A Multi-Compartment Single and Multiple Dose Pharmacokinetic Comparison of Rectally Applied Tenofovir 1% Gel and Oral Tenofovir Disoproxil Fumarate

Kuo-Hsiung Yang; Craig Hendrix; Namandje Bumpus; Julie Elliott; Karen Tanner; Christine Mauck; Ross Cranston; Ian McGowan; Nicola Richardson-Harman; Peter A. Anton; Angela D. M. Kashuba

doi:10.1371/journal.pone.0106196

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Open Access

Peer-reviewed

Research Article

A Multi-Compartment Single and Multiple Dose Pharmacokinetic Comparison of Rectally Applied Tenofovir 1% Gel and Oral Tenofovir Disoproxil Fumarate

Kuo-Hsiung Yang ,

* E-mail: kuohyang@email.unc.edu

Affiliation Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, Chapel Hill, North Carolina, United States of America
⨯
Craig Hendrix,

Affiliation Departments of Medicine and Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Namandje Bumpus,

Affiliation Departments of Medicine and Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Julie Elliott,

Affiliation Center for HIV Prevention Research, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
⨯
Karen Tanner,

Affiliation Department of Biostatistics, UCLA School of Public Health, Los Angeles, California, United States of America
⨯
Christine Mauck,

Affiliation CONRAD, Arlington, Virginia, United States of America
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Ross Cranston,

Affiliation Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Ian McGowan,

Affiliation Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Nicola Richardson-Harman,

Affiliation Alpha StatConsult LLC, Damascus, Maryland, United States of America
⨯
Peter A. Anton,

Affiliation Center for HIV Prevention Research, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
⨯
Angela D. M. Kashuba

Affiliation Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, Chapel Hill, North Carolina, United States of America
⨯

A Multi-Compartment Single and Multiple Dose Pharmacokinetic Comparison of Rectally Applied Tenofovir 1% Gel and Oral Tenofovir Disoproxil Fumarate

Kuo-Hsiung Yang,
Craig Hendrix,
Namandje Bumpus,
Julie Elliott,
Karen Tanner,
Christine Mauck,
Ross Cranston,
Ian McGowan,
Nicola Richardson-Harman,
Peter A. Anton

Published: October 28, 2014
https://doi.org/10.1371/journal.pone.0106196

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Rectum
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Blood plasma
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Interstitial fluid
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Oral administration
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Pharmacokinetics
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Biopsy
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Body fluids
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Dose prediction methods
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