Our study had two objectives: a) to systematically identify all existing systematic reviews of Chinese herbal medicines (CHM) published in Cochrane Library; b) to assess the methodological quality of included reviews.
We performed a systematic search of the Cochrane Database of Systematic Reviews (CDSR, Issue 5, 2010) to identify all reviews of CHM. A total of fifty-eight reviews were eligible for our study. Twenty-one of the included reviews had at least one Traditional Chinese Medicine (TCM) practitioner as its co-author. 7 reviews didn't include any primary study, the remaining reviews (n = 51) included a median of 9 studies and 936 participants. 50% of reviews were last assessed as up-to-date prior to 2008. The questions addressed by 39 reviews were broad in scope, in which 9 reviews combined studies with different herbal medicines. For OQAQ, the mean of overall quality score (item 10) was 5.05 (95% CI; 4.58-5.52). All reviews assessed the methodological quality of primary studies, 16% of included primary studies used adequate sequence generation and 7% used adequate allocation concealment. Of the 51 nonempty reviews, 23 reviews were reported as being inconclusive, while 27 concluded that there might be benefit of CHM, which was limited by the poor quality or inadequate quantity of included studies. 58 reviews reported searching a median of seven electronic databases, while 10 reviews did not search any Chinese database.
Now CDSR has included large numbers of CHM reviews, our study identified some areas which could be improved, such as almost half of included reviews did not have the participation of TCM practitioners and were not up-to-date according to Cochrane criteria, some reviews pooled the results of different herbal medicines and ignored the searching of Chinese databases.
Citation: Hu J, Zhang J, Zhao W, Zhang Y, Zhang L, Shang H (2011) Cochrane Systematic Reviews of Chinese Herbal Medicines: An Overview. PLoS ONE 6(12): e28696. https://doi.org/10.1371/journal.pone.0028696
Editor: Jos H. Verbeek, Finnish Institute of Occupational Health, Finland
Received: June 16, 2011; Accepted: November 14, 2011; Published: December 9, 2011
Copyright: © 2011 Hu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This study was supported in part by the National Significant Projects of New Drugs Creation (No. 2008ZX09312-001) and the program of New Century Excellent Talents in University (NCET-09-0900). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
Traditional Chinese Medicine (TCM) is an essential part of the healthcare system in several Asian countries, and is considered a complementary or alternative medical system in most Western countries . Chinese herbal medicines (CHM) are an essential part of TCM . The 2002 National Health Interview Survey showed that 18.6% of adults used CHM in the United States, while it was 12.1% in 1997 . With the increased use of CHM, questions arise from clinicians, patients, and policymakers as to the effectiveness of these interventions . In an era of evidence-based healthcare, systematic reviews of randomized controlled trials (RCTs) are becoming increasingly important as a source of evidence for decision-making. As the number of systematic reviews of CHM increase, the quality of which has been highlighted and called into question. Some studies have assessed the quality of CHM reviews published in Chinese journals, in general, they have been criticized for lacking a comprehensive search for clinical trials, ignoring the characteristics of TCM, using inappropriate criteria to assess the methodological quality of included studies, and addressing too broadly defined questions –. All  these aspects could have contributed to a poor quality review.
The Cochrane Collaboration is an international organization that aims to prepare and maintain rigorous systematic reviews in order to help people make well-informed decisions about health care . Compared with reviews published in paper-based journals, Cochrane reviews are noted to have greater methodological quality . Ever since 1999 when the first Cochrane review of CHM was published, a sharp increase has been observed in the number of similar reviews. However, no previous studies have systematically assessed the methodological quality of Cochrane reviews of CHM. Therefore, we did this overview of systematic reviews. Our study had two objectives: a) to systematically identify all existing Cochrane reviews of CHM; b) to assess the methodological quality of included reviews.
Data for this study was acquired through previously published work, no patient or hospital data was accessed. Therefore, written consent and institutional ethical review was not required for this research. The PRISMA checklist and flow diagram are available as supporting information; see PRISMA Checklist S1 and PRISMA Flow Diagram S1.
