Limited evidence of physical therapy on balance after stroke: A systematic review and meta-analysis

Background Stroke results in balance disorders and these directly affect autonomy and quality of life. The purpose of this systematic review and meta-analysis was to determine the efficacy of physical therapy (PT) on balance and postural control after stroke. Methods We included all randomized controlled trials assessing the efficacy of PT on balance and postural control in adult patients after stroke without language restriction. Medline, Embase/Scopus, Cochrane Central Register of Controlled Trials, PEDro, Pascal, and Francis databases were searched until January 2019. Primary outcomes were balance (Berg Balance scale and Postural Assessment Scale for Stroke) and postural control with postural deviation or stability measurement in sitting or standing static evaluation. A pair of independent reviewers selected studies, extracted data, and assessed risk of bias. Meta-analyses with subgroups (categories of PT, time post-stroke, and lesion location) and meta-regression (duration of PT) were conducted. Results A total of 145 studies (n = 5912) were selected from the 13,123 records identified. For balance, evidence was found in favor of the efficacy of functional task-training alone (standardized mean difference 0.39, 95% confidence interval [0.09; 0.68], heterogeneity I2 = 63%) or associated with musculoskeletal intervention and/or cardiopulmonary intervention (0.37, [0.19; 0.55], I2 = 48%), electrostimulation (0.91, [0.49; 1.34], I2 = 52%) immediately after intervention, compared to sham treatment or usual care (ST/UC). For postural deviation eyes open, assistive devices were more effective than no treatment (-0.21, [-0.37; -0.05], I2 = 0%) immediately after intervention; for postural stability eyes open, functional task-training and sensory interventions were more effective than ST/UC (0.97, [0.35; 1.59], I2 = 65% and 0.80, [0.46; 1.13], I2 = 37% respectively) immediately after intervention. Conclusions Functional task-training associated with musculoskeletal intervention and/or cardiopulmonary intervention and sensory interventions seem to be immediately effective in improving balance and postural stability, respectively. The heterogeneity of PT and the weak methodological quality of studies limited the interpretation and the confidence in findings.


Methods
We included all randomized controlled trials assessing the efficacy of PT on balance and postural control in adult patients after stroke without language restriction. Medline, Embase/ Scopus, Cochrane Central Register of Controlled Trials, PEDro, Pascal, and Francis databases were searched until January 2019. Primary outcomes were balance (Berg Balance scale and Postural Assessment Scale for Stroke) and postural control with postural deviation or stability measurement in sitting or standing static evaluation. A pair of independent a1111111111 a1111111111 a1111111111 a1111111111 a1111111111

Introduction
World-wide, approximately 25.7 million people suffered from stroke in 2013 [1], and this was the third most common cause of disability in 2015 [2]. Stroke frequently results in postural disorders characterized by a mediolateral deviation towards the unaffected lower limb and a greater instability of the center of pressure [3][4][5][6][7][8][9][10][11]. These dysfunctions lead to balance disorders [12] that are responsible for an increased risk of falls [13] and a lower level of activity and participation in stroke patients [14,15]. Balance is associated with ambulation abilities [16][17][18] and quality of life [19]. Moreover, balance is a predictor for achieving the ability to walk [16,20,21] and is also found among the factors potentially modifiable by physical activity [22]. Therefore, developing physical therapy (PT) interventions for the improvement of balance is relevant for patients with stroke.
PT includes interventions aiming to develop, maintain, and restore movement and functional ability [23]. Current recommendations regarding PT for the improvement of balance after stroke are based on a poor level of evidence [24][25][26]. Furthermore, most meta-analyses selected only studies published in English language despite it having been established that significant results are more often published in English-language journals [27,28], introducing language bias into article selection. In addition, among the meta-analyses that have investigated the effects of PT in patients with stroke these considered multiple outcomes or some specific approaches of PT [29][30][31][32][33][34][35][36][37][38][39][40][41][42]. Although these did include balance, to the best of our knowledge no meta-analysis has investigated the effects of all PTs specifically on balance and postural control after stroke without language restriction. Therefore, the objective of this systematic review and meta-analysis was to determine the efficacy of PT (overall and by category of PT) on these parameters in adult patients with stroke.

Methods
The protocol was developed using the PRISMA guidelines [43] and Cochrane recommendations [27], registered in PROSPERO (CRD42016037966), and published in BMJOpen [44] (S1 Checklist and S1 Protocol). Therefore, methods are described only briefly.

