The impact of postoperative delirium on post-discharge functional status of older patients remains unclear, and little is known regarding the interrelationship between cognitive impairment and post-operative delirium. Therefore, the main purpose was to evaluate the post-discharge functional status of patients who experience delirium after undergoing orthopaedic surgery and the interrelationship of postoperative delirium with underlying cognitive impairment.
This prospective cohort study, conducted at a tertiary care medical center from April 2011 to March 2012, enrolled all subjects aged over 60 years who were admitted for orthopaedic surgery. The baseline characteristics (age, gender, BMI, and living arrangement), surgery-related factors (ASA class, admission type, type of surgery, and length of hospital stay), results of geriatric assessment (postoperative delirium, cognition, depressive mood, comorbidity, pain, malnutrition, polypharmacy, ADL, and instrumental [I]ADL) and 1–12-month postoperative ADL and IADL functional status were collected for analysis.
Overall, 9.1% of 232 patients (mean age: 74.7±7.8 years) experienced postoperative delirium, which was significantly associated with IADL decline at only 6 and 12 months postoperatively (RR: 6.22, 95% CI: 1.08–35.70 and RR: 12.54, 95% CI: 1.88–83.71, respectively). Delirium superimposed on cognitive impairment was a significant predictor for poor functional status at 6 and 12 months postoperatively (RR: 12.80, 95% CI: 1.65–99.40 for ADL at the 6th month, and RR: 7.96, 95% CI: 1.35–46.99 at the 12th month; RR: 13.68, 95% CI: 1.94–96.55 for IADL at the 6th month, and RR: 30.61, 95% CI: 2.94–318.54 at the 12th month, respectively).
Postoperative delirium is predictive of IADL decline in older patients undergoing orthopaedic surgery, and delirium superimposed on cognitive impairment is an independent risk factor for deterioration of ADL and IADL functional status. Early identification of cognitive function and to prevent delirium are needed to improve functional status following orthopaedic surgery.
Citation: Liang C-K, Chu C-L, Chou M-Y, Lin Y-T, Lu T, Hsu C-J, et al. (2014) Interrelationship of Postoperative Delirium and Cognitive Impairment and Their Impact on the Functional Status in Older Patients Undergoing Orthopaedic Surgery: A Prospective Cohort Study. PLoS ONE 9(11): e110339. https://doi.org/10.1371/journal.pone.0110339
Editor: Stephen D. Ginsberg, Nathan Kline Institute and New York University School of Medicine, United States of America
Received: April 25, 2014; Accepted: September 15, 2014; Published: November 17, 2014
Copyright: © 2014 Liang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: The authors confirm that all data underlying the findings are fully available without restriction. Data are available from the Kaohsiung Veterans General hospital Institutional Data Access / Ethics Committee for researchers who meet the criteria for access to confidential data.
Funding: This work was supported by grants from the Veteran Affairs Commission of Taiwan. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
Delirium is an acute mental disorder that is characterized by rapid onset and a fluctuating course of consciousness disturbance and inattention, possibly leading to further adverse health consequences in the elderly population . Although delirium is a well-recognized geriatric syndrome, it is often overlooked by clinicians and nurses , . The incidence of delirium following orthopaedic surgery has been reported to be 4–65%. Considerable variation is seen and is dependent on the type of procedure, with the reported incidence being 35–65% in patients undergoing operative treatment of a hip fracture and 9–15% in patients undergoing elective orthopaedic procedures , . Risk factors for the development of postoperative delirium in older patients include older age, cognitive impairment, depressed mood, poor baseline physical function, comorbid diseases, type of surgery, and institutionalization before admission –. Although delirium is a common geriatric syndrome, its etiopathogenesis remains unclear. However, preventive strategies focused on early identification and management of risk factors are believed to be superior to strategies that emphasize treatment of delirium after it occurs –.
Delirium subsequent to surgery is associated with higher rates of in-hospital and long-term mortality –, as well as longer hospital stay, longer intensive care unit stay, and higher chance of discharge to nursing facilities –, . Although the adverse impact of postoperative delirium has been clearly identified, the impact of postoperative delirium on long-term functional status remains unclear. Dementia or cognitive impairment has been reported as an independent risk factor for delirium , and the overall incidence of new delirium was significantly higher among older patients with dementia than among older patients with no dementia . Moreover, pre-fracture cognitive impairment and post-fracture delirium were also strongly associated with higher mortality rate and risk for institutionalization , , and delirium might be an early indicator for post-discharge cognitive decline , . Although it can result in long-term cognitive decline, postoperative cognitive decline secondary to delirium does not occur in all patients . To date, little is known regarding the interrelationship between delirium and cognitive impairment and their impact on adverse functional status in older patients. Therefore, the purpose of the present study was to evaluate the impact of postoperative delirium, in the presence of underlying cognitive impairment, on changes in the post-discharge functional status of patients who underwent orthopaedic surgery.
This prospective cohort study was conducted in a tertiary care medical center in Southern Taiwan. All subjects aged 60 years and older who were admitted for orthopaedic surgery during the period April 2011 to March 2012 were screened for this study. Patients were excluded for the following reasons: (1) medical conditions that prevented comprehensive geriatric assessment (CGA), or admission or transfer to an intensive care unit before enrollment, (2) inability to complete the comprehensive geriatric assessment (CGA), (3) inability to provide informed consent, (4) limited life expectancy less than 6 months such as in cancer and terminal stage heart failure cases, (5) delirium occurring before enrollment or surgery, and (6) incomplete data. The study protocol was approved by the Institutional Review Board of Kaohsiung Veterans General Hospital and written informed consents were obtained from all participants before the study started. During a one-year period, a total of 232 patients were enrolled with mean age of 74.7±7.8 years (range: 60–93). Among them, 28 (12.1%) patients were admitted to the hospital from the emergency department. The incidence of postoperative delirium was 9.1% (21/232).
Demographic data and surgery characteristics.
Two research nurses interviewed all participants to collect the pre-operative demographic data (including age, gender, educational level, living arrangement, and body mass index [BMI]), and data on other characteristics including admission type (emergency or elective surgery), type of surgery (including spinal decompression only, spinal surgery with instrumented fusion, total knee arthroplasty, other elective knee surgery, elective total hip arthroplasty [total hip replacement]/bipolar hemiarthroplasty, revision hip surgery, and open reduction and internal fixation [ORIF]/arthroplasty for hip fracture), ASA (American Society of Anesthesiologists) physical status, and length of hospital stay.
Comprehensive geriatric assessment (CGA).
All participants were assessed by trained research nurses using the CGA before preceding the orthopaedic operation, and within the first 24 hours after hospital admission from the outpatient clinics or emergency department. The assessment covered visual and hearing impairments, polypharmacy (defined as currently using >4 prescription drugs for over 2 weeks), depressive symptoms (using the 15-item Chinese Geriatric Depression Scale) , , nutritional status (as determined by the Mini Nutritional Assessment) , comorbidity (as evaluated by the Charlson's Comorbidity Index) , symptoms of pain (rated on a Visual Analogue Scale) , cognitive function (as assessed by the Chinese version of the Mini-Mental State Examination at admission) , the Activities of Daily Living (ADL, evaluated by the Barthel Index) , and the Lawton-Brody Instrumental ADL (IADL) .
Patients were screened for delirium daily by the primary care nurses in the orthopaedic wards after orthopaedic surgery using the Confusion Assessment Method (CAM) , and a senior psychiatrist would confirm the diagnosis if the patient was deemed to be confused. The research nurses obtained ADL and IADL scores by conducting telephone interviews of the participating patients or their primary caregivers at 1, 3, 6, and 12 months after hospital discharge.
Continuous data are expressed as means ± SD, and categorical data are expressed as percentages. Dichotomous and ordinal variables were compared in those with and without delirium using the Chi-square test or Fisher exact test, and continuous variables were compared using the independent Student t-test or Mann-Whitney U test when appropriate.
