In developing countries, children under the age of five years who live in slums are highly vulnerable to diarrhea. However, there is a paucity of information on the relationship between sanitation facilities and hygienic conditions to acute diarrhea among under-five children in slum areas of Addis Ababa, Ethiopia. Therefore, this study examines the sanitation facilities and hygienic conditions in the slums of Addis Ababa and identifies the main factors significantly associated with acute diarrhea among children aged 0–50 months in those slums.
A community-based cross-sectional household survey was carried out between September and November 2014, that then served as the baseline survey of a longitudinal study. For this survey, 697 children aged 0–50 months were recruited from two slum districts in Addis Ababa. A pre-tested structured questionnaire and an observational checklist were used for data collection. Multivariable logistic regression analysis was used to identify sanitation facilities and hygiene-related factors that were significantly associated with acute diarrhea by controlling potential confounding effects of selected socio-demographic factors. Adjusted odds ratio (AOR) with corresponding 95% confidence interval (CI) was used to quantify the strength of association.
The prevalence of acute diarrhea among children aged 0–50 months in the study area was 11.9% and 94.6% of the sanitation facilities were unimproved. Sharing of a sanitation facility by six or more households (AOR = 4.7; 95% CI: 2.4–9.4), proximity of sanitation facilities within 15 meters of homes (AOR = 6.6; 95% CI: 2.5–17.0), presence of feces (AOR = 3.9; 95% CI: 1.5–10.3) and flies (AOR = 2.5; 95% CI: 1.3–5.0) on the floor of and/or around sanitation facilities, and presence of uncollected garbage inside house compounds (AOR = 3.2; 95% CI: 1.2–8.4) were significantly associated with acute diarrhea.
This study reveals the slum environment to be high risk for diarrhea due to close proximity of sanitation facilities to homes, sharing of sanitation facilities, and poor hygiene of the sanitation facilities and housing compounds. We recommend the development of a comprehensive diarrheal disease prevention program that focuses on improving the cleanliness of the sanitation facilities and housing compounds. Increasing the number of improved sanitation facilities at an appropriate distance from houses is also essential in order to reduce the number of households that share one latrine.
Citation: Adane M, Mengistie B, Kloos H, Medhin G, Mulat W (2017) Sanitation facilities, hygienic conditions, and prevalence of acute diarrhea among under-five children in slums of Addis Ababa, Ethiopia: Baseline survey of a longitudinal study. PLoS ONE 12(8): e0182783. https://doi.org/10.1371/journal.pone.0182783
Editor: Philip C. Hill, University of Otago, NEW ZEALAND
Received: March 6, 2017; Accepted: July 23, 2017; Published: August 30, 2017
This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
Data Availability: All relevant data are in the paper and its Supporting Information files.
Funding: Ethiopian Institute of Water Resources of Addis Ababa University funded this research project. The funders had no role in study design, data collection and analysis, decisions to publish, interpretation of the data and preparation of the manuscript for publication.
Competing interests: The authors declare that they have no competing interests.
Abbreviations: AOR, Adjusted odds ratio; CI, Confidence interval; JMP, Joint Monitoring Programme; OR, Crude odds ratio; UNICEF, United Nations Children's Fund; WHO, World Health Organization
The United Nations Human Settlements Programme has reported massive urban growth in low- and middle-income countries resulting in sprawling slums that are now home to more than half the population of cities such as Mumbai in India; Kibera slum in Nairobi, Kenya; Mexico City in Mexico ; and Addis Ababa in Ethiopia . The rapidity of urbanization in these countries has caused dynamic growth of urban slums and contributed to increasing numbers of informal slum dwellers [3, 4]. The result has been overcrowded living conditions ; inadequate sanitation facilities ; and exposure of slum dwellers, especially children under five years of age, to a high risk of disease . Worldwide, about eight million children died in 2010 before reaching the age of five, mainly due to poor sanitation facilities and unhygienic conditions .
Most people expect that urban areas have better child health and lower child mortality than rural areas [9, 10]. However, recent studies have consistently indicated that under-five children in cities of developing countries have been frequent victims of diarrhea, mainly due to lack of improved sanitation facilities, poor hygienic practices , and the low hygienic status of shared sanitation facilities . Despite the overall favorable health statistics in urban areas, several studies have pointed out large variations among countries and within urban areas and the potential influence of slums on these variations [9, 13–15]. Disparities in health determinants between slum and non-slum areas have varied within the socioeconomic context of each country . For example, researchers have found that urban caregivers in Ethiopia disposed of the feces of under-five children more safely than did rural caregivers and safe disposal was associated with having an improved sanitation facility . However, the mere presence of household sanitation facilities in urban areas did not necessarily result in favorable health outcomes . Thus, policies based on the current system of monitoring sanitation facilities fail to consider the ranges of challenges and solutions in meeting sanitation needs .
Slums are known in Ethiopia as “yedekemu betoch/seferoch,” meaning deteriorated/dilapidated houses or settlements . This definition of slums focuses on their physical structure without considering their socio-economic and health characteristics, both of which must also be addressed for remedial and preventive actions to succeed. According to Sclar et al. , national governments and global society in general could accumulate a massive health debt if countries neglect the health of children in urban slums. In 2011, the Demographic and Health Survey data revealed that diarrhea prevalence for under-five children in Addis Ababa was 9.4% ; the survey did not investigate sanitation facilities and hygiene-related factors associated with diarrhea. Recent studies in various developing countries have recommended that particular attention be given to examining health determinants for slum-dwelling children underfive [7, 22]. Furthermore, in the slums of Addis Ababa, to our knowledge, no other studies have been undertaken on sanitation facilities and hygienic conditions as factors associated with acute diarrhea. Lack of reliable data, particularly on sanitation facilities and hygienic conditions in slum areas of Addis Ababa, hinders planning for and implementation of diarrhea prevention programs among under-five children. Effective diarrhea prevention programs may facilitate the achievement of UN Sustainable Development Goals by 2030, specifically Goal 3 (ensure health and well-being for all, at every stage of life), particularly Target 3.2 (end preventable deaths of children under five years of age, with all countries aiming to reduce under-five mortality to at least as low as 25 per 1,000 live births) and Goal 6 (ensure availability and sustainable management of water and sanitation for all), particularly Target 6.2 (achieve access to adequate and equitable sanitation and hygiene for all, and end open defecation) .
