(A) Amino acid sequence alignment of the proximal C-terminal residues in human TRPV1-TRPV6. (B) Whole protein transmembrane view of the apo-state TRPV1 channels helical TRP domain interacting with the 18 carbon LC-CoA stearoyl CoA. (C) Synaptic view of the helical TRP domains basic residues R702 and K711 interacting with the 18 carbon LC-CoA stearoyl CoA. All molecular modeling is based on the 3.4 Å resolution TRPV1 structure determined by electron cryo-microscopy (PDB# 3J5P,,). Analysis was performed using Pymol software.
Citation: The PLOS ONE Staff (2015) Correction: Intracellular Long-Chain Acyl CoAs Activate TRPV1 Channels. PLoS ONE 10(2): e0118385. https://doi.org/10.1371/journal.pone.0118385
Published: February 17, 2015
Copyright: © 2015 The PLOS ONE Staff. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited