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Criticism and Depression among the Caregivers of At-Risk Mental State and First-Episode Psychosis Patients

  • Yumiko Hamaie ,

    Affiliations Department of Psychiatry, Tohoku University Hospital, Sendai, Miyagi, Japan, Department of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

  • Noriyuki Ohmuro,

    Affiliation Department of Psychiatry, Tohoku University Hospital, Sendai, Miyagi, Japan

  • Masahiro Katsura,

    Affiliation Department of Psychiatry, Tohoku University Hospital, Sendai, Miyagi, Japan

  • Chika Obara,

    Affiliation Department of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

  • Tatsuo Kikuchi,

    Affiliation Department of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

  • Fumiaki Ito,

    Affiliation Department of Psychiatry, Tohoku University Hospital, Sendai, Miyagi, Japan

  • Tetsuo Miyakoshi,

    Affiliation Chiba Prison, Chiba-shi, Chiba, Japan

  • Hiroo Matsuoka,

    Affiliations Department of Psychiatry, Tohoku University Hospital, Sendai, Miyagi, Japan, Department of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

  • Kazunori Matsumoto

    Affiliations Department of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan, Department of Preventive Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

Criticism and Depression among the Caregivers of At-Risk Mental State and First-Episode Psychosis Patients

  • Yumiko Hamaie, 
  • Noriyuki Ohmuro, 
  • Masahiro Katsura, 
  • Chika Obara, 
  • Tatsuo Kikuchi, 
  • Fumiaki Ito, 
  • Tetsuo Miyakoshi, 
  • Hiroo Matsuoka, 
  • Kazunori Matsumoto


27 May 2016: Hamaie Y, Ohmuro N, Katsura M, Obara C, Kikuchi T, et al. (2016) Correction: Criticism and Depression among the Caregivers of At-Risk Mental State and First-Episode Psychosis Patients. PLOS ONE 11(5): e0156590. View correction


Expressed emotion (EE), especially criticism, is an important predictor of outcomes for the patient for a wide range of mental health problems. To understand complex links between EE and various relevant variables in early phase psychosis, this study examined criticism, distress of caregivers, other patients’, and caregivers’ variables, and links between criticism and these variables in those with at-risk mental state (ARMS) for psychosis and first-episode psychosis (FEP). The participants were 56 patients (mean age 18.8 ± 4.2 years) with ARMS and their caregivers (49.4 ± 5.8 years) and 43 patients (21.7 ± 5.2 years) with FEP and their caregivers (49.3 ± 7.4 years). We investigated criticisms made by caregivers using the Japanese version of the Family Attitude Scale and caregiver depressive symptoms via the self-report Beck Depression Inventory. We also assessed psychiatric symptoms and functioning of the patients. Approximately one-third of caregivers of patients with ARMS or FEP had depressive symptoms, predominately with mild-to-moderate symptom levels, whereas only a small portion exhibited high criticism. The level of criticism and depression were comparable between ARMS and FEP caregivers. The link between criticism, caregivers’ depression, and patients’ symptoms were observed in FEP but not in ARMS caregivers. These findings imply that the interaction between criticism and caregivers’ and patients’ mental states may develop during or after the onset of established psychosis and interventions for the caregivers should be tailored to the patient’s specific stage of illness. Interventions for FEP caregivers should target their emotional distress and include education about patient’s general symptoms.


The family environment may alter both the onset [1] and outcome [2, 3] of psychosis and thus research investigating the family environment in early phase psychosis, that is, those with at-risk mental state (ARMS) and first-episode psychosis (FEP) [49], has important clinical implications. Although clinical guidelines recommend family interventions for ARMS and FEP [10], the nature of the family environment in early phase psychosis appears different from that of later or chronic phases [11, 12]. Conventional family interventions for families of people with early psychosis are not as effective as for families of chronic patients [1315]. Therefore, to optimize family interventions in the early phase of illness it is necessary to gain further understanding of the family environment in early psychosis, including ARMS and FEP.