Therefore, this study was designed to examine the sanitation facilities and hygiene practices in the slums of Addis Ababa in relation to acute diarrhea among under-five children. Results may help urban health policy makers and program managers in the development and implementation of improved sanitation facilities and hygiene programs for preventing acute diarrhea in the slum areas of Addis Ababa and other slums in Ethiopia and throughout sub-Saharan Africa.
Materials and methods
This study was conducted in two slum districts (woredas) in Addis Ababa: Gullele Sub-City’s District 01 and Lideta Sub-City’s District 05 (Fig 1). Addis Ababa’s population was estimated to be 3,273,000 in 2014–15, of which 1,551,000 (47.4%) were males and 1,722,000 (52.6%) were females . In 2008, the city-wide data on basic indicators in Addis Ababa showed that 26% of the houses and the majority of slum dwellers had no toilet facilities, 33% of households shared a toilet with more than six households, 35% of the generated garbage/refuse was never collected, and 71% of the households did not have adequate sanitation facilities .
Study design and outcome variable
A community-based cross-sectional study design was used to gather data regarding children aged 0–50 months in the slums of Addis Ababa between September and November 2014. Children over 50 months were not included because the study was a baseline survey in a longitudinal study consisting of four rounds of surveys to be conducted at three-month intervals among the same study participants. During recruitment of children for the baseline survey, one of the criteria was that all study participants should be under five years of age at the end of the longitudinal study, at the fourth round, in August 2015. Therefore, the age ranges of participants at each round were as follows: First round, 0–50 months; second round, 3–53 months; third round, 6–56 months; and fourth round, 9–59 months. Thus, for the baseline survey, we used the age category of 0–50 months.
The outcome variable of this study was acute diarrhea, denoted as yes (1) or no (0); where yes indicated the presence of acute diarrhea and no indicated the absence of acute diarrhea during the two weeks prior to the baseline survey. Using the outcome variable of presence of acute diarrhea, we estimated the prevalence of acute diarrhea among the participating children.
The sample size estimation for this study was based on the fact that the study was the baseline survey of a longitudinal study; sample size was calculated with the primary objective of studying the seasonal prevalence of acute diarrhea among under-five children. However, since the longitudinal study utilized a repeated cross-sectional survey through follow-up of the same study participants, the sample size estimation methods and assumptions for calculating the same sample size were the same. Hence, sample size was estimated using the single-proportion formula : n = (Z1-a/2)2*P(1-P)/W2 with the assumptions that Z1-a/2 is 95% CI, W has a margin of error of 3%, and P is 11% estimated prevalence of acute diarrhea among under-five children in the slums of Addis Ababa. The calculated sample size was 418. Considering a design effect of 1.5 and a 10% non-response rate, a final sample size of 697 children was determined.
Study population and sampling procedures
A multi-stage sampling method with two stages was employed to select the study population. In the first stage, two slum districts were randomly selected from the identified slum districts in Addis Ababa. During this stage, slum districts included in the city-wide slum upgrading plan (being implemented until 2025 by the Addis Ababa City Administration Housing Agency) were excluded from the study. To determine the sampling population in the study districts, a preliminary survey was conducted in the two selected slum districts through transect walks in a house-to-house enumeration of children whose maximum age would be 50 months at the end of the baseline survey period. Then, sample sizes were proportionally allocated for the two districts. By the second stage, systematic sampling techniques were used in every third household to select study participants. Households where study participants were not available during the survey were revisited once on the same day or the next day. If not available again, the study participant was considered a non-respondent.
Inclusion and exclusion criteria
Children aged 0–50 months were included during selection of the study participants. In households with more than one eligible child, one child was randomly selected and recruited into the study. Eligible children with bloody diarrhea and/or persistent diarrhea two weeks prior to the survey were excluded. Bloody diarrhea was excluded because it is frequently caused by dysentery, and persistent diarrhea was excluded because of its duration of 14 days or longer . Both of these conditions were beyond the scope of this study.
Diarrhea was identified using World Health Organization (WHO)  signs and symptoms for diarrhea by questioning the participants’ caregivers about signs and symptoms of diarrhea two weeks prior to data enumeration, such as consistency of bowel movements, fever, vomiting, blood in stool, mucus in stool, watery stool, and frequency of abnormal stool. The WHO protocol  defines diarrhea as the passage of three or more abnormally loose, watery, or liquid stools over a 24-hour period. However, the WHO protocol did not specify the recall period and the types of diarrhea (acute/watery diarrhea, bloody diarrhea, or persistent diarrhea). Because our study focused on acute diarrhea, we adopted a two-week recall period, as specified in the World Gastroenterology Organization global guidelines for acute diarrhea surveys .
WHO defines sanitation as the provision of facilities and services for the safe disposal of human feces and urine. Sanitation also refers to the maintenance of cleanliness (hygienic conditions) through services such as proper garbage collection and wastewater disposal.
Refers to unimproved sanitation facilities that are shared by two or more households, including public latrines.
