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Alcohol and tea consumption are associated with asymptomatic erosive esophagitis in Taiwanese men

  • Chung-Hsin Chang,

    Affiliation Division of Gastroenterology, Taichung Veterans General Hospital, Taichung, Taiwan

  • Cheng-Pin Wu,

    Affiliations Health Examination Center, China Medical University Hospital, Taichung, Taiwan, Preventive Medicine Center, China Medical University Hospital, Taichung, Taiwan

  • Jung-Der Wang,

    Affiliation Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan

  • Shou-Wu Lee,

    Affiliations Division of Gastroenterology, Taichung Veterans General Hospital, Taichung, Taiwan, Department of Internal Medicine, Chung Shan Medical University, Taichung, Taiwan

  • Chi-Sen Chang,

    Affiliations Division of Gastroenterology, Taichung Veterans General Hospital, Taichung, Taiwan, Department of Internal Medicine, Chung Shan Medical University, Taichung, Taiwan

  • Hong-Zen Yeh,

    Affiliations Division of Gastroenterology, Taichung Veterans General Hospital, Taichung, Taiwan, Department of Internal Medicine, National Yang-Ming University, Taipei, Taiwan

  • Chung-Wang Ko,

    Affiliations Division of Gastroenterology, Taichung Veterans General Hospital, Taichung, Taiwan, Department of Internal Medicine, National Yang-Ming University, Taipei, Taiwan

  • Han-Chung Lien

    lhc@vghtc.gov.tw

    Affiliations Division of Gastroenterology, Taichung Veterans General Hospital, Taichung, Taiwan, Department of Internal Medicine, National Yang-Ming University, Taipei, Taiwan

Alcohol and tea consumption are associated with asymptomatic erosive esophagitis in Taiwanese men

  • Chung-Hsin Chang, 
  • Cheng-Pin Wu, 
  • Jung-Der Wang, 
  • Shou-Wu Lee, 
  • Chi-Sen Chang, 
  • Hong-Zen Yeh, 
  • Chung-Wang Ko, 
  • Han-Chung Lien
PLOS
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Abstract

Objective

Asymptomatic erosive esophagitis (AEE) is commonly found in men, and might be a risk factor of developing esophageal adenocarcinoma. We aimed to determine if specific dietary habits increase the risk of AEE in asymptomatic Taiwanese men.

Methods

We recruited male adults undergoing upper gastrointestinal endoscopy for health check. We excluded subjects with reflux symptoms, or taking anti-reflux medications or drugs that potentially impair lower esophageal sphincter function or cause mucosal injury. The frequency of consuming reflux-provoking diets including alcohol, tea, coffee, tomato/citric juice, chocolate, sweet food, and spicy food was assessed. The erosive esophagitis was diagnosed based on the Los Angeles Classification after endoscopy. Frequent consumption of a specific diet was defined as ≥4 days/week of consuming that diet.

Results

A total of 1256 participants were recruited. After excluding 424 ineligible subjects, AEE was identified in 180 (22%) among 832 asymptomatic subjects. The risk of AEE increased with the number of days per week of consuming alcohol or tea: nondrinkers (19%, 17%), occasional drinkers (<1 day/week; 19%, 15%), regular drinkers (1–3 days/week; 26%, 21%), frequent drinkers (4–6 days/week; 32%, 22%), and daily drinkers (42%, 28%), respectively (trend test P < 0.001 for both). Multivariate analysis showed that hiatus hernia (adjusted odds ratio (aOR) 5.0, 95% confidence interval (CI) 2.6–9.6), drinking alcohol ≥4 days/week (aOR 2.3, 95% CI 1.3–4.0), and drinking tea ≥4 days/week (aOR 1.6, 95% CI 1.1–2.3) are independent risk factors of AEE. The risk of AEE was 3.8 times greater for those drinking both alcohol and tea ≥4 days/week than the non-drinkers.

Conclusions

Frequent alcohol and tea consumption increased the risk of AEE in Taiwanese men.

