Constraint-induced aphasia therapy (CIAT) has been widely used in post-stroke aphasia rehabilitation. An increasing number of clinical controlled trials have investigated the efficacy of the CIAT for the post-stroke aphasia.
To systematically review the randomized controlled trials (RCTs) concerning the effect of the CIAT in post-stroke patients with aphasia, and to identify the useful components of CIAT in post-stroke aphasia rehabilitation.
A computerized database search was performed through five databases (Pubmed, EMbase, Medline, ScienceDirect and Cochrane library). Cochrane handbook domains were used to evaluate the methodological quality of the included RCTs.
Eight RCTs qualified in the inclusion criteria. Inconsistent results were found in comparing the CIAT with conventional therapies without any component from the CIAT based on the results of three RCTs. Five RCTs showed that the CIAT performed equally well as other intensive aphasia therapies, in terms of improving language performance. One RCT showed that therapies embedded with social interaction were likely to enhance the efficacy of the CIAT.
CIAT may be useful for improving chronic post-stroke aphasia, however, limited evidence to support its superiority to other aphasia therapies. Massed practice is likely to be a useful component of CIAT, while the role of “constraint” is needed to be further explored. CIAT embedded with social interaction may gain more benefits.
Citation: Zhang J, Yu J, Bao Y, Xie Q, Xu Y, Zhang J, et al. (2017) Constraint-induced aphasia therapy in post-stroke aphasia rehabilitation: A systematic review and meta-analysis of randomized controlled trials. PLoS ONE 12(8): e0183349. https://doi.org/10.1371/journal.pone.0183349
Editor: Tifei Yuan, Nanjing Normal University, CHINA
Received: May 20, 2017; Accepted: August 2, 2017; Published: August 28, 2017
Copyright: © 2017 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: The data for meta-analyses can be found in the part of figures.
Funding: The authors received no specific funding for this work.
Competing interests: The authors have declared that no competing interests exist.
Aphasia, the acquired language disorder, is a common functional impairment after stroke. Approximately 40–60% of stroke survivors sustain aphasia at chronic stage , which is associated with their life dependence, less social participation, poorer rehabilitation outcomes and worsen quality of life [2–5]. Most conventional interventions for aphasia, such as pharmacological managements and rehabilitation programs (e.g. speech language therapy), have been proposed to be beneficial for improving language functions of stroke patients at acute and subacute phases, in addition to the spontaneous recovery [6, 7]. However, the rehabilitative potential of chronic aphasia is still extremely limited, which becomes a big challenge for doctors, speech language therapists and other professionals.
Patients with stroke greatly benefit from specific training programs, owning to the training-induced brain plasticity [8–15]. Various training strategies for stroke rehabilitation have been raised and then applied in real rehabilitative practice, such as mirror neuron system activation [8–10], enriched environment [11–12], non-invasive brain stimulation  and constraint-induced therapy (CIT) [14, 15]. Among them, CIT is one of the most widely used strategies that aimed to avoid the “learned nonuse” in patients with stroke. Therefore, it is also known as the “use-dependent learning”, which includes high-intensity repetitive tasks delivered in a relatively short duration [14, 15]. Constraint-induced movement therapy (CIMT), one of the CITs in the field of rehabilitation, focusing on improving the upper extremity motor dysfunctions due to stroke, have substantial benefits on arm motor functions with a long-term effect , even for these patients have reached the chronic stage of stroke [16, 17].