In order to identify reviews focusing on CHM, we searched the titles and abstracts of all reviews contained within the Cochrane Database of Systematic Reviews (CDSR) (Issue 5, 2010) using the following terms: Chinese or herb* or traditional or plant or medic*.
Inclusion and exclusion criteria
We included all Cochrane reviews of CHM. Protocols and reviews which have been withdrawn from publication were excluded. We defined CHM as preparations derived from plants or parts of plants (e.g. leaves, stems, buds, flowers, roots or tubers) that grow in China and have been widely used for medical purpose. CHM include single herbs (or extracts from single herbs) and compound formulas of several herbs in all forms of preparation formulation (e.g. oral liquid, tablet, capsule, pill, powder, plaster or injection liquid). It should be noted that our definition of CHM does not include plant-derived chemicals or synthetic chemicals which contain constituents of plants. For example, although Huperzia serrata has its origin in China, according to our definition, Huperzine A does not belong to CHM because it is a kind of alkaloid extracted from Huperzia serrata. In addition, we only included reviews discussing herbs which originated from China, reviews on herbs such as Passiflora and Echinacea, both of American origin, were invariably excluded.
Oxman-Guyatt Overview Quality Assessment Questionnaire (OQAQ) 
The OQAQ instrument was selected as the quality appraisal tool, which was designed to evaluate whether the authors of a systematic review conducted a comprehensive search, minimized bias in the selection of primary studies, evaluated the primary literature, and pooled the results appropriately. It consists of 10 questions, the first 9 questions are designed to assess different aspects of methodological quality and have set answers of “yes”, “partially/can't tell”, or “no”, question 10 is an assessment of the overall scientific quality of the systematic review on a scale of 1 to 7, it is answered based on how well the review scored on the first 9 questions.
We established a database (using Microsoft Excel 2007) to extract data. The database had two components: 1) general characteristics, including country of first author and number of authors, whether the review had the participation of TCM practitioners, number of trials and participants included, disease, the year of review last assessed as up-to-date, conclusions drawn by the reviewers (by assessing the reviewers' abstract conclusions statements), interventions in experimental groups, number of herbs included, and whether the results of different herbal medicines were pooled; 2) methodological quality of included reviews, including OQAQ scale, the approach to assessment of methodological quality of primary studies, the number of trials with adequate sequence generation and allocation concealment, and type and number of English and Chinese databases searched. Two reviewers (Jing Hu and Wei Zhao) independently extracted the information of each review, disagreements between the two reviewers were resolved by discussion.
The questions addressed by a review may be broad or narrow in scope, each review was assigned into one of the following two categories: 1) narrowly focused reviews, intervention in each review was single herb or herbal preparation, as an example of “Chinese herbal medicine suxiao jiuxin wan for angina pectoris”; 2) broadly focused reviews, including reviews concerned multiple Chinese herbs or a family of herbal medicines sharing similar efficacy, such as “Chinese herbal medicine for premenstrual syndrome” and “Chinese herbal medicine Huangqi type formulations for nephrotic syndrome”. For broadly focused reviews, we listed the number of herbs included and assessed whether the results of different herbal medicines were pooled.
A review was believed to have the participation of TCM practitioners if at least one author works in TCM department, university or hospital, or it stated that it had got suggestion from TCM practitioners.
When we assessed the type and number of English and Chinese databases searched, we only listed the databases which at least 4 reviews searched. In addition, the Cochrane Specialized Register and databases/websites for ongoing trials were also searched in some reviews, we did not list them in our study.
278 potentially relevant reviews were obtained, after selection (according to inclusion and exclusion criteria), a total of 58 Cochrane reviews – were eligible for our study, a full list of reviews is included in Table S1. Of the 58 reviews, one review  included herbs originated in China, India and Japan; interventions in another review  concerned both herbal and chemical medicines. In these two cases, we extracted and analyzed the information relating to CHM.
