Figure 2 is incorrect. The authors have provided a corrected version here.
(A) UGT1A1 transgene copy number per diploid genome equivalent (dGE) in liver, lung, testis, spleen, heart, kidney and duodenum of male Gunn rats at 62 weeks after portal vein injection of scAAV1, 5 or 8 as calculated by the ratio of UGT1A1 copies and the rat β-actin gene copies in 100 ng of DNA as quantified by qPCR. (B) Relative UGT1A1 mRNA levels in liver quantified by qPCR and normalized with 18S rRNA levels. The results obtained with AAV5 are statistically significant different (p<0.001) compared to the obtained with AAV1 and AAV8 using the nonparametric Mann–Whitney test.
Citation: The PLOS ONE Staff (2014) Correction: Adeno-Associated Viral Vector Serotype 5 Poorly Transduces Liver in Rat Models. PLoS ONE 9(6): e101857. https://doi.org/10.1371/journal.pone.0101857
Published: June 26, 2014
Copyright: © 2014 The PLOS ONE Staff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.