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Correction: Resistance to Oncolytic Myxoma Virus Therapy in Nf1−/−/Trp53−/− Syngeneic Mouse Glioma Models Is Independent of Anti-Viral Type-I Interferon

  • The PLOS ONE Staff

Correction: Resistance to Oncolytic Myxoma Virus Therapy in Nf1−/−/Trp53−/− Syngeneic Mouse Glioma Models Is Independent of Anti-Viral Type-I Interferon

  • The PLOS ONE Staff
PLOS
x

Figure 2 is incorrect; panels C-F are missing. The figure legend is correct. The authors have provided a corrected version here.

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Figure 2. K1492 and K1861 form aggressive intracranial tumours and MYXV treatment results in no efficacy and minimal viral infection with no viral replication.

A – Histopathology of 14 day K1492 and K1861 by H&E (first column 25×, second column 200×) and astrocytic markers S100b (200×) and GFAP (200×). 5×104 cells of K1492 (B) and K1861 (C) were intracranially implanted in C57Bl/6J mice and received 5×106 PFUs vMyx-FLuc (MYXV), UV-inactivated virus (DV), PBS, or no treatment (NT) on day 14. D – Luciferase measured (Total FLUX) from region-of-interest around the entire mouse skull following 5×106 PFUs vMyx-FLuc in K1492 (n  =  8), K1861 (n  =  10) or no tumour (n  =  5). Error bars represent standard error. E – Viral recovery from K1492 (n  =  4) and K1861 (n  =  4) tumours following intracranial treatment with vMyx-FLuc. Input virus represents mice where virus was recovered 1 hour post-injection. Error bars represent standard error. F – Immunohistochemical staining for early MYXV protein MT-7e in 14 day K1492 at 1, 3 and 7 days post-treatment (Top row 25×; Bottom row 100×).

https://doi.org/10.1371/journal.pone.0065801.g002

References

  1. 1. Zemp FJ, McKenzie BA, Lun X, Maxwell L, Reilly KM, et al. (2013) Resistance to Oncolytic Myxoma Virus Therapy in Nf1−/−/Trp53−/− Syngeneic Mouse Glioma Models Is Independent of Anti-Viral Type-I Interferon. PLoS ONE 8(6): e65801 doi:https://doi.org/10.1371/journal.pone.0065801.