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Open Access
Peer-reviewed
Research Article
The Implicitome: A Resource for Rationalizing Gene-Disease Associations
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Kristina M. Hettne ,
Contributed equally to this work with: Kristina M. Hettne, Mark Thompson, Herman H. H. B. M. van Haagen
* E-mail: k.m.hettne@lumc.nl
Affiliation Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
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Mark Thompson ,
Contributed equally to this work with: Kristina M. Hettne, Mark Thompson, Herman H. H. B. M. van Haagen
Affiliation Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
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Herman H. H. B. M. van Haagen ,
Contributed equally to this work with: Kristina M. Hettne, Mark Thompson, Herman H. H. B. M. van Haagen
Affiliation Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
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Eelke van der Horst,
Affiliation Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
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Rajaram Kaliyaperumal,
Affiliation Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
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Eleni Mina,
Affiliation Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
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Zuotian Tatum,
Affiliation Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
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Jeroen F. J. Laros,
Affiliation Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
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Erik M. van Mulligen,
Affiliations Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands, Department of Medical Informatics, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
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Martijn Schuemie,
Affiliation Department of Medical Informatics, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
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Emmelien Aten,
Affiliation Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
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Tong Shu Li,
Affiliation Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, United States of America
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Richard Bruskiewich,
Affiliation STAR Informatics / Delphinai Corporation, Port Moody, BC, Canada
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Benjamin M. Good,
Affiliation Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, United States of America
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Andrew I. Su,
Affiliation Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, United States of America
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Jan A. Kors,
Affiliation Department of Medical Informatics, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
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Johan den Dunnen,
Affiliation Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
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Gert-Jan B. van Ommen,
Affiliation Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
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Marco Roos,
Affiliation Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
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Peter A.C. ‘t Hoen,
Affiliation Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
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Barend Mons,
Affiliations Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands, Dutch Techcentre for Life Sciences, Utrecht, The Netherlands
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Erik A. Schultes
Affiliations Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands, Leiden Institute for Advanced Computer Science, Leiden, The Netherlands
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The Implicitome: A Resource for Rationalizing Gene-Disease Associations
- Kristina M. Hettne,
- Mark Thompson,
- Herman H. H. B. M. van Haagen,
- Eelke van der Horst,
- Rajaram Kaliyaperumal,
- Eleni Mina,
- Zuotian Tatum,
- Jeroen F. J. Laros,
- Erik M. van Mulligen,
- Martijn Schuemie
- Published: February 26, 2016
- https://doi.org/10.1371/journal.pone.0149621