The independent Student t-test or Mann-Whitney U test were used to compare the ADL or IADL scores between groups based on delirium status at 1, 3, 6, and 12 months. The differences in mean ADL and IADL scores between those with and without delirium at different time points were evaluated using the Analysis of Covariance (ANCOVA) with the inclusion of baseline ADL or IADL scores as covariates. To compare functional changes at 1, 3, 6, and 12 months, ADL or IADL functional decline was defined as lower ADL or IADL score at follow-up than at baseline. Multivariable logistic regression analysis was performed to determine whether delirium was an independent predictor of ADL or IADL decline at follow-up. In this model, age, gender, admission type, type of surgery, hearing impairment, polypharmacy, cognitive impairment, depressive symptoms, BMI, high risk of malnutrition, Charlson's Comorbidity Index (CCI), symptoms of pain, ASA class, and hospital length of stay were entered as explanatory variables.
To evaluate the effect of cognitive problems on long-term functional status (ADL and IADL scores at 1, 3, 6, and 12 months follow-up), four categorical variables representing four groups were defined (no cognitive problem [group A]; cognitive impairment alone indicated by MMSE <24 [group B]; postoperative delirium superimposed on cognitive problems [group C], and delirium only [group D]). ANCOVA was used to compare the mean ADL and IADL scores between these four groups after adjusting for baseline ADL and IADL scores (the covariates). The independent effect of each categorical variable on ADL and IADL outcomes was assessed using multivariable logistic regression analysis after controlling for age, gender, admission type, type of surgery, hearing impairment, polypharmacy, cognitive impairment, depressive symptoms, BMI, high risk of malnutrition, CCI, symptoms of pain, ASA class, and hospital length of stay and baseline IADL or ADL scores as covariates. For all tests, a P value (two-tailed) less than 0.05 was considered statistically significant. All statistical analyses were performed using IBM SPSS version 21 (SPSS Inc., Chicago, IL).
The effect of delirium on functional status
Demographic characteristics of all 232 patients are summarized in Table 1. Fifty of the 232 patients were lost to follow up and therefore excluded from the evaluation of post-discharge functional status. The demographic characteristics of the excluded patients were similar to those of the enrolled patients except for age (77.0±8.7 years vs 74.1±7.4 years, p = 0.018) and BMI (25.2±4.5 vs 26.7±4.1 kg/m2, p = 0.015). The number of patients who underwent spinal decompression only, spinal surgery with instrumented fusion, total knee arthroplasty, other elective knee surgery, elective total hip replacement/bipolar hemiarthroplasty, revision hip surgery, and ORIF/arthroplasty for hip fracture was 7 (3.0%), 53 (22.8%), 92 (39.7%), 8 (3.4%), 31 (13.4%), 8 (3.4%), and 33 (14.2%), respectively. These procedures were grouped into four categories (elective spine surgery, elective knee surgery, elective hip arthroplasty, and ORIF/arthroplasty for hip fracture) for further analysis. Comparing the 50 patients lost to follow up with the 182 included patients, the delirium occurred in a similar proportion of both groups (8.0% [4/50] vs 9.3% [17/182]; data not shown), indicating that delirium did not increase the likelihood of loss to follow up.
At baseline, the 182 enrolled subjects (17 with delirium and 165 without delirium) had an ADL score of 85.9 (standard error [SE] = 4.81) vs 95.6 ([SE] = 0.80) and an IADL score of 4.4 ([SE] = 0.40) vs 5.8 ([SE] = 0.09; Table 2). Figure 1 shows the change in ADL and IADL scores over time after hospitalization for both groups. ADL and IADL scores were significantly different between those who developed post-operative delirium and those who did not. When controlling for baseline ADL, IADL scores remained significantly lower in patients who developed postoperative delirium than in those who did not. Table 3 shows the differences in ADL and IADL decline between the two groups at different follow-up times. Results of univariate logistic regression analysis identified delirium as a predictor of ADL decline at 6 and 12 months (p value: 0.036 vs 0.014), and IADL decline at 3, 6, and 12 months after surgery (p value: 0.033 vs 0.005 vs 0.001). In addition, multivariable logistic regression analysis identified delirium as a predictor of only IADL decline at 6 and 12 months (for IADL at 6 months, adjusted RR: 6.22, 95% CI:1.08–35.70, p value = 0.040; for IADL at 12 months, adjusted RR: 12.54, 95% CI: 1.88–83.71, p value = 0.009).
