Annotation Cluster 1 Enrichment Score: 1.3305013621473873 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0016477~cell migration 4 0.851063829787234 0.029153337422290135 IFNG, ENPEP, SIX4, LEFTY1 39 240 13588 5.806837606837607 0.9999992999041234 0.9412468029128582 34.52425196341511 GOTERM_BP_FAT GO:0048870~cell motility 4 0.851063829787234 0.04453262449852272 IFNG, ENPEP, SIX4, LEFTY1 39 284 13588 4.907186710003611 0.9999999996662677 0.887192020682787 47.902201498115105 GOTERM_BP_FAT GO:0051674~localization of cell 4 0.851063829787234 0.04453262449852272 IFNG, ENPEP, SIX4, LEFTY1 39 284 13588 4.907186710003611 0.9999999996662677 0.887192020682787 47.902201498115105 GOTERM_BP_FAT GO:0006928~cell motion 4 0.851063829787234 0.08240426513168744 IFNG, ENPEP, SIX4, LEFTY1 39 367 13588 3.7973869908474813 1.0 0.8075133739659732 70.79818111407772 Annotation Cluster 2 Enrichment Score: 1.152084680859401 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS transcription regulation 11 2.3404255319148937 0.014379028739041396 HHEX, GCM2, MYOCD, HIPK1, KLF13, TRPS1, KLHL31, NEUROG3, SAP30BP, SIX4, ATOH7 54 1546 17854 2.3524747256959415 0.8316077633196443 0.8316077633196443 15.380270546475838 GOTERM_MF_FAT GO:0030528~transcription regulator activity 9 1.9148936170212765 0.018778708553103124 HHEX, GCM2, MYOCD, HIPK1, KLF13, TRPS1, NEUROG3, SIX4, ATOH7 39 1206 13288 2.5426712590891696 0.8659403392174483 0.8659403392174483 19.16174405484715 GOTERM_BP_FAT GO:0006357~regulation of transcription from RNA polymerase II promoter 6 1.276595744680851 0.027460496392504148 HHEX, MYOCD, HIPK1, KLF13, NEUROG3, SIX4 39 616 13588 3.393606393606394 0.9999983872271009 0.9987300500406919 32.870995661659755 GOTERM_BP_FAT GO:0045893~positive regulation of transcription, DNA-dependent 5 1.0638297872340425 0.028144763580981502 MYOCD, KLF13, IFNG, NEUROG3, SIX4 39 416 13588 4.187623274161735 0.9999988487852437 0.9895194168171084 33.543882657548174 GOTERM_BP_FAT GO:0051254~positive regulation of RNA metabolic process 5 1.0638297872340425 0.028797269208615778 MYOCD, KLF13, IFNG, NEUROG3, SIX4 39 419 13588 4.157640291291842 0.9999991654744441 0.9697754453635852 34.17968783778602 GOTERM_BP_FAT GO:0045449~regulation of transcription 12 2.553191489361702 0.037131540489379236 HHEX, GCM2, MYOCD, HIPK1, KLF13, TRPS1, IFNG, KLHL31, NEUROG3, SAP30BP, SIX4, ATOH7 39 2227 13588 1.8773790197229805 0.999999986554584 0.896230008686962 41.81843754241819 GOTERM_BP_FAT GO:0045941~positive regulation of transcription 5 1.0638297872340425 0.04266053752702574 MYOCD, KLF13, IFNG, NEUROG3, SIX4 39 475 13588 3.6674763832658566 0.9999999991476941 0.9017599926711469 46.421904051181485 GOTERM_BP_FAT GO:0010628~positive regulation of gene expression 5 1.0638297872340425 0.04634038006713633 MYOCD, KLF13, IFNG, NEUROG3, SIX4 39 488 13588 3.569777217318201 0.9999999998652789 0.8733293566160686 49.2954477871973 GOTERM_BP_FAT GO:0006355~regulation of transcription, DNA-dependent 9 1.9148936170212765 0.0464606267645538 HHEX, GCM2, MYOCD, HIPK1, KLF13, TRPS1, IFNG, NEUROG3, SIX4 39 1465 13588 2.140404305592019 0.9999999998731752 0.8502844187615624 49.38688198270681 GOTERM_BP_FAT GO:0051252~regulation of RNA metabolic process 9 1.9148936170212765 0.05020999836183264 HHEX, GCM2, MYOCD, HIPK1, KLF13, TRPS1, IFNG, NEUROG3, SIX4 39 1488 13588 2.1073200992555834 0.999999999980786 0.8283894072183798 52.1620972201166 GOTERM_BP_FAT GO:0006350~transcription 10 2.127659574468085 0.051670306513489625 HHEX, GCM2, MYOCD, HIPK1, KLF13, TRPS1, KLHL31, NEUROG3, SAP30BP, ATOH7 39 1772 13588 1.9661978352723273 0.9999999999908055 0.8162466712367772 53.204164746964054 GOTERM_BP_FAT GO:0045935~positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 5 1.0638297872340425 0.05296566164521015 MYOCD, KLF13, IFNG, NEUROG3, SIX4 39 510 13588 3.4157868275515333 0.9999999999952227 0.8039129418119011 54.11081213489892 GOTERM_BP_FAT GO:0051173~positive regulation of nitrogen compound metabolic process 5 1.0638297872340425 0.05809728863295284 MYOCD, KLF13, IFNG, NEUROG3, SIX4 39 526 13588 3.311884566637418 0.9999999999996461 0.7788541644875099 57.54439266666147 GOTERM_BP_FAT GO:0010557~positive regulation of macromolecule biosynthetic process 5 1.0638297872340425 0.05942122667692862 MYOCD, KLF13, IFNG, NEUROG3, SIX4 39 530 13588 3.2868892114175132 0.9999999999998196 0.7694238382942824 58.3906139727365 GOTERM_BP_FAT GO:0031328~positive regulation of cellular biosynthetic process 5 1.0638297872340425 0.06699425644430233 MYOCD, KLF13, IFNG, NEUROG3, SIX4 39 552 13588 3.1558900037160904 0.9999999999999962 0.7943751410095244 62.93716812207233 GOTERM_BP_FAT GO:0009891~positive regulation of biosynthetic process 5 1.0638297872340425 0.06878373428806128 MYOCD, KLF13, IFNG, NEUROG3, SIX4 39 557 13588 3.127560650002301 0.9999999999999986 0.7733038570168309 63.94176184697 SP_PIR_KEYWORDS Transcription 10 2.127659574468085 0.07465195519707636 HHEX, GCM2, MYOCD, HIPK1, KLF13, TRPS1, KLHL31, NEUROG3, SAP30BP, ATOH7 54 1769 17854 1.869019952683039 0.9999282984184905 0.9584558786354818 59.12319732345236 GOTERM_BP_FAT GO:0045944~positive regulation of transcription from RNA polymerase II promoter 4 0.851063829787234 0.07777430105197697 MYOCD, KLF13, NEUROG3, SIX4 39 358 13588 3.892852026930239 1.0 0.8012946685412365 68.6168249387493 SP_PIR_KEYWORDS developmental protein 6 1.276595744680851 0.09290083629383131 HHEX, GCM2, NEUROG3, SIX4, ATOH7, LEFTY1 54 814 17854 2.4370734370734373 0.9999938121997524 0.9501248664756576 67.51124693079824 GOTERM_BP_FAT GO:0010604~positive regulation of macromolecule metabolic process 5 1.0638297872340425 0.09900770020116031 MYOCD, KLF13, IFNG, NEUROG3, SIX4 39 633 13588 2.752055737837728 1.0 0.8107453464446139 77.51466801085499 SP_PIR_KEYWORDS dna-binding 8 1.702127659574468 0.11996092667157439 HHEX, GCM2, KLF13, TRPS1, POLB, NEUROG3, SIX4, ATOH7 54 1404 17854 1.8839295135591432 0.9999998508097397 0.89411850435758 77.08747657505283 GOTERM_MF_FAT GO:0003677~DNA binding 9 1.9148936170212765 0.12765787965470957 HHEX, GCM2, HIPK1, KLF13, TRPS1, POLB, NEUROG3, SIX4, ATOH7 39 1781 13288 1.721763918282728 0.9999994838150835 0.9731958939553341 78.4003903411104 GOTERM_MF_FAT GO:0003700~transcription factor activity 5 1.0638297872340425 0.1793927818510498 HHEX, GCM2, TRPS1, NEUROG3, SIX4 39 776 13288 2.1953476077187415 0.9999999992086925 0.902567234376593 89.1229558023212 GOTERM_MF_FAT GO:0043565~sequence-specific DNA binding 4 0.851063829787234 0.2115607041064022 HHEX, GCM2, TRPS1, SIX4 39 556 13288 2.4512082641579043 0.999999999988586 0.9195096953570263 93.05560130085946 SP_PIR_KEYWORDS nucleus 14 2.9787234042553195 0.33433978640136897 CDC14B, KLF13, POLB, ATAD5, NEUROG3, SAP30BP, SIX4, HHEX, OAZ3, GCM2, HIPK1, MYOCD, TRPS1, ATOH7 54 3808 17854 1.2155501089324618 1.0 0.9720006568581744 99.08379591697361 SP_PIR_KEYWORDS differentiation 3 0.6382978723404255 0.3980418638824703 HHEX, NEUROG3, ATOH7 54 460 17854 2.156280193236715 1.0 0.9414434933138044 99.71274883229752 SP_PIR_KEYWORDS activator 3 0.6382978723404255 0.4230488684975263 MYOCD, KLF13, NEUROG3 54 484 17854 2.0493572084481175 1.0 0.9472025350736518 99.82389000397686 Annotation Cluster 3 Enrichment Score: 1.1505280318426012 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042127~regulation of cell proliferation 6 1.276595744680851 0.016296479363680467 HHEX, MYOCD, HIPK1, IFNG, IL12A, LEFTY1 39 538 13588 3.885616242493566 0.9996180872851788 0.9996180872851788 20.957265124717537 GOTERM_MF_FAT GO:0030528~transcription regulator activity 9 1.9148936170212765 0.018778708553103124 HHEX, GCM2, MYOCD, HIPK1, KLF13, TRPS1, NEUROG3, SIX4, ATOH7 39 1206 13288 2.5426712590891696 0.8659403392174483 0.8659403392174483 19.16174405484715 GOTERM_BP_FAT GO:0006357~regulation of transcription from RNA polymerase II promoter 6 1.276595744680851 0.027460496392504148 HHEX, MYOCD, HIPK1, KLF13, NEUROG3, SIX4 39 616 13588 3.393606393606394 0.9999983872271009 0.9987300500406919 32.870995661659755 GOTERM_BP_FAT GO:0006355~regulation of transcription, DNA-dependent 9 1.9148936170212765 0.0464606267645538 HHEX, GCM2, MYOCD, HIPK1, KLF13, TRPS1, IFNG, NEUROG3, SIX4 39 1465 13588 2.140404305592019 0.9999999998731752 0.8502844187615624 49.38688198270681 GOTERM_BP_FAT