Introduction

The prevalence of erosive esophagitis (EE), the most common manifestation of esophageal injury of gastroesophageal reflux disease (GERD) [1], has increased throughout Asia over the past decade [2]. In Taiwan, it was estimated to range from 9.0% to 24.6% among adults who underwent a screening endoscopy during a health check [3]. These rates are within the range of those reported in general population studies conducted in Sweden (15.5%, Kalixanda) [4] and Italy (11.8%, Loiano-Monghidoro) [5]. Several health-check studies from Asia including Taiwan showed that 11.6% to 45.3% of subjects with EE had no reflux symptoms, i.e., asymptomatic erosive esophagitis (AEE), particularly in men [69], which was also in line with the Kalixanda and the Loiano-Monghidoro studies, showing up to 36.8% and 32.8% of patients with EE were asymptomatic, respectively [4,5]. Although the natural history and the significance of AEE remain unknown, it is important to note that EE is a major risk factor for developing Barrett’s esophagus (BE) [10], which is the precursor of esophageal adenocarcinoma (EAC) caused by chronic GERD, and was detected in 25% of asymptomatic men older than 50 years of age undergoing screening sigmoidoscopy for colorectal cancer [11]. Therefore, subjects with AEE may theoretically be at risk of developing EAC, as 40% of patients who develop EAC have never experienced any symptoms of reflux and are therefore less likely to seek medical attention [12].

Certain foods or beverages, such as chocolate or alcohol may provoke GERD. Therefore, dietary modifications are often used as a first-line treatment for subjects with GERD [13]. However, the current guidelines do not support dietary restrictions as being an effective therapy for GERD [14], because of a lack of evidence to support that either frequent consumption of certain foods cause the disease, or that an avoidance of specific diets reduces the disease’s occurrence. In fact, it is generally difficult to evaluate the cause and effect between dietary habits and GERD, because patients with reflux symptoms may tend to avoid certain foods that would provoke their symptoms [15]. In this regard, subjects with AEE may be considered the preferred study population when evaluating the relationship between dietary habits and GERD.

This study aimed to determine whether frequent consumption of potential reflux-provoking food and beverages such as alcohol, tea, coffee, tomato/citric juices, chocolate, sweet food, and spicy food [14] may be associated with the risk of AEE in Taiwanese men who were undergoing a screening upper endoscopy during a health check.

Materials and methods

Participants

The study population was 1256 male subjects who underwent self-paid health checks in Taichung Veterans General Hospital from March 2002 to September 2002. After obtaining their informed consent, each participant underwent an interview to discuss their medical history, along with a physical examination, an esophagogastroduodenoscopy (EGD), multiphasic blood screening, a chest radiograph, an abdominal ultrasound, and a colonoscopy. All participants were over 20 years of age, and most of them were middle-class citizen and were apparently healthy. We excluded subjects with upper gastrointestinal surgery or tumors, BE, any acute illness, refusal for EGD, refusal to participate in the study, or inability to verbally communicate. Subjects who were taking medications that commonly impair the lower esophageal sphincter (LES) such as aminophyllines, anticholinergics, beta-adrenergic agonists, nitroglycerins, and benzodiazepines; or cause direct mucosal injury such as bisphosphonates, ferrous sulfate, doxycycline, non-steroid anti-inflammatory drugs, and ascorbic acid, were also excluded. Participants who answered “yes” to any one of the following 3 questions were considered symptomatic and were also excluded: (1) “In the last 3 months, have you experienced any symptoms of heartburn at least once in a month? (The term “heartburn” was defined as a burning pain or discomfort behind the breast bone.)” [16] (2) “In the last 3 months, have you experienced any symptoms of acid regurgitation at least once in a month? (The term “acid regurgitation” was defined as a bitter or sour fluid rising to the throat or mouth.)” (3) “In the last 3 months, have you taken any anti-reflux medications to relieve your upper digestive tract from any symptoms such as upper abdominal, retrosternal, or throat discomfort, more than once in a month? (The anti-reflux medications may include antacids, proton pump inhibitors, anti-histamine 2 receptors blockers, or pro-motility agents).” The questionnaire was administered prior to the EGD exam.

The research protocol was first approved by the Institutional Review Board of Taichung Veterans General Hospital (TCVGH No: C06284) and follows the principles of the Declaration of Helsinki. All participants provided written informed consent prior to any procedures. The data and questionnaires were analyzed anonymously, so that subjects could not be personally identified in the data analysis.

