HIV-1 Replication Fitness of HLA-B*57/58:01 CTL Escape Variants Is Restored by the Accumulation of Compensatory Mutations in Gag

Esther F. Gijsbers; K. Anton Feenstra; Ad C. van Nuenen; Marjon Navis; Jaap Heringa; Hanneke Schuitemaker; Neeltje A. Kootstra

doi:10.1371/journal.pone.0081235

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Open Access

Peer-reviewed

Research Article

HIV-1 Replication Fitness of HLA-B*57/58:01 CTL Escape Variants Is Restored by the Accumulation of Compensatory Mutations in Gag

Esther F. Gijsbers,

Affiliation Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
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K. Anton Feenstra,

Affiliations Centre for Integrative Bioinformatics (IBIVU) and Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University, Amsterdam, The Netherlands, Netherlands Bioinformatics Centre (NBIC), Nijmegen, The Netherlands
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Ad C. van Nuenen,

Affiliation Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
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Marjon Navis,

Current address: Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

Affiliation Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
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Jaap Heringa,

Affiliations Centre for Integrative Bioinformatics (IBIVU) and Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University, Amsterdam, The Netherlands, Netherlands Bioinformatics Centre (NBIC), Nijmegen, The Netherlands
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Hanneke Schuitemaker,

Current address: Crucell Holland BV, Leiden, The Netherlands

Affiliation Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Neeltje A. Kootstra

* E-mail: N.A.Kootstra@amc.uva.nl

Affiliation Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯

HIV-1 Replication Fitness of HLA-B*57/58:01 CTL Escape Variants Is Restored by the Accumulation of Compensatory Mutations in Gag

Esther F. Gijsbers,
K. Anton Feenstra,
Ad C. van Nuenen,
Marjon Navis,
Jaap Heringa,
Hanneke Schuitemaker,
Neeltje A. Kootstra

Published: December 5, 2013
https://doi.org/10.1371/journal.pone.0081235

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Microbial mutation
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Viral replication
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Amino acid sequence analysis
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HIV-1
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Protein sequencing
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Molecular cloning
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