Combination of poly I:C and Pam3CSK4 enhances activation of B cells in vitro and boosts antibody responses to protein vaccines in vivo

Open Access

Peer-reviewed

Research Article

Genevieve M. Weir ,

* E-mail: gweir@imvaccine.com

Affiliations Research & Development, Immunovaccine Inc, Halifax, Nova Scotia, Canada, Department of Microbiology & Immunology, Dalhousie University, Halifax, Nova Scotia, Canada

http://orcid.org/0000-0002-6285-7187

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Mohan Karkada,

Affiliations Research & Development, Immunovaccine Inc, Halifax, Nova Scotia, Canada, Department of Microbiology & Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
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David Hoskin,

Affiliations Department of Microbiology & Immunology, Dalhousie University, Halifax, Nova Scotia, Canada, Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
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Marianne M. Stanford,

Affiliations Research & Development, Immunovaccine Inc, Halifax, Nova Scotia, Canada, Department of Microbiology & Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
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Lisa MacDonald,

Affiliation Research & Development, Immunovaccine Inc, Halifax, Nova Scotia, Canada
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Marc Mansour,

Affiliation Research & Development, Immunovaccine Inc, Halifax, Nova Scotia, Canada
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Robert S. Liwski

Affiliations Department of Microbiology & Immunology, Dalhousie University, Halifax, Nova Scotia, Canada, Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada, Department of Pathology and Laboratory Medicine, Division of Hematopathology, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
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B cells
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Immunologic adjuvants
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Vaccines
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Cytotoxic T cells
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Toll-like receptors
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Antibodies
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B cell receptors
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T cells
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