General characteristics of included reviews
The number of authors in the 58 reviews ranged from 1 to 10, the first authors were most often from China (46 [79%]), followed by UK (n = 8), and Netherlands, Canada, USA and Australia each have one first-authored review. Twenty-one (36%) of the included reviews had at least one TCM practitioner as its co-author. 7 (12%) reviews didn't include any primary study, of the remaining reviews (n = 51), a total of 671 studies and 75,609 participants were included, the median number of studies and participants included were 9 (Quartile: 3, 15) and 936 (Quartile: 492, 1567) respectively. 50% of the reviews were last assessed as up-to-date prior to 2008, of reviews considered out-of-date, one was last updated in 2000. In total, 44 diseases were investigated in the included reviews, 18 (31%) reviews addressed cerebral vascular and cardiovascular diseases (9 reviews focused on stroke), followed by reviews focused on respiratory diseases (n = 6) and gynecological/pregnancy diseases (n = 6).
Of the 51 nonempty reviews, only one review concluded positively, 27 (53%) concluded that there might be benefit of CHM for treating specific health conditions, which was limited by the poor quality or inadequate quantity of studies, 23 (45%) reviews concluded that the currently available data do not allow any conclusion to be drawn, generally because of low methodological quality of studies, small number of studies and participants included or publication bias.
Nineteen reviews focused on 13 single herbs or herbal preparations, while the remainder (39 [67%]) addressed broad questions, in which 34 reviews concerned multiple Chinese herbs or multiple formulations of Chinese herbs, 5 reviews involved a family of herbal medicines sharing similar efficacy, including Huangqi type formulations (including Huangqi injection and Huangqi-Danggui mixture), Chuanxiong preparations (including Nao-an capsule, Xifeng wan and Apoplexy Preventing Dry Ointment Powder), Dan Shen agents (including Compound Danshen Dripping Pill, Compound Danshen injection, Danshen injection, Yiqi huoxue injection, and Quyu huatan xiezhuo fang) and Sanchi (including Xinnaotai, Sanchitongshu capsule, Naoming injection, Xuesaitong soft capsule, Sanqitongshu capsule, Xuesaitong and Xueshuantong injection). Of the 39 reviews, 4 didn't include any primary study, of the remaining reviews (n = 35), the median number of herbal medicines involved was 6 within a range of 1 to 71, results of different herbal medicines were pooled in 9 reviews, in which 7 reviews pooled the results of all Chinese herbal medicines, one review pooled all Danshen agents, and one pooled Sanchi.
Methodological quality of included reviews
Table 1 presents a summary of OQAQ items of the included reviews, the mean score (item 10) was 5.05, 95% CI (4.58, 5.52). 41 of 58 reviews attempted to minimize bias during the selection of studies by at least two reviewers independently select eligible studies.
All reviews reported assessing the methodological quality of included primary studies, 21 (36%) reviews used the Cochrane Collaboration's ‘Risk of Bias’ tool, the Jadad scale was used in 6 reviews, 12 (21%) reviews used unnamed checklist. Among 671 included studies, 108 (16%) used adequate sequence generation, allocation concealment was adequate in 50 (7%) studies.
The median number of databases searched in 58 reviews was 7 within a range of 4 to 15. Regarding to the English language databases, the most searched was MEDLINE (98%), followed by EMBASE (97%) and CENTRAL (97%). CBM was the most searched Chinese database (78%), the second most used was CNKI (45%) and the third was VIP (24%) (Table 2). All reviews searched at least 2 English databases, while 10 reviews did not search any Chinese database. 41 (71%) reviews searched at least 3 English databases, while only 6 (10%) reviews searched at least 3 Chinese databases (Table 3).
Evidence-based health care involves the systematic collection, synthesis and application of scientific evidence to guide clinical practice and policy-making. Systematic reviews are a key component of evidence-based health care. Currently, CDSR has included 58 systematic reviews of CHM.