Research focusing on the family environment of people with mental illness has examined the clinical influence and underlying mechanisms of a family’s expressed emotion (EE). EE generally consists of criticism, hostility, and emotional over-involvement, and is an important predictor of outcome for a wide range of mental health problems [12, 16, 17]. Although previous studies examined the relationship between EE and symptoms and functioning of patients [18, 19], many did not differentiate the components of EE. However, critical components (i.e., criticism and hostility) and emotional over-involvement are known to be functionally different, at least in the early phase of mental illness [11, 2022]. Among the three components of EE, criticism is regarded as the principal component [17] and impacts negatively the course of psychotic illness. Receiving criticism from family members in the early stages of schizophrenia is known to be associated with the number of relapses and the severity positive symptoms over time [23], and family criticism in patients with ARMS predicts an increase in positive symptoms over time [7]. Thus, it seems reasonable to investigate separately the link between criticism and relevant variables in the early phase of mental illness, to prevent the negative effect of criticism in this early stage.

Among such variables, distress or burden of families [2, 4, 24] appear important in the early course of psychosis. Family members who care for people with mental illness experience psychological distress, including depression, anxiety, feelings of loss, and embarrassment [2527]. Some family members may also show psychiatric symptoms equivalent to psychiatric disorders themselves [4, 25, 2830] and the distress of families might be stronger earlier in the course of psychosis [31]. Previous studies have demonstrated that the distress of family members of individuals with schizophrenia is linked to EE [2, 25, 30], and several studies have showed that emotional over-involvement, but not criticism, is linked to distress within the family of those with FEP [11, 21, 32]. In contrast, one study recently demonstrated that criticism is also linked to the burden of families of those of early psychosis within 3 years of FEP [33]. Therefore, it remains inconclusive as to whether criticism is associated with the distress or burden of families of FEP. Further, research on the family environment of individuals with ARMS is in its infancy. Thus, despite the importance of families in the care of patients with ARMS, no studies have examined possible links between criticism and distress of caregivers of people with ARMS.

Another important variable that could affect criticism is patients’ symptoms. Although one might expect families to be more critical when patients are more symptomatic, findings across studies of FEP and ARMS are inconsistent. Some studies have found associations between criticism and symptoms of patients with FEP [9, 34, 35], but others did not [11]. Similarly, although one study found an association between criticism and symptoms of patients with ARMS [9], another did not [36].

To understand the complex links between EE and various relevant variables, and differences in the family environment between ARMS and FEP, this study examined criticism, distress of caregivers, other patients’, and caregivers’ variables, and links between criticism and these variables in FEP and ARMS. In particular, we were interested in whether the depression of family members and symptoms of patients were associated with family criticism toward patients with ARMS or FEP, and whether these associations differed between ARMS and FEP families.

Materials and Methods


Patients with ARMS and FEP were recruited through the Sendai ARMS and first episode (SAFE) clinic, which is a specialized clinic in the Department of Psychiatry, Tohoku University Hospital in Sendai, Japan [37, 38]. All participants were recruited by a psychiatrist of the SAFE clinic and were required to be Japanese speaking and between the ages of 15 and 35 years old. General exclusion criteria included any history of neurological disorder, head trauma with loss of consciousness, mental retardation by the Diagnostic and Statistical Manual of Mental Disorders IV Text Revision (DSM-IV-TR) criteria [39], or substance abuse or addiction within 1 year of recruitment. This study was conducted according to the principles of the Declaration of Helsinki and approved by the Ethics Committee of Tohoku University Graduate School of Medicine and Tohoku University Hospital. All caregivers and patients provided written informed consent. If patients were under 18 years of age, parents provided written informed consent and the participant gave written assent.

ARMS cohort.

Patients with ARMS met one or more of the following ultra-high risk criteria [40, 41] for: (i) attenuated psychotic symptoms; (ii) brief, limited intermittent psychotic symptoms; or, (iii) state and trait risk factors (a recent decline in functioning, plus a first-degree relative with either psychosis or a schizotypal personality disorder). Attenuated psychotic symptoms were assessed using a previously validated Japanese version [42] of the Comprehensive Assessment of ARMS (CAARMS) [43], a semi-structured interview tool designed to evaluate psychopathology and determine whether the ultra-high risk criteria are met [42]. Exclusion criteria for ARMS were (i) history of previous psychotic disorder or manic episodes that fulfilled the diagnostic criteria of bipolar I disorder specified in the DSM-IV-TR [39]; (ii) patients with a serious risk of suicide or violence due to personality disorder.

