Peer Review History

Original SubmissionDecember 5, 2019
Decision Letter - Frédéric Denis, Editor

PONE-D-19-33768

Do factors across The World Health Organisation International Classification of Functioning, Disability and Health framework explain perceived caregiver availability for community dwelling older adults in Ghana?

PLOS ONE

Dear Dr Awuviry-Newton,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

We would appreciate receiving your revised manuscript by Mar 07 2020 11:59PM. When you are ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter.

To enhance the reproducibility of your results, we recommend that if applicable you deposit your laboratory protocols in protocols.io, where a protocol can be assigned its own identifier (DOI) such that it can be cited independently in the future. For instructions see: http://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols

Please include the following items when submitting your revised manuscript:

  • A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). This letter should be uploaded as separate file and labeled 'Response to Reviewers'.
  • A marked-up copy of your manuscript that highlights changes made to the original version. This file should be uploaded as separate file and labeled 'Revised Manuscript with Track Changes'.
  • An unmarked version of your revised paper without tracked changes. This file should be uploaded as separate file and labeled 'Manuscript'.

Please note while forming your response, if your article is accepted, you may have the opportunity to make the peer review history publicly available. The record will include editor decision letters (with reviews) and your responses to reviewer comments. If eligible, we will contact you to opt in or out.

We look forward to receiving your revised manuscript.

Kind regards,

Frédéric Denis, Ph.D.

Academic Editor

PLOS ONE

Journal Requirements:

1. When submitting your revision, we need you to address these additional requirements.

Please ensure that your manuscript meets PLOS ONE's style requirements, including those for file naming. The PLOS ONE style templates can be found at

http://www.journals.plos.org/plosone/s/file?id=wjVg/PLOSOne_formatting_sample_main_body.pdf and http://www.journals.plos.org/plosone/s/file?id=ba62/PLOSOne_formatting_sample_title_authors_affiliations.pdf

2.  Please include captions for your Supporting Information files at the end of your manuscript, and update any in-text citations to match accordingly. Please see our Supporting Information guidelines for more information: http://journals.plos.org/plosone/s/supporting-information.

3. During our internal checks, the in-house editorial staff noted that you conducted research or obtained samples in another country. Please check the relevant national regulations and laws applying to foreign researchers and state whether you obtained the required permits and approvals. Please address this in your ethics statement in both the manuscript and submission information.

4. Please include additional information regarding the survey or questionnaire used in the study and ensure that you have provided sufficient details that others could replicate the analyses. For instance, if you developed a questionnaire as part of this study and it is not under a copyright more restrictive than CC-BY, please include a copy, in both the original language and English, as Supporting Information.

5. Please amend either the title on the online submission form (via Edit Submission) or the title in the manuscript so that they are identical.

6.  Thank you for stating the following in the Acknowledgments Section of your manuscript:

The University of Newcastle International Postgraduate Research Scholarship (UNIPRS) and

The University of Newcastle Research Scholarship Central 50:50 funded this study

(UNRSC50:50).

The Australian Research Council Centre of Excellence in Population Ageing Research (project

number CE170100005) supported this research.

We note that you have provided funding information that is not currently declared in your Funding Statement. However, funding information should not appear in the Acknowledgments section or other areas of your manuscript. We will only publish funding information present in the Funding Statement section of the online submission form.

Please remove any funding-related text from the manuscript and let us know how you would like to update your Funding Statement. Currently, your Funding Statement reads as follows:

No funding

7.  In your Data Availability statement, you have not specified where the minimal data set underlying the results described in your manuscript can be found. PLOS defines a study's minimal data set as the underlying data used to reach the conclusions drawn in the manuscript and any additional data required to replicate the reported study findings in their entirety. All PLOS journals require that the minimal data set be made fully available. For more information about our data policy, please see http://journals.plos.org/plosone/s/data-availability.

Upon re-submitting your revised manuscript, please upload your study’s minimal underlying data set as either Supporting Information files or to a stable, public repository and include the relevant URLs, DOIs, or accession numbers within your revised cover letter. For a list of acceptable repositories, please see http://journals.plos.org/plosone/s/data-availability#loc-recommended-repositories. Any potentially identifying patient information must be fully anonymized.