Almost seventy percent of included reviews' topics were too broad, the percentage was much higher than that of similar reviews published in Chinese journals, which was 38 percent (41 among 107 reviews) . It is difficult to develop a comprehensive search strategy for broadly focused reviews, for instance, one hundred and sixty herbal medicines are now available for coronary heart diseases treatment, a systematic review of CHM for coronary heart disease will have to include clinical trials of all these herbal medicines, it is easily to cause the incomplete identification of relevant studies. Choosing broad topics for reviews will require more resources in data collection and analysis, the results may also be too complicated to interpret. So topic selection of CHM reviews should focus on specific clinical problems, the extensive titles are not recommended.
As broad questions of reviews may be addressed by large sets of heterogeneous studies, the data synthesis may be particularly challenging. In our study, 9 reviews (among the 39 broadly focused reviews) pooled the results of different herbs, which did not identify potentially important differences in effects across different interventions. Systematic reviews can, but do not have to use meta-analysis when combining data from primary studies, prior to conducting a meta-analysis, reviewers should examine the consistency of the interventions. It is recommended that the data of each intervention should be analyzed and presented separately if several different interventions for the same condition were tested in one review.
The goal of a systematic review is to identify relevant studies completely and unbiasedly . It has been demonstrated ,  that significant amounts of evidence would potentially be missed if the search is limited to English-only sources. Because a considerable number of clinical trials on CHM were published only in the Chinese language journals, so a comprehensive search of Chinese databases is essential for a systematic review of CHM. However, we were disappointed to find that almost twenty percent of reviews did not search any Chinese database in our study. One study  compared four Chinese databases and concluded that CBM is the preferred database for systematic reviewers to retrieve relevant Chinese studies, while CNKI is recommended for non-Chinese-speaking researchers due to its free searched English version website (www.global.cnki.net) and “Cross-Language Search” functions. CBM has no English website and a fee is charged for searching, now many Chinese medical universities have got the permission to search CBM, so maybe the most cost-and time-efficient way to search it is to enhance collaboration with Chinese researchers.
In doing a review of CHM, professional advice from TCM practitioners is of great value. It is generally assumed that the characteristics of TCM would be well taken into account in a review if one or some of its reviewers majored in TCM. In our study, we found that more than sixty percent of reviews did not have one TCM practitioner in the authors list, which might lead to insufficient consideration of the characteristics of TCM (e.g. determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs) and incorrect results. We suggest that future reviews should be authored by a group of individuals with both clinical expertise and methodological expertise.
Of the 671 primary studies included, less than twenty percent of studies used adequate sequence generation, and only seven percent used adequate allocation concealment. Because of the poor methodological quality of primary studies, nearly half of reviews were reported as being inconclusive, while 27 reviews provided preliminary evidence of CHM's benefits to certain conditions, which should be considered tentative and need to be confirmed with rigorous RCTs. The Chinese government has been aware of the importance of conducting scientifically sound RCTs and has made substantial investments into funding clinical researches of CHM, now many well-designed RCTs of CHM with rigorous methodology are in progress or have been completed in China , we believe future updates of currently inconclusive Cochrane reviews of CHM may reach more definitive conclusions.
Limitations of the study
Although we believed a review has a greater chance of considering the characteristics of TCM if at least one author works in TCM department, university or hospital, or it stated that it had got suggestion from TCM practitioners, it is quite possible that some reviewers had consulted TCM experts while designing and doing the review, but did not report it in articles. As cases of this kind could not be ruled out, we therefore might have underestimated the proportion of reviews getting support from TCM practitioners. In addition, we restricted our search to Cochrane reviews because they are generally less prone to bias than systematic reviews published in paper-based journals , , . However, this might cause the results of this study to be only applicable to review articles in the Cochrane database. Further evaluation is needed in order to know whether the systematic reviews of CHM published in English paper-based journals even in the leading journals have the same problem.
List of all included Cochrane reviews of CHM.
The authors thank Mu Wei, Ph.D., Tianjin University of TCM, China, and Xiao Lu, M.S., Tianjin University of TCM, China, for their help with reviewing and revising the entire manuscript for English Language editing.