GO:0051252~regulation of RNA metabolic process 9 1.9148936170212765 0.05020999836183264 HHEX, GCM2, MYOCD, HIPK1, KLF13, TRPS1, IFNG, NEUROG3, SIX4 39 1488 13588 2.1073200992555834 0.999999999980786 0.8283894072183798 52.1620972201166 GOTERM_BP_FAT GO:0006350~transcription 10 2.127659574468085 0.051670306513489625 HHEX, GCM2, MYOCD, HIPK1, KLF13, TRPS1, KLHL31, NEUROG3, SAP30BP, ATOH7 39 1772 13588 1.9661978352723273 0.9999999999908055 0.8162466712367772 53.204164746964054 GOTERM_BP_FAT GO:0045892~negative regulation of transcription, DNA-dependent 4 0.851063829787234 0.0543333938973896 HHEX, MYOCD, HIPK1, TRPS1 39 308 13588 4.524808524808525 0.9999999999976092 0.7928027574705317 55.05036580490884 GOTERM_BP_FAT GO:0051253~negative regulation of RNA metabolic process 4 0.851063829787234 0.05519380371052286 HHEX, MYOCD, HIPK1, TRPS1 39 310 13588 4.4956162117452445 0.9999999999984541 0.7792794733470672 55.63221627476553 SP_PIR_KEYWORDS Transcription 10 2.127659574468085 0.07465195519707636 HHEX, GCM2, MYOCD, HIPK1, KLF13, TRPS1, KLHL31, NEUROG3, SAP30BP, ATOH7 54 1769 17854 1.869019952683039 0.9999282984184905 0.9584558786354818 59.12319732345236 GOTERM_BP_FAT GO:0016481~negative regulation of transcription 4 0.851063829787234 0.08502795671550868 HHEX, MYOCD, HIPK1, TRPS1 39 372 13588 3.7463468431210365 1.0 0.7932972663460214 71.97083508410151 GOTERM_BP_FAT GO:0045934~negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4 0.851063829787234 0.09867939384563579 HHEX, MYOCD, HIPK1, TRPS1 39 397 13588 3.510430795065556 1.0 0.8202244986664995 77.39710852875528 GOTERM_BP_FAT GO:0051172~negative regulation of nitrogen compound metabolic process 4 0.851063829787234 0.10094346139481354 HHEX, MYOCD, HIPK1, TRPS1 39 401 13588 3.475414029029989 1.0 0.8068322269397129 78.19634020074756 GOTERM_BP_FAT GO:0010629~negative regulation of gene expression 4 0.851063829787234 0.10611513744097271 HHEX, MYOCD, HIPK1, TRPS1 39 410 13588 3.3991244527829894 1.0 0.794106102180552 79.92442447147101 SP_PIR_KEYWORDS repressor 4 0.851063829787234 0.10985031046526778 HHEX, TRPS1, KLHL31, SAP30BP 54 391 17854 3.3824003031164156 0.9999993919287102 0.9079566500823496 73.8616974624602 GOTERM_BP_FAT GO:0010558~negative regulation of macromolecule biosynthetic process 4 0.851063829787234 0.11080032358453865 HHEX, MYOCD, HIPK1, TRPS1 39 418 13588 3.3340694393325974 1.0 0.7903922677523078 81.37910940310083 GOTERM_BP_FAT GO:0031327~negative regulation of cellular biosynthetic process 4 0.851063829787234 0.11797877353279129 HHEX, MYOCD, HIPK1, TRPS1 39 430 13588 3.2410256410256406 1.0 0.8031322588252603 83.4189071101391 GOTERM_BP_FAT GO:0009890~negative regulation of biosynthetic process 4 0.851063829787234 0.12041068140612121 HHEX, MYOCD, HIPK1, TRPS1 39 434 13588 3.2111544369608884 1.0 0.7931557515718486 84.06140798850119 GOTERM_MF_FAT GO:0016564~transcription repressor activity 3 0.6382978723404255 0.12176394744781381 HHEX, HIPK1, TRPS1 39 211 13288 4.844331024425811 0.999998946113823 0.9898235125171206 76.70509928375725 GOTERM_BP_FAT GO:0000122~negative regulation of transcription from RNA polymerase II promoter 3 0.6382978723404255 0.13605087085453837 HHEX, MYOCD, HIPK1 39 231 13588 4.524808524808526 1.0 0.8264415151334337 87.67115976150312 GOTERM_BP_FAT GO:0010605~negative regulation of macromolecule metabolic process 4 0.851063829787234 0.1671790331246985 HHEX, MYOCD, HIPK1, TRPS1 39 506 13588 2.7542312759704064 1.0 0.8696886220120615 92.7085394790341 Annotation Cluster 4 Enrichment Score: 1.1501968819970585 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042127~regulation of cell proliferation 6 1.276595744680851 0.016296479363680467 HHEX, MYOCD, HIPK1, IFNG, IL12A, LEFTY1 39 538 13588 3.885616242493566 0.9996180872851788 0.9996180872851788 20.957265124717537 GOTERM_BP_FAT GO:0009952~anterior/posterior pattern formation 3 0.6382978723404255 0.06803996960301323 HHEX, HIPK1, LEFTY1 39 153 13588 6.8315736551030675 0.9999999999999978 0.7843768068284929 63.527336414733405 GOTERM_BP_FAT GO:0003002~regionalization 3 0.6382978723404255 0.12014089864747357 HHEX, HIPK1, LEFTY1 39 214 13588 