The Joint Monitoring Programme (JMP) for water supply and sanitation of WHO and UNICEF defines improved sanitation as flush toilets and pit latrines using the flush/pour-flush method that are connected to either a sewer or a septic system, ventilated improved pit latrines, and pit latrines with slab and composting toilet 
The JMP for water supply and sanitation of WHO and UNICEF defines unimproved sanitation as pit latrines without a slab, open defecation, and public latrines. Improved sanitation facilities that are shared by two or more households are classified as unimproved because shared sanitation facilities tend to be less hygienic and less accessible than private sanitation facilities used by a single household .
In this study, open defecation is a self-reported behavior, including defecating in fields, bushes, forests, open bodies of water, or other open spaces.
Houses rented from government and private owners.
Houses rented from the government are affordable for low-income citizens, whereas houses rented from private owners are expensive. However, renting private houses did not reflect a higher household income or socio-economic variation; it merely indicated a relatively larger expense.
Ethical clearance for this study was obtained from the Institutional Ethical Review Committee of Wollo University, College of Medicine and Health Sciences. The committee provided approval after reviewing both the protocol and the consent forms. Permission to conduct the study was obtained from Addis Ababa City Health Administration Bureau, Gullele and Lideta Sub-City health offices, and the respective study area slum district health offices. Written informed assent and consent were obtained from the caregivers of participating children, assent on behalf of the participating children and consent for the caregivers themselves. Confidentiality was assured by collecting the data anonymously and coding the names of the respondents.
Data collection and data quality assurance
Household survey data were collected using a pre-tested structured questionnaire and an observational checklist. The questionnaire and the observational checklist were first prepared in English and then translated into Amharic for participating household use. The questionnaire was pre-tested on 10% of the study households in one randomly selected nearby slum district to evaluate face validity and to ensure that the caregivers understood the questions. Any amendment made in the questionnaire was based on the pre-test. Seven trained female nurses and environmental health professionals administered the survey by interviewing primary caregivers (mothers) using a pre-tested structured questionnaire. To reduce bias, the data enumerators were blinded and did not know if they were surveying study areas in slums or non-slums.
Data enumerators and study respondents were also blinded about the hypothesis of the study to reduce bias. Daily supervision was provided by two public health professionals and the principal investigator checking the completeness of the questionnaires and the consistency of the data. Data were entered using EpiData Version 3.1 (EpiData Association, Odense, Denmark) statistical software and then exported to the Statistical Package for the Social Sciences (SPSS) Version 24.0 (IBM Corp., Armonk, N.Y., USA) for data cleaning. In order to verify the accuracy of data entries, two generic data verification strategies were employed as described elsewhere .
Nine socio-demographic and child-related variables were considered in this analysis as potential confounders (Table 1). Ten selected sanitation facilities and hygiene variables were also included in this study. One sanitation variable was self-reported (number of households sharing a latrine), one sanitation variable was measured by data enumerators (proximity of latrines to home), and sanitation status (improved or unimproved) was classified by the researcher based on the types of sanitation facilities reported and the number of households sharing a latrine. Types of sanitation facilities were measured by data enumerators using both self-report (open defecation) and direct observation (public latrine, pit latrine with slab, and pit latrine without slab). Four hygiene variables were directly observed by data enumerators (feces and flies on the floor and/or around the sanitation facilities, garbage/refuse and domestic sewage inside the housing compound), and two waste management variables were self-reported (garbage/refuse disposal methods and domestic sewage discharge methods) (Table 1).
Data were analyzed using STATA Version 14.0 (StataCorp LP, College Station, TX). Descriptive statistics were calculated including means and ±SD (standard deviations) for continuous variables. Data analysis was performed using a binary logistic regression model at 95% CI. The modeling strategy involved estimating the crude odds ratio (OR) using bivariate analysis and adjusted odds ratio (AOR) using multivariable analysis.
Bivariate analysis was employed to identify factors associated with acute diarrhea at p < 0.05 without controlling confounders, whereas in the multivariable analysis, the association between sanitation and hygiene factors with acute diarrhea was examined by controlling for potential confounders [32, 33] of socio-demographic factors. Multi-collinearity of variables was assessed by calculating the variance inflation factor. Hosmer-Lemeshow statistic was used to test the goodness-of-fit of the model . The adjusted model estimated the overall effect of all variables to select the significant determinants after adjustment for confounding factors. From the adjusted analysis, variables with p < 0.05 were taken as statistically significant and independently associated with acute diarrhea.
Of the 697 study participants, seven caregivers were non-respondents (1%). The prevalence of acute diarrhea was 11.9%. The majority (79.4%) of the caregivers were literate; 64.2% of slum residents lived in houses rented from their district administration and 17% rented from private owners. Almost one-third (31%) of the households had six or more persons. Characteristics of other socio-demographic factors and the results of the bivariate analysis of acute diarrhea are summarized in Table 2.
Characteristics of sanitation facilities and hygienic conditions
The majority (94.6%) of the sanitation facilities were unimproved. Of these unimproved facilities, 11.6% were an improved type but because the improved facilities were shared by two or more households, they were categorized as unimproved. Only 5.4% of sanitation facilities were improved and used by one household. By excluding open defecation users, 353 (54%) households shared one sanitary facility with one to five other households and 301 (46%) households shared a sanitary facility with six or more households. Feces and flies were observed on the floor and/or around 63.4% and 39.4%, respectively, of the sanitation facilities. Uncollected garbage/refuse and domestic sewage were observed inside 55.4% and 50.7% of house compounds, respectively (Table 2).
Factors associated with acute diarrhea in multivariable analysis
The multivariable analysis shows that shared use of sanitation facilities by six or more households, proximity of sanitation facilities within 15 meters of homes, presence of feces and flies on the floor and/or around the sanitation facilities, and/or presence of uncollected garbage/refuse inside the house compounds were significantly associated with acute diarrhea.