Conceived and designed the experiments: JH JZ HS. Performed the experiments: JH HS. Analyzed the data: JH LZ YZ. Contributed reagents/materials/analysis tools: LZ YZ. Wrote the paper: JH JZ. Searched and selected studies: JH WZ. Extracted the data: JH WZ.
- 1. Chan E, Tan M, Xin JN, Sudarsanam S, Johnson DE (2010) Interactions between traditional Chinese medicines and Western therapeutics. Curr Opin Drug Discov Devel 13: 50–65.
- 2. Vickers A, Zollman C (1999) ABC of complementary medicine: herbal medicine. BMJ 319: 1050–1053.
- 3. Tindle HA, Davis RB, Phillips RS, Eisenberg DM (2005) Trends in use of complementary and alternative medicine by US adults: 1997-2002. Altern Ther Health Med 11: 42–49.
- 4. Firenzuoli F, Gori L (2007) Herbal Medicine Today: Clinical and Research Issues. Evid Based Complement Alternat Med 4: 37–40.
- 5. Liu JP, Xia Y (2007) Quality appraisal of systematic reviews or meta-analysis on traditional Chinese medicine published in Chinese journals. Zhongguo Zhong Xi Yi Jie He Za Zhi 27: 306–311.
- 6. Li TQ, Liu XM, Zhang MM, Ma JX, Du L, et al. (2007) Assessment of Systematic Reviews and Meta-analyses on Traditional Chinese Medicine Published in Chinese Journals. Chin J Evid-based Med 7: 180–188.
- 7. Hu D, Kang DY, Hong Q (2010) Heterogeneity Analysis of Systematic Reviews on Traditional Chinese Medicine. Chin J Evid-based Med 10: 488–491.
- 8. Green S, Higgins JPT, Alderson P, Clarke M, Mulrow CD, et al. (2008) Cochrane Handbook. The Cochrane Library. Version 5.0.2:
- 9. Jadad AR, Cook DJ, Jones A, Klassen TP, Tugwell P, et al. (1998) Methodology and Reports of Systematic Reviews and Meta-analyses: A Comparison of Cochrane Reviews with Articles Published in Paper-Based Journals. JAMA 280: 278–280.
- 10. Oxman AD, Guyatt G (1991) Validation of an index of the quality of review articles. J Clin Epidemiol 44: 1271–8.
- 11. Liu JP, McIntosh H, Lin H (2009) Chinese medicinal herbs for chronic hepatitis B. Cochrane Database of Systematic Reviews 1: CD001940.
- 12. Li WZ, Liu M, Feng SJ, Wu B, Zhang SH, et al. (2009) Acanthopanax for acute ischaemic stroke. Cochrane Database of Systematic Reviews 3: CD007032.
- 13. Zhang WY, Leonard T, Bath-Hextall FJ, Chambers C, Lee CF, et al. (2009) Chinese herbal medicine for atopic eczema. Cochrane Database of Systematic Reviews 4: CD002291.
- 14. Cui XJ, Trinh K, Wang YJ (2010) Chinese herbal medicine for chronic neck pain due to cervical degenerative disc disease. Cochrane Database of Systematic Reviews 1: CD006556.
- 15. Flower A, Liu JP, Chen SS, Lewith G, Little P (2009) Chinese herbal medicine for endometriosis. Cochrane Database of Systematic Reviews 3: CD006568.
- 16. Jing Z, Yang XZ, Khaled MK, Chen XY, Wu TX (2009) Chinese herbal medicine for premenstrual syndrome. Cochrane Database of Systematic Reviews 3: CD006414.
- 17. Zhu ZS, Proctor M, Bensoussan A, Wu E, Smith CA (2009) Chinese herbal medicine for primary dysmenorrhoea. Cochrane Database of Systematic Reviews 1: CD005288.
- 18. Rathbone J, Zhang L, Zhang MM, Xia J, Liu XH, et al. (2008) Chinese herbal medicine for schizophrenia. Cochrane Database of Systematic Reviews 3: CD003444.
