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Open Access

Peer-reviewed

Research Article

Prenatal Immune Challenge Is an Environmental Risk Factor for Brain and Behavior Change Relevant to Schizophrenia: Evidence from MRI in a Mouse Model

  • Qi Li ,

    Contributed equally to this work with: Qi Li, Charlton Cheung

    Affiliations Department of Psychiatry, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region (S.A.R.), China, Centre for Reproduction Growth and Development, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region (S.A.R.), China

    ⨯
  • Charlton Cheung ,

    Contributed equally to this work with: Qi Li, Charlton Cheung

    Affiliation Department of Psychiatry, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region (S.A.R.), China

    ⨯
  • Ran Wei,

    Affiliation Department of Psychiatry, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region (S.A.R.), China

    ⨯
  • Edward S. Hui,

    Affiliation Laboratory for Biomedical Imaging and Signal Processing, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region (S.A.R.), China

    ⨯
  • Joram Feldon,

    Affiliation Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology Zurich (ETH), Schwerzenbach, Switzerland

    ⨯
  • Urs Meyer,

    Affiliation Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology Zurich (ETH), Schwerzenbach, Switzerland

    ⨯
  • Sookja Chung,

    Affiliation Department of Anatomy, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region (S.A.R.), China

    ⨯
  • Siew E. Chua,

    Affiliations Department of Psychiatry, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region (S.A.R.), China, Centre for Reproduction Growth and Development, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region (S.A.R.), China, State Key Laboratory for Brain and Cognitive Sciences, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region (S.A.R.), China

    ⨯
  • Pak C. Sham,

    Affiliations Department of Psychiatry, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region (S.A.R.), China, Centre for Reproduction Growth and Development, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region (S.A.R.), China, State Key Laboratory for Brain and Cognitive Sciences, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region (S.A.R.), China

    ⨯
  • Ed X. Wu,

    Affiliation Laboratory for Biomedical Imaging and Signal Processing, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region (S.A.R.), China

    ⨯
  • Grainne M. McAlonan

    * E-mail: mcalonan@hkucc.hku.hk

    Affiliations Department of Psychiatry, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region (S.A.R.), China, Centre for Reproduction Growth and Development, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region (S.A.R.), China, State Key Laboratory for Brain and Cognitive Sciences, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region (S.A.R.), China

    ⨯

Prenatal Immune Challenge Is an Environmental Risk Factor for Brain and Behavior Change Relevant to Schizophrenia: Evidence from MRI in a Mouse Model

  • Qi Li, 
  • Charlton Cheung, 
  • Ran Wei, 
  • Edward S. Hui, 
  • Joram Feldon, 
  • Urs Meyer, 
  • Sookja Chung, 
  • Siew E. Chua, 
  • Pak C. Sham, 
  • Ed X. Wu
PLOS
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  • Published: July 24, 2009
  • https://doi.org/10.1371/journal.pone.0006354
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  • Voxel-based morphometry  

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