The odds of developing acute diarrhea in households that shared one latrine among six or more households were 4.7 times (AOR = 4.7; 95% CI: 2.4–9.4) higher than for those sharing one latrine among one to five households. The odds of developing acute diarrhea in households with proximity of latrines within 15 meters were 6.6 times (AOR = 6.6; 95% CI: 2.5–17.0) higher than in households having latrines farther away. The likelihood of children developing acute diarrhea where feces were observed on the floor and/or around the sanitation facilities was 3.9 times (AOR = 3.9; 95% CI: 1.5–10.3) higher than for children having clean latrines. Furthermore, the likelihood of children developing acute diarrhea where flies were observed on the floor and/or around the sanitation facilities was 2.5 times (AOR = 2.5; 95% CI: 1.3–5.0) higher than for children having sanitation facilities where no flies were observed. The likelihood of children developing acute diarrhea in households having uncollected garbage/refuse observed inside the house compound was 3.2 times (AOR = 3.2; 95% CI: 1.2–8.4) higher than for those in households where refuse was regularly collected (Table 3).
This community-based cross-sectional study examined the relationship between acute diarrhea in children aged 0–50 months and sanitation and hygiene practices in slum areas of Addis Ababa. We found that prevalence of acute diarrhea was 11.9% and that most slum households used unimproved sanitation facilities, including public latrines, pit latrines without a slab, and open defecation. Acute diarrhea was significantly associated with presence of feces and flies on the floor and /or around the sanitation facilities, shared use of sanitation facilities by six or more households, proximity of latrines within 15 meters of homes, and the presence of uncollected garbage/refuse inside the house compound.
The acute diarrhea prevalence in our study is similar to the 12% prevalence of diarrhea reported by the Demographic and Health Survey for Ethiopia in 2016 . However, whereas the overall diarrhea prevalence for Ethiopia was reported from aggregated data, the acute diarrhea statistic in our study was to a large extent due to poor sanitary facilities and poor hygienic practices. Studies in slums of Kenya , Rwanda , India [38, 39], and Nepal  reported higher diarrhea prevalence, apparently due to even poorer sanitation and hygiene status than in the Addis Ababa slums. The relatively lower prevalence of acute diarrhea in our study compared to the rates in the other slum areas mentioned might be due to the implementation of urban health extension programs by the Ethiopian government; these programs focus on improving sanitation and hygiene conditions in rural and urban areas, including slums, through the use of urban health extension workers. The active involvement of health professionals in hygiene and sanitation is crucial to accelerating and consolidating progress in disease prevention .
Our study showed that widespread sharing of sanitation facilities by households was associated with acute diarrhea. The widespread sharing of sanitation facilities among six or more households in Addis Ababa slums appears to be due primarily to lack of space for the construction of private latrines. A study in the Kibera slums in Nairobi in 2010 found that respondents used public latrines due to scarcity of private household latrines and the poor condition of other existing sanitation facilities in that crowded area . Consistent with our findings, several other studies showed that sharing of sanitation facilities was associated with diarrhea [42, 43]. Heijenen et al. [42, 44] reported that households sharing sanitation facilities were generally poorer than those that did not share, and also had an increased risk for diarrhea, not necessarily because of sharing sanitation facilities, but because of poverty. In contrast to our findings, Demographic and Health Survey data covering 51 countries between 2001 and 2011 indicated that sharing sanitation facilities was a protective factor in diarrhea among under-five children, particularly in Nigeria, Mali, Senegal, and Liberia . Baker et al. did not find that sharing of sanitation facilities in Bangladesh posed higher risks of diarrhea . In our study, the indication that the sharing of sanitation facilities is a major concern may be due to a higher number of households (six or more) sharing one sanitation facility, a higher number of people per household, the predominance of unimproved sanitation facilities, and widespread sharing of both unimproved and improved sanitation facilities. The number of users per shared sanitation facility tends to be inversely related to the cleanliness of the sanitation facilities [12, 46].
The proportion of households practicing open defecation in our study was relatively low and not a risk factor in acute diarrhea. A higher rate (11%) of open defecation was reported in eastern Ethiopia . The open defecation practice in our study was self-reported, indicating questionable reliability of the data. Another study in Ethiopia revealed that open defecation practice was underreported . In contrast to our findings, a multicenter study in Kenya reported that practicing open defecation was a risk factor for moderate to severe diarrhea . This discrepancy might be due to the low proportion of households practicing open defecation in Addis Ababa slum areas. Our finding is supported by previous studies in slums of Addis Ababa showing similar rates of open defecation . Bartlett  found that the lack of latrines in poor communities causes many people to defecate in the open or into plastic bags and papers that are then discarded with the household garbage. The practice of open defecation in slums of Addis Ababa appears to be due largely to a combination of lack of latrine access; unusable, overflowing latrines; and poor hygienic conditions of shared latrines. A recent study in eastern Ethiopia found a lack of effective social mobilization to be the main cause for open defecation .
We also found that the presence of flies and feces on the floor and/or around the sanitation facilities was significantly associated with acute diarrhea. The presence of flies on the floor and/or around sanitation facilities appears to be due to poor cleanliness of the sanitation facilities, disposal of garbage close to sanitation facilities and inside the housing compound, and discharge of domestic sewage around the sanitation facilities and inside the housing compound. The presence of interruptions to water supplies in slums of Addis Ababa  might also be an obstacle to the regular cleaning of latrines. The lack of cleanliness of the sanitation facilities and housing compounds in our study might arise from the unwillingness of users to clean shared (versus private) sanitation facilities and a lack of commitment to regular cleaning of the overcrowded general living environment. Another study revealed that shared sanitation facility users are not committed to cleaning shared latrines . A consistent finding in the slums of Huye Town in Rwanda was that the presence of flies within and around sanitation facilities was significantly associated with increased odds of contracting diarrhea .