Important: If there are ethical or legal restrictions to sharing your data publicly, please explain these restrictions in detail. Please see our guidelines for more information on what we consider unacceptable restrictions to publicly sharing data: http://journals.plos.org/plosone/s/data-availability#loc-unacceptable-data-access-restrictions. Note that it is not acceptable for the authors to be the sole named individuals responsible for ensuring data access.

We will update your Data Availability statement to reflect the information you provide in your cover letter.

[Note: HTML markup is below. Please do not edit.]

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Partly

Reviewer #2: Yes

**********

2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: No

Reviewer #2: I Don't Know

**********

3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

**********

4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

**********

5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: WHO-ICF is an essential topic among researchers. However, I think that the vital elements are not provided to understand the findings. Also, the introduction and discussion would not be strong arguments. It requires additional literature reviews.

ABSTRACT

The background is missing.

INTRODUCTION:

1. The introduction needs to have extensive literature reviews linking to what the authors examined. Especially any relationship among the WHO-ICF and caregiver availability is not clear. Please describe how the authors use the WHO-ICF model in caregiver availability well. Why did you use the WHO-ICF? Instead, you can use the social support theory.

2. Please explore more about the relationship between physical disability and caregiver more in details

3. What are your hypotheses?

Methods.

3. What is the terminally ill? Please define it.

4. understudy sample, Did you collect the data from the participants of the WHO on AGEing and adult health study? It is not clear.

5. Please include the references for the measurements. Some of them came from the articles. How about the rest?

6. Data analysis. Please write more details about the software, code to obtain the odds ratios.

7. The order of subsection n the method section is not correct.

8. Please explain the relationships between the selected variables and subdomains in the WHOICF.

Discussion

The first paragraph is repetitive, like results. Please summarize it.

Please exam your findings based on your hypotheses.

Since Ns of variables per domain is small. Instead of using the WHO-ICF, it would be better to examine the variable itself. Like marital status, chronic conditions. Your findings are similar to previous studies. Please explain why and how it happened. Please expand your conclusions to your unique area for the implication section.

Reviewer #2: This is an interesting manuscript that is worthy of publication.

A few minor points that need to be addressed:

The first sentence of the second paragraph of the intrduction does not make sense "...they need to do to live and those they most cherish." In addition, the reference that goes with this and the examples of self care is inappropriate (Shiel) and does not illustrate the point. 3rd paragraph of the introduction - the Heaton reference is not listed. Last paragraph of the introduction - the WHO 2002 references should read 2005.

In the methods section, it is unclear as to whether the participants had to come back into the hospital to complete the survey, or if it was completed during their hospitalisation. If they had to come back, this is a bias because more participants with caregivers might be expected to have been able to arrange to come back than those without, i.e. the sample will be biased towards those with support.

In the results, in the third sentence of the paragraph 'Bivariate analysis' the sentence "Participants with no caregiver available had some no form of non-government support" does not make sense. In the paragraph commencing 'In Model 6...', the sentence "Participants living alone was not statistically significant" needs completing.

Discussion last sentence of third paragraph repetition of the word 'modernisation'.

References: the Ghana statistical Service reference is not cited in the text.

**********

6. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

Reviewer #2: No

[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files to be viewed.]

While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email us at figures@plos.org. Please note that Supporting Information files do not need this step.

Revision 1

Dear Dr Frederic Dennis,

We are very grateful for the privilege to revise the manuscript. In this letter, we have responded to the reviewers’ and your comments.

Journal Requirements:

1. When submitting your revision, we need you to address these additional requirements.

Please ensure that your manuscript meets PLOS ONE's style requirements, including those for file naming. The PLOS ONE style templates can be found at

http://www.journals.plos.org/plosone/s/file?id=wjVg/PLOSOne_formatting_sample_main_body.pdf and http://www.journals.plos.org/plosone/s/file?id=ba62/PLOSOne_formatting_sample_title_authors_affiliations.pdf

Response:

We have ensured that the manuscript meets PLOS ONE style requirement.

2. Please include captions for your Supporting Information files at the end of your manuscript, and update any in-text citations to match accordingly. Please see our Supporting Information guidelines for more information: http://journals.plos.org/plosone/s/supporting-information.

Response:

A caption for the Supporting Information files have been provided.

3. During our internal checks, the in-house editorial staff noted that you conducted research or obtained samples in another country. Please check the relevant national regulations and laws applying to foreign researchers and state whether you obtained the required permits and approvals. Please address this in your ethics statement in both the manuscript and submission information.