Definitions
According to the World Health Organization, stroke is defined as "rapidly developing clinical signs of focal (at times global) disturbance of cerebral function, lasting more than 24 h or leading to death with no apparent cause other than that of vascular origin" [45]. PT is defined by the World Confederation for Physical Therapy as "services to individuals and populations to develop, maintain and restore maximum movement and functional ability throughout the life-span" and "physical therapy is concerned with identifying and maximizing quality of life and movement potential within the spheres of promotion, prevention, treatment/intervention, habilitation and rehabilitation" (http://www.wcpt.org/policy/ps-descriptionPT) [23]. Human posture is the position of body parts relative to each other [46]. We defined postural control as the function of body stabilization based on a sensorimotor complex skill, and of body orientation based on internal representation of body scheme [47]. We further defined balance as a posture in which an ideal body mass distribution is achieved and which provides the body carriage stability and conditions for normal functions in stationary position or in movement (Medline Subject Heading; MeSH).

Eligibility criteria
All types of randomized controlled trials assessing the efficacy of PT on balance or postural control in adult patients (18 years or above) with stroke were included without language restriction. Inspired by the meta-analysis conducted by Pollock et al. [40], we included all PTs that may be used by physiotherapists during rehabilitation without restriction to only PTs that had a stated objective of promoting recovery of balance or postural control. We included PTs using electric devices (such as functional electric stimulation), treadmills, and assistive devices (such as a cane or orthosis). The classification of PT categories, based on that used by Pollock et al. [40], included assistive devices, constraint-induced therapy, cardiopulmonary intervention, functional task-training, musculoskeletal intervention, sensory interventions, and other intervention (Table 1). Only the outcomes defined as primary in the following paragraph were considered for selection of trials.

Outcomes
For this meta-analysis, we studied both balance and postural control. Based on the International Classification of Functioning, Disability and Health (ICF), we considered balance as a level of activity reflecting functional abilities, and postural control as a body structure function reflecting both orientation and stabilization body [47]. Therefore, the primary outcomes were: balance measured by the Berg Balance Scale (BBS) or the Postural Assessment Scale for Stroke (PASS); postural deviation measured by the weight bearing asymmetry (WBA) on lower limbs or the mediolateral and anteroposterior position of the center of pressure (COP); and postural stability measured by all COP sway or limit of stability (LOS) parameters. BBS and PASS are two clinical scales measuring the functional abilities of patients for various balance skills [44] (S1 Protocol). BBS is very widely used in studies and has metrological properties that make it a gold standard to assess balance in patients with stroke. We included studies that assessed postural control with postural deviation or stability measurement in sitting or standing static evaluation on a force plate with eyes open (EO) or closed (EC). Postural deviation included mediolateral postural deviation (measured by WBA and mediolateral position of COP) and anteroposterior postural deviation (measured by anteroposterior position of COP). Additionally, we included studies that measured WBA by means of another device than force plate, such as weight scale, if the measure was done in static position. The secondary outcome was autonomy measured by the Barthel Index, the Functional Independence Measure, the Activities of Daily Living or the Instrumental Activities of Daily Living scales.

Data sources
Medline, Elsevier databases (i.e. EMBASE until October 2015, SCOPUS thereafter), Cochrane Central Register of Controlled Trials, PEDro, Pascal, and Francis databases were searched from inception until January 14, 2019 (S1 Table and S1 Protocol for search strategy [44]). Scopus was replaced by Embase because we had no longer access to it. These two databases are both produced by Elsevier and the recall by Scopus of references found by Embase was optimal or suboptimal that is considered as acceptable [48]. Unpublished studies, conferences, and presentations were searched without language restriction.

Study selection
Based on eligibility criteria, two authors (AH, JDM) independently selected the studies. The judgment of three other authors (IB, FG, GR) was used to resolve potential conflicts [44] (S1 Protocol). No language restriction was applied.

Data extraction
Two authors (AH and JDM) independently extracted data; potential conflicts were resolved with the help of three other authors (IB, FG, GR). In case of unclear or missing data, we contacted the authors of the respective studies. Extracted data included: study design, participant characteristics, risk of bias, PT characteristics, and outcomes (S1 Protocol [44]). All outcomes were statistically treated as continuous measures. We extracted the mean value, the standard deviation (SD), and the number of participants to the outcome measurements in each intervention group. The change-from-baseline was used to determine the outcome. Due to poor, variable or incomplete reporting of change score, different methods were used to obtain the mean and SD of changes when necessary. The most parsimonious statistical treatment was preferred. Finally, when only mean and SD values for before and after intervention

Categories Component of categories Definition
Other intervention Acupuncture Described in additional Table 2  assessments were given, SD was imputed by using a correlation coefficient with respect to the most conservative approach.