To date, CIT has been expanded into cognitive rehabilitation for patients with stroke, including the aphasia rehabilitation . Constraint-induced aphasia therapy (CIAT), which was firstly developed by Pulvermuller F et al in 2001, has been applied in aphasia rehabilitation through a force-used approach . The original protocol of CIAT has three principles: (1) constraint, the patients are strongly encouraged to use verbal communication approaches rather than the non-verbal ways, like gestures; (2) massed practice, the original CIAT protocol includes a total of 10-day interventions delivered 3 hours per day; and (3) shaping, the difficulty of required tasks is gradually enhanced according to patients’ functional performance . Generally, the benefits of CIAT result from expressing the rehabilitation potentials of the lesioned hemisphere to the most extent, by the revision of learned nonuse . Also, it has been proposed that the recovery of aphasia is correlated with the plasticity of neural activities. One of the pathological brain changes of stroke-induced aphasia is the transcallosal disinhibition, it means that, the activities in the lesioned region are down-regulated owning to brain injuries, and then the hyperactive states are noted in collateral regions. Therefore, re-balancing the bilateral activities of hemispheres might contribute to the rehabilitation of aphasia . Brain activities adjustment related to language improvements, which was induced by CIAT, have been found in previous studies. It is likely that CIAT could positively affect the brain activities related to language processes measured by the electroencephalograph (EEG) or the magnetoencephalography (MEG) [21–23], and induces activation in some regions of the brain observed by the functional magnetic resonance image (fMRI) [24, 25]. Those results showed that CIAT was correlated with the positive neuroplasticity in both hemispheres, and the improvements observed by aphasia assessments after the CIAT intervention were associated with the down-regulation of ipsilesional regions (usually left hemisphere) [22, 23] and the up-regulation of contralesional regions (usually right hemisphere) [21, 26].
An increasing number of clinical controlled trials regarding the effects of the CIAT have been published since 2001 [19, 27–32], and some modified protocols of CIAT, like adding every-day communications with family members , have been practiced. The participants of CIAT trials were not limited to chronic stroke patients with aphasia nowadays. Some studies have tried to explore the strength of the CIAT for patients at acute phase and subacute phase [27, 31, 34, 35]. However, some controversies were raised about the components in the CIAT. The main controversy is whether the “constraint” and “high-intensity” are useful. Some studies showed that CIAT with less constraint and less intensity still had the similar effect on post-stroke chronic aphasia [36, 37]. A study comparing the intensive and distributed speech therapy gave a conclusion that intensive speech therapy may be not better than distributed speech therapy with the same dosage . Thus, an increasing number of studies started to pay more attention to the difference between the CIAT with other speech therapy programs delivered in the same intensity, and tried to explain which component of the CIAT is useful. Also, studies on modified CIAT (e.g. Intensive language action therapy, ILAT) highlighted the effect from a special session of social interaction in aphasia rehabilitation [28, 39].
Our review was aimed to systematically evaluate the randomized controlled trials (RCTs) published since 2001, and to answer some questions based on currently available evidence: (1) whether CIAT is superior to conventional speech therapies, in terms of improving the language performance and relevant activities of patients with aphasia, at different stages of stroke (examining the effect of combined components of CIAT); (2) whether CIAT is better than other speech therapies delivered in the same intensity in aphasia rehabilitation, and whether CIAT delivered by a distributed way still has favorable effect in aphasia rehabilitation (examining the effect of constraint); (3) whether CIAT embedded with social activities can gain more benefits (examining the effect of social interaction). By critically appraising RCTs of the CIAT, we may identify the useful components of CIAT for successful aphasia rehabilitation.
Five computerized databases, including PubMed (via website), EMBASE (via Ovid), the Cochrane library (via Ovid), Medline (via Ovid) and ScienceDirect (via website), were searched for studies published from 2001 up to 18th January 2017. The keywords used for identifying CIAT were: CIAT, use-dependent learning, constraint induced aphasia therapy, constraint induced language therapy, ILAT and intensive language action therapy. The keywords used for identifying stroke included stroke, hemiplegia, hemiparesis, hemiplegic, cerebrovascular accident, CVA. First author read all identifies titles and excluded the obviously irrelevant papers. Papers were included if: (1) RCTs, or the first phase of RCTs with a cross-over design was also included in the present review; (2) patients had a diagnosis of stroke/cerebrovascular accident (CVA); (3) CIAT, modified CIAT, or ILAT  was applied in the study, compared with a control group, including different forms of CIAT, other speech therapy programs or the nonintervention control; Papers were excluded if: (1) quasi-RCTs, non-randomized controlled studies, pre-post design studies or case reports; (2) the CIAT group received additional intervention focus on aphasia (e.g. medicine); (3) study did not explore the useful components of CIAT (constraint, massed practice, shaping, social interaction or others). (4) papers were not published in English. The reference list from previous reviews and included RCTs was assessed for relevant records. Two of the authors read through the potentially relevant full-text independently. Disagreements were resolved by consensus discussion between the two assessors.