Response:

We obtained two ethics approval, one from Ghana and one from The University of Newcastle. The study has been conducted within the various national regulations.

4. Please include additional information regarding the survey or questionnaire used in the study and ensure that you have provided sufficient details that others could replicate the analyses. For instance, if you developed a questionnaire as part of this study and it is not under a copyright more restrictive than CC-BY, please include a copy, in both the original language and English, as Supporting Information.

Response:

Survey instruments has been attached.

5. Please amend either the title on the online submission form (via Edit Submission) or the title in the manuscript so that they are identical.

Response:

We have amended the title for identical purpose

6. Thank you for stating the following in the Acknowledgments Section of your manuscript:

The University of Newcastle International Postgraduate Research Scholarship (UNIPRS) and

The University of Newcastle Research Scholarship Central 50:50 funded this study

(UNRSC50:50).

The Australian Research Council Centre of Excellence in Population Ageing Research (project

number CE170100005) supported this research.

We note that you have provided funding information that is not currently declared in your Funding Statement. However, funding information should not appear in the Acknowledgments section or other areas of your manuscript. We will only publish funding information present in the Funding Statement section of the online submission form.

Please remove any funding-related text from the manuscript and let us know how you would like to update your Funding Statement. Currently, your Funding Statement reads as follows:

No funding

Response:

We have removed the funding statement in the manuscript. We will like you to update our funding statement as Funding Statement “The University of Newcastle International Postgraduate Research Scholarship (UNIPRS) and The University of Newcastle Research Scholarship Central 50:50 funded this study (UNRSC50:50).

The Australian Research Council Centre of Excellence in Population Ageing Research (project number CE170100005) supported this research.”

7. In your Data Availability statement, you have not specified where the minimal data set underlying the results described in your manuscript can be found. PLOS defines a study's minimal data set as the underlying data used to reach the conclusions drawn in the manuscript and any additional data required to replicate the reported study findings in their entirety. All PLOS journals require that the minimal data set be made fully available. For more information about our data policy, please see http://journals.plos.org/plosone/s/data-availability.

Upon re-submitting your revised manuscript, please upload your study’s minimal underlying data set as either Supporting Information files or to a stable, public repository and include the relevant URLs, DOIs, or accession numbers within your revised cover letter. For a list of acceptable repositories, please see http://journals.plos.org/plosone/s/data-availability#loc-recommended-repositories. Any potentially identifying patient information must be fully anonymized.

Important: If there are ethical or legal restrictions to sharing your data publicly, please explain these restrictions in detail. Please see our guidelines for more information on what we consider unacceptable restrictions to publicly sharing data: http://journals.plos.org/plosone/s/data-availability#loc-unacceptable-data-access-restrictions. Note that it is not acceptable for the authors to be the sole named individuals responsible for ensuring data access.

We will update your Data Availability statement to reflect the information you provide in your cover letter.

Response:

We have made amendment to the Data Availability statement. As a result upload of the dataset is not required for this submission.

Response to reviewers

Response to reviewers: Do factors across the World Health Organisation International Classification of Functioning, Disability and Health framework explain perceived caregiver availability for community-dwelling older adults in Ghana?

Reviewer #1

WHO-ICF is an essential topic among researchers. However, I think that the vital elements are not provided to understand the findings. Also, the introduction and discussion would not be strong arguments. It requires additional literature reviews.

Authors appreciate reviewer’s acknowledgment of the essential need of WHO-ICF framework, and other advice. Our responses below show how we have addressed these issues.

ABSTRACT, The background is missing.

We have provided additional information in the abstract introduction. Please see bold text in introduction.

INTRODUCTION:

1. The introduction needs to have extensive literature reviews linking to what the authors examined. Especially any relationship among the WHO-ICF and caregiver availability is not clear.

Thank you for this feedback. We have added in additional information to the background. Authors have provided the relationship between components of the WHO-ICF and caregiver availability (page 5, and page 8). Given the gap in literature, our study will contribute to the body of knowledge related to WHO-ICF and caregiver availability.

2. Please describe how the authors use the WHO-ICF model in caregiver availability well.

We have provided how we applied WHO-ICF model in caregiver availability, drawing attention to how the caregiver availability among older adults is understood by us, within the framework of the WHO-ICF (highlighted in black in page 8).

