Large Animal Model for Development of Functional Restoration Paradigms Using Epidural and Intraspinal Stimulation

Jan T. Hachmann; Ju Ho Jeong; Peter J. Grahn; Grant W. Mallory; Loribeth Q. Evertz; Allan J. Bieber; Darlene A. Lobel; Kevin E. Bennet; Kendall H. Lee; J. Luis Lujan

doi:10.1371/journal.pone.0081443

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Open Access

Peer-reviewed

Research Article

Large Animal Model for Development of Functional Restoration Paradigms Using Epidural and Intraspinal Stimulation

Jan T. Hachmann,

Affiliations Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, United States of America, Mayo Graduate School, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Ju Ho Jeong,

Affiliations Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Neurosurgery, Kosin University College of Medicine, Busan, Korea
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Peter J. Grahn,

Affiliation Mayo Graduate School, Mayo Clinic, Rochester, Minnesota, United States of America
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Grant W. Mallory,

Affiliation Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, United States of America
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Loribeth Q. Evertz,

Affiliation Mayo Graduate School, Mayo Clinic, Rochester, Minnesota, United States of America
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Allan J. Bieber,

Affiliations Mayo Graduate School, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
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Darlene A. Lobel,

Affiliation Department of Neurosurgery, Cleveland Clinic, Cleveland, Ohio, United States of America
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Kevin E. Bennet,

Affiliations Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, United States of America, Division of Engineering, Mayo Clinic, Rochester, Minnesota, United States of America
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Kendall H. Lee,

Affiliations Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
J. Luis Lujan

* E-mail: lujan.luis@mayo.edu

Affiliations Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America
⨯

Large Animal Model for Development of Functional Restoration Paradigms Using Epidural and Intraspinal Stimulation

Jan T. Hachmann,
Ju Ho Jeong,
Peter J. Grahn,
Grant W. Mallory,
Loribeth Q. Evertz,
Allan J. Bieber,
Darlene A. Lobel,
Kevin E. Bennet,
Kendall H. Lee,
J. Luis Lujan

Published: December 5, 2013
https://doi.org/10.1371/journal.pone.0081443

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Functional electrical stimulation
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Spinal cord
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Epidural block
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Spinal cord injury
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Electromyography
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Motor neurons
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Body limbs
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Musculoskeletal mechanics
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