Questionnaire

A structured, self-administered questionnaire was developed to evaluate the dietary habits of Taiwanese and the potential reflux-provoking food and beverages commonly consumed by them. These include coffee, chocolate, alcohol, tea, tomato/citric juices, sweet food, and spicy food. The questionnaire contained 7 items, each asking the number of days per week one certain kind of food or beverage was consumed. For example, “Within the prior 3 months, how often on average did you drink alcohol per week? (at least a glass of wine or spirits, or a can of beer each time)”. Another estimated amount of beverage use was defined as at least one cup of coffee or tea, one bottle of tomato/citric juice each time, and one occasion for consuming chocolate, sweet foods, and spicy foods. Subjects were allowed to choose either one of the following answers: (1) never, (2) less than one day per week, (3) between one to three days per week, (4) between four to six days per week, or (5) almost daily or more frequently than daily.

Before the study, a pre-test of the questionnaire was conducted among 25 randomly selected hospital staff members to see whether or not they had any difficulty in understanding the questionnaire, which was then modified according to their suggestions. Subsequently, the test-retest reliability was conducted in the same group, by comparison of the two tests 7–14 days apart, and showed a median kappa statistic of 0.85 (interquartile range, 0.79–0.9). The questionnaire would usually be completed within one minute. The same study nurse confirmed the completeness of the questionnaire which had been filled out by the participants immediately before the EGD exam.

Esophagogastroduodenoscopy

The standard practice in this program employed a group of experienced endoscopists (H-C,L; C-S,C; H-Z,Y; C-W,K) to perform EGDs in order to screen for early upper gastrointestinal malignancy. The endoscopists were unaware of each subject’s symptoms prior to the procedure, in order to avoid any information bias during the endoscopic assessment [17]. Each subject underwent an unsedated EGD. A standard electronic video gastroscope system (Olympus Inc., Tokyo, Japan) was used to assess EE, including the use of an Olympus GIF XQ-240 for the study, and static photographs were recorded on compact disks (CD-ROM). The severity of esophagitis was classified according to the Los Angeles classification (grades A-D) [18]. To evaluate the reliability of endoscopic diagnosis of EE, another experienced endoscopist (S-K,P) reexamined 80 endoscopic images randomly selected from study subjects. The inter-observer agreement between the performing endoscopist and the reviewing endoscopist was good to excellent with a kappa statistic of 0.8.

Statistical analysis

To determine the effect of dietary habits on AEE, we measured the prevalence of AEE as determined through the frequency of each food or beverage consumption (never, <1 day/week, 1–3 days/week, 4–6 days/week, daily) and then evaluated the dose-response effect using the Cochran-Armitage trend test. All data, including demographic data (age, body mass index (BMI)), dietary habits (alcohol, tea, coffee, chocolate, tomato/citric juice, spicy and sweet food intake), and endoscopic findings, were compared between subjects with and without AEE. The Chi-square test was used for analyzing categorical data, and the Student’s t test was used for continuous data. BMI categories were defined as, normal weight (<23.9 kg/m2), overweight (24 to 26.9 kg/m2) and obesity (≥27 kg/m2), as based on Taiwan criteria [19]. Frequent food or beverage consumption was defined as ≥4 days per week for a specific food or beverage consumed in the last 3 months. Using unconditional logistic regression, we calculated the odds ratios (OR) as estimates of the relative risk and related 95% confidence intervals (CIs), in order to measure the association between frequent dietary consumption and AEE. Variables having a p <0.25 in the univariate analysis were entered as candidate risk factors in the multivariate logistic regression analysis, in order to identify independent risk factors of AEE [20]. All analyses were performed with SPSS 15.0 for Windows (Chicago, IL). A 2-sided probability value of less than 0.05 was considered statistically significant.

Results

Of the 1256 men screened for EGD, 832 subjects were deemed eligible after excluding all subjects experiencing reflux symptoms, those taking anti-reflux medications or drugs that potentially impair LES function or cause mucosal injury (n = 417), those with a history of gastric cancer or previous upper gut surgery (n = 2), BE (n = 4), and any who refused to participate (n = 1), upon completion of a dietary habit evaluation (Fig 1). Among them, 21.6% (n = 180) were diagnosed with AEE and the vast majority (73.9%) of those with AEE were at a grade A severity level (Table 1). Dietary habits varied among the participants: 60.7% drank tea at least once weekly, while 39.2% drank tea almost daily (Table 1). Subjects found to have AEE were more likely to have a hiatus hernia (p < 0.0001), to drink alcohol (p = 0.003), and to drink tea (p = 0.008) than subjects without AEE (Table 1). There was no difference in age, BMI, or the frequency of consuming remaining foods or beverages between the two groups. Subjects with a history of reflux symptoms or those taking any anti-reflux medications appeared to have lower frequencies in the consumption of various food items which might provoke any symptoms.

