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Long-Term Pancreatic Beta Cell Exposure to High Levels of Glucose but Not Palmitate Induces DNA Methylation within the Insulin Gene Promoter and Represses Transcriptional Activity
- Kota Ishikawa,
- Shin Tsunekawa,
- Makoto Ikeniwa,
- Takako Izumoto,
- Atsushi Iida,
- Hidetada Ogata,
- Eita Uenishi,
- Yusuke Seino,
- Nobuaki Ozaki,
- Yoshihisa Sugimura
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- Published: February 6, 2015
- https://doi.org/10.1371/journal.pone.0115350