FEP cohort.

Individuals with FEP met the CAARMS-J criteria for psychosis [44]. In addition, each had a Positive and Negative Syndrome Scale [45] score of 4 or more, with positive scale items of delusion, hallucinatory behavior, grandiosity, or suspiciousness, or general scale items of unusual thought content for more than 1 week.


Primary caregivers were defined as close relatives responsible for the care of the individuals with ARMS or FEP, and included parents, spouses, and other relatives. If there was more than one caregiver, they were asked to determine who was the most involved in providing care to the patients.


Participants were consecutively recruited between July 2008 and March 2015. During the period of study, 151 patients (78 ARMS and 73 FEP) met the eligibility criteria. Sixteen patients (8 ARMS and 8 FEP) did not have proper caregivers nearby. Among the caregivers of the remaining 135 patients, those of 99 (73%) patients (56 ARMS and 43 FEP) consented to participate in this study.


Both patients and their caregivers were assessed within 1 month of intake by one of psychiatrists of the SAFE clinic who had sufficient experience of seeing patients with ARMS and FEP, and who had been trained as a clinical researcher more than 3 years, and was familiar with all of the instruments used in this study.

Assessment of patients.

Psychopathological symptoms associated with psychotic illness were assessed using the Positive and Negative Syndrome Scale (PANSS, [45]), a 30-item scale with three symptom subscales: positive, negative, and general. The extensively used Japanese version of PANSS was translated and applied by Yamada et al. [46, 47]. Global functioning was assessed using the Global Assessment of Functioning (GAF) scale, and the current level of social and occupational functioning was assessed using the Social and Occupational Functioning Assessment Scale (SOFAS), which is included in the DSM-IV-TR[39].

Assessment of caregivers.

Criticism was assessed by means of the Family Attitude Scale (FAS, [48, 49]), which was validated in a Japanese sample by Fujita et al. [48]. The FAS is a self-report measure of critical comments by family members, consisting of 30 questions (e.g., ‘I wish he were not here’; ‘He is a real burden’; ‘I find myself saying nasty or sarcastic things to him’), using a Likert scale rating from 0 (never) to 4 (everyday). Thus, FAS scores are in the range 0–120, with higher scores indicating higher levels of criticism. Compared with the Camberwell Family Interview (CFI), a standard interview method for EE assessment, the sensitivity and specificity of the Japanese FAS to detect high criticism were 100% and 88.5%, respectively, using a cut-off point of 60 [48]. This cut-off was used for the present study.

Caregiver depressive symptoms were assessed through the 21-item self-report Beck Depression Inventory, 2nd edition (BDI-II, [50]), with scores in the range 0–63. Severity of depression was categorized into 4 levels: normal to minimal (0–13), mild (14–19), moderate (20–28), and severe (29–63) [51]. The reliability and validity of the Japanese version of the BDI-II has been established by Kojima et al. [52].

Statistical analysis

For continuous variables, the statistical significance of differences between groups was assessed with Student t-tests if variances were normally distributed, and otherwise with Mann-Whitney U-tests. Categorical variables were analyzed using chi-square tests. Bivariate correlations were performed to examine associations of the FAS score with the BDI-II, PANSS, GAF, and SOFAS scores, and with demographic data. To determine which variables best predicted the FAS score, a series of stepwise regression analyses were performed. Statistical differences were determined using two-tailed tests and a significance level of p < 0.05. All statistical analyses were performed using the Statistical Package for the Social Sciences (SPSS) 20.0 for Windows (SPSS Inc., Chicago, Illinois).


Sample characteristics

The demographic and clinical data of patients are presented in Table 1. Both patient groups were predominantly female (ARMS 68% vs. FEP 67%). Those with ARMS were younger and had a lower educational level than patients with FEP. Of the 56 patients with ARMS, 86% (n = 48) were classified into the attenuated psychotic symptoms group, 4% (n = 2) were classified into the brief limited intermittent psychotic symptoms group, 9% (n = 5) were classified into a group of both attenuated psychotic symptoms and state and trait risk factors, and 2% (n = 1) were classified into a group of both attenuated psychotic symptoms and brief limited intermittent psychotic symptoms. The FEP group consisted of schizophrenia (n = 28), schizophreniform disorder (n = 4), bipolar disorder with psychotic features (n = 3), delusional disorder (n = 1), brief psychotic disorder (n = 1), and psychosis not otherwise specified (n = 6) according to the DSM-IV-TR [39]).