Another study found that the disposal of garbage close to homes was a significant risk factor for high fly densities and the presence of flies around the sanitation facilities was, in turn, associated with acute diarrhea . Strina et al.  found in Salvador, Brazil, that people in latrine-owning households behaver more hygienically than those without latrines. Public latrines are unhygienic and characterized by the presence of flies and floors dirty with feces [37, 54]. A similar finding in Rajshahi City slums in Bangladesh revealed that 61% of the latrines had observable feces . Unsanitary conditions of latrines and poor hygiene behavior were significantly associated with acute diarrhea episodes in slums of An-Nasr in Jordan, Tebbaneh in Libya , and Ikare-Akoko in Nigeria . Findings that substandard latrine construction contributes to the presence of flies indicate that improved superstructures may decrease fly densities around latrines [58, 59].
This study also revealed that the presence of uncollected garbage inside the housing compounds was significantly associated with acute diarrhea, consistent with studies in the slum areas of Huye Town in Rwanda and Dhaka slums in Bangladesh [37, 60]. Sanitation problems are usually aggravated by inadequate waste management [23, 49], a situation also characteristic of the slums in Addis Ababa. A study in urban slums in southern India revealed that the majority (66.1%) of the households indiscriminately dumped garbage/refuse outside . The lower proportion of waste dumping in our study might be due to the urban health extension programs in Addis Ababa headed by health extension workers, who advocate proper disposal of garbage/refuse. Other studies in Ethiopia revealed that households following the recommendations of health extension workers showed lower diarrhea prevalence rates [62, 63] and better performance in primary healthcare .
We found that proximity of sanitation facilities to homes was inversely associated with acute diarrhea. This may be due to increased risk of transmission of pathogens via flies. Studies in Bangladesh and Kenya also revealed that closer proximity of latrines increased contamination of tube-well water sources and thereby contributed to diarrheal disease [65, 66]. Increased housing density in Addis Ababa in general, and in the slums in particular, as a result of rapid urbanization in recent years tended to decrease the distance between houses and latrines.
Limitations of the study and gaps for future research
Our findings should be interpreted in light of certain limitations. First, although we used an adjusted multivariable logistic regression model, statistical adjustment can control for measured confounders but not for other complex confounding covariates that were not measured. Therefore, because there is residual confounding due to unmeasured variables, further studies are recommended that consider sanitation facility and hygiene variables that were not included in this study.
Another limitation is that our study was not conducted in the rainy season. During this time, diarrhea incidence tends to peak  and unsealed latrines in slums may overflow and disperse pathogens , although a study by Mukabutera et al. reported high diarrhea rates during the dry season . Furthermore, cleaning of shared sanitation facilities in slums is impacted by the wet season, which worsens the already bad sanitation situation , as indicated by the seasonal trend of diarrhea cases . Therefore, we encourage further studies to investigate the cleanliness of shared sanitation facilities and factors associated with poor hygienic practices in shared sanitation facilities during the rainy seasons in the slums of Addis Ababa and other urban slums in Ethiopia. Such studies may lead to comprehensive measures that can help to reduce acute diarrhea.
Various studies indicate that malnutrition increases the risk of diarrhea [72, 73] and that open defecation and heavy diarrhea burden increase the risk of stunting [60, 74, 75]. Children exposed over time to poor sanitation and poor hygiene may develop environmental enteropathy (tropical enteropathy), which is implicated as a cause of malnutrition [76–79]. Therefore, further studies that explore the linkage between environmental enteropathy and malnutrition and the effect of malnutrition on diarrhea (and vice versa) among under-five children in slum areas of Addis Ababa are also encouraged.
Shared use of sanitation facilities, poor cleanliness of sanitation facilities, proximity of sanitation facilities to homes, and indiscriminate dumping of garbage/refuse inside house compounds were independently associated with acute diarrhea. Public health measures, such as further improvements of the existing municipal garbage/refuse collection and disposal system, construction of more improved sanitation facilities, and intensification of sanitation and hygiene promotion programs at the district and household levels may improve the cleanliness of the sanitation facilities and housing compounds and thereby reduce the risk of acute diarrhea among under-five children.
The slum renewal programs that have been in progress since 2005 in Addis Ababa  and the Urban Safety Net Program enacted in January 2017 by the Ethiopian government to enhance the livelihoods of poor urban residents  together with urban WASH (water, sanitation, and hygiene)  and the urban health extension  programs, are encouraging steps towards sustainable improvements in the cleanliness of slum sanitation facilities and housing compounds. These programs may achieve significant improvement in the sanitation facilities and hygiene status of the slums if they are carried out within an integrated framework that also addresses the livelihoods of the predominantly poor population and if interventions are monitored comprehensively and outcomes evaluated.
S1 File. Sanitation facilities and hygienic conditions data.
We acknowledge Addis Ababa Gullele Sub-City District 01 and Lideta Sub-City District 05 health offices and administrators for their kind assistance in providing necessary information and support during data collection. We thank the caregivers of the studied children for their dedication and commitment in providing information during the survey. We also acknowledge the support of Shirley Lewis, Linda A. Willis, and Adrienne Cruise for their financial assistance. Ann Byers, Lisa Penttila and Linda M. Weller are acknowledged and highly thanked for their language editing of the manuscript.
UN-HABITAT. The challenge of slums. Global report on Human settlements. London and Sterling VA: Earth Scan Publications. 2003.
UN-HABITAT. The Ethiopian case of condominium housing. The integrated housing development program. United Nations Human Settlement Program. Nairobi: United Nations. 2010.