4.884255930984903 1.0 0.8007891973201521 83.99129192251357 GOTERM_BP_FAT GO:0007389~pattern specification process 3 0.6382978723404255 0.1882191006534542 HHEX, HIPK1, LEFTY1 39 284 13588 3.6803900325027086 1.0 0.8966957580605847 94.94465335576056 Annotation Cluster 5 Enrichment Score: 0.8719305048628399 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048514~blood vessel morphogenesis 3 0.6382978723404255 0.10564930834163233 MYOCD, ITGA7, ENPEP 39 198 13588 5.278943278943279 1.0 0.8022442797327328 79.7741564226197 GOTERM_BP_FAT GO:0001568~blood vessel development 3 0.6382978723404255 0.14852531309037986 MYOCD, ITGA7, ENPEP 39 244 13588 4.283732660781841 1.0 0.8471724799003928 89.98820638528487 GOTERM_BP_FAT GO:0001944~vasculature development 3 0.6382978723404255 0.1543623390073984 MYOCD, ITGA7, ENPEP 39 250 13588 4.180923076923077 1.0 0.8522408226551854 90.92699145396391 Annotation Cluster 6 Enrichment Score: 0.7031790615024147 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006793~phosphorus metabolic process 7 1.4893617021276597 0.03164672544521632 ALPK1, HIPK1, FGR, CDC14B, MAP3K9, IFNG, PDE6H 39 866 13588 2.8162491857641974 0.9999997957310249 0.9232578901489 36.89047749243621 GOTERM_BP_FAT GO:0006796~phosphate metabolic process 7 1.4893617021276597 0.03164672544521632 ALPK1, HIPK1, FGR, CDC14B, MAP3K9, IFNG, PDE6H 39 866 13588 2.8162491857641974 0.9999997957310249 0.9232578901489 36.89047749243621 GOTERM_BP_FAT GO:0006468~protein amino acid phosphorylation 6 1.276595744680851 0.03169163198736727 ALPK1, HIPK1, FGR, MAP3K9, IFNG, PDE6H 39 640 13588 3.266346153846154 0.9999998002185725 0.8896082941093947 36.93235521386627 GOTERM_BP_FAT GO:0016310~phosphorylation 6 1.276595744680851 0.04821213341942459 ALPK1, HIPK1, FGR, MAP3K9, IFNG, PDE6H 39 718 13588 2.9115063209770735 0.9999999999474299 0.838084813323127 50.70144057406753 GOTERM_MF_FAT GO:0032553~ribonucleotide binding 9 1.9148936170212765 0.13228036282165068 DNAHC3, ALPK1, HIPK1, FGR, KIF17, MAP3K9, ATAD5, RAB6B, PDE6H 39 1796 13288 1.7073839301010794 0.9999997060867569 0.9506094535721255 79.65047217751261 GOTERM_MF_FAT GO:0032555~purine ribonucleotide binding 9 1.9148936170212765 0.13228036282165068 DNAHC3, ALPK1, HIPK1, FGR, KIF17, MAP3K9, ATAD5, RAB6B, PDE6H 39 1796 13288 1.7073839301010794 0.9999997060867569 0.9506094535721255 79.65047217751261 UP_SEQ_FEATURE nucleotide phosphate-binding region:ATP 6 1.276595744680851 0.14239010311050096 DNAHC3, HIPK1, FGR, KIF17, MAP3K9, ATAD5 50 907 16021 2.1196471885336274 0.9999999999999998 0.9999999843359252 86.11987886269203 GOTERM_MF_FAT GO:0001883~purine nucleoside binding 8 1.702127659574468 0.14679903069559086 DNAHC3, ALPK1, HIPK1, FGR, KIF17, MAP3K9, ATAD5, PDE6H 39 1548 13288 1.7608162724441794 0.9999999508592186 0.9394788725816028 83.16063375634862 GOTERM_MF_FAT GO:0001882~nucleoside binding 8 1.702127659574468 0.15039538681714726 DNAHC3, ALPK1, HIPK1, FGR, KIF17, MAP3K9, ATAD5, PDE6H 39 1558 13288 1.749514499193575 0.9999999685958272 0.915249737650325 83.94016696407203 GOTERM_MF_FAT GO:0017076~purine nucleotide binding 9 1.9148936170212765 0.15673144327692404 DNAHC3, ALPK1, HIPK1, FGR, KIF17, MAP3K9, ATAD5, RAB6B, PDE6H 39 1871 13288 1.6389425646507423 0.9999999857968023 0.8955163665893416 85.23402948317242 GOTERM_MF_FAT GO:0005524~ATP binding 7 1.4893617021276597 0.2262164625427384 DNAHC3, ALPK1, HIPK1, FGR, KIF17, MAP3K9, ATAD5 39 1443 13288 1.6528244220551913 0.999999999998438 0.9155310954077435 94.37403435750392 GOTERM_MF_FAT GO:0004672~protein kinase activity 4 0.851063829787234 0.23197150865896257 ALPK1, HIPK1, FGR, MAP3K9 39 583 13288 2.3376874697629413 0.999999999999292 0.9028372587100026 94.82611469444866 GOTERM_MF_FAT GO:0032559~adenyl ribonucleotide binding 7 1.4893617021276597 0.23436016399464454 DNAHC3, ALPK1, HIPK1, FGR, KIF17, MAP3K9, ATAD5 39 1460 13288 1.633579206181946 0.9999999999994912 0.8866676768629849 95.00383361112785 GOTERM_MF_FAT GO:0030554~adenyl nucleotide binding 7 1.4893617021276597 0.27142054616949174 DNAHC3, ALPK1, HIPK1, FGR, KIF17, MAP3K9, ATAD5 39 1535 13288 1.553762632589994 0.9999999999999973 0.9090602362499464 