Safety, Immunogenicity and Dose Ranging of a New Vi-CRM197 Conjugate Vaccine against Typhoid Fever: Randomized Clinical Testing in Healthy Adults

Pierre van Damme; Froukje Kafeja; Alessandra Anemona; Venere Basile; Anne Katrin Hilbert; Ilse De Coster; Simona Rondini; Francesca Micoli; Rana M. Qasim Khan; Elisa Marchetti; Vito Di Cioccio; Allan Saul; Laura B. Martin; Audino Podda

doi:10.1371/journal.pone.0025398

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Open Access

Peer-reviewed

Research Article

Safety, Immunogenicity and Dose Ranging of a New Vi-CRM₁₉₇ Conjugate Vaccine against Typhoid Fever: Randomized Clinical Testing in Healthy Adults

Pierre van Damme,

Affiliation Center for the Evaluation of Vaccination, Vaccine & Infectious Disease Institute, University of Antwerp, Antwerp, Belgium
⨯
Froukje Kafeja,

Affiliation Center for the Evaluation of Vaccination, Vaccine & Infectious Disease Institute, University of Antwerp, Antwerp, Belgium
⨯
Alessandra Anemona,

Affiliation Novartis Vaccines Institute for Global Health, Siena, Italy
⨯
Venere Basile,

Affiliation Novartis Vaccines Institute for Global Health, Siena, Italy
⨯
Anne Katrin Hilbert,

Affiliation Novartis Vaccines & Diagnostics, Clinical Serology Laboratories, Marburg, Germany
⨯
Ilse De Coster,

Affiliation Center for the Evaluation of Vaccination, Vaccine & Infectious Disease Institute, University of Antwerp, Antwerp, Belgium
⨯
Simona Rondini,

Affiliation Novartis Vaccines Institute for Global Health, Siena, Italy
⨯
Francesca Micoli,

Affiliation Novartis Vaccines Institute for Global Health, Siena, Italy
⨯
Rana M. Qasim Khan,

Affiliation Novartis Vaccines Institute for Global Health, Siena, Italy
⨯
Elisa Marchetti,

Affiliation Novartis Vaccines Institute for Global Health, Siena, Italy
⨯
Vito Di Cioccio,

Affiliation Novartis Vaccines Institute for Global Health, Siena, Italy
⨯
Allan Saul,

Affiliation Novartis Vaccines Institute for Global Health, Siena, Italy
⨯
Laura B. Martin,

Affiliation Novartis Vaccines Institute for Global Health, Siena, Italy
⨯
Audino Podda

* E-mail: audino.podda@novartis.com

Affiliation Novartis Vaccines Institute for Global Health, Siena, Italy
⨯

Safety, Immunogenicity and Dose Ranging of a New Vi-CRM₁₉₇ Conjugate Vaccine against Typhoid Fever: Randomized Clinical Testing in Healthy Adults

Pierre van Damme,
Froukje Kafeja,
Alessandra Anemona,
Venere Basile,
Anne Katrin Hilbert,
Ilse De Coster,
Simona Rondini,
Francesca Micoli,
Rana M. Qasim Khan,
Elisa Marchetti

Published: September 30, 2011
https://doi.org/10.1371/journal.pone.0025398

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Vaccine development
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Conjugate vaccines
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Vaccination and immunization
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Enzyme-linked immunoassays
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Vaccines
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Typhoid
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Fevers
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