- 3. Fotso JC, Ezeh AC, Madise NJ, Ciera J. Progress towards the child mortality millennium development goal in urban sub-Saharan Africa: The dynamics of population growth, immunization, and access to clean water. BMC Public Health. 2007;7:218. pmid:17725826
Worldwatch Institue. State of the World 2007: Our urban future. A Worldwatch Institue report on progress towards a sustainable society. 24th ed. Washington, DC: The Worldwatch Institue: Routledge. 2013.
UN. The Millennium Development Goals report 2013. United Nations, New York. 2013.
- 6. Schouten MAC, Mathenge RW. Communal sanitation alternatives for slums: A case study of Kibera, Kenya. Phys Chem Earth. 2010;35(13–14):815–22.
- 7. Unger A. Children’s health in slum settings. Arch Dis Child. 2013;98:799–805. pmid:23899920
UNICEF. The state of the world's children 2012. Children in an urban world. United Nations Children's Fund. United Nations, New York. 2012.
- 9. Garenne M. Urbanization and child health in resource poor settings with special reference to under-five mortality in Africa. Arch Dis Child. 2010;95:464–8. pmid:20371583
- 10. Leon D. Cities, urbanization and health. Int J Epidemiol. 2008;37(1):4–8. pmid:18187525
- 11. Semba RD, Kraemer K, Sun K, de Pee S, Akhter N, Moench-Pfanner R, et al. Relationship of the presence of a household improved latrine with diarrhea and under-five child mortality in Indonesia. Am J Trop Med Hyg. 2011;84(3):443–50. pmid:21363984
- 12. Simiyu S, Swilling M, Cairncross S, Rheingans R. Determinants of quality of shared sanitation facilities in informal settlements: Case study of Kisumu, Kenya. BMC Public Health. 2017;17:68. pmid:28077103
- 13. Fotso J. Child health inequities in developing countries: Differences across urban and rural areas. Int J Equity Health. 2006;5:9. pmid:16831231
- 14. Gould W. African mortality and the new urban penalty. Health Place. 1998;4(2):171–81. pmid:10671021
- 15. Ezeh A, Oyebode O, Satterthwaite D, Chen Y-F, Ndugwa R, Sartori J, et al. The history, geography, and sociology of slums and the health problems of people who live in slums. Lancet. 2017;389(10068):547–58. pmid:27760703
- 16. Azage M, Haile D. Factors associated with safe child feces disposal practices in Ethiopia: Evidence from demographic and health survey. Arch Public Health. 2015;73:40. pmid:26504520
- 17. Vedachalam S, Riha SJ. Who’s the cleanest of them all? Sanitation scores in Indian cities. Environ urban 2015;27(1):117–36.
- 18. Vedachalam S, MacDonald L, Shiferaw S, Seme A, Schwab K. Underreporting of high-risk water and sanitation practices undermines progress on global targets. PLoS ONE. 2017;12(5):e0176272. pmid:28489904
- 19. Alemayehu EY. Revisiting slums, revealing responses: Urban upgrading in tenant-dominated inner-city settlements in Addis Ababa, Ethiopia. Doctoral theses at Norwegian University of Science and Technology (NTNU), Trondheim. 2008.
- 20. Sclar ED, Garau P, Carolini G. The 21st century health challenge of slums and cities: Millennium Project. Lancet. 2005;365:901–3.
Central Statistical Agency, ICF-International. Ethiopia Demographic and Health Survey 2011. Addis Ababa, Ethiopia, and Calverton, Maryland, USA: Central Statistical Agency [Ethiopia] and ORC Macro. 2012.
- 22. Riley LW, Ko AI, Unger A, Reis MG. Slum health: Diseases of neglected populations. BMC Int Health Hum Rights. 2007;7:2. pmid:17343758
UN. The Sustainable Development Goals Report 2016. United Nations, New York. 2016.
Central Statistical Agency. Population Projection of Ethiopia for all Regions, at Wereda Level from 2014–2017. Central Statistical Agency (CSA). Addis Ababa. 2013.
UN-HABITAT. Ethiopia: Addis Ababa Urban Profile. United Nation's Human Settlements Programme Regional and Technical Cooperation Division, Nairobi, United Nations. 2008.
Kelsey J, Whittemore A, Evans A, Thompson W. Methods of sampling and estimation of sample size. Methods in observational epidemiology. New York, NY: Oxford University Press. 1996.
Keusch G, Fontaine O, Bhargava A, Bhargava A, Boschi-Pinto C, Bhutta Z, et al. Diarrheal diseases. In: Jamison DT, Breman JG, Measham AR, et al., editors. Disease control priorities in developing countries. 2nd ed. Washington: Chapter 19. World Bank, co-published by Oxford University Press, New York. 2006.
WHO. The treatment of diarrhea. A manual for physicians and other senior health workers. Department of Child and Adolescent Health and Development. Geneva: World Health Organization. 2005.
- 29. Farthing M, Salam M, Lindberg G, Dite P, Khalit I, Lindo S, et al. World Gastroenterology Organization Global Guidelines. Acute diarrhea in adults and children: A global perspective. World Gastroenterology Organization. pp:1–24. 2012.
WHO, UNICEF. Progress on drinking water and sanitation: Special focus on sanitation. World Health Organization and United Nations Children’s Fund Joint Monitoring Programme (JMP) for water supply and sanitation. New York, Geneva. 2008.
- 31. Adane M, Mengistie B, Mulat W, Kloos H, Medhin G. Utilization of health facilities and predictors of health-seeking behavior for under-five children with acute diarrhea in slums of Addis Ababa, Ethiopia: A community-based cross-sectional study. J Health Popul Nutr. 2017;36:9. pmid:28376916
Kirkwood BR, Sterne J. Medical statistics: Chapter 29: Regression modelling. In: Essential medical statistics. 2nd ed (eds Kirkwood BR and Sterne JAC). Hoboken, New York: Blackwell Science. 2003.
