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Correction: Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis

  • Kayode K. Ojo,
  • Ranae M. Ranade,
  • Zhongsheng Zhang,
  • David M. Dranow,
  • Janette B. Myers,
  • Ryan Choi,
  • Steve Nakazawa Hewitt,
  • Thomas E. Edwards,
  • Douglas R. Davies,
  • Donald Lorimer,
  • Stephen M. Boyle,
  • Lynn K. Barrett,
  • Frederick S. Buckner,
  • Erkang Fan,
  • Wesley C. Van Voorhis

Correction: Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis

  • Kayode K. Ojo, 
  • Ranae M. Ranade, 
  • Zhongsheng Zhang, 
  • David M. Dranow, 
  • Janette B. Myers, 
  • Ryan Choi, 
  • Steve Nakazawa Hewitt, 
  • Thomas E. Edwards, 
  • Douglas R. Davies, 
  • Donald Lorimer
PLOS
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There is an error in the third-to-last sentence of the “BmMetRS in complex with inhibitors” section. The correct sentence is: A superposition of 4PY2 Chain B and 4MVW Chain A gives a good illustration of this (Fig 7).

There is an error in the caption for Fig 7. Please see the correct Fig 7 caption here.

thumbnail
Fig 7. A superposition of BmMetRS (PDB ID 4PY2 Chain B) and TbMetRS (PDB ID 4MVW Chain) bound to compound 1433.

A key difference is the interaction of BmMetRS Phe213 which is functionally equivalent to Leu456 in TbMetRS but led to different protein geometry. The TbMetRS structure is shown in blue and the 2 different residues in orange.

https://doi.org/10.1371/journal.pone.0163641.g001

Additionally, in Table 2, the “PDB code” value for “1433” should read “4PY2”. Please view the corrected Table 2 here.

Reference

  1. 1. Ojo KK, Ranade RM, Zhang Z, Dranow DM, Myers JB, Choi R, et al. (2016) Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis. PLoS ONE 11(8): e0160350. pmid:27500735