PONE-D-19-33652

Prevalence and associated factors of pneumonia among children under five in peri-urban areas of Dessie City, northeastern Ethiopia: A community-based cross-sectional study

PLOS ONE

Dear Dr Adane (PhD),

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PLOS ONE

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Partly

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: I Don't Know

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Table 1 is missing.The serial starts from Table 2. However table 1 is referenced in the legend.To attach the table 1.

Justify how weaning period of 12 or more months is taken as reference category with WHO recommendations of weaning at 6 months of age.

Reviewer #2: The manuscript entitle ¨Prevalence and associated cactors of pneumonia among children under five in peri-urban areas of Dessie City, northeastern Ethiopia: A community-based cross sectional study¨ described by Kelleb A. et al., is very well written, interesting with values information about pneumonia. It is very difficult to perform a field study , moreover in Kebeles population. The authors accumulated an impressive data that should be used for others studies and diseases.

The questionnaire and analyses were intensely performed and the results and conclusions included all comments of the observational study.

In my opinion, the authors should develop more the subject about vaccination. It is a relevant thematic in the pneumonia domain and some information are missed, such us, the definition about fully vaccinated¨ and ¨not fully vaccinated. I am not aware about the vaccination system in Ethiopia.

Congratulations for this beautiful study.

Reviewer #3: The study is about children with clinical signs of pneumonia not confirmed cases of pneumonia since no microbological or radiological diagnosis done.

Table 1,2,3,4,5 and 6 tne first line and column 2 it is write (Pnrumonia N = 539) this is confusing, 539 is it the number of participant or number of children with pneumonia ? What are the meaning of yes and no of this colum ? What about presence and absence of pneumonia knowng that 92 children had pneumonia ?

Table 4 : the pneumonia vaccin and age at which it was administred was not mentionned in the study and out of 492 (75+417) children vaccinated against pneimonia 417 (yes) have pneumonia. Vaccination and occurence of pneumonia is an important point that should be discussed ?

The word Kebele have been used many times without giving the meaning.

Line 314-315 comparism of pneumonia prevalence of localised peri-urban area of Ethiopia to that of National level of Brazil done. What is the aim of this ?

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Reviewer #1: Yes: Dr Gothankar J S

Reviewer #2: Yes: Glaucia Paranhos-Baccala

Reviewer #3: Yes: Ibrahim Dan Dano

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Prevalence and associated factors of pneumonia among children under five in peri-urban areas of Dessie City, northeastern Ethiopia

PONE-D-19-33652R1

Dear Dr. Adane (PhD),

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Ray Borrow, Ph.D., FRCPath

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #2: All comments have been addressed

Reviewer #3: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: (No Response)

Reviewer #2: The revised manuscript is much more clear after inclusion of all comments suggested by the reviewers. All questions were answered and the revised manuscript is now ready to be accepted and published.

Pneumonia studies in children under 5 years of age are primordial in peri-urbans regions. The intrinsic conditions of life were the children are living was described and pointed out as a major indicator for pneumonia risk factors. Others risk factors such as malnutrition despite are known, it is relevant to be compared with urban area. The study design and study management were performed very well. This kind of study is very complex and in this study, it was conducted very seriously. It is important to have this date in Ethiopia since no major data was described until now from Ethiopian researchers.

Thank you very much to give me the opportunity to review this manuscript.

Reviewer #3: All my comments have been taken into account and I am satisfied with the corrections done. The article is well written and provide valus informations about pneumonie.

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: Yes: Dr Jayashree Gothankar

Reviewer #2: Yes: Gláucia Paranhos-Baccalà

Reviewer #3: Yes: Dan Dano Ibrahim