- 33. McNamee R. Confounding and confounders. Occup Environ Med. 2003;60(3):227–34. pmid:12598677
Hosmer J, Lemeshow S, Sturdivant R. Applied logistic regression. 3rd ed. Hoboken, NJ: Johns Wiley and Sons. 2013.
Central Statistical Agency, ICF. Ethiopia Demographic and Health Survey 2016: Key Indicators Report. Addis Ababa, Ethiopia, and Rockville, Maryland, USA. CSA and ICF. 2016.
- 36. Corburn J, Hildebrand C. Slum sanitation and the social determinants of women’s health in Nairobi, Kenya. J Environ Public Health. 2015;2015:1–7.
- 37. Uwizeye D, Sokoni CH, Kabiru CW. Prevalence and correlates for diarrhoea in the mountainous informal settlements of Huye town, Rwanda. SpringerPlus. 2014;3(1):745.
- 38. Borah H, Gogoi G, Saikia H. Prevalence of diarrhoea among under-five children and health-seeking behavior of their mothers in slums of Dibrugarh Town, Assam. Ind J Sci Res and Tech. 2014;2(1):16–9.
- 39. Basa S. Prevalence of diarrhoea among under-five children and health seeking behavior of their mothers in an urban slum of Delhi. Asian J Biomed Pharm Sci. 2015;5(45):8–11.
- 40. Kalakheti B, Panthee K, Jain KC. Risk factors of diarrhea in children under-five years in urban slums: An epidemiological study. J Lumbini Med Coll. 2017;4(2):94–8.
- 41. Bartram J, Cairncross S. Hygiene, sanitation, and water: Forgotten foundations of health. PLoS Med. 2010;7(11):e1000367. pmid:21085694
- 42. Heijnen M, Cumming O, Peletz R, Chan GK-S, Brown J, Baker K, et al. Shared sanitation versus individual household latrines: A systematic review of health outcomes. PLoS ONE. 2014;9(4):e93300. pmid:24743336
- 43. Baker K, Reilly C, Levine M, Kotloff K, Nataro J, Ayers T, et al. Sanitation and hygiene-specific risk factors for moderate-to-severe diarrhea in young children in the global enteric multicenter study, 2007–2011: Case-control study. PLoS Med. 2016;13(5):e1002010. pmid:27138888
- 44. Heijnen M, Rosa G, Fuller J, Eisenberg JN, Clasen T. The geographic and demographic scope of shared sanitation: An analysis of national survey data from low-and middle-income countries. Trop Med Int Health. 2014;19(11):1334–45. pmid:25158032
- 45. Fuller JA, Clasen T, Heijnen M, Eisenberg JN. Shared sanitation and the prevalence of diarrhea in young children: Evidence from 51 countries, 2001–2011. Am J Trop Med Hyg. 2014;91(1):173–80. pmid:24865679
- 46. Nelson KB, Karver J, Kullman C, Graham JP. User perceptions of shared sanitation among rural households in Indonesia and Bangladesh. PLoS ONE. 2014;9(8):e103886. pmid:25090096
- 47. Tessema RA. Assessment of the implementation of community-led total sanitation, hygiene, and associated factors in Diretiyara district, Eastern Ethiopia. PLoS ONE. 2017;12(4):e0175233. pmid:28407003
- 48. Beyene A, Hailu T, Faris K, Kloos H. Current state and trends of access to sanitation in Ethiopia and the need to revise indicators to monitor progress in the Post-2015 era. BMC Public Health. 2015;15:451. pmid:25933607
- 49. Bartlett S. Water sanitation and urban children: The need to go beyond improved provision. Environ Urban. 2003;15(2):57–70.
- 50. Adane M, Mengistie B, Medhin G, Kloos H, Mulat W. Piped water supply interruptions and acute diarrhea among under-five children in Addis Ababa slums, Ethiopia: A matched case-control study. PLoS ONE. 2017;12(7):e0181516. pmid:28723927
- 51. Tumwebaze IK, Mosler H-J. Shared toilet users’ collective cleaning and determinant factors in Kampala slums, Uganda. BMC Public Health. 2014;14:1260. pmid:25494556
- 52. Collinet-Adler S, Babji S, Francis M, Kattula D, Premkumar P, Sarkar R, et al. Environmental factors associated with high fly densities and diarrhea in Vellore, India. Appl Environ Microbiol. 2015;81(17):6053–8. pmid:26116684
- 53. Strina A, Cairncross S, Barreto M, Larrea C, Prado M. Childhood diarrhea and observed hygiene behavior in Salvador, Brazil. Am J Epidemiol. 2003;157(11):1032–8. pmid:12777367
- 54. Boadi KO, Markku K. Childhood diarrheal morbidity in the Accra Metropolitan Area, Ghana: socio-economic, environmental and behavioral risk determinants. J Health Popul Dev Ctries. 2005;7:1–13.
- 55. Alam MZ, Rahman MA, Al Firoz MA. Water supply and sanitation facilities in urban slums: A case study of Rajshahi City corporation slums. Am J Civ Eng Archit. 2013;1(1):1–6.
- 56. Fadel ME, Maroun R, Quba'a R, Mawla D, Sayess R, Massoud M, et al. Determinants of diarrhoea prevalence in urban slums: A comparative assessment towards enhanced environmental management. Environ Monit Assess. 2014;186(2):665–77. pmid:24078142
- 57. Owolabi AA. Domestic water use, sanitation and diarrhea incidence among various communities of Ikare Akoko, Southwestern, Nigeria. Afr J Microbiol Res. 2012;6(14):3465–79.