Primary outcomes were the severity of aphasia (e.g. Western aphasia battery—aphasia quotient, WAB-AQ) and language performances (e.g. Aachen aphasia test, AAT), including total scores and subscale scores if applicable. Secondary outcomes included the subjective experience of language performance (e.g. Communicative activity log, CAL), functional communication and any activity related to language functions.
Data extraction and quality assessment
The quality of RCTs was evaluated based on Cochrane handbook domains : (1) random sequence generation, (2) allocation concealment, (3) blinding of researchers (4) blinding of participants, (5) blinding of outcome assessors, (6) drop-out and exclusion and (7) intention to treat analysis. Two authors assessed each article independently. Disagreements were resolved by consensus discussion with the third author.
All statistical analyses were performed using RevMan 5.3 (http://ims.cochrane.org/revman). Mean and standard deviations for each outcome were extracted for each group and pooled to obtain mean difference (MD) and 95% confidence intervals (CI). Heterogeneity was examined using I2 statistic. Studies with an I2 of 25% to 50% were considered to have low heterogeneity, I2 of values of 50% to 75%, and ˃ 75% were considered indicative of moderate and high level of heterogeneity, respectively. Fixed-effect models were used to combine studies if I2 test was not significant (P for heterogeneity<0.1). Otherwise, random effect models were used. P < 0.05 was considered indicative of a statistically significant between-group difference. Publication bias was investigated with funnel plots if more than 10 studies were included in the meta-analysis . If there is not available data or varying outcomes used in different studies, a descriptive analysis would be conducted.
The initial search on computerized databases retrieved a total of 202 citations. After removing duplication, 167 articles were found, of which 57 records were subjected to full-text review. We excluded 48 articles for the following reasons: quasi-RCTs or non-RCTs (n = 7), patients in the experimental arm received other aphasia therapies (n = 1), studies without control groups (n = 34) and reviews (n = 6). One study  compared the therapist-led and layperson-led CIAT, so we excluded it. Finally, eight RCTs were included in this review [19, 27–31, 35, 42]. (Fig 1)
Due to various protocols of included studies, we divided them into different groups based on their trial designs: Comparison A: CIAT vs. the controls without any component from CIAT; Comparison B: constraint vs. unconstraint; Comparison C: social interaction in CIAT, to examine the useful components of the original CIAT protocol. (Tables 1, 2 and 3)
Comparison A: CIAT vs. the controls (no any component from CIAT).
Comparison B: constraint vs. unconstraint.
Comparison C: social interaction in CIAT.
Comparison A: CIAT vs. conventional therapy
Three trials included in this review compared the CIAT and conventional speech therapy programs (unconstraint, lower intensity and relatively long duration) or the nonintervention group. Two studies focused on patients at chronic stage [19, 29], while one study  enrolled patients at acute phase. The study of Pulvermuller F et al  reported that the significant difference in favor of CIAT was noted in naming, expression, comprehension and token test, assessed by AAT, and CAL, in relation to the convention speech therapy. Szaflarski J et al  showed an inconsistent result that the immediate effect and long-term effect (12-week follow-up) of the CIAT cannot be found when compared with nonintervention group, except the Mini-CAL (p = 0.019). Woldag H et al  had three groups: (1) CIAT; (2) intensive conventional treatment (the same intensity with CIAT); and (3) the conventional therapy (14-hour at total over 10 days), which showed that no statistical difference can be noted among three groups in both AAT and CAL (Table 1).
Comparison B: Constraint vs. unconstraint
Four studies [30, 31, 35, 42] and Woldag H et al’s  trial compared the CIAT and other intensive speech therapy programs (same intensity as the CIAT but without the component of constraint). Wilssens I et al and Kurland J et al [30, 42] focused on the chronic aphasia, while Ciccone N et al  and Sickert A et al  explored the CIAT for patient with acute and subacute stroke, respectively. Wilssens I et al  only enrolled patients with fluent aphasia. The therapy modality in the control group of Wilssens I et al’s  study was the semantic therapy (BOX) and the control group of Kurland’s study received the promoting aphasia communicative effectiveness (PACE) intervention, while the remaining studies did not use specific therapy in the control arms. All control groups allowed patients to use any communication modalities. Ciccone N et al  did not find the superiority of distributed CIAT (45–60 minutes/session, 20 sessions for 5 weeks) over the control training with the same dosage for stroke patients at very acute phase. Sickert A et al  found both groups showed improvement compared with the baseline, however, no significant difference was noted in any outcomes between two group, which was similar in the study of Kurland et al. Wilssens I et al  showed that the CIAT positively affected the language production and phonology, while the group of BOX posed more beneficial effects on the language comprehension and semantics, and Kurland J et al  found that the CIAT gained better generalization into the untrained words, compared with the PACE group, in picture naming (23.4% for CIAT and 15.2% for PACE, p<0.001) (Table 2).