3. Why did you use the WHO-ICF? Instead, you can use the social support theory.

Thank you for this suggestion. We employed WHO-ICF because we hypothesized that “perceived caregiver availability” for older adults may be related to the five components of WHO-ICF (personal factors, environmental factors, health condition, body function and structure, activity and participation). Social support theory would focus on one component of the ICF. Social support, including caregivers, would protect people from poor help and assist them in dealing with health events.

4. Please explore more about the relationship between physical disability and caregiver more in details

We have updated the information on relationship between physical disability and caregiver availability (bottom of page 5). During our literature review we identified that not much research has explored the relationship between physical disability and caregiver availability, which makes this study a novel one.

5. What are your hypotheses?

We have orientated the reader to our hypothesis in text at the end of the introduction (bottom of page 8). Moreover, for each of the independent variables in the Method section, we have provided the expected relationship between each component and perceived caregiver availability (page 10- page 14).

Methods.

1. What is the terminally ill? Please define it.

We have updated it as “seriously ill or unconscious “ and as determined by the health care staff. (page 9, under Study Sampling)

2. Under study sample, Did you collect the data from the participants of the WHO on AGEing and adult health study? It is not clear.

The data was not collected from the participants of WHO SAGE study. I have updated the sentence as “This study sampled participants from a hospital setting, unlike the World Health Organisation study on AGEing and adult health (WHO-SAGE) that sampled older adults from their homes Kowal et al. (2012)” ( under Study Sampling on Page 9).

3. Please include the references for the measurements. Some of them came from the articles. How about the rest?

I have provided reference of each of the independent variables (page 10-page 14).

4. Data analysis. Please write more details about the software, code to obtain the odds ratios.

We have provided the detail as: “STATA version 15 was used to manage the analysis. And Because the analysis was logistic regression, we used logit with the dependent variable and the independent variables (i.e. logit dependent variable i.categorical independent variable continuous independent variable, or) (bolded black on page 14 under Data Analysis).”

5. The order of subsection in the method section is not correct.

We have reordered the subsections.

6. Please explain the relationships between the selected variables and subdomains in the WHOICF.

Thanks for the opportunity for the clarification.

In the Method Section, we have specified the relationship of the selected variables and the subdomains of the WHO-ICF. We have also defined them to highlight how the variables selected are better for the subdomains. For instance, in the “activity limitation (AL)”, we have updated that “Activity limitation or disability refer to the difficulty older adults may experience in engaging activities necessary for life (World Health Organization, 2005). Based on previous finding that lower limb fracture have caregivers available to them (Li et al., 2017), we that older adults experiencing difficulty in engaging functional activities (disability), will have caregiver available to them.” (see page 10- page 14).

Discussion

1. The first paragraph is repetitive, like results. Please summarize it.

Thanks for your feedback. We have summarized the first paragraph of the discussion. In the first paragraph, we gave a summary of the applicability of the WHO-ICF framework to predicting perceived caregiver availability. This was important for us to establish the usefulness of the framework in the classification of factors affecting caregiver availability of older adults.

2. Please exam your findings based on your hypotheses.

Since our hypothesis was in relationship to the WHO-ICF framework, we have discussed the finding in relations to the this framework.

3. Since Ns of variables per domain is small. Instead of using the WHO-ICF, it would be better to examine the variable itself. Like marital status, chronic conditions.

Thank you for your feedback. We appreciate there are a limited number of variables in each domain, and considered this in the discussion. We still feel that the WHO-ICF is a useful framework for considering how caregiver availability relates to needs.

4. Your findings are similar to previous studies. Please explain why and how it happened.

Thanks for your feedback. We have discussed the findings in relation to the previous studies, with particular consideration on the application of the WHO-ICF framework.

5. Please expand your conclusions to your unique area for the implication section.

We have expanded on the conclusion.(under conclusion on page 25).

Reviewer #2: This is an interesting manuscript that is worthy of publication.

The authors appreciate the acknowledgement.

A few minor points that need to be addressed:

1. The first sentence of the second paragraph of the introduction does not make sense "...they need to do to live and those they most cherish." In addition, the reference that goes with this and the examples of self care is inappropriate (Shiel) and does not illustrate the point.