97.13680561339139 GOTERM_MF_FAT GO:0000166~nucleotide binding 9 1.9148936170212765 0.27932294034934335 DNAHC3, ALPK1, HIPK1, FGR, KIF17, MAP3K9, ATAD5, RAB6B, PDE6H 39 2183 13288 1.4047006589379472 0.9999999999999991 0.9012127417215391 97.46658932693725 SP_PIR_KEYWORDS serine/threonine-protein kinase 3 0.6382978723404255 0.3161650259352029 ALPK1, HIPK1, MAP3K9 54 384 17854 2.583043981481481 1.0 0.9796646845824164 98.7500701768518 SP_PIR_KEYWORDS atp-binding 6 1.276595744680851 0.3346384544067017 DNAHC3, HIPK1, FGR, KIF17, MAP3K9, ATAD5 54 1287 17854 1.5413968747302078 1.0 0.9645943054770172 99.08852476530208 GOTERM_MF_FAT GO:0004674~protein serine/threonine kinase activity 3 0.6382978723404255 0.3400568212648516 ALPK1, HIPK1, MAP3K9 39 421 13288 2.427918874474694 1.0 0.9362865890610113 99.05663575571562 SP_PIR_KEYWORDS kinase 4 0.851063829787234 0.35056302693993036 ALPK1, HIPK1, FGR, MAP3K9 54 707 17854 1.8706061082298704 1.0 0.9476396066793553 99.31065793132575 SP_PIR_KEYWORDS nucleotide-binding 7 1.4893617021276597 0.3547129328295039 DNAHC3, HIPK1, FGR, KIF17, MAP3K9, ATAD5, RAB6B 54 1631 17854 1.4190112859640756 1.0 0.9413320723136857 99.35977450477897 SP_PIR_KEYWORDS transferase 6 1.276595744680851 0.3937187484900584 ST6GALNAC6, ALPK1, HIPK1, FGR, MAP3K9, POLB 54 1385 17854 1.4323305254713197 1.0 0.9466552870858025 99.68804119516498 INTERPRO IPR017441:Protein kinase, ATP binding site 3 0.6382978723404255 0.41707017058416834 HIPK1, FGR, MAP3K9 55 467 17763 2.0747128674323534 1.0 1.0 99.84899291625354 UP_SEQ_FEATURE domain:Protein kinase 3 0.6382978723404255 0.4298421361929273 HIPK1, FGR, MAP3K9 50 476 16021 2.0194537815126052 1.0 0.9999999930294765 99.92702978351973 INTERPRO IPR000719:Protein kinase, core 3 0.6382978723404255 0.4422678897345337 HIPK1, FGR, MAP3K9 55 491 17763 1.9733012405110164 1.0 1.0 99.91127987440814 UP_SEQ_FEATURE binding site:ATP 3 0.6382978723404255 0.5003409764802611 HIPK1, FGR, MAP3K9 50 545 16021 1.7637798165137613 1.0 0.999999985360808 99.98662668941121 UP_SEQ_FEATURE active site:Proton acceptor 3 0.6382978723404255 0.6068334778824714 HIPK1, FGR, MAP3K9 50 662 16021 1.4520543806646526 1.0 0.9999999996740951 99.99938624342401 Annotation Cluster 7 Enrichment Score: 0.6896304825271045 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042981~regulation of apoptosis 4 0.851063829787234 0.2002658804237955 GCM2, HIPK1, POLB, SAP30BP 39 553 13588 2.52014652014652 1.0 0.902418256510248 95.91858882901958 GOTERM_BP_FAT GO:0043067~regulation of programmed cell death 4 0.851063829787234 0.205331952030272 GCM2, HIPK1, POLB, SAP30BP 39 560 13588 2.4886446886446887 1.0 0.9038954065909 96.27345093983489 GOTERM_BP_FAT GO:0010941~regulation of cell death 4 0.851063829787234 0.20751287733915053 GCM2, HIPK1, POLB, SAP30BP 39 563 13588 2.4753837045133666 1.0 0.9018192221226172 96.41719538783016 Annotation Cluster 8 Enrichment Score: 0.6501274084183609 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042127~regulation of cell proliferation 6 1.276595744680851 0.016296479363680467 HHEX, MYOCD, HIPK1, IFNG, IL12A, LEFTY1 39 538 13588 3.885616242493566 0.9996180872851788 0.9996180872851788 20.957265124717537 GOTERM_MF_FAT GO:0005125~cytokine activity 3 0.6382978723404255 0.0934598347553442 IFNG, IL12A, LEFTY1 39 180 13288 5.678632478632479 0.9999695892326314 0.9944854041518333 66.74635433145275 SP_PIR_KEYWORDS cytokine 3 0.6382978723404255 0.0970462372971511 IFNG, IL12A, LEFTY1 54 177 17854 5.603892027620842 0.9999964774433443 0.9188344758877469 69.18262107195116 GOTERM_CC_FAT GO:0005615~extracellular space 3 0.6382978723404255 0.4218502013537248 IFNG, IL12A, LEFTY1 36 511 12504 2.039138943248532 1.0 0.9969224579355602 99.75770948256383 GOTERM_CC_FAT GO:0044421~extracellular region part 3 0.6382978723404255 0.6468265403946791 IFNG, IL12A, LEFTY1 36 774 12504 1.34625322997416 1.0 0.9995024510427901 99.99892486488089 SP_PIR_KEYWORDS Secreted 4 0.851063829787234 0.8041198565810297 IFNG, IL12A, OLFM2, LEFTY1 54 1420 17854 0.9313510693792384 1.0 0.9977035596085606 99.9999993141837 GOTERM_CC_FAT GO:0005576~extracellular region 4 0.851063829787234 0.8672489067672551 IFNG, IL12A, OLFM2, LEFTY1 36 1680 12504 0.8269841269841269 1.0 0.9999316983799597 99.9999999770706 Annotation Cluster 9 Enrichment Score: 0.5067635025035166 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE glycosylation site:N-linked (GlcNAc...) 