S1 File. Includes supplemental patient data; supplemental materials, methods, and patient selection methodology; supplemental results; supplement references, and 12 tables.
Table A. Exclusion criteria for genetic testing in patients with a first degree relative with a pacemaker. Table B. HaloPlex NGS depth of coverage for Coriell and pacemaker samples.Table C. Selected HGMD and nonHGMD VUSs in pacemaker patients. Table D. Pacemaker variants filtering analysis and classification (number of variants). Table E. HGMD variants with disease association in pacemaker patients. Table F. Major co-morbidities at the time of pacemaker implantation in patients with ICCD or SSS without structural heart disease. Table G. Variant annotation file description. Table H. HGMD initial variant classification. Table I.Primers for Sanger/Big Dye variant confirmation. Table J. HaloPlex intra-run performance.Table K. Overall Performance of SNP variant calling in genotype known Coriell samples. Table L. Selective analyses of SNP performance in Coriell samples.
Citation: Celestino-Soper PBS, Doytchinova A, Steiner HA, Uradu A, Lynnes TC, Groh WJ, et al. (2016) Correction: Evaluation of the Genetic Basis of Familial Aggregation of Pacemaker Implantation by a Large Next Generation Sequencing Panel. PLoS ONE 11(1): e0147455. https://doi.org/10.1371/journal.pone.0147455
Published: January 15, 2016
Copyright: © 2016 Celestino-Soper et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.