Risk of bias assessment
Two authors (AH and JDM) independently assessed the seven items of the risk of bias tool from the Cochrane Collaboration [27] for each study, and used the Grades of Recommendation, Assessment, Development, and Evaluations (GRADE) as reported in Cochrane Handbook [27] to assess the overall quality of evidence of this meta-analysis. The judgment of two other authors (MC, FG) was used to resolve potential conflicts.

Data synthesis and analysis
Statistical analyses were performed using R (R Foundation for Statistical Computing, Vienna, Austria; available in http://www.R-project.org/; version 3.5.2). Concordance between authors for the selection of studies was estimated using the Cohen's Kappa coefficient and the recommendations of Landis and Kock [49]. Post-intervention effects were investigated by calculating the change from baseline to the immediate post-intervention assessment, and persisting effects by computing the change from baseline to the last follow-up assessment. These changes were compared between groups. The inverse-variance method was applied to summarize effects across studies. The summary effect estimate for all scales was calculated as the mean difference and its 95% confidence interval (95%CI). The estimate for outcomes was calculated as the standardized mean difference (SMD) and its 95%CI [44] because each outcome pooled several scales. We used Hedges'g to calculate SMD. The fixed-effect model was applied by default and the random-effect model was used in case of substantial heterogeneity (I 2 �50%) [44] (S1 Protocol). We summarize effects of crossover trials by following the recommendations of Cochrane Handbook (chapter 16.4) [27]. When several scales were available for the same outcome and to prevent any overweight of a study in a same SMD analysis, we ranked the scales based on the frequency of use in all trials. We selected the most frequent scales. We performed subgroup analyses according to categories of PT, time post-stroke, and location of stroke lesion. We also performed sensitivity analyses to explore the effects of methodological quality according to appraisal of risk of bias. We investigated publication bias by funnel plots, contour-enhanced funnel plot, and Egger tests [27,50,51]. If publication bias was suspected, we performed the trim and fill method as a form of sensitivity analysis of the pooled estimate [50,52,53]. To determine the impact of the dose of PT, effect estimates were correlated with parameters of duration of PT using meta-regression. We compared PT versus no treatment (NT) and PT versus sham treatment (ST) or usual care (UC), irrespective of the design of study used (direct design, e.g. A versus B; or "add-on" design, e.g. A+C versus B+C). ST was a placebo treatment or a control treatment different from a PT, such as music or relaxation, delivered using the same protocol as that used in the experimental group. UC was various and non-protocoled standard care freely defined by therapists according to practices at that time.

Study selection
Among the 13,123 records identified, 10,663 single records were screened. For title screening, 8345 studies were excluded because they clearly did not address the topic of stroke or that did not include human subjects, or that the design mentioned in the title was explicitly different from a randomized controlled trial. The reasons for exclusion of records during the abstract screening then the full-text assessment are reported in the flow chart (Fig 1). For assessment of full-text eligibility, 56 studies were translated by co-authors (Chinese: n = 27, German: n = 6, Korean: n = 5, Spanish: n = 4, Russian: n = 3, Italian: n = 2, Persian: n = 2, Portuguese: n = 2, Turkish: n = 2, Japanese: n = 1, Norwegian: n = 1, Polish: n = 1). A total of 145 studies were selected (Fig 1 and S2 Table). The mean concordance between the two independent authors for the three steps of selection process, was substantial (kappa = 0.64). The authors of 130 of the 145 studies regarding unclear or missing data were contacted; answers were received for 20 studies.

Study and participant characteristics
A total of 91 comparisons of PT versus NT in 76 studies and 81 comparisons of PT versus ST/ UC in 70 studies were analyzed; 1 study was included in both comparisons. Among these 145 studies, 18 were of crossover design and 127 parallel group design; they included a total of 5912 participants (mean: 40.8, SD: 42.9, range: 7-408). Weighted participant age was 60.8 years (SD: 44.3, range: 46.9-78.5; S3 Table).

Risk of bias
Risk of bias was low for random sequence generation in 55% of studies, for allocation concealment in 13% of studies, for blinding outcome assessment in 44% of studies, for incomplete outcome data in 17% of studies, and for selective reporting in 16% of studies. Most studies had a high or unclear risk of bias for blinding of patients and therapists (99%) but a low risk for other bias (92%; S1 Fig and S4 Table). Funnel plots and Egger tests found no evidence of publication bias for PT versus NT on balance, mediolateral postural deviation EO, postural stability EO, or autonomy; whereas for comparison PT versus ST/UC, there was a potential publication bias on balance (post-intervention effects and persisting effects), postural stability EO (postintervention effects), and autonomy (post-intervention effects and persisting effects). The number of unpublished studies estimated by the trim and fill method was 0 for post-intervention effects on postural stability EO and post-intervention effects on autonomy, 1 for postintervention effects on balance, 4 for persisting effects on autonomy, and 9 for persisting effects on balance (S2 Fig and S5 Table).

