONE policies on sharing data and materials, it will be necessary to first define the methods of storage, transmission, access rights, and scope of intended use prior to making any such data available, for the purposes of compliance with de-identification and data protection specifications and requirements under HIPAA. Please refer any questions or requests regarding data used in this manuscript to Melissa Tucker and Amy Abernethy using the following email address: email@example.com.
Funding: The sponsor, F. Hoffmann-La Roche Ltd, designed the protocol and statistical analysis plan for this retrospective cohort study, based on which the data were extracted from the Flatiron database and analyzed. Roche also supported the preparation of the manuscript (no grant number is applicable). The authors contributed with data interpretation and analyses as well as with the decision to publish the results and review of the manuscript.
Competing interests: With regards to conflicts of interest, Yulin Li, Anita Appius, and Andrea Feyereislova are Roche employees; Thirupathi Pattipaka and Adrian Cassidy were employees of Roche at the time the analyses were conducted; Apar Kishor Ganti has no conflicts of interest to disclose. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.
Non–small-cell lung cancer (NSCLC) comprises up to 80% of all newly diagnosed lung cancer cases, and more than half of all patients (57%) are diagnosed with metastatic disease . Despite advances in treatment, 5-year survival rates for advanced NSCLC remain low, at around 15–20% [1–3]. Approximately 19% of Western patients (Europe, North America, or Australia) with NSCLC have tumors that harbor a mutation in the epidermal growth factor receptor gene (EGFR Mut+) while the corresponding prevalence in Asian patients is around 48% . The introduction of tyrosine kinase inhibitors (TKIs) directed against EGFR, such as erlotinib, afatinib, and gefitinib, has improved the outlook for this subgroup of patients  and these drugs now represent standard first-line treatment for EGFR Mut+ NSCLC .
The superiority of EGFR TKIs over platinum-doublet chemotherapy has been demonstrated in a number of randomized, phase III studies in treatment-naïve advanced EGFR Mut+ NSCLC [7–16]. For example, erlotinib significantly prolonged progression-free survival (PFS) compared with chemotherapy in the ENSURE study (hazard ratio [HR] 0.34; [95% confidence interval (CI) 0.22–0.51], p < 0.0001; median PFS 11.0 months vs 5.5 months, respectively) . The superiority of gefitinib over chemotherapy was demonstrated in patients with EGFR Mut+ NSCLC enrolled in the IPASS study; the HR for progression/death was 0.48 (95% CI 0.36–0.64), p < 0.001; median PFS 10.9 months vs 7.4 months, respectively) . Prolonged PFS relative to chemotherapy was also demonstrated with afatinib in the LUX-Lung 3 trial (HR 0.47 [95% CI 0.34–0.65], p < 0.001; median PFS 13.6 months vs 6.9 months, respectively) . However, overall survival (OS) did not differ significantly between the treatment arms in the ENSURE study (median OS: erlotinib 26.3 months vs chemotherapy 25.5 months) , nor in the individual LUX Lung-3 or LUX Lung-6 studies when comparing afatinib with chemotherapy .
Despite the wealth of published clinical trial data, information concerning the use of EGFR TKIs in a real-world setting is limited. Real-world data complement results from randomized clinical trials and generate evidence on the effectiveness and use of medical products in daily practice , often providing a better understanding of patient response, disease patterns, safety data, and economic outcomes in patients of all ages . This study was designed to evaluate the management and clinical outcomes of patients with EGFR Mut+ NSCLC by analyzing real-world data from a large US healthcare database.
Materials and methods
This study used data extracted from the Flatiron Health Cloud-based Oncology Electronic Health Record (EHR)-derived database. The longitudinal database represents one of the most comprehensive sources of real-world evidence in oncology. At the data cut-off date of August 31, 2017, the Flatiron Health database included data from more than 265 cancer clinics (~800 sites of care) representing more than 2 million active US cancer patients available for analysis. This database captures data from both structured and unstructured EHR fields using a technology-enabled abstraction process and multi-pronged quality assurance approaches. Data are refreshed monthly to provide near real-time research-ready datasets .