Impact of combined cognitive problems on functional status
The 182 included patients were divided into four groups based on delirium and cognitive status. The patients in group D (with delirium, but without baseline cognitive impairment) were excluded because of small sample size (N = 4). Baseline ADL and IADL scores were significantly different between patients with no cognitive problems (group A), and those with both baseline cognitive dysfunction and delirium (group C) or with baseline cognitive dysfunction only (group B; Table 4). In terms of the decline in ADL and IADL scores at 1, 3, 6, and 12 months of follow up, ANCOVA (after adjustment for baseline ADL and IADL values) found significant ADL and IADL decline only in group C (Figure 2). After controlling for confounders (Table 5), multivariable logistic regression still showed the tendency for ADL and IADL to decline in patients in group C at 6 and 12 months (Adjusted RR for ADL at 6 months: 12.80, 95% CI: 1.65–99.40; Adjusted RR for ADL at 12 months: 7.96, 95% CI: 1.35–46.99; Adjusted RR for IADL at 6 months: 13.68, 95% CI: 1.94–96.55; Adjusted RR for IADL at 12 months: 30.61, 95% CI: 2.94–318.54).
This prospective study investigated the effects of postoperative delirium on functional status (defined as decline in ADL and IADL scores) in patients who underwent orthopaedic surgery, and examined the interrelationship between underlying cognitive impairment and post-operative delirium. Postoperative delirium was an important predictor for poor IADL but not for poor ADL results. Moreover, delirium superimposed on cognitive problems was a stronger predictor of poor post-discharge functional status than cognitive impairment alone. The risk factors for the development of postoperative delirium identified in this study were in agreement with those identified by previous studies –. However, the incidence of postoperative delirium was lower in the present study than in previous studies, and the difference might be attributed to the higher percentage of elective surgery patients in our study (elective vs emergency surgery: 87.9% vs 12.1%). Moreover, patients in critical condition and unable to give their informed consent, such as some demented patients, were excluded from our study, thereby reducing the incidence of postoperative delirium.
Postoperative delirium had a strong adverse impact on IADL score after controlling for common geriatric problems, comorbidity, polypharmacy, and surgery-related conditions. A previous study reported that delirium had no significant effect on ADL score 6 months after surgery and attributed the relationship between delirium and mortality to some significant underlying medical problems . An association between postoperative delirium and change in functional status at the time of hospital discharge and/or during follow up has also been shown in past studies –. However, the focus of most of these studies is short-term functional status. Although Vida et al. reported that delirium had an adverse effect on long-term IADL functional status 18 months after hospitalization, the effect disappeared after controlling for confounders . In contrast to our results showing a relationship of postoperative delirium to IADL functional decline, those of Edelstein et al. demonstrated that decline in basic ADL but not IADL at 1-year follow-up was more likely in hip fracture surgery patients with postoperative delirium . All the patients in the study by Edelstein et al. underwent hip fracture surgery, which has a greater impact on postoperative delirium and functional status than elective orthopaedic surgery. Furthermore, our study placed more emphasis on geriatric problems as confounders, e.g., malnutrition, polypharmacy, mood status, and symptoms of pain, which impact the risk of postoperative delirium as well as postoperative function. To the best of our knowledge, this is the first study to demonstrate the adverse impact of postoperative delirium on post-discharge ADL and IADL functional status after controlling for most geriatric problems considered as potential confounders. The adverse impact of postoperative delirium in this study was more profound on the IADL than ADL score. The baseline ADL scores for patients developing postoperative delirium and not developing postoperative delirium (85.9±4.81 and 95.6±0.80, respectively) indicated only mild impairment. It implied that the adverse effect of postoperative delirium might be reduced in robust elderly patients. Moreover, the predictive effect of delirium on IADL functional status was only noted 6 and 12 months after surgery. Therefore, factors other than delirium might have a greater effect on short-term functional status of elderly patients undergoing orthopaedic surgery.