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Fig 1. Enrollment of study subjects.

(PPI, proton pump inhibitor; H2RA, histamine-2-receptor antagonist).

https://doi.org/10.1371/journal.pone.0173230.g001

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Table 1. Demography, endoscopic findings, and dietary habits of asymptomatic male subjects with or without erosive esophagitis, and symptomatic male subjects.

https://doi.org/10.1371/journal.pone.0173230.t001

The prevalence of AEE increased in step with the increase in the number of days per week alcohol or tea was consumed (trend test, p = 0.0003 for alcohol and p = 0.0005 for tea, respectively), but not for other foods or beverages (Fig 2). The prevalence of AEE in participants drinking alcohol increased from 19.0% among non-drinkers, to 41.9% among daily drinkers (OR 3.1, 95% CI 1.6–5.9, p = 0.001); whereas with tea consumption, the AEE increased from 16.9% among non-drinkers, to 27.6% among daily drinkers (OR 1.9, 95% CI 1.1–3.1, p = 0.01; Fig 2).

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Fig 2. Proportions of asymptomatic erosive esophagitis by frequency of dietary habits in Taiwanese men.

(trend test, p = 0.0003 for alcohol and p = 0.0005 for tea, respectively)

https://doi.org/10.1371/journal.pone.0173230.g002

In a multivariate logistic regression analysis model, a hiatal hernia (adjusted odds ratio (aOR) 5.0, 95% CI 2.6–9.6, p < 0.0001), drinking alcohol ≥4 days/week (aOR 2.3, 95% CI 1.3–4.0, p = 0.002), and drinking tea ≥4 days/week (aOR 1.6, 95% CI 1.1–2.3, p = 0.008) are all independently associated with AEE (Table 2). When compared with men who did not drink alcohol or tea, the estimated risk of AEE for men who drank both alcohol and tea ≥4 days/week, was 3.8 times greater (95% CI 1.7–8.7, Table 3).

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Table 2. Crude and adjusted odds ratios and 95% confidence intervals of asymptomatic erosive esophagitis and associated factors in Taiwanese men.

https://doi.org/10.1371/journal.pone.0173230.t002

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Table 3. Adjusted odds ratios and 95% confidence interval of asymptomatic erosive esophagitis by frequency of alcohol and tea consumption in Taiwanese men.

https://doi.org/10.1371/journal.pone.0173230.t003

Discussion

This study explored the prevalent rates and risk factors of AEE among asymptomatic Taiwanese men, focusing on their dietary habits. Although we discovered that frequent consumption of alcohol and/or tea were independently associated with increased risks of AEE, with an apparent dose-response relationship, it does not necessarily imply that they are causally related. However, we make the following arguments to support such a hypothesis: First, we have deliberately included participants without any previous history of reflux symptoms, or those taking any medications that may be related to reflux or esophageal mucosal injury. Thus, the association cannot be explained by any possible coexistence of symptomatic GERD or medications. Secondly, because we have constructed a multivariable, logistic regression model by including hiatal hernia, coffee, chocolate, and other common dietary habits, the potential confounders by all these factors were also under control. Thirdly, the positive association between hiatal hernia and AEE in our final model corroborates previous reports [4,8,9,21,22] and the validity of statistical analysis. Therefore, we have tentatively concluded that frequent consumption of alcohol and/or tea, independently associates with AEE in Taiwanese asymptomatic men. Based on the magnitude of the odds ratio, alcohol appeared to be a stronger reflux promoter than tea. Moreover, an additive risk of AEE was also observed when drinking both beverages frequently, implicating a role of dietary habits or the subject’s associated lifestyle, in the development of AEE.