Table 1. Baseline Characteristics of Patients with At-risk Mental State (ARMS) and First-episode Psychosis (FEP).

More patients with ARMS lived with their caregivers than patients with FEP, and most patients were students or employed. Total PANSS scores as well as positive symptoms, negative symptoms, general psychopathology, and global and social functioning were worse in individuals with FEP than those with ARMS.

The demographic data of caregivers is presented in Table 2. The study enrolled 56 caregivers of patients with ARMS and 43 caregivers of patients with FEP. There were no differences in age and educational level between these groups, but mothers were more likely to be the primary caregivers than fathers (ARMS 75% vs. FEP 81%).

Table 2. Baseline Characteristics of Caregivers of Patients with At-risk Mental State (ARMS) and First-episode Psychosis (FEP).

FAS and BDI-II scores of caregivers

Caregivers of ARMS and FEP patients differed in neither the mean FAS scores nor the proportion given high criticism. The mean BDI-II scores were comparable; the proportion of mild-to-moderate depression [51] was 30.3% (n = 17) in caregivers of ARMS patients and 23.8% (n = 10) in caregivers of FEP patients. However, only 1 (1.8%) and 3 (7.3%) caregivers of ARMS and FEP patients, respectively, presented severe depressive symptomatology.

Relationship between FAS and variables in caregivers and patients

Criticism of FEP caregivers was correlated with depression of the caregivers and patients’ negative and general psychopathology symptoms (Table 3). In contrast, the criticism of ARMS caregivers was only correlated with the educational levels of caregivers.

Table 3. Correlations Between FAS Scores and Patients’ Clinical and Functional Variables, Caregivers’ Depressive Symptoms, and Demographic Variables.

The comparison of correlation coefficients between ARMS and FEP groups (Table 4) revealed that the correlation between criticism and depression of the caregiver was significantly larger in the FEP than the ARMS group. Although the correlations between criticism and patients’ symptoms did not differ between the two groups, those between criticism and the patients’ negative symptoms approached significance, with a tendency toward larger correlations in the FEP than the ARMS group. The correlation between criticism and the educational level of the caregivers was significantly larger in the ARMS than the FEP group.

Regression analysis revealed that in the ARMS group FAS scores were only explained by the educational level of the caregiver (adjusted R2 = 0.19, multiple R = 0.46, F (1, 44) = 11.58, p = .001), which made a significant independent contribution when all variables were considered simultaneously (β = 0.46, B = 4.98, p = .001). In the FEP group, FAS scores were explained by the BDI-II scores of caregivers and the general psychopathology scores of PANSS (adjusted R2 = 0.46, multiple R = 0.70, F (2, 30) = 14.39, p < .001). Both made significant independent contributions when all of the variables were considered simultaneously (depressive symptoms of caregiver: β = 0.47, B = 0.96, p = .001; general psychopathology score: β = 0.42, B = 0.71, p = .004).


The present study examined family environmental variables that may be linked with criticism of patients by caregivers and found that links between criticism, patients’ symptoms, and caregivers’ depression were observed in FEP caregivers but not in ARMS caregivers.

The finding that criticism by caregivers was associated with their depressive symptoms in the FEP group is consistent with earlier research that uncovered correlations between criticism and depression, and anxiety, in caregivers of individuals with early psychosis who were within 3 years of first psychosis episode [33]. In contrast, criticism by ARMS caregivers was not associated with their depressive symptoms. Although the level of criticism and depression was comparable among ARMS and FEP caregivers, the link of criticism with caregiver depression was only observed in the FEP caregivers. This suggests that the interaction between the emotional distress of caregivers and criticism might only be observed after the onset of psychosis, i.e., not at the at-risk stage. Generally, individuals with FEP present more severe symptoms than those with ARMS, and FEP caregivers have typically been involved in a patient’s illness longer than ARMS caregivers. Thus, the interaction between criticism and caregiver distress may develop during the course of the illness. This notion is consistent with the repeatedly replicated finding of an association between criticism and duration of untreated psychosis in patients with FEP [11, 53]. EE was hypothesized to be an adaptive reaction to perceived loss [53] or a coping strategy to reduce the perceived stressfulness of the caring role [18]. Therefore, the present finding of an association between criticism and depression in the FEP families implies that interventions to reduce the burden and distress of the family may be effective to prevent maladaptive reactions or coping of families, and thus reduce the risk of increasing criticism of patients with early psychosis by their families.