- 58. Irish S, Aiemjoy K, Torondel B, Abdelahi F, Ensink JH. Characteristics of latrines in central Tanzania and their relation to fly catches. PLoS ONE. 2013;8(7):e67951. pmid:23874475
- 59. Nakagiri A, Kulabako RN, Nyenje PM, Tumuhairwe JB, Niwagaba CB, Kansiime F. Performance of pit latrines in urban poor areas: A case of Kampala, Uganda. Habitat Int. 2015;49:529–37.
- 60. Choyon K. Dynamics of risk determinants regarding diarrhoea affected slum children in urban Dhaka: A dysfunctional health care system. Curr Res J Soc Sci. 2012;4(4):304–13.
- 61. Nirgude S, Naik NP, Prassad VG, Nagaraj K. Solid waste disposal practices in an urban slum area of south India. Indian J Appl Res. 2014;4:11.
- 62. Gebru T, Taha M, Kassahun W. Risk factors of diarrhoeal disease in under-five children among health extension model and non-model families in Sheko district rural community, Southwest Ethiopia: Comparative cross-sectional study. BMC Public Health. 2014;14:395. pmid:24758243
- 63. Berhe F, Berhane Y. Under five diarrhea among model household and non model households in Hawassa, South Ethiopia: A comparative cross-sectional community based survey. BMC Public Health. 2014;14:187. pmid:24555706
- 64. Fetene N, Linnander E, Fekadu B, Alemu H, Omer H, Canavan M, et al. The Ethiopian health extension program and variation in health systems performance: What matters? PLoS ONE. 2016;11(5):e0156438. pmid:27227972
- 65. Escamilla V, Knappett PS, Yunus M, Streatfield P, Emch M. Influence of latrine proximity and type on tubewell water quality and diarrheal disease in Bangladesh. Ann Assoc Am Geogr. 2013;103(2):299–308.
- 66. Kimani M, Ngindu AM. Quality of water the slum dwellers use: The case of a Kenyan slum. J Urban Health: Bull N Y Acad Med. 2007;84(6):829–838.
- 67. Carlton EJ, Eisenberg JNS, Gold stick J, Cevallos W, Trostle J, and Karen L. Heavy rainfall events and diarrhoea incidence: The role of social and environmental factors. Am J Epidemiol. 2013;179:344–52. pmid:24256618
- 68. Mutisya M, Orindi B, Emina J, Zulu E, Ye Y. Is mortality among under-five children in Nairobi slums seasonal? Trop Med Int Health. 2010;15(1):132–9. pmid:19883400
- 69. Mukabutera A, Thomson D, Murray M, Basinga P, Nyirazinyoye L, Atwood S, et al. Rainfall variation and child health: Effect of rainfall on diarrhea among under five children in Rwanda, 2010. BMC Public Health. 2016;16:731. pmid:27495307
- 70. Kwiringira J, Atekyereza P, Niwagaba C, Kabumbuli R, Rwabukwali C, Kulabako R, et al. Seasonal variations and shared latrine cleaning practices in the slums of Kampala city, Uganda. BMC Public Health. 2016;16:361. pmid:27121388
- 71. Azage M, Kumie A, Worku A, Bagtzoglou AC. Childhood diarrhea exhibits spatiotemporal variation in northwest Ethiopia: A SaTScan spatial statistical analysis. PLoS ONE. 2015;10(12):e0144690. pmid:26690058
- 72. Melo MC, Taddei JA, Diniz-Santos DR, Vieira C, Carneiro NB, Melo RF, et al. Incidence of diarrhoea in children living in urban slums in Salvador, Brazil. Braz J Infect Dis. 2008;12(1):89–93. pmid:18553022
- 73. Ferdous F, Das SK, Ahmed S, Farzana FD, Latham JR, Chisti MJ, et al. Severity of diarrhea and malnutrition among under five-year-old children in rural Bangladesh. Am J Trop Med Hyg. 2013;89(2):223–8. pmid:23817334
- 74. Spears D, Ghosh A, Cumming O. Open defecation and childhood stunting in India: An ecological analysis of new data from 112 districts. PLoS ONE. 2013;8(9):e73784. pmid:24066070
- 75. Checkley W, Buckley G, Gilman R, Assis A, Guerrant R, Morris S, et al. Multi-country analysis of the effects of diarrhoea on childhood stunting. Int J Epidemiol. 2008;37:816–30. pmid:18567626
- 76. Gilmartin AA, Petri WA. Exploring the role of environmental enteropathy in malnutrition, infant development and oral vaccine response. Phil Trans R Soc B. 2015;370:20140143. pmid:25964455
- 77. Korpe PS, Petri WA. Environmental enteropathy: Critical implications of a poorly understood condition. Trends Mol Med. 2012;18(6):328–36. pmid:22633998
- 78. Guerrant RL, Leite AM, Pinkerton R, Medeiros PH, Cavalcante PA, DeBoer M, et al. Biomarkers of environmental enteropathy, inflammation, stunting, and impaired growth in children in Northeast Brazil. PLoS ONE. 2016;11(9):e0158772. pmid:27690129
- 79. Humphrey JH. Child undernutrition, tropical enteropathy, toilets, and handwashing. Lancet. 2009;374(9694):1032–5. pmid:19766883
Ministry of Urban Development and Housing of Ethiopia. Strategic scale up of safety net from rural to urban to address poverty. Social protection in cities: A forward looking view. The Ethiopian perspective. 2015.
Federal Democratic Republic of Ethiopia. The water supply sanitation and hygiene (WASH) implementation frame work. Ethiopian WASH implementation frame work. One WASH Plans. Addis Ababa. 2011.
Federal Democratic Republic of Ethiopa. Minisitry of Health. Health Sector Development Program IV 2010/11–2014/15. Addis Ababa. 2010.