PONE-D-23-33791Prenatal vitamin D levels of immigrant mothers and language, scholastic, coordination and mixed developmental disorders in offspringPLOS ONE

Dear Dr. Arrhenius,

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PLOS ONE

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

Reviewer #4: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

Reviewer #4: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

Reviewer #4: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

Reviewer #4: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: what the criteria of low or medium human development index (HDI) line 150

line 158 Coordination disorders are characterized by impaired fine and gross motor coordination development no surgical or accidents matters

line 200 25(OH)D vitamin D or 1, 25 Di (OH) D

vitamin D have role in immunity do you have any results about immunity or disease resistance

Reviewer #2: Prenatal vitamin D levels of immigrant mothers and language, scholastic, coordination and mixed developmental disorders in offspring

Vitamin D deficiency causes health issues not only in children as well in young and old age livings both in human and animals. Prenatal vitamin D levels of immigrant mothers and language, scholastic, coordination and mixed developmental disorders in offspring is an interesting study with respect to immigrant population in Finland. I will suggest few changes in the manuscript before publication. These changes are following:

On line # 84: write full spellings of ADHD as used first time in the text.

On line # 229: Can authors add data of % age of different countries rather than immigrant’s continents having vit D deficiency used in the present study samples?

was there any deficiency of Ca, P etc in immigrants mothers related with the deficiency of vit D?

is there any relationship between the year of migration of immigrant’s mothers, present study and Vit D deficiency?

Need to improve table #02 for readers.

Reviewer #3: I do not like the title of the paper. It needs to be made more precise. Otherwise, the paper is a very good attempt. Methodology is sound. Discussion is extremely comprehensive. Methodology is well detailed.

Reviewer #4: Congrats to the authors on their hard work. It is an original study—the introduction, discussion, and conclusion were well-written and robust statistical analysis performed. I would advise the author to consider enhancing the visual cues by adding more graphics, not just tables.

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Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: Yes: Hamada A. Ahmed

Reviewer #2: No

Reviewer #3: No

Reviewer #4: No

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Vitamin D levels of pregnant immigrant women and developmental disorders of language, learning and coordination in offspring

PONE-D-23-33791R1

Dear Dr. Arrhenius,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

Kind regards,

Ramune Jacobsen

Academic Editor

PLOS ONE

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #2: All comments have been addressed

Reviewer #3: All comments have been addressed

Reviewer #4: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

Reviewer #4: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

Reviewer #4: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

Reviewer #4: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

Reviewer #4: Yes

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6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The data provided as part of the manuscript or its supporting information. he statistical analysis been performed appropriately. Authors have adequately addressed my comments raised in a previous round of review and I feel that this manuscript is now acceptable for publication.

Reviewer #2: Authors addressed all the questions. Please, consider paper entitled as Vitamin D levels of pregnant immigrant women and developmental disorders of language, learning and coordination in offspring for publication.

Reviewer #3: Good work done. I think the authors have addressed all the queries which were raised by the reviewers.

Good work done. I think the authors have addressed all the queries which were raised by the reviewers.

Reviewer #4: The author addressed all the comments. They added the figures, changed the paper title and did all the reviewers suggested modifications.

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: Yes: Hamada A. Ahmed

Reviewer #2: No

Reviewer #3: No

Reviewer #4: No

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