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Open Access
Peer-reviewed
Research Article
Allele-Specific Silencing of Mutant Huntingtin in Rodent Brain and Human Stem Cells
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Valérie Drouet ,
Contributed equally to this work with: Valérie Drouet, Marta Ruiz
Affiliations Institute of Biomedical Imaging (I2BM) and Molecular Imaging Research Center (MIRCen), Atomic Energy Commission (CEA), Fontenay-aux-Roses, France, URA2210, Centre National de Recherché Scientifique (CNRS), Fontenay-aux-Roses, France
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Marta Ruiz ,
Contributed equally to this work with: Valérie Drouet, Marta Ruiz
Affiliations Institute of Biomedical Imaging (I2BM) and Molecular Imaging Research Center (MIRCen), Atomic Energy Commission (CEA), Fontenay-aux-Roses, France, URA2210, Centre National de Recherché Scientifique (CNRS), Fontenay-aux-Roses, France
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Diana Zala,
Affiliations Institut Curie, Orsay, France, UMR3306, Centre National de Recherché Scientifique (CNRS), Orsay, France, U1005, Institut National de la Santé et de la Recherche Médicale (INSERM), Orsay France
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Maxime Feyeux,
Affiliations U861, Institut National de la Santé et de la Recherche Médicale (INSERM), AFM, Evry, France, UEVE U861, I-STEM, AFM, Evry, France
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Gwennaëlle Auregan,
Affiliations Institute of Biomedical Imaging (I2BM) and Molecular Imaging Research Center (MIRCen), Atomic Energy Commission (CEA), Fontenay-aux-Roses, France, URA2210, Centre National de Recherché Scientifique (CNRS), Fontenay-aux-Roses, France
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Karine Cambon,
Affiliations Institute of Biomedical Imaging (I2BM) and Molecular Imaging Research Center (MIRCen), Atomic Energy Commission (CEA), Fontenay-aux-Roses, France, URA2210, Centre National de Recherché Scientifique (CNRS), Fontenay-aux-Roses, France
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Laetitia Troquier,
Affiliation Department of Clinical Neurosciences (DNC), Lausanne University Hospital (CHUV), Lausanne, Switzerland
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Johann Carpentier,
Affiliations Institute of Biomedical Imaging (I2BM) and Molecular Imaging Research Center (MIRCen), Atomic Energy Commission (CEA), Fontenay-aux-Roses, France, URA2210, Centre National de Recherché Scientifique (CNRS), Fontenay-aux-Roses, France
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Sophie Aubert,
Affiliation CECS, I-STEM, AFM, Evry, France
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Nicolas Merienne,
Affiliation Department of Clinical Neurosciences (DNC), Lausanne University Hospital (CHUV), Lausanne, Switzerland
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Fany Bourgois-Rocha,
Affiliations U861, Institut National de la Santé et de la Recherche Médicale (INSERM), AFM, Evry, France, UEVE U861, I-STEM, AFM, Evry, France
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Raymonde Hassig,
Affiliations Institute of Biomedical Imaging (I2BM) and Molecular Imaging Research Center (MIRCen), Atomic Energy Commission (CEA), Fontenay-aux-Roses, France, URA2210, Centre National de Recherché Scientifique (CNRS), Fontenay-aux-Roses, France
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Maria Rey,
Affiliation Department of Clinical Neurosciences (DNC), Lausanne University Hospital (CHUV), Lausanne, Switzerland
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Noëlle Dufour,
Affiliations Institute of Biomedical Imaging (I2BM) and Molecular Imaging Research Center (MIRCen), Atomic Energy Commission (CEA), Fontenay-aux-Roses, France, URA2210, Centre National de Recherché Scientifique (CNRS), Fontenay-aux-Roses, France
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Frédéric Saudou,
Affiliations Institut Curie, Orsay, France, UMR3306, Centre National de Recherché Scientifique (CNRS), Orsay, France, U1005, Institut National de la Santé et de la Recherche Médicale (INSERM), Orsay France
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Anselme L. Perrier,
Affiliations U861, Institut National de la Santé et de la Recherche Médicale (INSERM), AFM, Evry, France, UEVE U861, I-STEM, AFM, Evry, France
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Philippe Hantraye,
Affiliations Institute of Biomedical Imaging (I2BM) and Molecular Imaging Research Center (MIRCen), Atomic Energy Commission (CEA), Fontenay-aux-Roses, France, URA2210, Centre National de Recherché Scientifique (CNRS), Fontenay-aux-Roses, France
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Nicole Déglon
* E-mail: nicole.deglon@chuv.ch
Affiliations Institute of Biomedical Imaging (I2BM) and Molecular Imaging Research Center (MIRCen), Atomic Energy Commission (CEA), Fontenay-aux-Roses, France, URA2210, Centre National de Recherché Scientifique (CNRS), Fontenay-aux-Roses, France, Department of Clinical Neurosciences (DNC), Lausanne University Hospital (CHUV), Lausanne, Switzerland
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Allele-Specific Silencing of Mutant Huntingtin in Rodent Brain and Human Stem Cells
- Valérie Drouet,
- Marta Ruiz,
- Diana Zala,
- Maxime Feyeux,
- Gwennaëlle Auregan,
- Karine Cambon,
- Laetitia Troquier,
- Johann Carpentier,
- Sophie Aubert,
- Nicolas Merienne
- Published: June 13, 2014
- https://doi.org/10.1371/journal.pone.0099341