- 19. uan W, Wang J, Wu TX (2009) Chinese herbal medicine Huangqi type formulations for nephrotic syndrome. Cochrane Database of Systematic Reviews 3: CD006335.
- 20. Duan X, Zhou LK, Wu TX, Liu GJ, Qiao JQ, et al. (2009) Chinese herbal medicine suxiao jiuxin wan for angina pectoris. Cochrane Database of Systematic Reviews 4: CD004473.
- 21. Wang Q, Guo Z, Zhao PC, Wang YP, Gan T, et al. (2009) Chinese herbal medicines for acute pancreatitis. Cochrane Database of Systematic Reviews 3: CD003631.
- 22. Zeng XX, Yuan Y, Wu TX, Yan L, Su H (2009) Chinese herbal medicines for hyperthyroidism. Cochrane Database of Systematic Reviews 1: CD005450.
- 23. Gan T, Wu ZY, Tian L, Wang YP (2010) Chinese herbal medicines for induction of remission in advanced or late gastric cancer. Cochrane Database of Systematic Reviews 1: CD005096.
- 24. Grant SJ, Bensoussan A, Chang D, Kiat H, Klupp NL, et al. (2009) Chinese herbal medicines for people with impaired glucose tolerance or impaired fasting blood glucose. Cochrane Database of Systematic Reviews 4: CD006690.
- 25. Li WJ, Tang LL, Wu TX, Zhang J, Liu GJ, et al. (2010) Chinese herbal medicines for treating pre-eclampsia. Cochrane Database of Systematic Reviews 1: CD005126.
- 26. Liu JP, Zhang M, Wang WY, Grimsgaard S (2009) Chinese herbal medicines for type 2 diabetes mellitus. Cochrane Database of Systematic Reviews 1: CD003642.
- 27. Wang DF, Hu LN, Marjoribanks J, Jia HJ, Sun Y, et al. (2009) Chinese herbal medicines in the treatment of ectopic pregnancy. Cochrane Database of Systematic Reviews 1: CD006224.
- 28. Liu XM, Zhang MM, He L, Li YP, Kang YK (2008) Chinese herbs combined with Western medicine for severe acute respiratory syndrome (SARS). Cochrane Database of Systematic Reviews 4: CD004882.
- 29. Wu TX, AJ , Liu GJ (2008) Chinese medical herbs for chemotherapy side effects in colorectal cancer patients. Cochrane Database of Systematic Reviews 4: CD004540.
- 30. Wei JF, Ni J, Wu TX, Chen XY, Duan X, et al. (2010) Chinese medicinal herbs for acute bronchitis. Cochrane Database of Systematic Reviews 2: CD004560.
- 31. Liu JP, McIntosh H, Lin H (2009) Chinese medicinal herbs for asymptomatic carriers of hepatitis B virus infection. Cochrane Database of Systematic Reviews 1: CD002231.
- 32. Chen XY, Wu TX, Liu GJ, Wang Q, Zheng J, et al. (2010) Chinese medicinal herbs for influenza. Cochrane Database of Systematic Reviews 2: CD004559.
- 33. Zheng YL, Gu R, Wu TX (2010) Chinese medicinal herbs for measles. Cochrane Database of Systematic Reviews 2: CD005531.
- 34. Shi YY, Gu R, Liu C, Ni J, Wu TX, et al. (2010) Chinese medicinal herbs for sore throat. Cochrane Database of Systematic Reviews 2: CD004877.
- 35. Zhang XG, Wu TX, Zhang J, Yan Q, Xie LX, et al. (2010) Chinese medicinal herbs for the common cold. Cochrane Database of Systematic Reviews 2: CD004782.
- 36. Zhang MM, Liu XM, Li J, He L, Tripathy D (2009) Chinese medicinal herbs to treat the side-effects of chemotherapy in breast cancer patients. Cochrane Database of Systematic Reviews 1: CD004921.
- 37. Yang XZ, Zeng XX, Wu TX (2010) Chuanxiong preparations for preventing stroke. Cochrane Database of Systematic Reviews 1: CD006765.