In the present study, criticism was associated with patients’ general symptoms in FEP caregivers. Although there was an association between criticism and patients’ negative symptoms in the correlation analysis, the association was not present in the regression analysis. The association between families’ criticism and general symptoms other than positive and negative symptoms of FEP patients is consistent with previous studies [9, 33]. According to the attribution model of EE [3, 54], criticism would be associated with caregivers’ attribution style. Therefore, FEP caregivers may view general symptoms such as anxiety and behavioral problems as more controllable and reactive factors, rather than being indicative of an underlying illness [55]. In contrast to FEP caregivers, criticism was not associated with any symptoms in ARMS patients. This suggests that the interaction between criticism and symptoms of patients develops after psychosis is established. However, the finding contradicts a previous study [9] that found associations of criticism with positive, negative, and general symptoms of patients in a mixed sample of ARMS and FEP, with no group differences, suggesting that criticism and patients’ symptoms might interact even during the at-risk stage. The partially inconsistent findings between the present and the previous study [9] may lie in the different symptom characteristics of patients with ARMS and FEP. In the previous study, in contrast to the present study, there was no difference in positive and negative symptoms between ARMS and FEP groups, and general symptoms were more severe in ARMS than FEP [9]. Differences in symptom characteristics could reasonably affect the interaction of criticism with patients’ symptoms.

Contrary to our expectation, the education level of ARMS caregivers was moderately associated with criticism. Although the precise reason is unclear, we speculate that parents with a high educational level have high expectations of their child’s ability to control his or her illness and behavior; thus the parents become more critical [2022, 56]. More research is necessary to determine what factors mediate this relationship.

Several methodological limitations are apparent in this study. First, the sample size was relatively small and the number of caregivers was also small, which may restrict the generalizability of the findings. Second, we only measured criticism using self-report ratings and did not rate other EE components such as emotional over-involvement and hostility. Therefore, the results should be replicated using comprehensive interview-based ratings (e.g., the CFI). Finally, the cross-sectional study design limits extrapolation of the findings beyond the time of the investigation. A longitudinal follow-up study should examine whether criticism and distress among caregivers can predict outcomes among patients with FEP and ARMS.


According to the present findings, family interventions for FEP should focus preferentially on the understanding of, and efforts to alleviate, the distress and burden of families. In addition, because ARMS caregivers had depressive symptoms equivalent to FEP caregivers, and the link between criticism and family depression had been established before the initial treatment of FEP, interventions should be also provided for caregivers of patients with ARMS. Moreover, education that promotes the understanding of caregivers regarding general symptoms and negative symptoms of patients should be more important for FEP caregivers. Interventions for the caregivers should be tailored to the patient’s specific stage of illness and should target the emotional distress of caregivers. Moreover, interventions should aim to prevent exacerbation of the criticism of patients by their caregivers during early psychosis. Such an approach would reduce the burden of disease for both the patient and caregiver.

Supporting Information


We would like to thank Dr. H. Fujita for providing us with the Japanese version of the FAS, Editage ( for English language editing, and all the participants and the staff of the SAFE clinic.

Author Contributions

Conceived and designed the experiments: KM YH. Performed the experiments: KM NO MK TM FI CO TK. Analyzed the data: YH. Contributed reagents/materials/analysis tools: YH MK NO CO. Wrote the paper: KM YH. Managed the project: HM.