Although delirium alone is not predictive for ADL decline during follow-up (after adjusting for confounders such as MMSE), delirium superimposed on cognitive impairment was significantly associated with ADL and IADL decline after surgery. In addition, postoperative delirium was more likely to develop in patients with severe cognitive impairment than in patients with moderate cognitive impairment (mean MMSE scores: group A 26.7±1.8 vs group B 19.8±3.8 vs group C 16.0±4.2). Underlying cognitive impairment (MMSE score <24) alone was not associated with postoperative ADL and IADL decline. The effects of severe cognitive impairment and postoperative delirium were highly interactive. Recovery from postoperative functional impairment by elderly patients undergoing orthopaedic surgery was dependent on the cognitive ability to adhere to rehabilitation programs. Givens et al. reported that each additional cognitive or mood disorder was associated with a greater risk of poor functional status . Therefore, the results of this current study not only confirm the need to identify patients at risk for postoperative delirium, but also the highly interactive nature of the effects of baseline cognitive impairment and superimposed delirium on both ADL and IADL decline.
Despite the effort put into it, this study has several limitations. First, 21.6% (50/232) of the study subjects did not complete follow-up interviews. It has been reported that patients who experience delirium are more likely to miss follow-up appointments . Although the incidence of delirium and the demographic data were similar between patients who completed follow-up and those who did not, there may still be a high risk of systematic attrition bias. Followed-up patients may have poorer clinical outcomes, therefore, the impact of delirium on long-term functional status may be underestimated in these patients. Second, the incidence of postoperative delirium was lower in our study than in previously published studies. Though delirium in this study was detected by the CAM and confirmed by a senior psychiatrist, who avoided overestimation, underestimation was still possible because we excluded patients who were admitted or transferred to ICU or unable to give informed consent, e.g., demented patients. Third, although the baseline cognitive function (assessed on admission before orthopaedic surgery) may be influenced by fracture or pain and lead to overestimation of cognitive impairment, it was not a predictor of ADL and IADL decline in our studies. Fourth, use of a wide range of procedures (performed within a single anatomic region) will impact both the risk of delirium as well as postoperative functional status. Because there were few patients undergoing operations, such as spinal decompression only, other elective knee surgery, and revision hip surgery, we treated similar types of surgery as single covariates, grouping them into four categories (elective spine surgery, elective knee surgery, elective hip arthroplasty, and ORIF/arthroplasty for hip fracture). Further work is needed to investigate the link between postoperative delirium and functional status in patients undergoing orthopaedic surgery at single operative site.
In conclusion, this prospective study evaluated the impact of different cognitive factors on ADL and IADL decline in elderly people undergoing orthopaedic surgery, and it was noted that delirium superimposed on cognitive impairment strongly affects both long-term ADL and IADL functional status. Early identification of patients with baseline cognitive impairment and implementation of strategies to prevent delirium may reduce the likelihood of functional decline following orthopaedic surgery in older patients. Further study is needed to confirm this.
Our local Institutional Review Board approved the present study protocol. The study was supported by the Veteran Affairs Commission of Taiwan. All authors declare no conflicts of interest.
The authors would like to thank all staff in the Orthopaedic Department for their valuable assistance in collecting the delirium symptom data. We also wish to thank Mr. Zhao-Rong Li, Associate Professor, Department of Business Management, National Kaohsiung Normal University, for his statistical assistance.
Conceived and designed the experiments: CKL CLC YTL LKC. Performed the experiments: CKL CLC MYC TL CJH. Analyzed the data: CKL CLC LKC. Contributed reagents/materials/analysis tools: CLC MYC TL CJH. Wrote the paper: CKL YTL LKC.
- 1. Inouye SK (2006) Delirium in older persons. N Engl J Med 354: 1157–1165.
- 2. Élie M, Rousseau F, Cole M, Primeau F, McCusker J, et al. (2000) Prevalence and detection of delirium in elderly emergency department patients. CMAJ 163(8): 977–981.
- 3. Inouye SK, Foreman MD, Mion LC, Katz KH, Cooney LM Jr (2001) Nurses' recognition of delirium and its symptoms: comparison of nurse and researcher ratings. Arch Intern Med 161(20): 2467–2473.