Thanks for the feedback. Authors have corrected the sentence, and have cited a more appropriate reference most appropriate. The new reference cited shows examples of self-care activities including feeding, toileting etc. (bottom of page 3)

2. 3rd paragraph of the introduction - the Heaton reference is not listed.

The reference for Heaton has been provided (see page 4)

3. Last paragraph of the introduction - the WHO 2002 references should read 2005.

We have provided the appropriate references. We used WHO, 2002 and WHO, 2005).(see page 7, last paragraph of the introduction)

5. In the methods section, it is unclear as to whether the participants had to come back into the hospital to complete the survey, or if it was completed during their hospitalisation. If they had to come back, this is a bias because more participants with caregivers might be expected to have been able to arrange to come back than those without, i.e. the sample will be biased towards those with support.

Data was collected during participants’ hospitalisation. This clarification has been made in the work. (see page 10 under study sampling)

6. In the results, in the third sentence of the paragraph 'Bivariate analysis' the sentence "Participants with no caregiver available had some no form of non-government support" does not make sense.

We have revised the expression in the manuscript by deleting “some”. It is now read as “Participants with no caregiver available had no form of non-government support (100%)”.(under Bivariate analysis” on page 16)

7. In the paragraph commencing 'In Model 6...', the sentence "Participants living alone was not statistically significant" needs completing.

Revision to the sentence has been made in the manuscript. The sentence now read as “There was no statistically significant association between being single, separated or divorced and perceived caregiver availability (33% (p>0.05), compared to the married or cohabiting.”

8. Discussion last sentence of third paragraph repetition of the word 'modernisation'.

We have deleted one “Modernisation” in the last sentence of third paragraph.

9. References: the Ghana statistical Service reference is not cited in the text.

Thanks for the feedback. However, Ghana Statistical Service reference is already cited in the text in the “Material and Method” under “Study area”. (page 9)

Attachments
Attachment
Submitted filename: Response to Reviewers.docx
Decision Letter - Frédéric Denis, Editor

Do factors across the World Health Organisation International Classification of Functioning, Disability and Health framework relate to perceived caregiver availability for community-dwelling older adults in Ghana?

PONE-D-19-33768R1

Dear Dr. Awuviry-Newton,

We are pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it complies with all outstanding technical requirements.

Within one week, you will receive an e-mail containing information on the amendments required prior to publication. When all required modifications have been addressed, you will receive a formal acceptance letter and your manuscript will proceed to our production department and be scheduled for publication.

Shortly after the formal acceptance letter is sent, an invoice for payment will follow. To ensure an efficient production and billing process, please log into Editorial Manager at https://www.editorialmanager.com/pone/, click the "Update My Information" link at the top of the page, and update your user information. If you have any billing related questions, please contact our Author Billing department directly at authorbilling@plos.org.

If your institution or institutions have a press office, please notify them about your upcoming paper to enable them to help maximize its impact. If they will be preparing press materials for this manuscript, you must inform our press team as soon as possible and no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

With kind regards,

Frédéric Denis, Ph.D.

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Formally Accepted
Acceptance Letter - Frédéric Denis, Editor

PONE-D-19-33768R1

Do factors across the World Health Organisation International Classification of Functioning, Disability and Health framework relate to perceived caregiver availability for community dwelling older adults in Ghana?

Dear Dr. Awuviry-Newton:

I am pleased to inform you that your manuscript has been deemed suitable for publication in PLOS ONE. Congratulations! Your manuscript is now with our production department.

If your institution or institutions have a press office, please notify them about your upcoming paper at this point, to enable them to help maximize its impact. If they will be preparing press materials for this manuscript, please inform our press team within the next 48 hours. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information please contact onepress@plos.org.

For any other questions or concerns, please email plosone@plos.org.

Thank you for submitting your work to PLOS ONE.

With kind regards,

PLOS ONE Editorial Office Staff

on behalf of

Dr. Frédéric Denis

Academic Editor

PLOS ONE

Open letter on the publication of peer review reports

PLOS recognizes the benefits of transparency in the peer review process. Therefore, we enable the publication of all of the content of peer review and author responses alongside final, published articles. Reviewers remain anonymous, unless they choose to reveal their names.

We encourage other journals to join us in this initiative. We hope that our action inspires the community, including researchers, research funders, and research institutions, to recognize the benefits of published peer review reports for all parts of the research system.

Learn more at ASAPbio .