  1. 1. Tienari P, Wynne LC, Laksy K, Moring J, Nieminen P, Sorri A, et al. Genetic boundaries of the schizophrenia spectrum: evidence from the Finnish Adoptive Family Study of Schizophrenia. Am J Psychiatry. 2003;160(9):1587–94. pmid:12944332
  2. 2. Scazufca M, Kuipers E. Links between expressed emotion and burden of care in relatives of patients with schizophrenia. Br J Psychiatry. 1996;168(5):580–7. pmid:8733796
  3. 3. Hooley JM. Expressed emotion and relapse of psychopathology. Annu Rev Clin Psychol. 2007;3:329–52. pmid:17716059
  4. 4. Kuipers E, Raune D. The early development of expressed emotion and burden in the families of first-onset psychosis. In: Birchwood M, Fowler D, Jackson C, editors. Early intervention in psychosis. Chicester: John Wiley Sons Ltd; 2000. p. 128–40.
  5. 5. Addington J, Coldham EL, Jones B, Ko T, Addington D. The first episode of psychosis: the experience of relatives. Acta Psychiatr Scand. 2003;108(4):285–9. pmid:12956829
  6. 6. McFarlane WR, Cook WL. Family expressed emotion prior to onset of psychosis. Fam Process. 2007;46(2):185–97. pmid:17593884
  7. 7. Schlosser DA, Zinberg JL, Loewy RL, Casey-Cannon S, O'Brien MP, Bearden CE, et al. Predicting the longitudinal effects of the family environment on prodromal symptoms and functioning in patients at-risk for psychosis. Schizophr Res. 2010;118(1–3):69–75. pmid:20171848
  8. 8. Meneghelli A, Alpi A, Pafumi N, Patelli G, Preti A, Cocchi A. Expressed emotion in first-episode schizophrenia and in ultra high-risk patients: results from the Programma2000 (Milan, Italy). Psychiatry Res. 2011;189(3):331–8. pmid:21529969
  9. 9. Dominguez-Martinez T, Medina-Pradas C, Kwapil TR, Barrantes-Vidal N. Relatives illness attributions mediate the association of expressed emotion with early psychosis symptoms and functioning. Psychiatry Res. 2014;218(1–2):48–53. pmid:24768246
  10. 10. National Institute for Health and Clinical Excellanece. Psychosis and schizophrenia in adults: prevention and management. London: National Institute for Health and Clinical Excellaence. 2014; CG178.
  11. 11. Alvarez-Jimenez M, Gleeson JF, Cotton SM, Wade D, Crisp K, Yap MB, et al. Differential predictors of critical comments and emotional over-involvement in first-episode psychosis. Psychol Med. 2010;40(1):63–72. pmid:19079825
  12. 12. Butzlaff RL, Hooley JM. Expressed emotion and psychiatric relapse: a meta-analysis. Arch Gen Psychiatry. 1998;55(6):547–52. pmid:9633674
  13. 13. Gleeson J, Jackson HJ, Stavely H, Burnett P. Family intervention in early psychosis. In: McGorry PD, Jackson HJ, editors. The Recognition and Management of Early Psychosis. New York: Cambridge University Press; 1999; p.376–406.
  14. 14. Linszen D, Dingemans P, Van der Does JW, Nugter A, Scholte P, Lenior R, et al. Treatment, expressed emotion and relapse in recent onset schizophrenic disorders. Psychol Med. 1996;26(2):333–42. pmid:8685289
  15. 15. Pilling S, Bebbington P, Kuipers E, Garety P, Geddes J, Orbach G, et al. Psychological treatments in schizophrenia: I. Meta-analysis of family intervention and cognitive behaviour therapy. Psychol Med. 2002;32(5):763–82. pmid:12171372
  16. 16. Vaughn C, Leff J, Sarner M. Relatives' expressed emotion and the course of inflammatory bowel disease. J Psychosom Res. 1999;47(5):461–9. pmid:10624844
  17. 17. Wearden AJ, Tarrier N, Barrowclough C, Zastowny TR, Rahill AA. A review of expressed emotion research in health care. Clin Psychol Rev. 2000;20(5):633–66. pmid:10860170
  18. 18. Raune D, Kuipers E, Bebbington PE. Expressed emotion at first-episode psychosis: investigating a carer appraisal model. Br J Psychiatry. 2004;184:321–6. pmid:15056576