Physical therapy
Functional task-training (including balance training) and assistive devices were the most common categories of PT that were compared to NT. Functional task-training, musculoskeletal interventions, and sensory interventions were the most common categories of PT that were compared to ST/UC (S6 Table).
Expressed as median values, participants received an additional 300 minutes dispensed in 12 sessions of 20 minutes for 3 weeks (PT versus NT). When PT was compared to ST/UC, treatment was delivered over 570 minutes, and dispensed in 16 sessions of 30 minutes for 5 weeks (S7 Table).

Outcomes/Measures
BBS was the most common scale of balance used in studies for both post-intervention and persisting effects. For autonomy, the Barthel Index was the most frequent scale used. Sixty-four different parameters for WBA, LOS, and COP were identified. Fifty-one of these were assessed in �5 studies and the most common parameter was assessed in 23 studies (S8 Table). Significant positive SMDs were found for constraint-induced therapy, functional task-training, functional task-training associated with musculoskeletal intervention and/or cardiopulmonary intervention, musculoskeletal intervention with body awareness therapy, and musculoskeletal intervention by active strengthening; and non-significant SMDs for acupuncture, musculoskeletal intervention by electrostimulation, sensory interventions and other intervention (no significant between-subgroup difference, p = 0.29; Fig 2). There were significant positive SMDs for acute-subacute stroke patient and chronic stroke patient subgroups without significant between-subgroup difference (p = 0.50; S9 Table). A significant positive SMD was found for a subgroup of studies that included only supratentorial stroke patients (S10 Table). There There was a non-significant SMD between PT and NT for persisting effects (11 studies, 493 participants, SMD 0.29, 95%CI [-0.02; 0.59]) with substantial heterogeneity (I 2 = 60%). A significant between-subgroup difference was found (p<0.01); there were significant positive SMDs for subgroups of functional task-training, of musculoskeletal intervention with body awareness therapy and of musculoskeletal intervention by active strengthening; a significant negative SMD for the subgroup of constraint-induced therapy; and non-significant SMDs for the subgroup of functional task-training associated with musculoskeletal intervention and/or cardiopulmonary intervention (Fig 3). There was a significant positive SMD for the subgroup of chronic stroke patients and a non-significant SMD for the subgroup of acute-subacute stroke patients, without significant difference between subgroups (p = 0.64; S9 Table).
PT had a significantly beneficial post-intervention effect compared to ST/UC (46 studies, 2051 participants, SMD 0.43, 95%CI [0.28; 0.59]) with substantial heterogeneity (I 2 = 61%). There was a significant between-subgroup difference (p<0.01). There were significant positive SMDs for functional task-training alone or associated with musculoskeletal intervention and/ or cardiopulmonary intervention, musculoskeletal intervention by electrostimulation, and respiratory training; and non-significant SMDs for musculoskeletal intervention by active strengthening or by immobilization and sensory interventions (Fig 4). There were significant positive SMDs for acute-subacute stroke patient and chronic stroke patient subgroups, without between significant between-subgroup difference (p = 0.16; S9 Table). A non-significant SMD was found for a subgroup of studies that included only supratentorial stroke patients (S10 Table). PT had a significantly beneficial persisting effect compared to ST/UC (18 studies, 1150 participants, SMD 0.18, 95%CI [0.06; 0.30]) with moderate heterogeneity (I 2 = 49%). A significant positive SMD was only found for the subgroup of musculoskeletal intervention by electrostimulation (Fig 5). There were significant positive SMDs for acute-subacute stroke patient and chronic stroke patient subgroups (S9 Table); and a non-significant SMD for a subgroup of Limited evidence of physical therapy on balance after stroke studies that included only supratentorial stroke patients (S10 Table). The summary persisting effect estimate adjusted for the potential publication bias on balance for the comparison PT versus ST/UC became non-significant (9 missing points, SMD 0.03, 95%CI [-0.17; 0.23], I 2 = 67%, according to the trim and fill method).