- 4. Rudolph JL, Marcantonio ER (2011) Review articles: postoperative delirium: acute change with long-term implications. Anesth Analg 112: 1202–1211.
- 5. Gustafson Y, Berggren D, Brännström B, Bucht G, Norberg A, et al. (1988) Acute confusional states in elderly patients treated for femoral neck fracture. J Am Geriatr Soc 36: 525–530.
- 6. Schor JD, Levkoff SE, Lipsitz LA, Reilly CH, Cleary PD, et al. (1992) Risk factors for delirium in hospitalized elderly. JAMA 267: 827–831.
- 7. Levkoff SE, Evans DA, Liptzin B, Cleary PD, Lipsitz LA, et al. (1992) Delirium. The occurrence and persistence of symptoms among elderly hospitalized patients. Arch Intern Med 152: 334–340.
- 8. Wu CH, Chang CI, Chen CY (2012) Overview of studies related to geriatric syndrome in Taiwan. J Clin Gerontol Geriatr 3: 14–20.
- 9. Pompei P, Foreman M, Rudberg MA, Inouye SK, Braund V, et al. (1994) Delirium in hospitalized older persons: outcomes and predictors. J Am Geriatr Soc 42: 809–815.
- 10. Sanders RD, Pandharipande PP, Davidson AJ, Ma D, Maze M (2011) Anticipating and managing postoperative delirium and cognitive decline in adults. BMJ 343: d4331.
- 11. Chu CL, Liang CK, Lin YT, Chow PC, Pan CC, et al. (2011) Biomarkers of delirium: Well evidenced or not? J Clin Gerontol Geriatr 2: 100–104.
- 12. Inouye SK, Bogardus ST Jr, Charpentier PA, Leo-Summers L, Acampora D, et al. (1999) A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med 340: 669–676.
- 13. Marcantonio ER, Flacker JM, Wright RJ, Resnick NM (2001) Reducing delirium after hip fracture: a randomized trial. J Am Geriatr Soc 49: 516–522.
- 14. Rudolph JL, Jones RN, Rasmussen LS, Silverstein JH, Inouye SK, et al. (2007) Independent vascular and cognitive risk factors for postoperative delirium. Am J Med 120: 807–813.
- 15. Norkiene I, Ringaitiene D, Misiuriene I, Samalavicius R, Bubulis R, et al. (2007) Incidence and precipitating factors of delirium after coronary artery bypass grafting. Scand Cardiovasc J 41: 180–185.
- 16. Marcantonio ER, Flacker JM, Michaels M, Resnick NM (2000) Delirium is independently associated with poor functional recovery after hip fracture. J Am Geriatr Soc 48: 618–624.
- 17. Robinson TN, Raeburn CD, Tran ZV, Angles EM, Brenner LA, et al. (2009) Postoperative delirium in the elderly: risk factors and outcomes. Ann Surg 249: 173–178.
- 18. Koster S, Hensens AG, van der Palen J (2009) The long-term cognitive and functional outcomes of postoperative delirium after cardiac surgery. Ann Thorac Surg 87: 1469–1474.
- 19. Gottesman RF, Grega MA, Bailey MM, Pham LD, Zeger SL, et al. (2010) Delirium after coronary artery bypass graft surgery and late mortality. Ann Neurol 67: 338–344.
- 20. Lundstrom M, Edlund A, Bucht G, Karlsson S, Gustafson Y (2003) Dementia after delirium in patients with femoral neck fractures. J Am Geriatr Soc 51: 1002–1006.
- 21. Witlox J, Eurelings LS, de Jonghe JF, Kalisvaart KJ, Eikelenboom P, et al. (2010) Delirium in elderly patients and the risk of postdischarge mortality, institutionalization, and dementia: a meta-analysis. JAMA 304: 443–451.
- 22. Fick DM, Steis MR, Waller JL, Inouye SK (2013) Delirium superimposed on dementia is associated with prolonged length of stay and poor outcomes in hospitalized older adults. J Hosp Med 8: 500–505.
