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Open Access
Peer-reviewed
Research Article
Streptococcus pneumoniae Cell-Wall-Localized Phosphoenolpyruvate Protein Phosphotransferase Can Function as an Adhesin: Identification of Its Host Target Molecules and Evaluation of Its Potential as a Vaccine
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Yaffa Mizrachi Nebenzahl ,
* E-mail: ymizr@bgu.ac.il
Affiliations Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel, The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Karin Blau,
Affiliations Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel, The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Tatyana Kushnir,
Affiliations Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel, The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Marilou Shagan,
Affiliations Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel, The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Maxim Portnoi,
Affiliations Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel, The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Aviad Cohen,
Affiliations Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel, The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Shalhevet Azriel,
Affiliations Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel, The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Itai Malka,
Affiliations Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel, The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Asad Adawi,
Affiliations Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel, The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Daniel Kafka,
Affiliations Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel, The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Shahar Dotan,
Affiliation NasVax Ltd, Ness Ziona, Israel
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Gali Guterman,
Affiliations Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel, The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Shany Troib,
Affiliations Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel, The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Tali Fishilevich,
Affiliations Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel, The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Jonathan M Gershoni,
Affiliation Department of Cell Research and Immunology, Tel-Aviv University, Tel-Aviv, Israel
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Alex Braiman,
Affiliation The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Andrea M Mitchell,
Affiliation Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
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Timothy J Mitchell,
Affiliation Department of Cell Research and Immunology, Tel-Aviv University, Tel-Aviv, Israel
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Nurith Porat,
Affiliations Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel, The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Inna Goliand,
Affiliations National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel, Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Vered Chalifa Caspi,
Affiliation National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel
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Edwin Swiatlo,
Affiliation Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, MS, United States of America
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Michael Tal,
Affiliation NasVax Ltd, Ness Ziona, Israel
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Ronald Ellis,
Affiliation NasVax Ltd, Ness Ziona, Israel
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Natalie Elia,
Affiliations National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel, Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Ron Dagan
Affiliation The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Streptococcus pneumoniae Cell-Wall-Localized Phosphoenolpyruvate Protein Phosphotransferase Can Function as an Adhesin: Identification of Its Host Target Molecules and Evaluation of Its Potential as a Vaccine
- Yaffa Mizrachi Nebenzahl,
- Karin Blau,
- Tatyana Kushnir,
- Marilou Shagan,
- Maxim Portnoi,
- Aviad Cohen,
- Shalhevet Azriel,
- Itai Malka,
- Asad Adawi,
- Daniel Kafka
- Published: March 18, 2016
- https://doi.org/10.1371/journal.pone.0150320