Comparison C: Social interaction in CIAT
One study used the ILAT, which was an extend form of CIAT embedding verbal utterances in the context of communication and social interaction, in the experiment . This study compared the ILAT with the naming therapy focusing on speech production with the same intensity (3.5 hours/session for 6 days), and showed a significant effect from the ILAT in AAT, relatively to the naming therapy (Table 3).
Meta-analysis was only conducted among studies that employed same outcomes under the same comparison. After screening the characteristic of included studies, we only pooled the AAT subscores from two studies (Willssen I et al and Sicker A et al) and BNT from two studies (Kurland J et al and Willssens I et al).
Available post-treatment data, including naming, repetition, token test written language and comprehension, was recruited in meta-analysis. Meta-analysis revealed that no significant difference was identified between CIAT and other intensive therapy programs, in terms of naming (MD, 3.97, 95% CI, -7.86 to 15.79; P = 0.51; I2 = 0%), repetition (MD, 0.08, 95% CI, -11.88 to 12.03; P = 0.99; I2 = 0%), token test (MD, -0.67, 95% CI, -5.62 to 4.28; P = 0.79; I2 = 0%), written language (MD, -1.96, 95% CI, -9.08 to 5.16; P = 0.59; I2 = 0%) and comprehension (MD, -4.34, 95% CI, -12.58 to 3.91; P = 0.30; I2 = 38%). (Fig 2)
Meta-analysis revealed that there was no significant difference between the CIAT and other intensive therapy programs, in terms of BNT. (MD, -3.54, 95% CI, -14.91 to 7.84; P = 0.54; I2 = 0%). (Fig 3)
Therefore, the results of our meta-analyses showed that the CIAT was not superior to other intensive therapy programs.
CIAT is likely to be a successful treatment strategy in aphasia rehabilitation, particularly the chronic aphasia, based on currently available evidence. Rather than focusing on activating or modulating the functions of specific brain regions or neuron system, CIAT is mainly aimed to revise the learned nonuse and boost the rehabilitative potential of lesioned hemisphere . Also, the benefits of CIAT can be attributed to training-induced plasticity by balancing the bilateral hemispheres [21–25]. Beside some RCTs included in this review, many case reports or pre-post design studies also showed the benefits of CIAT on chronic aphasia [35, 43–45]. Usually, CIAT was delivered via a therapeutic group. Also, literature provided the evidence about the feasibility of trained laypersons-given CIAT , thus, an increasingly number of studies have introduced trained students or volunteers into the therapeutic groups [30, 36], which make it more feasible in rehabilitation settings by saving the human powers. Moreover, recent studies showed that the CIAT implemented at acute phase and subacute phase [27, 31, 35] was tolerable by stroke patients. However, the long-term effects of CIAT were still inconsistent [29, 33].
It seems that the positive effects from CIAT in patients with aphasia, especially in chronic aphasia patients, have been established. Further, we would like to explore whether the CIAT could outperform than conventional aphasia therapy. The first RCT by Pulvermuller F et al  provided the evidence that CIAT was superior to the conventional aphasia therapy in improving chronic aphasia patients’ language performance and self-report communication confidence. However, the results were inconsistent with the study of Szaflarski J et al , which revealed the CIAT group only could gain more benefits on self-report communication confidence, but not in the language performance, when compared with the nonintervention group. The main problem that hindered us to reach an agreement is the small sample size of these RCTs. Also, literature evidence of the application of CIAT in acute phase of stroke is still limited. Due to the trend of spontaneous recovery, it seems that the advantage of CIAT may not be obvious in comparison with the conventional therapy [27, 31, 35].