Approval of the study protocol was obtained from Copernicus Group Independent Review Board (CGIRB) prior to study conduct, and included a waiver of informed consent. Data provided to third parties were de-identified and provisions were in place to prevent re-identification in order to protect patients’ confidentiality.
Patients and methods
This retrospective study examined treatment patterns, demographic and disease characteristics, and clinical outcomes of patients with locally advanced unresectable or metastatic, EGFR Mut+ NSCLC. The patient cohort for this study was selected from the Flatiron advanced NSCLC population, which included patients with a diagnosis of lung cancer, ≥2 clinical visits on or after January 1, 2011, and evidence of stage IIIB, IV, or recurrent metastatic NSCLC on or after January 1, 2011.
The selection criteria for this study included: age ≥18 years at diagnosis, histologically confirmed stage IIIB/IV NSCLC (American Joint Committee on Cancer [AJCC], 7th edition), documented EGFR Mut+ disease (exon 19 deletion or exon 21 L858R mutation), and receipt of systemic therapy within 90 days of diagnosis and between January 1, 2011–June 30, 2016. Patients with evidence of data discrepancies, such as diagnosis date before birth year, date of treatment initiation before diagnosis date, mortality date before last visit date, were excluded. The start of treatment of interest in the first-line setting was defined as the index date to evaluate clinical outcomes for the treatment subgroup. Patients were retrospectively followed up until June 30, 2017, to allow at least 1-year follow up for each patient.
Demographic variables evaluated were age, gender, race, and smoking status. Disease clinical characteristics included tumor histology, stage at diagnosis, absence or presence of brain metastases, Eastern Cooperative Oncology Group performance status, and EGFR mutation information. The proportions and sequence of patients receiving chemotherapy and targeted agents, with a focus on TKIs, were examined.
Time to next treatment (TTNT) was used as a surrogate for PFS and was defined as the time from the start of first-line treatment for advanced EGFR Mut+ NSCLC until initiation of second-line treatment, discontinuation of first-line treatment, the data cut-off, or death. OS was defined as the time from initiation of first-line treatment until death from any cause. Due to the de-identification processing of the analysis dataset, all death dates were approximated to the 15th of the month. Patients were censored at the last visit date or at the data cut-off date, whichever occurred first, if they had no death information or if they were still on treatment at the end of the study period.
The predefined variable of line of therapy in the Flatiron database was used to define the first-line setting. However, since this variable was derived from administrative or prescription dates, and name and dosage of regimens, rather than date of disease progression, line of therapy described in the study should be interpreted as a surrogate to line of therapy in a clinical trial.
Baseline patient and clinical characteristics were described at the start of the first-line treatment in the overall study cohort and by treatment subgroups. Categorical variables were described as frequency and percentages. For continuous variables, means, standard deviations, medians, range and percentiles (25th and 75th) were reported when appropriate. Comparisons between treatment subgroups were made using chi-square tests for categorical variables and Wilcoxon rank-sum test for continuous variables (two-sided test, p-value threshold ≤ 0.05). No formal hypotheses were tested and p-values were reported purely for descriptive purposes. All analyses were performed in the overall study cohort and by treatment subgroups (e.g., TKIs, erlotinib, afatinib, chemotherapy, or other non-TKI target therapy in the first-line). A Kaplan–Meier analysis was conducted to estimate median TTNT and OS with 95% CIs; HRs and 95% CIs with p-values were calculated using a Cox-proportional hazards model after adjusting for patient age, gender, race, smoking status, and histology. All statistical analyses were conducted using SAS software (SAS Institute, Cary, NC) or R.
In total, 22,258 patients aged ≥18 years with stage IIIB/IV NSCLC were identified from the Flatiron advanced NSCLC cohort (Fig 1). Of these, 1,564 patients had an activating EGFR mutation in their tumors, and 1,293 patients received first-line systemic therapy for NSCLC between January 1, 2011–June 30, 2016. After excluding patients with evidence of data discrepancies, a total of 961 patients were included in the main analysis. Since only 13 patients were treated with gefitinib, these patients were not included in subgroup analyses.