- 23. Steiner JF, Kramer AM, Eilertsen TB Kowalsky JC (1997) Development and validation of a clinical prediction rule for prolonged nursing home residence after hip fracture. J Am Geriatr Soc 45: 1510–1514.
- 24. Holmes J, House A (2000) Psychiatric illness predicts poor outcome after surgery for hip fracture: A prospective cohort study. Psychol Med 30: 921–929.
- 25. Francis J, Kapoor WN (1992) Prognosis after hospital discharge of older medical patients with delirium. J Am Geriatr Soc 40: 601–606.
- 26. Koponen H, Stenbäck U, Mattila E, Soininen H, Reinikainen K, et al. (1989) Delirium among elderly persons admitted to a psychiatric hospital: clinical course during the acute stage and one-year follow-up. Acta Psychiatr Scand 79: 579–585.
- 27. Liao YC, Yeh TL, Ko HC, Luoh CM, Lu HF (1995) Geriatric depression scale (GDS) – a preliminary report of reliability and validity for Chinese version. Changhua Med J 1: 11–17 (in Chinese).
- 28. Nyunt MS, Fones C, Niti M, Ng TP (2009) Criterion-based validity and reliability of the Geriatric Depression Screening Scale (GDS-15) in a large validation sample of community-living Asian older adults. Aging Ment Health 13: 376–382.
- 29. Kaiser MJ, Bauer JM, Ramsch C, Uter W, Guigoz Y, et al. (2009) Validation of the Mini Nutritional Assessment Short-Form (MNA-SF): a practical tool for identification of nutritional status. J Nutr Health Aging 13: 782–788.
- 30. Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40: 373–383.
- 31. Huskisson EC (1974) Measurement of pain. Lancet 2(7889): 1127–1131.
- 32. Folstein MF, Folstein SE, McHugh PR (1975) Mini-mental status: a practical method for grading the cognitive state of patients for the clinical use. J Psychiatr Res 12: 189–198.
Collin C, Wade DT, Davies S, Horne V (1988) “The Barthel ADL Index: a reliability study.” Int Disability Study 10: : 61–63.
- 34. Lawton MP, Brody EM (1969) Assessment of older people: Self-maintaining and instrumental activities of daily living. The Gerontologist 9: 179–186.
- 35. Inouye SK, Van Dyck CH, Alessi CA, Balkin S, Siegal AP, et al. (1990) Clarifying confusion: the confusion assessment method. A new method for detection of delirium. Ann Intern Med 113: 941–948.
- 36. Francis J, Kapoor WN (1990) Delirium in hospitalized elderly. J Gen Intern Med 5: 65–79.
- 37. Inouye SK, Rushing JT, Foreman MD, Palmer RM, Pompei P (1998) Does delirium contribute to poor hospital outcomes? A three-site epidemiologic study. J Gen Intern Med 13: 234–242.
- 38. Marcantonio ER, Flacker JM, Michaels M, Resnick NM (2000) Delirium is independently associated with poor functional recovery after hip fracture. J Am Geriatr Soc 48: 618–624.
- 39. Quinlan N, Rudolph JL (2011) Postoperative delirium and functional decline after noncardiac surgery. J Am Geriatr Soc 59 Suppl 2: S301–304.
- 40. Vida S, Galbaud du Fort G, Kakuma R, Arsenault L, Platt RW, et al. (2006) An 18-month prospective cohort study of functional outcome of delirium in elderly patients: activities of daily living. Int Psychogeriatr 18: 681–700.
- 41. Edelstein DM, Aharonoff GB, Karp A, Capla EL, Zuckerman JD, et al. (2004) Effect of postoperative delirium on outcome after hip fracture. Clin Orthop Relat Res (422): 195–200.
- 42. Givens JL, Sanft TB, Marcantonio ER (2008) Functional recovery after hip fracture: the combined effects of depressive symptoms, cognitive impairment, and delirium. J Am Geriatr Soc 56: 1075–1079.
- 43. Rudolph JL, Marcantonio ER, Culley DJ, Silverstein JH, Rasmussen LS, et al. (2008) Delirium is associated with early postoperative cognitive dysfunction. Anaesthesia 63: 941–947.