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Open Access
Peer-reviewed
Research Article
Large Scale Replication Study of the Association between HLA Class II/BTNL2 Variants and Osteoarthritis of the Knee in European-Descent Populations
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Ana M. Valdes ,
* E-mail: ana.valdes@kcl.ac.uk
Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
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Unnur Styrkarsdottir,
Affiliation deCODE Genetics, Reykjavik, Iceland
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Michael Doherty,
Affiliation Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom
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David L. Morris,
Affiliation Divisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Diseases, King's College London, London, United Kingdom
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Massimo Mangino,
Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
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Agu Tamm,
Affiliation Department of Internal Medicine, University of Tartu, Tartu, Estonia
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Sally A. Doherty,
Affiliation Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom
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Kalle Kisand,
Affiliation Department of Internal Medicine, University of Tartu, Tartu, Estonia
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Irina Kerna,
Affiliation Department of Internal Medicine, University of Tartu, Tartu, Estonia
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Ann Tamm,
Affiliations Department of Internal Medicine, University of Tartu, Tartu, Estonia, Department of Sports Medicine and Rehabilitation, University of Tartu, Tartu, Estonia
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Margaret Wheeler,
Affiliation Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom
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Rose A. Maciewicz,
Affiliation Respiratory & Inflammation Research Area, AstraZeneca, Loughborough, United Kingdom
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Weiya Zhang,
Affiliation Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom
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Kenneth R. Muir,
Affiliation Health Sciences Research Institute, Warwick Medical School University of Warwick, Coventry, United Kingdom
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Elaine M. Dennison,
Affiliation Medical Research Council Lifecourse Epidemiology Unit University of Southampton Southampton, United Kingdom
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Deborah J. Hart,
Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
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Sarah Metrustry,
Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
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Ingileif Jonsdottir,
Affiliations deCODE Genetics, Reykjavik, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
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Gudbjorn F. Jonsson,
Affiliation deCODE Genetics, Reykjavik, Iceland
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Helgi Jonsson,
Affiliations Faculty of Medicine, University of Iceland, Reykjavik, Iceland, Department of Medicine, Landspitali University Hospital, Reykjavik, Iceland
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Thorvaldur Ingvarsson,
Affiliations Faculty of Medicine, University of Iceland, Reykjavik, Iceland, University Hospital, Institution of Health Science, University of Akureyri, Akureyri, Iceland
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Cyrus Cooper,
Affiliations Medical Research Council Lifecourse Epidemiology Unit University of Southampton Southampton, United Kingdom, Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom
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Timothy J. Vyse,
Affiliation Divisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Diseases, King's College London, London, United Kingdom
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Tim D. Spector,
Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
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Kari Stefansson ,
Contributed equally to this work with: Kari Stefansson, Nigel K. Arden
Affiliations deCODE Genetics, Reykjavik, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
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Nigel K. Arden
Contributed equally to this work with: Kari Stefansson, Nigel K. Arden
Affiliations Medical Research Council Lifecourse Epidemiology Unit University of Southampton Southampton, United Kingdom, Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom
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Large Scale Replication Study of the Association between HLA Class II/BTNL2 Variants and Osteoarthritis of the Knee in European-Descent Populations
- Ana M. Valdes,
- Unnur Styrkarsdottir,
- Michael Doherty,
- David L. Morris,
- Massimo Mangino,
- Agu Tamm,
- Sally A. Doherty,
- Kalle Kisand,
- Irina Kerna,
- Ann Tamm
- Published: August 10, 2011
- https://doi.org/10.1371/journal.pone.0023371