18 3.829787234042553 0.0230242011392135 ES22, PLXNC1, LYPD5, ARSG, TMC4, ENPEP, FCRL5, FCAMR, LEFTY1, ST6GALNAC6, CHRM4, IFNG, ITGA7, IL12A, CALR3, TMTC2, OLFM2, 1810033B17RIK 50 3444 16021 1.6746689895470381 0.9957065091500532 0.9957065091500532 25.877645251134286 SP_PIR_KEYWORDS glycoprotein 18 3.829787234042553 0.027711567451469566 ES22, PLXNC1, LYPD5, ARSG, TMC4, ENPEP, FCRL5, FCAMR, LEFTY1, ST6GALNAC6, CHRM4, IFNG, ITGA7, IL12A, CALR3, TMTC2, OLFM2, 1810033B17RIK 54 3600 17854 1.653148148148148 0.9684645068238914 0.8224176439617139 27.67805327743138 SP_PIR_KEYWORDS disulfide bond 11 2.3404255319148937 0.18977663566349995 ES22, ST6GALNAC6, CHRM4, ITGA7, IL12A, CALR3, ENPEP, FCAMR, FCRL5, OLFM2, LEFTY1 54 2469 17854 1.4730360169809338 0.9999999999942669 0.9248656416833181 91.16603037042555 SP_PIR_KEYWORDS signal 12 2.553191489361702 0.2588828576620089 ES22, PLXNC1, ARSG, LYPD5, IFNG, ITGA7, IL12A, CALR3, FCAMR, FCRL5, OLFM2, LEFTY1 54 2970 17854 1.335877291432847 0.9999999999999999 0.9649168555249887 96.83980183160985 UP_SEQ_FEATURE signal peptide 12 2.553191489361702 0.28873052196034865 ES22, PLXNC1, ARSG, LYPD5, IFNG, ITGA7, IL12A, CALR3, FCAMR, FCRL5, OLFM2, LEFTY1 50 2963 16021 1.2976847789402632 1.0 0.9999999999971249 98.74744956743599 UP_SEQ_FEATURE disulfide bond 10 2.127659574468085 0.2988890452443261 ES22, ST6GALNAC6, CHRM4, ITGA7, IL12A, CALR3, FCAMR, FCRL5, OLFM2, LEFTY1 50 2379 16021 1.3468684321143338 1.0 0.9999999990482452 98.95892924499014 UP_SEQ_FEATURE topological domain:Extracellular 9 1.9148936170212765 0.34485234100903994 PLXNC1, CLDN18, CHRM4, TMC4, ITGA7, ENPEP, FCAMR, FCRL5, 1810033B17RIK 50 2174 16021 1.3264857405703772 1.0 0.9999999974609325 99.56457720731524 UP_SEQ_FEATURE topological domain:Cytoplasmic 10 2.127659574468085 0.4838297927111268 ST6GALNAC6, PLXNC1, CLDN18, CHRM4, TMC4, ITGA7, ENPEP, FCAMR, FCRL5, 1810033B17RIK 50 2780 16021 1.152589928057554 1.0 0.9999999960263161 99.97968807118993 GOTERM_CC_FAT GO:0031224~intrinsic to membrane 18 3.829787234042553 0.5060454727288922 PLXNC1, CLDN18, OLFR460, LYPD5, GPR123, TMC4, ENPEP, FCRL5, FCAMR, ST6GALNAC6, CHRM4, OLFR557, ITGA7, OLFR1165, RAB6B, TMTC2, SLC25A43, 1810033B17RIK 36 5914 12504 1.0571525194453837 1.0 0.9977376005396084 99.95704710211727 SP_PIR_KEYWORDS cell membrane 6 1.276595744680851 0.5840601019638411 CLDN18, CHRM4, LYPD5, GPR123, FCAMR, FCRL5 54 1713 17854 1.1580722578971263 1.0 0.9816146184629597 99.99595251777905 SP_PIR_KEYWORDS transmembrane 16 3.404255319148936 0.616642089672363 CLDN18, PLXNC1, OLFR460, GPR123, TMC4, ENPEP, FCRL5, FCAMR, ST6GALNAC6, CHRM4, OLFR557, ITGA7, OLFR1165, TMTC2, SLC25A43, 1810033B17RIK 54 5237 17854 1.0101344422520668 1.0 0.9828640399707497 99.99841984634992 GOTERM_CC_FAT GO:0016021~integral to membrane 16 3.404255319148936 0.690861874529481 CLDN18, PLXNC1, OLFR460, GPR123, TMC4, ENPEP, FCRL5, FCAMR, ST6GALNAC6, CHRM4, OLFR557, ITGA7, OLFR1165, TMTC2, SLC25A43, 1810033B17RIK 36 5709 12504 0.9734337595609271 1.0 0.9985846866853857 99.99975126748566 GOTERM_CC_FAT GO:0005886~plasma membrane 8 1.702127659574468 0.7366014684634137 PHACTR1, CLDN18, CHRM4, LYPD5, ITGA7, ENPEP, FCAMR, FCRL5 36 2906 12504 0.9561826106905252 1.0 0.9987321532927386 99.99995720883427 UP_SEQ_FEATURE transmembrane region 12 2.553191489361702 0.7472987723655782 ST6GALNAC6, PLXNC1, CLDN18, CHRM4, TMC4, ITGA7, ENPEP, TMTC2, FCAMR, SLC25A43, FCRL5, 1810033B17RIK 50 4113 16021 0.9348504741064915 1.0 0.9999999999977569 99.99999791023552 SP_PIR_KEYWORDS membrane 15 3.1914893617021276 0.8002560375332171 CLDN18, PLXNC1, LYPD5, GPR123, TMC4, ENPEP, FCRL5, FCAMR, ST6GALNAC6, CHRM4, ITGA7, RAB6B, TMTC2, SLC25A43, 1810033B17RIK 54 5507 17854 0.9005709904565906 1.0 0.997952633303138 99.99999914093713 Annotation Cluster 10 Enrichment Score: 0.3755179045895035 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005874~microtubule 