Prospective associations between coffee consumption and psychological well-being

PONE-D-21-29419

Dear Dr. Trudel-Fitzgerald,

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: No

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Based on a large sample from the Nurses Health Study cohort, the authors examined in the present study whether coffee consumption might be related to happiness, positive mood and hence better well-being. This research hypothesis was undertaken on the basis of the fact that coffee consumption alleviates some depression symptoms and reduces risk of depression. Surprisingly, at the other end of the spectrum, happiness and good mood, coffee consumption has almost no effect.

The study was well-designed and carefully performed with a thorough analysis grouping several models and the results were homogeneous. I really congratulate the authors for their study which was truly needed in light of what we know about the relationship between depression and suicide. This study will prevent people to extrapolate from the depression end to the effects of coffee consumption in individuals with normal levels of mood. The present manuscript is well written, easy to read and does not need any change in my eyes.

Reviewer #2: This is a comprehensive analysis of the association between coffee consumption and optimism as well as happiness, with both outcomes approached by self-reported participant’s information using well-recognized tests. Although previous work showed an inverse association between coffee and lower risk of depression and suicide, the authors were not able to find an association for the studied outcomes.

Strengths of this work include an exhaustive information about Methods, a very careful use of adjustment for potential confounders, and the use of a large population from a well characterized cohort, with prolonged follow-up.

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Reviewer #1: No

Reviewer #2: No