Baseline demographic and clinical characteristics
Patients were older than the median age observed in clinical trials of EGFR Mut+ NSCLC (~60 years) [7,13,16] with a median age of 69 years (range: 61–78) (Table 1). The majority of patients were female (68.0%, n = 653), with stage IV (93.9%, n = 902) non-squamous non-small cell carcinoma (97.4%, n = 936). Symptomatic brain metastases were absent or not prospectively diagnosed for a large proportion of patients (83.7%, n = 804). Most patients were treated within a community setting (91.3%, n = 877) and received monotherapy (69.0%, n = 663) as first-line treatment. No obvious differences in other demographic or clinical characteristics were observed among the treatment groups.
Rates of EGFR mutation testing steadily rose from 30.5% in 2011 to 78.4% in 2016 (Table 2). Of 12,148 patients who underwent EGFR testing, 17.1% (n = 2,080) had a confirmed diagnosis of EGFR Mut+ NSCLC, with exon 19 deletion (41.5%, n = 864) or exon 21 L858R point mutation (31.0%, n = 645) identified most frequently (Fig 2). De novo T790 mutations were present in 3.5% of patients (n = 73) and other/unknown EGFR mutations in 24.0% of patients (n = 499).
Of the 961 patients in the main analysis, EGFR TKIs (72.8%, n = 700) were the most widely prescribed first-line therapy (erlotinib 61.7% [n = 593], afatinib 9.1% [n = 87], gefitinib 1.4% [n = 13]). Seven patients received a combination of these TKIs. First-line chemotherapy was prescribed to 17.6% (n = 169) of patients and first-line chemotherapy ± non-EGFR TKI targeted therapy (either bevacizumab or cetuximab) to 8.8% of patients (n = 85) (Table 3).
Amongst patients receiving treatments other than EGFR TKIs (n = 261), carboplatin/pemetrexed (23.4%, n = 61), carboplatin/paclitaxel (20.3%, n = 53), and bevacizumab/carboplatin/pemetrexed (16.9%, n = 44) were the most frequently prescribed first-line therapies.
Fewer than half of all patients (43.9%, n = 422) received second-line treatment (Table 3), which was most commonly erlotinib (32.7%, n = 138), chemotherapy (32.5%, n = 137), or afatinib (16.1%, n = 68).
The likelihood of receiving an EGFR TKI was generally unaffected by the type of medical insurance patients had (Table 1). The most common insurance type was a commercial health plan, which was held by 36.9% (n = 258) of patients who received EGFR TKIs, 40.8% (n = 99) of patients who received chemotherapy alone and by 41.2% (n = 35) of patients on other non-TKI targeted treatments (Table 1). Patterns of insurance were similar among patients receiving an EGFR TKI and patients receiving other systemic therapy.
Patients who received erlotinib (n = 593) or afatinib (n = 87) as their first-line therapy had a significantly longer TTNT than patients receiving non-EGFR TKI therapy (n = 261) (both p < 0.0001; Fig 3A). Median TTNT was 13.1 months (95% CI 12.1–14.3) in the erlotinib group, 12.1 months (95% CI 9.7–14.9) in the afatinib group, 5.3 months (95% CI 3.7–7.2) in the non-EGFR TKI targeted treatment group, and 4.2 months (95% CI 3.7–4.9) for patients receiving chemotherapy.
Kaplan-Meier estimates of (A) TTNT, and (B) OS stratified by treatment group.
Among the 961 patients included in the main analysis, 549 patients (57.1%) had died at the time of the analysis. These included 40 (46% of 87), 338 (57% of 593), and 104 (61.5% of 169) patients treated with afatinib, erlotinib, and chemotherapy, respectively. Estimated median OS with erlotinib (median 23.2 months, 95% CI 21.2–24.9) and afatinib (median 20.7 months, 95% CI 16.2–35.1) was comparable to that seen with non-EGFR TKI targeted treatment (median 24.1 months, 95% CI 20.9–29.5) and chemotherapy (median 22.1 months, 95% CI 18.3–30.0) (Fig 3B).
Similar results were seen in exploratory subgroup analyses in patients diagnosed with advanced EGFR Mut+ NSCLC after May 2013 (n = 744), following the US Food and Drug Administration approval of afatinib in this setting. Median OS with erlotinib (n = 461) was 23.1 months (95% CI 20.4–25.5), compared with 20.7 months (95% CI 16.2–35.1) with afatinib (n = 87) and 19.3 months (95% CI 17.0–26.2) with chemotherapy (n = 115) (Fig 4).