3 0.6382978723404255 0.1447781491056054 DNAHC3, KIF17, POLB 36 240 12504 4.341666666666667 0.9999996472354686 0.9999996472354686 82.07716186596731 GOTERM_CC_FAT GO:0015630~microtubule cytoskeleton 3 0.6382978723404255 0.3605946853607983 DNAHC3, KIF17, POLB 36 450 12504 2.3155555555555556 1.0 0.9999999994051992 99.26703519139349 GOTERM_CC_FAT GO:0044430~cytoskeletal part 4 0.851063829787234 0.3697013548335232 DNAHC3, KIF17, POLB, 5430421N21RIK 36 774 12504 1.7950043066322137 1.0 0.9999995509426276 99.37395707199404 GOTERM_CC_FAT GO:0005856~cytoskeleton 5 1.0638297872340425 0.38560376752830583 DNAHC3, KIF17, POLB, WAS, 5430421N21RIK 36 1122 12504 1.5478312537136065 1.0 0.9999043858135447 99.52726665503182 GOTERM_CC_FAT GO:0043228~non-membrane-bounded organelle 6 1.276595744680851 0.6409796223005366 DNAHC3, KIF17, CDC14B, POLB, WAS, 5430421N21RIK 36 1919 12504 1.08598228243877 1.0 0.9996993742313327 99.99871220189817 GOTERM_CC_FAT GO:0043232~intracellular non-membrane-bounded organelle 6 1.276595744680851 0.6409796223005366 DNAHC3, KIF17, CDC14B, POLB, WAS, 5430421N21RIK 36 1919 12504 1.08598228243877 1.0 0.9996993742313327 99.99871220189817 SP_PIR_KEYWORDS coiled coil 5 1.0638297872340425 0.7690800923512136 DNAHC3, MYOCD, KIF17, OLFM2, 5430421N21RIK 54 1732 17854 0.9544735266444273 1.0 0.9970188831135921 99.99999542582705 Annotation Cluster 11 Enrichment Score: 0.33252360587879415 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0070013~intracellular organelle lumen 5 1.0638297872340425 0.3928304959918556 ES22, MYOCD, HIPK1, CDC14B, CALR3 36 1133 12504 1.5328037658134746 1.0 0.9996292559295077 99.58491927182916 GOTERM_CC_FAT GO:0043233~organelle lumen 5 1.0638297872340425 0.39480043315690777 ES22, MYOCD, HIPK1, CDC14B, CALR3 36 1136 12504 1.528755868544601 1.0 0.9989033891358383 99.59948477228609 GOTERM_CC_FAT GO:0031974~membrane-enclosed lumen 5 1.0638297872340425 0.41969378495933896 ES22, MYOCD, HIPK1, CDC14B, CALR3 36 1174 12504 1.4792731402612154 1.0 0.9984389043645439 99.74758867610039 GOTERM_CC_FAT GO:0031981~nuclear lumen 3 0.6382978723404255 0.7184395342868981 MYOCD, HIPK1, CDC14B 36 883 12504 1.1800679501698752 1.0 0.9987555953726116 99.9999109435413 Annotation Cluster 12 Enrichment Score: 0.3006278943642702 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS cell junction 3 0.6382978723404255 0.3249289822238108 PHACTR1, CLDN18, CHRM4 54 392 17854 2.530328798185941 1.0 0.975712468175115 98.92280864653593 GOTERM_CC_FAT GO:0030054~cell junction 3 0.6382978723404255 0.38094553676751297 PHACTR1, CLDN18, CHRM4 36 470 12504 2.2170212765957444 1.0 0.9999886874528149 99.4863425171649 GOTERM_CC_FAT GO:0044459~plasma membrane part 5 1.0638297872340425 0.688025448904103 PHACTR1, CLDN18, CHRM4, ITGA7, ENPEP 36 1633 12504 1.0634823433353746 1.0 0.9993747005207334 99.99972499941974 GOTERM_CC_FAT GO:0005886~plasma membrane 8 1.702127659574468 0.7366014684634137 PHACTR1, CLDN18, CHRM4, LYPD5, ITGA7, ENPEP, FCAMR, FCRL5 36 2906 12504 0.9561826106905252 1.0 0.9987321532927386 99.99995720883427 Annotation Cluster 13 Enrichment Score: 0.12216608228543123 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS calcium 4 0.851063829787234 0.3702101715436267 ARSG, ITGA7, CALR3, ENPEP 54 731 17854 1.8091908598064548 1.0 0.9417825472292608 99.51627281785514 GOTERM_MF_FAT GO:0005509~calcium ion binding 4 0.851063829787234 0.434390924689415 ARSG, ITGA7, CALR3, ENPEP 39 840 13288 1.6224664224664225 1.0 0.9713670053200892 99.8328981148638 SP_PIR_KEYWORDS zinc 5 1.0638297872340425 0.8251169635092017 GCM2, KLF13, TRPS1, ENPEP, RNF148 54 1886 17854 0.8765366639173637 1.0 0.9978182800224018 99.99999981447245 SP_PIR_KEYWORDS metal-binding 7 1.4893617021276597 0.8276445667746335 GCM2, ARSG, KLF13, TRPS1, POLB, ENPEP, RNF148 54 2682 17854 0.8629408677879967 1.0 0.9975389599791114 99.99999984314309 GOTERM_MF_FAT GO:0008270~zinc ion binding 5 1.0638297872340425 0.8730921437720948 GCM2, KLF13, TRPS1, ENPEP, RNF148 39 2105 13288 0.8093062914915645 1.0 0.9999900365540199 99.9999999912858 SP_PIR_KEYWORDS zinc-finger 3 0.6382978723404255 0.8809314720472307 KLF13, TRPS1, RNF148 