The use-dependence neuroplasticity suggests that the high intensity (also called massed practice) is a critical factor in stroke rehabilitation, particularly for chronic stroke patients . A recent systematic review regarding the effect of the high-intensity in aphasia, also supported the opinion that chronic aphasia could be influenced positively by high-intensity speech therapy programs [46, 47]. We could regard “high-intensity (massed practice)” as a useful component of CIAT in aphasia rehabilitation, although the opinion was challenged by a controlled study with small sample, which showed CIAT administered in both intensive and distributed ways with the same dosage resulted in similar positive changes in aphasia severity and language functions .
Constraint, the principle focusing on the spoken response and avoiding non-verbal communications, is a controversial point in aphasia rehabilitation. Our studies summarized trials on comparing the CIAT and other intensive speech therapy programs, and did not find the evidence to support the CIAT was superior to the other intensive therapy programs, in terms of improving the language performance [30, 31, 35]. Also, a study compared the CIAT-distributed (constraint and low intensity) and conventional therapy (unconstraint and low intensity), and showed no statistical difference in any outcomes . Some studies with pre-post design reported the effect of less constraint or unconstraint [36, 37]. However, the effect from constraint was found by some study, for example, a case study comparing with constraint and unconstraint therapy, the language performance was in favor of constraint group, which also was associated with the change in fMRI . The principle of constraint in CIAT is changing nowadays, rather than the absolute inhibition of the compensatory communication strategies, researchers tend to allow patients to perform any compensatory strategies that may elicit spoken response [24, 37], thus, real practices become much more difficult, which become a factor that may affect us to explore the real effect of “constraint”. Also, we noted that some benefits were from the constraint, rather than the unconstraint strategies. William I et al  showed the CIAT group gained more benefits in the language production, relatively to the BOX group with the same treatment intensity and Kurland J et al  mentioned that CIAT may help achieve better generalization to untrained pictures in naming tasks, relatively to the unconstraint treatment with the same high-intensity. It is hard to conclude whether the “constraint” is useful based on RCTs included in this review, however, exploring the special effects from the “constraint” in different aspects of language is still worth in further studies.
Although everyday communication tasks are not available in the original protocol of CIAT, it becomes a common element in further modified CIAT protocols. CIAT plus , by adding everyday communications and family involvements in the original CIAT protocol, gained more benefits than the CIAT, in terms of quality of everyday communication. We included one RCT with a cross-over design, which showed that the CIAT embedded with social interaction was superior to the intensive naming therapy, in terms of enhancing patients’ language performance . Social interaction is increasingly paid attention by aphasia rehabilitation practitioners. Lack of generalization of the improvement of language performance in pencil and paper tasks into functional communication is a problem for many previous aphasia studies [1, 49]. In studies of CIAT, rare assessment focused on social participation has been conducted. The only one was CAL, which was used in the first CIAT study . CAL worked as a self-report questionnaire to evaluate the patients’ confidence in communication [19, 29]. Included studies showed that the strength of the CIAT in improving the CAL, in comparison with the control group, which may result from the social interaction . In order to save cost and human power, most CIAT interventions were delivered as the group-based therapy, therefore, the positive effect from the group dynamic cannot be ignored . ILAT, the extend form of CIAT, has paid more attention to the effect of social interaction [28, 39]. Further CIAT studies is needed to regard the functional communication and participation of language-relevant activities as the more important outcomes.
Some limitations could be noted in this review. Firstly, a frim conclusion was unable to be drawn based on the small number of heterogeneous RCTs. Secondly, we can only try to explore the effect from high-intensity (massed practice), constraint and social interaction, however, for other important principles, such as the shaping, could not be well-explained based on currently available literature. Thirdly, we only included the published English language papers. Some unpublished articles, or papers published in other languages might be ignored in this review, which may result in language bias.
CIAT may be useful for improving chronic post-stroke aphasia, however, limited evidence to support its superiority to other aphasia therapies. Massed practice is likely to be a useful component of the CIAT, while the role of “constraint” is needed to be further explored. Social interaction may be useful for enhancing the benefits of CIAT programs. More rigorous studies about CIAT programs should be conducted before drawing a firm conclusion.