Exon 19 deletion was identified in 52 patients in the afatinib group and 326 patients in the erlotinib group, and exon 21 mutation was found in 35 and 268 patients, respectively. Median TTNT was similar between these treatment groups for both mutations; median TTNT was 12.6 months (95% CI 9.0–17.5) with afatinib and 14.0 months (95% CI 12.4–15.3) with erlotinib for patients with an exon 19 deletion, and 11.2 months (95% CI 8.7–16.2) and 12.1 months (95% CI 10.6–14.2), respectively, for those with an exon 21 mutation (S1 Table). Median OS appeared numerically longer in patients whose tumors harbored an exon 21 mutation treated with erlotinib (19.9 months, 95% CI 17.3–24.2) vs afatinib (16.2 months, 95% CI 11.0–26.1), but this difference was not statistically significant. In patients with exon 19 deletion, median OS was similar between the treatment groups: 23.0 months (95% CI 18.1–not reached) with afatinib and 24.6 months (95% CI 23.2–29.0) with erlotinib.
This retrospective study evaluated real-world treatment patterns of patients with advanced EGFR Mut+ NSCLC in oncology practices across the USA, and examined demographic and disease characteristics among patients receiving EGFR TKIs vs other systemic anti-cancer therapies. With the exception of age (clinical trial patients are approximately 9 years younger), the baseline characteristics of the patients eligible for this analysis were similar to those observed in randomized, clinical trials of EGFR Mut+ NSCLC [7,13,16].
The rate of EGFR mutation testing in our analysis was low in 2011, at just 30.5%. This contrasts with rates of up to 65% reported in Japan during the same year, although testing rates in China were only 18% . Following a steady increase in testing rates between 2011 and 2015, we observed a rise in EGFR mutation testing during 2016 to approximately 78%. Apart from the potential bias introduced by data completeness during the earlier years, this increase probably reflects an enhanced awareness of the need for EGFR mutation testing in patients with advanced NSCLC before initiation of first-line therapy, as recommended in clinical practice guidelines published at that time [21,22], or to a wider availability of a validated test. Notably, the results of a retrospective chart review in patients with advanced non-squamous NSCLC initiating therapy between 2011 and 2013, with follow-up until 2016, revealed EGFR mutation testing rates of more than 97% in Taiwan . Compared with our study population, fewer of the Taiwanese patients were aged >75 years (22% vs 32%, respectively), with a history of smoking (33% vs 44%, respectively), and a greater proportion of them received first-line therapy for advanced NSCLC (100% vs 83%, respectively) . Reports from the Western literature during the same time-period have suggested testing rates in the region of 70%, congruent with the results of our analysis . These results suggest that the introduction of the broad use of molecular testing took more than 5 years to achieve levels of almost 80%, assuming that in about 5–10% of patients tumor testing cannot be performed for various reasons (e.g., no tumor tissue available, no biopsy possible, or need for immediate treatment intervention without a delay).
Treatment patterns were as expected, based on the mutation status of the patients’ tumors, with single-agent EGFR TKIs, predominantly erlotinib, having been the most widely prescribed first-line therapy. The type of medical insurance that patients had did not influence the likelihood of them receiving an EGFR TKI. There has been a lack of evidence supporting the efficacy of combining EGFR TKIs with chemotherapy, nevertheless, erlotinib and afatinib were used in combination with chemotherapy in a few patients (n = 32; 3.3% of the entire cohort). We speculate that a TKI was intercalated with chemotherapy rather than given concomitantly.
Approximately 27% of patients with EGFR Mut+ NSCLC were treated with a platinum-containing chemotherapy doublet either with or without bevacizumab. Single-agent erlotinib was the second-line therapy of choice in the majority of patients who continued with treatment, presumably given to those patients who did not receive a TKI as first-line treatment.
