Peer Review History

Original SubmissionDecember 24, 2019
Decision Letter - HASNAIN SEYED EHTESHAM, Editor

PONE-D-19-35601

Tuberculosis treatment among HIV adults on ART in rural southern Mozambique. A retrospective cohort study.

PLOS ONE

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HASNAIN SEYED EHTESHAM

Academic Editor

PLOS ONE

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Additional Editor Comments (if provided):

Minor Revision

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Reviewers' comments:

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Comments to the Author

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Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: I Don't Know

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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5. Review Comments to the Author

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Reviewer #1: The manuscript by Nacarapa et. al, describes the use of Xpert MTB/RIF technology in tuberculosis diagnosis in a resource-limited, high-burden TB/HIV coinfection settings. The authors used a large sample size over a long time for this study. This manuscript addresses an important and timely topic regarding clinical TB screening before initiating ART in TB/HIV co-infection cases. This additional information can be useful in designing more effective treatment strategy for this particular risk group.

The authors have described some positive factors associated with a favorable TB treatment. It would be important to know, why and how these factors are linked to favorable TB treatment. I think the authors should critically discuss such aspects along with suitable literature references to support their views. This would also tremendously increase the value of the manuscript.

Reviewer #2: 1. The title of the paper does not justify the aim of the study and should be modified accordingly.

2. The authors should include information about rate of mortality in TB patients and TB- HIV co-infected patients before and after introduction of genexpert (Year-wise data would be better).

3. The authors should add few lines explaining the scheme of treatment followed in TB and TB-HIV co-infected patient in their country. The authors can also add information about if any changes has been incorporated and why the changes were done and in which year they were done.

4.Does any government health agency/NGO monitors the treatment and diagnosis of TB ? A Brief information about the policy for controlling TB in the country will provide better idea to the readers.

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Reviewer #1: No

Reviewer #2: No

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Revision 1

Dear reviewers,

Thank you very much for your very informative comments. We have attached a point by point response to your comments along with the manuscript.

Attachments
Attachment
Submitted filename: Response to reviewers.docx
Decision Letter - HASNAIN SEYED EHTESHAM, Editor

Effect of Xpert MTB/RIF testing introduction and favorable outcome predictors for tuberculosis treatment among HIV infected adults in rural southern Mozambique. A retrospective cohort study.

PONE-D-19-35601R1

Dear Dr. Valverde,

We are pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it complies with all outstanding technical requirements.

Within one week, you will receive an e-mail containing information on the amendments required prior to publication. When all required modifications have been addressed, you will receive a formal acceptance letter and your manuscript will proceed to our production department and be scheduled for publication.

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With kind regards,

HASNAIN SEYED EHTESHAM

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

I have gone through this revised manuscript and also the Author response to the comments of the Reviewers. The authors have satisfactorily addressed all the comments made by the reviewers and added more information, treatment regimens and have revised the manuscript accordingly.

I recommend this manuscript for publication.

Reviewers' comments:

Formally Accepted
Acceptance Letter - HASNAIN SEYED EHTESHAM, Editor

PONE-D-19-35601R1

Effect of Xpert MTB/RIF testing introduction and favorable outcome predictors for tuberculosis treatment among HIV infected adults in rural southern Mozambique. A retrospective cohort study.

Dear Dr. Valverde:

I am pleased to inform you that your manuscript has been deemed suitable for publication in PLOS ONE. Congratulations! Your manuscript is now with our production department.

If your institution or institutions have a press office, please notify them about your upcoming paper at this point, to enable them to help maximize its impact. If they will be preparing press materials for this manuscript, please inform our press team within the next 48 hours. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information please contact onepress@plos.org.

For any other questions or concerns, please email plosone@plos.org.

Thank you for submitting your work to PLOS ONE.

With kind regards,

PLOS ONE Editorial Office Staff

on behalf of

Prof HASNAIN SEYED EHTESHAM

Academic Editor

PLOS ONE

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