- 1. Balardin JB, Miotto EC. A review of Constraint-Induced Therapy applied to aphasia rehabilitation in stroke patients. Dement Neuropsychol. 2009; 3: 275–282.
- 2. Fang Y, Chen X, Li H, Lin J, Huang R, Zeng J. A study on additional early physiotherapy after stroke and factors affecting functional recovery. Clin Rehabil. 2003; 17(6): 608–617. pmid:12971705
- 3. Lee H, Lee Y, Choi H, Pyun SB. Community Integration and Quality of Life in Aphasia after Stroke. Yonsei Med J. 2015; 56(6): 1694–1702. pmid:26446656
- 4. Boehme AK, Martin-Schild S, Marshall RS, Lazar RM. Effect of aphasia on acute stroke outcomes. Neurology. 2016; 87(22): 2348–2354. pmid:27765864
- 5. Koleck M, Gana K, Lucot C, Darrigrand B, Mazaux JM, Glize B. Quality of life in aphasic patients 1 year after a first stroke. Qual Life Res. 2017; 26(1): 45–54. pmid:27405871
- 6. Berthier ML, Pulvermuller F, Davila G, Casares NG, Gutierrez A. Drug therapy of post-stroke aphasia: a review of current evidence. Neuropsychol Rev. 2011; 21(3): 302–317. pmid:21845354
- 7. Brady MC, Kelly H, Godwin J, Enderby P, Campbell P. Speech and language therapy for aphasia following stroke. Cochrane Database Syst Rev. 2016(6): Cd000425. pmid:27245310
- 8. Mei Toh SF, Fong KNK. Systematic Review on the Effectiveness of Mirror Therapy in Training Upper Limb Hemiparesis after Stroke. HKJOT. 2012; 22(2): 84–95.
- 9. Hung GKN, Li CTL, Yiu AM, Fong KNK. Systematic Review: Effectiveness of Mirror Therapy for Lower Extremity Post-Stroke. HKJOT. 2015; 26: 51–59.
- 10. Chen W, Ye Q, Ji X, Zhang S, Yang X, Zhou Q, et al. Mirror neuron system based therapy for aphasia rehabilitation. Front Psychol. 2015; 6: 1665. pmid:26579046
- 11. Rosbergen IC, Grimley RS, Hayward KS, Walker KC, Rowley D, Campbell AM, et al. Embedding an enriched environment in an acute stroke unit increases activity in people with stroke: a controlled before-after pilot study. Clin Rehabil. 2017: 269215517705181.
- 12. Yu K, Wu Y, Zhang Q, Xie H, Liu G, Guo Z, et al. Enriched environment induces angiogenesis and improves neural function outcomes in rat stroke model. J Neurol Sci. 2014; 347(1–2): 275–280. pmid:25455300
- 13. Norise C, Hamilton RH. Non-invasive Brain Stimulation in the Treatment of Post-stroke and Neurodegenerative Aphasia: Parallels, Differences, and Lessons Learned. Front Hum Neurosci. 2016; 10: 675. pmid:28167904
- 14. Morris DM, Crago JE, Deluca SC, Pidikiti RD, Taub E. Constraint-induced movement therapy for moter recovery after stroke. NeuroRehabilitation. 1997; 9(1): 29–43. pmid:24526089
- 15. Thrane G, Friborg O, Anke A, Indredavik B. A meta-analysis of constraint-induced movement therapy after stroke. J Rehabil Med. 2014; 46(9): 833–842. pmid:25182341
- 16. Bang DH, Shin WS, Choi HS. Effects of modified constraint-induced movement therapy combined with trunk restraint in chronic stroke: A double-blinded randomized controlled pilot trial. NeuroRehabilitation. 2015; 37(1): 131–137. pmid:26409698
- 17. Leung DP, Ng AK, Fong KN. Effect of small group treatment of the modified constraint induced movement therapy for clients with chronic stroke in a community setting. Hum Mov Sci. 2009; 28(6): 798–808. pmid:19837473
- 18. Meinzer M, Elbert T, Djundja D, Taub E, Rockstroh B. Extending the Constraint-Induced Movement Therapy (CIMT) approach to cognitive functions: Constraint-Induced Aphasia Therapy (CIAT) of chronic aphasia. NeuroRehabilitation. 2007; 22(4): 311–318. pmid:17971622
- 19. Pulvermuller F, Neininger B, Elbert T, Mohr B, Rockstroh B, Koebbel P, et al. Constraint-induced therapy of chronic aphasia after stroke. Stroke. 2001; 32(7): 1621–1626. pmid:11441210