Patients who were given an EGFR TKI as first-line therapy had significantly longer TTNT, a surrogate for PFS, than those receiving other systemic treatments. Median TTNT was 13.1 months (95% CI 12.1–14.3) with erlotinib and 12.1 months (95% CI 9.7–14.9) with afatinib. Erlotinib and afatinib demonstrated comparable efficacy in this regard (both p < 0.0001 vs other systemic therapies). The slightly longer duration of TTNT in this study compared with PFS in clinical trials [7–9, 13–15] most likely reflects the time that would typically elapse between clinical or radiologic progression and the start of the next course of treatment in eligible patients. The comparable values seen for TTNT in this real-world setting and PFS observed in a clinical trial setting are important and reassuring. The patients in our study had a higher median age than patients enrolled in clinical trials, confirming that increased age is not associated with reduced efficacy in the real-world setting. As observed in randomized studies [7,25], no significant difference in OS was noted among patients receiving EGFR TKIs vs those receiving chemotherapy as their initial therapy. This may be because almost half of the patients who received chemotherapy initially, received an EGFR TKI on progression (49.7%, n = 84/169). However, 31.9% of patients (n = 54) who received chemotherapy upfront were never exposed to an EGFR TKI. While the reason for this may vary, this finding requires further investigation. The median OS of 23.2 months (95% CI 21.2–24.9) achieved with erlotinib and 20.7 months (95% CI 16.2–35.1) achieved with afatinib were in-line with the survival times reported in phase III studies [7,11,16]. Of note, a much higher number of patients received treatment with erlotinib than with afatinib throughout the study (n = 593 vs n = 87, respectively).
The results from this real-world study support the efficacy of the EGFR TKIs established in clinical trials. However, the population studied in the USA may not be representative of a global population, and additional analyses may be needed to evaluate real-world treatment patterns in other countries. In a retrospective chart review examining real-world practice patterns in 175 Japanese patients treated for stage IIB/IV NSCLC between 2011 and 2013, EGFR TKIs were the most commonly prescribed therapies for EGFR Mut+ NSCLC across all treatment lines , similar to our findings. Of note, median OS from the start of first-line therapy was 9.9 months (95% CI 7.6–11.7) for all patients compared with 17.9 months (95% CI 9.9–24.4) for those with EGFR/ALK Mut+ tumors. The authors note that due to the retrospective nature of the study, these results are not reflective of the current clinical landscape, given the availability of newer therapies for NSCLC, namely third-generation EGFR TKIs [26,27].
Limitations of this analysis are reflective of the data source and collection. Flatiron data are generated from real-world clinical practice, and are subject to miscoding and errors. The data are mainly drawn from community oncology centers and therefore may not be representative of treatment patterns at academic medical centers. Since information about patients prior to the clinical oncology practice’s adoption of the EHR may not be available, particularly in the structured data, the extent to which historical data are entered into the EHR is a practice-specific decision and varies widely. An important strength of the present study over previous real-world data studies [28,29] was the availability of information on mortality in patients with EGFR Mut+ NSCLC from which OS data could be estimated. Moreover, the sensitivity and specificity of mortality in the advanced NSCLC dataset is 91% and 96%, respectively, which supports its application to evaluate clinical outcomes in this setting . Finally, the study enabled a description of longitudinal treatment patterns with a minimum of 12 months of follow-up for every patient. Notwithstanding the limitations, our results represent the largest available real-world data in this setting. Concurrence between these data and clinical trial evidence is reassuring, with respect to the accuracy and validity of our findings on one hand and applicability of the clinical data in real-life practice on the other.
These real-world data reflect the results of randomized clinical trials of EGFR Mut+ NSCLC, with the exception of patients in this analysis being generally older, by approximately 9 years. Testing rates for EGFR mutations steadily increased over time, reaching approximately 78% in 2016, although there is room for improvement. The majority of patients with EGFR Mut+ disease received EGFR TKIs as first-line therapy, which were predominantly administered as monotherapy. Patients who received first-line EGFR TKIs had significantly longer TTNT than those who received other non-EGFR TKI systemic therapies. No significant differences in OS were observed by treatment type.
Third-party medical writing assistance, under the direction of the authors, was provided by Fiona Fernando, PhD, of Gardiner-Caldwell Communications, and was funded by F. Hoffmann-La Roche Ltd.
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