  19. 19. Kuipers E, Bebbington P, Dunn G, Fowler D, Freeman D, Watson P, et al. Influence of carer expressed emotion and affect on relapse in non-affective psychosis. Br J Psychiatry. 2006;188:173–9. pmid:16449706
  20. 20. Brewin CR, MacCarthy B, Duda K, Vaughn CE. Attribution and expressed emotion in the relatives of patients with schizophrenia. J Abnorm Psychol. 1991;100(4):546–54. pmid:1757668
  21. 21. McNab C, Haslam N, Burnett P. Expressed emotion, attributions, utility beliefs, and distress in parents of young people with first episode psychosis. Psychiatry Res. 2007;151(1–2):97–106. pmid:17376540
  22. 22. Vasconcelos ESD, Wearden A, Barrowclough C. Expressed emotion, types of behavioural control and controllability attributions in relatives of people with recent-onset psychosis. Soc Psychiatry Psychiatr Epidemiol. 2013.
  23. 23. Cechnicki A, Bielanska A, Hanuszkiewicz I, Daren A. The predictive validity of expressed emotions (EE) in schizophrenia. A 20-year prospective study. J Psychiatr Res. 2013;47(2):208–14. pmid:23158233
  24. 24. Smith J, Birchwood M, Cochrane R, George S. The needs of high and low expressed emotion families: a normative approach. Soc Psychiatry Psychiatr Epidemiol. 1993;28(1):11–6. pmid:8465236
  25. 25. Barrowclough C, Tarrier N, Johnston M. Distress, expressed emotion, and attributions in relatives of schizophrenia patients. Schizophr Bull. 1996;22(4):691–702. pmid:8938922
  26. 26. Lowyck B, De Hert M, Peeters E, Wampers M, Gilis P, Peuskens J. A study of the family burden of 150 family members of schizophrenic patients. Eur Psychiatry. 2004;19(7):395–401. pmid:15504645
  27. 27. Magliano L, Fiorillo A, De Rosa C, Malangone C, Maj M. Family burden in long-term diseases: a comparative study in schizophrenia vs. physical disorders. Soc Sci Med. 2005;61(2):313–22. pmid:15893048
  28. 28. Dyck DG, Short R, Vitaliano PP. Predictors of burden and infectious illness in schizophrenia caregivers. Psychosom Med. 1999;61(4):411–9. pmid:10443748
  29. 29. Steele A, Maruyama N, Galynker I. Psychiatric symptoms in caregivers of patients with bipolar disorder: a review. J Affect Disord. 2010;121(1–2):10–21. pmid:19443040
  30. 30. Shimodera S, Mino Y, Inoue S, Izumoto Y, Fujita H, Ujihara H. Expressed emotion and family distress in relatives of patients with schizophrenia in Japan. Compr Psychiatry. 2000;41(5):392–7. pmid:11011837
  31. 31. Martens L, Addington J. The psychological well-being of family members of individuals with schizophrenia. Soc Psychiatry Psychiatr Epidemiol. 2001;36(3):128–33. pmid:11465784
  32. 32. Jansen JE, Harder S, Haahr UH, Lyse HG, Pedersen MB, Trauelsen AM, et al. The Role of Metacognitions in Expressed Emotion and Distress: A Study on Caregivers of Persons with First-Episode Psychosis. Clin Psychol Psychother. 2014.
  33. 33. Tomlinson E, Onwumere J, Kuipers E. Distress and negative experiences of the caregiving relationship in early psychosis: does social cognition play a role? Early intervention in psychiatry. 2014;8(3):253–60. pmid:23489370
  34. 34. King S. Is expressed emotion cause or effect in the mothers of schizophrenic young adults? Schizophr Res. 2000;45(1–2):65–78. pmid:10978874
  35. 35. Mo FYM, Chung WS, Wong SW, Chun DYY, Wong KS. Expressed Emotion in Relatives of Chinese Patients with First-Episode Psychosis in Hong Kong. Hong Kong J Psychiatry. 2007;17(2):38–44.
  36. 36. O'Brien MP, Gordon JL, Bearden CE, Lopez SR, Kopelowicz A, Cannon TD. Positive family environment predicts improvement in symptoms and social functioning among adolescents at imminent risk for onset of psychosis. Schizophr Res. 2006;81(2–3):269–75. Epub 2005 Nov 23. pmid:16309893