- 20. Hamilton RH, Chrysikou EG, Coslett B. Mechanisms of aphasia recovery after stroke and the role of noninvasive brain stimulation. Brain Lang. 2011; 118(1–2): 40–50. pmid:21459427
- 21. Pulvermuller F, Hauk O, Zohsel K, Neininger B, Mohr B. Therapy-related reorganization of language in both hemispheres of patients with chronic aphasia. Neuroimage. 2005; 28(2): 481–489. pmid:16099176
- 22. Breier JI, Juranek J, Maher LM, Schmadeke S, Men D, Papanicolaou AC. Behavioral and neurophysiologic response to therapy for chronic aphasia. Arch Phys Med Rehabil. 2009; 90(12): 2026–2033. pmid:19969164
- 23. Mohr B, MacGregor LJ, Difrancesco S, Harrington K, Pulvermuller F, Shtyrov Y. Hemispheric contributions to language reorganisation: An MEG study of neuroplasticity in chronic post stroke aphasia. Neuropsychologia. 2016; 93(Pt B): 413–424. pmid:27063061
- 24. Kurland J, Pulvermuller F, Silva N, Burke K, Andrianopoulos M. Constrained versus unconstrained intensive language therapy in two individuals with chronic, moderate-to-severe aphasia and apraxia of speech: behavioral and fMRI outcomes. Am J Speech Lang Pathol. 2012; 21(2): S65–87. pmid:22294409
- 25. Mohr B, Difrancesco S, Harrington K, Evans S, Pulvermuller F. Changes of right-hemispheric activation after constraint-induced, intensive language action therapy in chronic aphasia: fMRI evidence from auditory semantic processing. Front Hum Neurosci. 2014; 8: 919. pmid:25452721
- 26. Meinzer M, Rodriguez AD, Gonzalez Rothi LJ. First decade of research on constrained-induced treatment approaches for aphasia rehabilitation. Arch Phys Med Rehabil. 2012; 93(1 Suppl): S35–45. pmid:22202189
- 27. Woldag H, Voigt N, Bley M, Hummelsheim H. Constraint-Induced Aphasia Therapy in the Acute Stage: What Is the Key Factor for Efficacy? A Randomized Controlled Study. Neurorehabil Neural Repair. 2017; 31(1): 72–80. pmid:27506677
- 28. Stahl B, Mohr B, Dreyer FR, Lucchese G, Pulvermuller F. Using language for social interaction: Communication mechanisms promote recovery from chronic non-fluent aphasia. Cortex. 2016; 85: 90–99. pmid:27842269
- 29. Szaflarski JP, Ball AL, Vannest J, Dietz AR, Allendorfer JB, Martin AN, et al. Constraint-Induced Aphasia Therapy for Treatment of Chronic Post-Stroke Aphasia: A Randomized, Blinded, Controlled Pilot Trial. Med Sci Monit. 2015; 21: 2861–2869. pmid:26399192
- 30. Wilssens I, Vandenborre D, van Dun K, Verhoeven J, Visch-Brink E, Marien P. Constraint-induced aphasia therapy versus intensive semantic treatment in fluent aphasia. Am J Speech Lang Pathol. 2015; 24(2): 281–294. pmid:25765602
- 31. Sickert A, Anders LC, Munte TF, Sailer M. Constraint-induced aphasia therapy following sub-acute stroke: a single-blind, randomised clinical trial of a modified therapy schedule. J Neurol Neurosurg Psychiatry. 2014; 85(1): 51–55. pmid:23828834
- 32. Maher LM, Kendall D, Swearengin JA, Rodriguez A, Leon SA, Pingel K, et al. A pilot study of use-dependent learning in the context of Constraint Induced Language Therapy. J Int Neuropsychol Soc. 2006; 12(6): 843–852. pmid:17064447
- 33. Meinzer M, Djundja D, Barthel G, Elbert T, Rockstroh B. Long-term stability of improved language functions in chronic aphasia after constraint-induced aphasia therapy. Stroke. 2005; 36(7): 1462–1466. pmid:15947279
- 34. Kristensen LF, Steensig I, Pedersen AD, Pedersen AR, Nielsen JF. Constraint-induced aphasia therapy in subacute neurorehabilitation. Aphasiology. 2015; 29(10): 1152–1163.