- 38. Yuan Y, Zeng XX, Luo YK, Li ZG, Wu TX (2008) Chuanxiong-type preparations for acute ischemic stroke. Cochrane Database of Systematic Reviews 4: CD005569.
- 39. Wu B, Liu M, Zhang SH (2008) Dan Shen agents for acute ischaemic stroke. Cochrane Database of Systematic Reviews 4: CD004295.
- 40. Wu TX, Ni J, Wei JF (2009) Danshen (Chinese medicinal herb) preparations for acute myocardial infarction. Cochrane Database of Systematic Reviews 1: CD004465.
- 41. Cao WZ, Liu WM, Wu TX, Zhong DC, Liu GJ (2008) Dengzhanhua preparations for acute cerebral infarction. Cochrane Database of Systematic Reviews 4: CD005568.
- 42. Dong R, Chen XY, Wu TX, Liu GJ (2009) Elemene for the treatment of lung cancer. Cochrane Database of Systematic Reviews 1: CD006054.
- 43. Evans JR (2009) Ginkgo biloba extract for age-related macular degeneration. Cochrane Database of Systematic Reviews 2: CD001775.
- 44. Zeng XR, Liu M, Yang YS, Li Y, Asplund K (2009) Ginkgo biloba for acute ischaemic stroke. Cochrane Database of Systematic Reviews 1: CD003691.
- 45. Birks J, Grimley EJ (2009) Ginkgo biloba for cognitive impairment and dementia. Cochrane Database of Systematic Reviews 2: CD003120.
- 46. Nicolaï SPA, Kruidenier LM, Bendermacher BLW, Prins MH, Teijink JAW (2009) Ginkgo biloba for intermittent claudication. Cochrane Database of Systematic Reviews 2: CD006888.
- 47. Hilton MP, Stuart EL (2010) Ginkgo biloba for tinnitus. Cochrane Database of Systematic Reviews 3: CD003852.
- 48. Guo RL, Pittler MH, Ernst E (2009) Hawthorn extract for treating chronic heart failure. Cochrane Database of Systematic Reviews 1: CD005312.
- 49. Arnold E, Clark CE, Lasserson TJ, Wu TX (2008) Herbal interventions for chronic asthma in adults and children. Cochrane Database of Systematic Reviews 4: CD005989.
- 50. Gagnier JJ, Tulder MW, Berman BM, Bombardier C (2010) Herbal medicine for low back pain. Cochrane Database of Systematic Reviews 2: CD004504.
- 51. Liu JP, Manheimer E, Yang M (2009) Herbal medicines for treating HIV infection and AIDS. Cochrane Database of Systematic Reviews 1: CD003937.
- 52. Liu JP, Yang M, Liu YX, Wei ML, Grimsgaard S (2008) Herbal medicines for treatment of irritable bowel syndrome. Cochrane Database of Systematic Reviews 4: CD004116.
- 53. Liu JP, Yang M, Du XM (2009) Herbal medicines for viral myocarditis. Cochrane Database of Systematic Reviews 1: CD003711.
- 54. Liu JP, Yang H, Xia Y, Cardini F (2009) Herbal preparations for uterine fibroids. Cochrane Database of Systematic Reviews 2: CD005292.
- 55. Wu HM, Tang JL, Sha ZH, Li YP (2009) Interventions for preventing infection in nephrotic syndrome. Cochrane Database of Systematic Reviews 2: CD003964.
- 56. Yang WM, Hao ZL, Zhang SH, Dong W, Wu TX, et al. (2009) Mailuoning for acute ischaemic stroke. Cochrane Database of Systematic Reviews 2: CD007028.
- 57. Liu JP, Manheimer E, Tsutani K, Gluud C (2009) Medicinal herbs for hepatitis C virus infection. Cochrane Database of Systematic Reviews 1: CD003183.
- 58. Tan Y, Liu M, Wu B (2009) Puerarin for acute ischaemic stroke. Cochrane Database of Systematic Reviews 1: CD004955.
