Correction: DCE-MRI-Derived Parameters in Evaluating Abraxane-Induced Early Vascular Response and the Effectiveness of Its Synergistic Interaction with Cisplatin

[This corrects the article DOI: 10.1371/journal.pone.0162601.].

The underlying data supporting the updated versions of Figs 6 and 7 are provided in S1-S3 Files with this notice.
The corrected figures have been reviewed by a member of the PLOS ONE editorial board.They commented that the selected images from the initial publication and the updated Fig 6 do not align with the quantitative graphs.The authors confirmed that the data presented in the new panels do not align with the originally published graphs, but clarified that although there are differences between the original published graph and the updated graph in the corrected figure, the overall trend remains and the conclusions are not affected.
The editorial board member also stated that the figures clearly show that combination therapy is very effective in reducing tumor proliferation rate, as a potentially effective treatment, but that the data and histology do not show modified vascularization as stated in the conclusions.Furthermore, the board members stated that drug synergism outcomes, as suggested in the title, is also not discernible due to the lack of Cis only cohort.Furthermore, they commented that the conclusion that Abx improves Cis delivery is not clearly defined without pharmacokinetic assessment of drug in tumor tissues.The authors' response confirmed that there was no obvious difference in MVD among the C group, A group, and A-P groups, but indicated that the CD31 immunofluorescence staining results presented blood vessels in the control group that were dilated and irregular, whereas those in the treated groups tended to be small and regular.The authors also pointed out that the α-SMA staining results presented in Fig 8 supported the conclusions.The authors clarify that the definitions of dilated and irregular differs per individual and that this should be acknowledged as a limitation to the study.
As part of this review, the authors have provided the following additional information to clarify the methodology of the reported study: • The MDA-MB-435 tumor model was established via the injection of 8×10 6 cells in the left mammary fat pad of athymic nude mice (female, 6 weeks).The mice were used for studies when the tumor volume reached about 250 +/-60 mm 3 (14~21 d after implantation).Then, the tumor-bearing mice were randomly divided into three groups (n = 10/group) and underwent baseline DCE-MRI (day 0).
• Treatment, including PBS for the control group, the second Abraxane for A group and the second cisplatin for A-P group, was administered at day 3.These treatments were administered in the morning and the DCE-MR imaging was performed as late as possible to allow time for drug distribution and treatment.The S1  • In the methodology section for the ROI measurement, the authors referred to previous studies which used Philips Healthcare software.The current study was pre-clinical and different from the referred study; the current study required calculation of the arterial input function (AIF) first and the ROI covered the large vessels.The aorta cross sectional area was very small for the Axial MR mice imaging, so the ROI size was smaller.During assessment of the tumors, effort was made to try and use a consistent size for the ROI and the aorta.Tumor ROI Measurements were repeated 3~5 times and the liquefacient necrotic areas were excluded.The sizes of ROIs and the T10 values were also recorded by the software for calculating the resulting output maps, including K trans , V e , and K ep .
• The "Statistical Analysis" section of the Methodology should be updated to: "All quantitative data were expressed as means ± SD.Statistical comparisons of sequence-dependent effects of each time-point were conducted by one way ANOVA, followed by the Dunnett's multiple comparisons test, was performed (GraphPad Prism 8.0.2).P values <0.05 were considered statistically significant." The article's [1] Data Availability Statement provides links for the publicly available DCE-MRI DICOM data, but the yunpan.cndomain is no longer publicly available.The authors indicate that these data remain available upon request, and the Data Availability Statement of this article now should read: All original data underlying the results reported in this article are available upon request from the corresponding author.
The corresponding author apologizes for the errors in the article.

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The wrong figure was cited in the fifth sentence of the first paragraph of the "Morphology of tumor vascularity modulated by Abraxane in combination with cisplatin" subsection.The sentence is corrected to: "As shown in Fig 7, there was no obvious difference in MVD among the C group, A group and A-P group at different time points."