- 35. Ciccone N, West D, Cream A, Cartwright J, Rai T, Granger A, et al. Constraint-induced aphasia therapy (CIAT): a randomised controlled trial in very early stroke rehabilitation. Aphasiology. 2016; 30(5): 566–584.
- 36. Nickels L, Osborne A. Constraint Induced Aphasia Therapy: Volunteer-led, unconstrained and less intense delivery can be effective. NeuroRehabilitation. 2016; 39(1): 97–109. pmid:27341364
- 37. Rose ML. Releasing the constraints on aphasia therapy: the positive impact of gesture and multimodality treatments. Am J Speech Lang Pathol. 2013; 22(2): S227–239. pmid:23695899
- 38. Dignam J, Copland D, McKinnon E, Burfein P, O'Brien K, Farrell A, et al. Intensive Versus Distributed Aphasia Therapy: A Nonrandomized, Parallel-Group, Dosage-Controlled Study. Stroke. 2015; 46(8): 2206–2211. pmid:26106114
- 39. Difrancesco S, Pulvermüller F, Mohr B. Intensive language-action therapy (ILAT): The methods. Aphasiology. 2012; 26(11): 1317–1351.
- 40. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
- 41. Meinzer M, Streiftau S, Rockstroh B. Intensive language training in the rehabilitation of chronic aphasia: efficient training by laypersons. J Int Neuropsychol Soc. 2007; 13(5): 846–853. pmid:17697416
- 42. Kurland J, Stanek EJ 3rd, Stokes P, Li M, Andrianopoulos M. Intensive Language Action Therapy in Chronic Aphasia: A Randomized Clinical Trial Examining Guidance by Constraint. Am J Speech Lang Pathol. 2016; 25(4S): S798–S812. pmid:27997954
- 43. Johnson ML, Taub E, Harper LH, Wade JT, Bowman MH, Bishop-McKay S, et al. An enhanced protocol for constraint-induced aphasia therapy II: a case series. Am J Speech Lang Pathol. 2014; 23(1): 60–72. pmid:24018698
- 44. Kavian S, Khatoonabadi AR, Ansari NN, Saadati M, Shaygannejad V. A Single-subject Study to Examine the Effects of Constrained-induced Aphasia Therapy on Naming Deficit. Int J Prev Med. 2014; 5(6): 782–786. pmid:25013699
- 45. Szaflarski JP, Ball A, Grether S, Al-Fwaress F, Griffith NM, Neils-Strunjas J, et al. Constraint-induced aphasia therapy stimulates language recovery in patients with chronic aphasia after ischemic stroke. Med Sci Monit. 2008; 14(5): Cr243–250. pmid:18443547
- 46. Cherney LR, Patterson JP, Raymer A, Frymark T, Schooling T. Evidence-based systematic review: effects of intensity of treatment and constraint-induced language therapy for individuals with stroke-induced aphasia. J Speech Lang Hear Res. 2008; 51(5): 1282–1299. pmid:18812489
- 47. Dignam JK, Rodriguez AD, Copland DA. Evidence for Intensive Aphasia Therapy: Consideration of Theories From Neuroscience and Cognitive Psychology. PM R. 2016; 8(3): 254–267. pmid:26107539
- 48. Mozeiko J, Coelho CA, Myers EB. The role of intensity in constraint-induced language therapy for people with chronic aphasia. Aphasiology. 2016; 30(4): 339–363.
- 49. van de Sandt-Koenderman ME, van der Meulen I, Ribbers GM. Aphasia rehabilitation: more than treating the language disorder. Arch Phys Med Rehabil. 2012; 93(1 Suppl): S1–3. pmid:22119073
- 50. Fama ME, Baron CR, Hatfield B, Turkeltaub PE. Group therapy as a social context for aphasia recovery: a pilot, observational study in an acute rehabilitation hospital. Top Stroke Rehabil. 2016; 23(4): 276–283. pmid:27077989