- 59. Wang Q, Wu TX, Chen XY, Duan X, Zheng J, et al. (2009) Puerarin injection for unstable angina pectoris. Cochrane Database of Systematic Reviews 1: CD004196.
- 60. Chen XY, Zhou MK, Li QF, Yang J, Zhang Y, et al. (2008) Sanchi for acute ischaemic stroke. Cochrane Database of Systematic Reviews 4: CD006305.
- 61. Chen J, Wu G, Li SQ, Yu T, Xie Y, et al. (2009) Shengmai (a traditional Chinese herbal medicine) for heart failure. Cochrane Database of Systematic Reviews 1: CD005052.
- 62. Wu TX, Harrison RA, Chen XY, Ni J, Zhou LK, et al. (2009) Tongxinluo (Tong xin luo or Tong-xin-luo) capsule for unstable angina pectoris. Cochrane Database of Systematic Reviews 1: CD004474.
- 63. Zhuo Q, Yang XZ, Wu TX, Liu GJ, Zhou LK (2008) Tongxinluo capsule for acute stroke. Cochrane Database of Systematic Reviews 4: CD004584.
- 64. Adams D, Wu TX, Yang XZ, Tai SS, Vohra S (2009) Traditional Chinese medicinal herbs for the treatment of idiopathic chronic fatigue and chronic fatigue syndrome. Cochrane Database of Systematic Reviews 4: CD006348.
- 65. Li QF, Chen XY, He L, Zhou D (2009) Traditional Chinese medicine for epilepsy. Cochrane Database of Systematic Reviews 3: CD006454.
- 66. Wu TX, Li QP, Yuan ZY (2009) Yizhi capsule for vascular dementia. Cochrane Database of Systematic Reviews 2: CD005382.
- 67. Yue JR, Yang XY, Wu TX, Shu DF, Dong BR (2008) Zhiling decoction for vascular dementia. Cochrane Database of Systematic Reviews 3: CD004670.
- 68. Zhuo Q, Yuan ZY, Chen HX, Wu TX (2010) Traditional Chinese herbal products for stable angina. Cochrane Database of Systematic Reviews 5: CD004468.
- 69. Zhang JH, Shang HC, Gao XM, Zhang BL, Xiang YZ, et al. (2007) Methodology and Reporting Quality of Systematic Review/Meta-Analysis of Traditional Chinese Medicine. J Altern Complement Med 13: 797–805.
- 70. Lui S, Smith EJ, Terplan M (2010) Heterogeneity in search strategies among Cochrane acupuncture reviews: is there room for improvement? Acupunct Med 28: 149–53.
- 71. Moher D, Fortin P, Jadad AR, Juni P, Klassen T, et al. (1996) Completeness of reporting of trials published in languages other than English: implications for conduct and reporting of systematic reviews. Lancet 347: 363–6.
- 72. Ezzo J, Berman B, Vickers A, Linde K (1998) Complementary medicine and the Cochrane Collaboration. JAMA 280: 1628–1630.
- 73. Ai CL, Duan YR, Wiffen P, Zhang MM, Li J (2010) Chinese Biomedical Databases: Selection and Search for Trials to Conduct Systematic Reviews. Chin J Evid-based Med 10(6): 749–53.
- 74. Shang HC, Zhang BL (2010) To improve the overall level of traditional chinese medicine research by government leading and multiple participation. Chin J Evid-based Med 10(6): 640–41.
- 75. Delaney A, Bagshaw SM, Ferland A, Laupland K, Manns B, et al. (2007) The quality of reports of critical care meta-analyses in the Cochrane Database of Systematic Reviews: an independent appraisal. Crit Care Med 35(2): 589–94.
- 76. Moseley AM, Elkins MR, Herbert RD, Maher CG, Sherrington C (2009) Cochrane reviews used more rigorous methods than non-Cochrane reviews: survey of systematic reviews in physiotherapy. Journal of Clinical Epidemiology 62: 1021–1030.