Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity

Laura James; Ke Yan; Lisa Pence; Pippa Simpson; Sudeepa Bhattacharyya; Pritmohinder Gill; Lynda Letzig; Gregory Kearns; Richard Beger

doi:10.1371/journal.pone.0131010

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Open Access

Peer-reviewed

Research Article

Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity

Laura James ,

* E-mail: jameslaurap@uams.edu

Affiliations Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, United States of America, Arkansas Children’s Hospital Research Institute, Little Rock, AR 72202, United States of America
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Ke Yan,

Affiliation Medical College of Wisconsin, Milwaukee, WI 53226, United States of America
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Lisa Pence,

Affiliation Division of Systems Biology, National Center for Toxicological Research, Jefferson, AR 72079, United States of America
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Pippa Simpson,

Affiliation Medical College of Wisconsin, Milwaukee, WI 53226, United States of America
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Sudeepa Bhattacharyya,

Affiliations Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, United States of America, Arkansas Children’s Hospital Research Institute, Little Rock, AR 72202, United States of America
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Pritmohinder Gill,

Affiliations Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, United States of America, Arkansas Children’s Hospital Research Institute, Little Rock, AR 72202, United States of America
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Lynda Letzig,

Affiliations Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, United States of America, Arkansas Children’s Hospital Research Institute, Little Rock, AR 72202, United States of America
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Gregory Kearns,

Affiliation Division of Pediatric Pharmacology, Medical Toxicology and Therapeutic Innovation, The Children’s Mercy Hospital, Kansas City, MO 64108, United States of America
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Richard Beger

Affiliation Division of Systems Biology, National Center for Toxicological Research, Jefferson, AR 72079, United States of America
⨯

Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity

Laura James,
Ke Yan,
Lisa Pence,
Pippa Simpson,
Sudeepa Bhattacharyya,
Pritmohinder Gill,
Lynda Letzig,
Gregory Kearns,
Richard Beger

Published: July 24, 2015
https://doi.org/10.1371/journal.pone.0131010

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Bile
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Toxicity
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Drug metabolism
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Fatty liver
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Biomarkers
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Metabolomics
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Protein metabolism
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Serum proteins
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