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Open Access
Peer-reviewed
Research Article
Acute multi-sgRNA knockdown of KEOPS complex genes reproduces the microcephaly phenotype of the stable knockout zebrafish model
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Tilman Jobst-Schwan ,
Contributed equally to this work with: Tilman Jobst-Schwan, Johanna Magdalena Schmidt
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing
Affiliation Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Johanna Magdalena Schmidt ,
Contributed equally to this work with: Tilman Jobst-Schwan, Johanna Magdalena Schmidt
Roles Data curation, Formal analysis, Investigation, Methodology
Affiliation Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Ronen Schneider,
Roles Formal analysis, Investigation
Affiliation Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Charlotte A. Hoogstraten,
Roles Formal analysis, Investigation
Affiliation Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Jeremy F. P. Ullmann,
Roles Data curation, Formal analysis, Methodology, Software, Validation, Writing – review & editing
Affiliation Epilepsy Genetics Program and F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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David Schapiro,
Roles Investigation
Affiliation Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Amar J. Majmundar,
Roles Methodology, Writing – review & editing
Affiliation Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Amy Kolb,
Roles Investigation, Project administration
Affiliation Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Kaitlyn Eddy,
Roles Investigation
Affiliation Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Shirlee Shril,
Roles Data curation, Formal analysis, Software
Affiliation Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Daniela A. Braun,
Roles Formal analysis, Investigation
Affiliation Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Annapurna Poduri,
Roles Methodology, Supervision, Writing – review & editing
Affiliation Epilepsy Genetics Program and F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Friedhelm Hildebrandt
Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing
* E-mail: friedhelm.hildebrandt@childrens.harvard.edu
Affiliation Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Acute multi-sgRNA knockdown of KEOPS complex genes reproduces the microcephaly phenotype of the stable knockout zebrafish model
- Tilman Jobst-Schwan,
- Johanna Magdalena Schmidt,
- Ronen Schneider,
- Charlotte A. Hoogstraten,
- Jeremy F. P. Ullmann,
- David Schapiro,
- Amar J. Majmundar,
- Amy Kolb,
- Kaitlyn Eddy,
- Shirlee Shril
- Published: January 18, 2018
- https://doi.org/10.1371/journal.pone.0191503