  37. 37. Mizuno M, Nemoto T, Tsujino N, Funatogawa T, Takeshi K. Early psychosis in Asia: insights from Japan. Asian J Psychiatr. 2012;5(1):93–7.
  38. 38. Katsura M, Ohmuro N, Obara C, Kikuchi T, Ito F, Miyakoshi T, et al. A naturalistic longitudinal study of at-risk mental state with a 2.4 year follow-up at a specialized clinic setting in Japan. Schizophr Res. 2014;158(1–3):32–8. pmid:25034763
  39. 39. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (4th ed. text revision). Washington, DC: American Psychiatric Association 2000.
  40. 40. Yung AR, McGorry PD, McFarlane CA, Jackson HJ, Patton GC, Rakkar A. Monitoring and care of young people at incipient risk of psychosis. Schizophr Bull. 1996;22(2):283–303. pmid:8782287
  41. 41. Yung AR, Phillips LJ, Yuen HP, Francey SM, McFarlane CA, Hallgren M, et al. Psychosis prediction: 12-month follow up of a high-risk ("prodromal") group. Schizophr Res. 2003;60(1):21–32. pmid:12505135
  42. 42. Miyakoshi T, Matsumoto K, Ito F, Ohmuro N, Matsuoka H. Application of the Comprehensive Assessment of At-Risk Mental States (CAARMS) to the Japanese population: reliability and validity of the Japanese version of the CAARMS. Early intervention in psychiatry. 2009;3(2):123–30. pmid:21352185
  43. 43. Yung AR, Yuen HP, McGorry PD, Phillips LJ, Kelly D, Dell'Olio M, et al. Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental States. Aust N Z J Psychiatry. 2005;39(11–12):964–71. pmid:16343296
  44. 44. Yung AR, Phillips LJ, McGorry PD, McFarlane CA, Francey S, Harrigan S, et al. Prediction of psychosis. A step towards indicated prevention of schizophrenia. Br J Psychiatry Suppl. 1998;172(33):14–20. pmid:9764121
  45. 45. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 1987;13(2):261–76. pmid:3616518
  46. 46. Kay SR, Opler LA, Fiszbein A. Positive and negative symdrome scale. Tronto, Canada: Multi-Health System Inc.; 1991.
  47. 47. Yamada H, Masui K, Kikumoto K. Positive and Negative Syndrome Scale (PANSS) Rating Manual. Tokyo: Seiwa Shoten; 1991.
  48. 48. Fujita H, Shimodera S, Izumoto Y, Tanaka S, Kii M, Mino Y, et al. Family attitude scale: measurement of criticism in the relatives of patients with schizophrenia in Japan. Psychiatry Res. 2002;110(3):273–80. pmid:12127477
  49. 49. Kavanagh DJ, O'Halloran P, Manicavasagar V, Clark D, Piatkowska O, Tennant C, et al. The Family Attitude Scale: reliability and validity of a new scale for measuring the emotional climate of families. Psychiatry Res. 1997;70(3):185–95. pmid:9211580
  50. 50. Beck A, Steer R, Brown G. Beck Depression Inventory-II (BDI-II). The Psychological Corporation. San Antonio, TX. 1996;1996.
  51. 51. Beck AT, Steer RA, Ball R, Ranieri W. Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients. J Pers Assess. 1996;67(3):588–97. pmid:8991972
  52. 52. Kojima M, Furukawa TA, Takahashi H, Kawai M, Nagaya T, Tokudome S. Cross-cultural validation of the Beck Depression Inventory-II in Japan. Psychiatry Res. 2002;110(3):291–9. pmid:12127479
  53. 53. Patterson P, Birchwood M, Cochrane R. Expressed emotion as an adaptation to loss: prospective study in first-episode psychosis. Br J Psychiatry Suppl. 2005;48:s59–64. pmid:16055810
  54. 54. Hooley JM. Expressed emotion and locus of control. J Nerv Ment Dis. 1998;186(6):374–8. pmid:9653423
  55. 55. Clarke K, Couchman G. Caregiver causal attributions in youth psychosis. Early intervention in psychiatry. 2012;6(3):309–16. pmid:22225619
  56. 56. Hooley JM, Campbell C. Control and controllability: beliefs and behaviour in high and low expressed emotion relatives. Psychol Med. 2002;32(6):1091–9. pmid:12216554