The mass spectrum of the fungal extract showed a (M+H+) peak at a molecular mass of 825.46, which was identical to that observed in the mass spectrum of the VCR standard.
The mass spectrum of the fungal extract showed a (M+H+) peak at a molecular mass of 811.51, which was identical to that observed in the mass spectrum of the VBL standard.
The sub-G0/G1, G1, S and G2/M phases are represented on the histogram as P5, P2, P4 and P3, respectively. A—control, B—fungal VCR (5 μg/ml), C—fungal VCR (10 μg/ml), D—fungal VCR (25 μg/ml) and E—percent apoptosis.
A—untreated cells, B—cells + FITC, C—cells + PI, D—cells + FITC + PI, E—cells + FITC + PI + fungal VCR (5 μg/ml), F—cells + FITC + PI + fungal VCR (10 μg/ml), G—cells + FITC + PI +
A—cells alone, B—cells + JC1 stain, C—cells + JC1 + 25 μM valinomycin (+ ve control), D—cells + JC1 + fungal VCR (5 μg/ml), E—cells + JC1 + fungal VCR (10 μg/ml), F—cells + JC1 + fungal VCR (25 μg/ml), G—standard VCR (2 nM) and H—percent loss of mitochondrial membrane depolarization.
Citation: Palem PPC, Kuriakose GC, Jayabaskaran C (2016) Correction: An Endophytic Fungus, Talaromyces radicus, Isolated from Catharanthus roseus, Produces Vincristine and Vinblastine, Which Induce Apoptotic Cell Death. PLoS ONE 11(4): e0153111. https://doi.org/10.1371/journal.pone.0153111
Published: April 5, 2016
Copyright: © 2016 Palem et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.