AEE is a silent GERD based on the Montreal definition [1], given the specificity of endoscopic mucosal lesions in the diagnosis of EE. Epidemiological studies have shown that the prevalence of AEE among asymptomatic Asian adults undergoing health check, ranged from 12% to 18.5% in Taiwan [6,9,23] and from 1.6% to 7% in other Asian countries [8,21,22,24], respectively. Our data showed a high prevalence of AEE of 21.6% in Taiwanese men, which was consistent with the findings of male predominance in AEE across most Asian large-scale studies [69,21,22,24]. In this study, we confined the scope of our investigation of the risk of dietary habits on AEE to the male gender, as men are not only more likely to have EE [25,26], (possibly due to a greater parietal cell mass [27], a higher prevalence of hiatus hernia [28], and poor lifestyle habits such as smoking or alcohol consumption [29,30]), but also report fewer symptoms than women [31]. Thus, men may carry a higher risk of developing severe EE, BE and EAC [26,32]. In addition to the aforementioned hiatal hernia and male gender, data regarding other risk factors of AEE in community-based studies such as obesity, age, and H. pylori are scant and still inconsistent. For example, unlike the positive association with obesity in EE, data on AEE were mixed as three studies showed a positive association [4,6,22], while 4 other studies, including ours, found no association with obesity [8,9,21]. Moreover, the association between obesity and EE was mainly found in women but not in men [3335], which may be related to the reflux-promoting effect of estrogen [36]. In addition, older age was not a risk factor for AEE in most studies, including ours, that used asymptomatic non-AEE subjects as controls [6,8,9,21,22,24], except one study that compared subjects with symptomatic EE (SEE) [8]. Despite the association between the severe form of EE (regardless of symptoms) and older age [37], the results on the association between the prevalence of EE and older age in large observational studies were also mixed [25,26,3840], indicating the possibility that other factors such as hiatus hernia or obesity, which were commonly found in the elderly, may contribute to the severe form of EE [28]. The inverse association with H. pylori found in two AEE studies [9,21], was consistent with that of other EE studies in Asia [41], though H. pylori was not investigated in this study. Finally, when compared between patients with AEE and SEE, the risk factors including age, gender, and obesity were inconsistent amongst studies [7,8,2124], except that psychological distress, overlap of dyspepsia or irritable bowel syndrome were less common in AEE [22,24], indicating a higher pain threshold in patients with AEE.

The lifestyle, particularly, the role of dietary habits on AEE has rarely been studied, and the results from the limited data seemed mixed [6,8,9,21]. Given the assumption of there not being any specific diet restrictions in patients with AEE, this may be an ideal model in which to investigate the relationship between reflux and diets in population-based studies.

Alcohol may promote reflux by reducing LES tone, increasing intra-gastric acidity, decreasing salivary bicarbonate, and also impairing the mucosal barrier in physiological studies regardless of the type and amounts involved [42]. However, large observational studies investigating the effects of alcohol exposure on GERD have been inconsistent, presumably due to different definitions of alcohol consumption, different disease outcome measures, and different population studied, particularly ethnically or culturally-related geographic variations, amongst the studies [13]. To support the reverse causality regarding the outcome measure, we searched available literature and found that 16 out of 22 studies (73%) using EE (or AEE) as an (objective) outcome measure demonstrated an association with alcohol consumption in univariate analysis, as compared to only 4 of 13 studies (31%) using reflux symptoms (or non-erosive reflux disease) as a (subjective) outcome measure (S1 Table), indicating that the concomitant occurrence of reflux symptoms could influence the level of alcohol exposure [43]. In addition, the association between alcohol consumption and GERD (either EE or reflux symptoms) seemed to be more common in Asian studies, as compared to the western counterparts (88% vs. 48%, S1 Table), raising the possibility of contributory roles of genetic predisposition, and culturally-related drinking habits. In fact, acetaldehyde dehydrogenase deficiency, a genetic aberrant predisposition of alcohol metabolism commonly found in Asian populations has recently been linked to BE [44] and esophageal cancer [45] in Asian drinkers. Besides, alcohol drinking is also a culturally-related behavior [30], as Chinese culture encourages binge drinking for middle-aged men during mealtime [46], a scenario resulting in promotion of reflux in this susceptible group, In contrast, heavy episodic drinking can be prevalent in youths in West regardless of whether meals are being eaten [47]. Thus, it is conceivable that frequent alcohol consumption or its associated lifestyle contribute to the occurrence of EE or AEE, particularly in Asian populations.