54 1204 17854 0.8238279808047251 1.0 0.9991534561970467 99.99999999779523 GOTERM_MF_FAT GO:0046872~metal ion binding 9 1.9148936170212765 0.8989730094464659 GCM2, ARSG, KLF13, TRPS1, ITGA7, CALR3, POLB, ENPEP, RNF148 39 3850 13288 0.7964835164835166 1.0 0.9999947092370237 99.99999999932582 GOTERM_MF_FAT GO:0043169~cation binding 9 1.9148936170212765 0.9049814946994448 GCM2, ARSG, KLF13, TRPS1, ITGA7, CALR3, POLB, ENPEP, RNF148 39 3885 13288 0.7893079893079893 1.0 0.9999930758706584 99.99999999966118 GOTERM_MF_FAT GO:0043167~ion binding 9 1.9148936170212765 0.9129152035995185 GCM2, ARSG, KLF13, TRPS1, ITGA7, CALR3, POLB, ENPEP, RNF148 39 3934 13288 0.7794767510070002 1.0 0.9999921936240944 99.99999999987263 GOTERM_MF_FAT GO:0046914~transition metal ion binding 5 1.0638297872340425 0.9568232178385634 GCM2, KLF13, TRPS1, ENPEP, RNF148 39 2608 13288 0.6532169262230612 1.0 0.9999994868032888 99.99999999999996 Annotation Cluster 14 Enrichment Score: 0.11847300687443217 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS receptor 9 1.9148936170212765 0.4518709701029216 PLXNC1, CHRM4, OLFR460, OLFR557, GPR123, ITGA7, OLFR1165, FCAMR, FCRL5 54 2465 17854 1.2071670047329275 1.0 0.9541040494505688 99.90246604364343 GOTERM_BP_FAT GO:0007166~cell surface receptor linked signal transduction 8 1.702127659574468 0.5621242178935202 HHEX, CHRM4, OLFR460, HIPK1, OLFR557, GPR123, ITGA7, OLFR1165 39 2495 13588 1.117147114742305 1.0 0.9993413573026945 99.9992646914322 SP_PIR_KEYWORDS g-protein coupled receptor 5 1.0638297872340425 0.6119187843390537 CHRM4, OLFR460, OLFR557, GPR123, OLFR1165 54 1411 17854 1.1716145628264691 1.0 0.9843614744503292 99.99818020946714 SP_PIR_KEYWORDS transducer 5 1.0638297872340425 0.6432669628249003 CHRM4, OLFR460, OLFR557, GPR123, OLFR1165 54 1467 17854 1.126890353202555 1.0 0.9853914315907985 99.99931096804792 GOTERM_BP_FAT GO:0007600~sensory perception 4 0.851063829787234 0.7662692868999195 OLFR460, OLFR557, OLFR1165, PDE6H 39 1402 13588 0.9940378214272649 1.0 0.9999968224794051 99.99999990793357 GOTERM_BP_FAT GO:0007186~G-protein coupled receptor protein signaling pathway 5 1.0638297872340425 0.7895406796834701 CHRM4, OLFR460, OLFR557, GPR123, OLFR1165 39 1877 13588 0.9281040394519349 1.0 0.9999983756839286 99.99999997948107 GOTERM_BP_FAT GO:0050890~cognition 4 0.851063829787234 0.7985740723986007 OLFR460, OLFR557, OLFR1165, PDE6H 39 1480 13588 0.9416493416493416 1.0 0.9999985805260492 99.99999998904929 INTERPRO IPR000276:7TM GPCR, rhodopsin-like 4 0.851063829787234 0.8310808349175985 CHRM4, OLFR460, OLFR557, OLFR1165 55 1458 17763 0.886045641601197 1.0 1.0 99.99999994936222 GOTERM_BP_FAT GO:0007608~sensory perception of smell 3 0.6382978723404255 0.8312961392935667 OLFR460, OLFR557, OLFR1165 39 1117 13588 0.9357482267061497 1.0 0.9999995858871465 99.99999999913416 GOTERM_MF_FAT GO:0004984~olfactory receptor activity 3 0.6382978723404255 0.8474897948218773 OLFR460, OLFR557, OLFR1165 39 1135 13288 0.9005760759064725 1.0 0.9999844926353897 99.99999993148573 GOTERM_BP_FAT GO:0007606~sensory perception of chemical stimulus 3 0.6382978723404255 0.8582647210176122 OLFR460, OLFR557, OLFR1165 39 1192 13588 0.8768714506969542 1.0 0.9999998708329928 99.99999999992845 GOTERM_BP_FAT GO:0050877~neurological system process 4 0.851063829787234 0.8655570432448907 OLFR460, OLFR557, OLFR1165, PDE6H 39 1681 13588 0.8290547445812169 1.0 0.9999998896356507 99.9999999999664 INTERPRO IPR000725:Olfactory receptor 3 0.6382978723404255 0.8675456861496719 OLFR460, OLFR557, OLFR1165 55 1134 17763 0.8544011544011543 1.0 1.0 99.9999999972877 INTERPRO IPR017452:GPCR, rhodopsin-like superfamily 4 0.851063829787234 0.8688025307405539 CHRM4, OLFR460, OLFR557, OLFR1165 55 1575 17763 0.8202251082251082 1.0 1.0 99.99999999758175 PIR_SUPERFAMILY PIRSF800006:rhodopsin-like G protein-coupled receptors 3 0.6382978723404255 0.8884778868004479 CHRM4, OLFR460, OLFR1165 25 1200 8136 0.8136 1.0 1.0 99.99999951596538 KEGG_PATHWAY mmu04740:Olfactory transduction 3 0.6382978723404255 0.9038960006853215 OLFR460, OLFR557, OLFR1165 23 960 5738 0.7796195652173913 1.0 1.0 99.9999999359261