Tea, processed from the leaf of Camellia sinensis, is consumed by two-thirds of the people in the world as a healthy beverage [48]. However, tea is also associated with heartburn [49]. The proposed mechanisms include increased gastric acid secretion through suppressing the H. pylori proliferation [50], and the decreased LES pressure [51], thereby increasing esophageal acid reflux [52]. Theophylline, a major component in tea, may relax the LES [53] and also has a significant inhibitory effect on visceral pain [54], thus may theoretically contribute to AEE. Recent data have shown that long-term use of LES relaxing medications, such as theophylline, is associated with EAC [55]. However, the epidemiological studies investigating the effects of tea on GERD are scant and the results are conflicting [6,15,29,5661], possibly because of difficulty in assessing the quantity and the quality of tea in a population-based study. Many culturally-related drinking habits, such as the consumption of black tea, green tea and strong tea [56], along with drinking tea at hot temperatures [62], and adding nutrients such as cream or sugar [49], may contribute differently to the reflux or irritation of esophageal mucosa. For example, drinking strong tea was found highly correlated to the occurrence of GERD in the Han Chinese from a population-based study in Urumqi, China [63]. In our study, 39.2% of the participants were daily tea drinkers. Given the worldwide popularity of tea drinking, clinicians should recognize that even small increases in risk may possibly translate into a larger number of EE cases when the beverage is consumed in large amounts. Future research will be needed to clarify the quantity and the quality of tea consumption, when analyzing the occurrence of GERD in heavy tea drinkers.

Coffee is also a potent stimulant of gastric acid secretion and has similarly been associated with heartburn [64,65]. However, the results of the effects of coffee on LES pressure and postprandial acid reflux time, or the number of acid reflux episodes, were conflicting [6669]. A recent meta-analysis of epidemiological studies showed no association between coffee consumption and GERD [70]. Other diets which included chocolate, tomato/citric juices, sweet food, and spicy food have also been found to be associated with acid regurgitation or heartburn; however, none have been reported with EE [6,13,56].

There have been limitations in our study. First, because the sample examined in this study was taken from a population of self-selection for those undergoing a health check-up, the result of seeing a prevalent rate of AEE may not be generalized to fit the overall population in Taiwan. However, such self-paid, health check-ups are generally affordable and easily accessible to most residents in Taiwan, who care to know their own health status, particularly for those interested in early cancer screening. As we had already excluded 417 subjects experiencing reflux symptoms, and those taking medications or drugs that potentially impair esophageal sphincter function or cause mucosal injury, all of whom were found to have a prevalence of 35.5% for esophagitis or even more severe lesions (Table 1), those who were included in our study would appear to represent apparently healthy Taiwanese men to some extent. Secondly, because it is difficult to accurately assess the exposure of beverage consumption without objective biomarkers in epidemiological studies [71], we assumed that the frequency of alcohol or tea consumption for a duration of at least 3 months represented the dietary habit or life-style habit related to that beverage and paralleled the amount of intake. Further studies are needed to investigate the concentrations, fermentation methods, accompanying food or additive nutrients, and drinking temperatures of both types of beverages, and if possible, to employ objective biomarkers to validate the true exposure. However, because the data of dietary habits and symptoms were collected immediately before the endoscopy, kept blind to the endoscopists, and a photo confirmation study was reviewed by a different experienced endoscopist, we were able to minimize or avoid information bias and misclassification. Thirdly, it is also possible that food items or lifestyles such as smoking or large meals that accompanies alcohol or tea consumption confound the occurrence of AEE, and were not recorded in our study. However, the possibility of such biased conclusion is unlikely to be fully explained by a clear dose-response relationship existing between AEE and the frequency of alcohol or tea consumption. Further studies are needed to clarify this issue.

Conclusion

In conclusion, our present study demonstrated that frequent consumption of alcohol and tea increased the risk of AEE in Taiwanese men. Future research to corroborate our hypotheses is warranted for these two common beverages, both of which have been strongly embedded in our dietary culture.

Supporting information

S1 Table. Alcohol consumption and the risk of erosive esophagitis and reflux symptoms from epidemiological studies.

https://doi.org/10.1371/journal.pone.0173230.s001

(DOC)

Acknowledgments

We thank Miss Kareen Chong for her secretarial work.

Author Contributions

  1. Conceptualization: HCL CSC HZY CWK.
  2. Data curation: HCL.
  3. Formal analysis: HCL SWL CSC HZY CWK.
  4. Funding acquisition: CSC.
  5. Investigation: HCL.
  6. Methodology: HCL SWL CSC HZY CWK.
  7. Project administration: HCL CSC.
  8. Resources: HCL CSC.
  9. Software: HCL.
  10. Supervision: CSC.
  11. Validation: JDW.
  12. Visualization: JDW.
  13. Writing – original draft: CHC HCL CPW.
  14. Writing – review & editing: CHC HCL CPW.

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