Mediolateral postural deviation. PT had a significantly beneficial post-intervention effect EO compared to NT (11 studies, 329 participants, SMD -0.23, 95%CI [-0.36; -0.09]) without heterogeneity (I 2 = 0%). There were significant negative SMDs for assistive device and functional task-training; and a non-significant SMD for constraint-induced therapy and musculoskeletal intervention by immobilization; with a significant between-subgroup difference (p = 0.06; Fig 6). There was a significant negative SMD for the subgroup of acute-subacute stroke patients and a non-significant SMD for the subgroup of chronic stroke patients (1 study), without between significant between-subgroup difference (p = 0.34). There was a nonsignificant SMD for a subgroup of studies that included only supratentorial stroke patients (S9 and S10 Tables). We found no significant meta-regression with duration of PT. Removing all studies judged as having high or unclear risk for incomplete outcome data and other bias showed a similar direction of SMDs favoring PT, whereas for random sequence generation and selective reporting, SMDs became non-significant (S6 Fig). A non-significant SMD was found between PT and NT for persisting effects EO (3 studies, 50 participants, SMD -0.44, 95%CI [-1.05; 0.16]), without heterogeneity (I 2 = 0%) and significant difference between categories of PT (p = 0.96; Fig 6). Limited evidence of physical therapy on balance after stroke A non-significant SMD was found between PT and ST/UC for post-intervention effects EO (4 studies, 122 participants, SMD -0.15, 95%CI [-0.52; 0.21]) with moderate heterogeneity (I 2 = 38%). All category of PTs such as functional task-training associated with musculoskeletal intervention and/or cardiopulmonary intervention, or with another intervention and sensory interventions had non-significant SMDs (Fig 6). There was a significant negative SMD for chronic stroke patients subgroup and a non-significant SMD for acute-subacute stroke patients subgroup (1 study), without significant between-subgroup difference (p = 0.11; S9 Table). A non-significant SMD was found for a subgroup of study that included only supratentorial stroke patients (1 study; S10 Table). There was a positive meta-regression between SMD and the overall duration of PT (5 studies, p = 0.052). Removing all studies judged as having Limited evidence of physical therapy on balance after stroke high or unclear risk for blinding of outcome assessment and blinding of patients and therapists changed the direction of SMDs favoring PT, whereas for incomplete outcome data and other bias, SMDs still were non-significant (S7 Fig). No study investigated persisting effects of PT compared to ST/UC. Postural stability. PT had a significantly beneficial post-intervention effect EO compared to NT (16 studies, 504 participants, SMD 0.47, 95%CI [0.29; 0.65]) with low heterogeneity (I 2 = 29%). There was a significant positive SMDs for acupuncture, functional task-training, musculoskeletal intervention by mobilization, and sensory interventions; and non-significant SMDs for functional task-training associated with musculoskeletal intervention and/or cardiopulmonary intervention and for other interventions; without significant between-subgroup difference (p = 0.26; Fig 7). There was a significant positive SMD for acute-subacute stroke patients subgroup, and a non-significant SMD for chronic stroke patients subgroup, without significant between-subgroup difference (p = 1.00; S9 Table). A non-significant SMD was found for a subgroup of study that included only supratentorial stroke patients (S10 Table). There was no significant meta-regression with duration of PT. Removing all studies judged as having high or unclear risk for random sequence generation, blinding of outcome assessment, incomplete outcome data and other bias showed a similar direction of SMD favoring PT, whereas for concealment allocation and selective reporting, SMDs became non-significant (S8 Fig). For EC, PT had a significantly beneficial post-intervention effect compared to NT (9 studies, 229 participants, SMD 0.34, 95%CI [0.08; 0.61]) without heterogeneity (I 2 = 0%; S9 Fig).
PT had a significantly beneficial post-intervention effect EO compared to ST/UC (15 studies, 574 participants, SMD 0.96, 95%CI [0.55; 1.37]) with substantial heterogeneity (I 2 = 78%). There were significant positive SMDs for functional task-training, musculoskeletal intervention by mobilization, and sensory interventions; and non-significant SMDs for assistive devices, functional task-training associated with musculoskeletal intervention and/or cardiopulmonary intervention or with another intervention, musculoskeletal intervention by active strengthening and musculoskeletal intervention by immobilization; without significant between-subgroup difference (p = 0.29; Fig 8). There was a significant positive SMD for chronic stroke patients subgroup and a non-significant SMD for acute-subacute stroke patients subgroup, with a significant between-subgroup difference (p = 0.09; S9 Table). We found a non-significant SMD for a subgroup of study that included only supratentorial stroke patients (1 study; S10 Table). There was a significant positive meta-regression between postintervention effects and the overall duration of PT for the subgroup of sensory interventions (S4 Fig). Removing all studies judged as having high or unclear risk for random sequence generation, blinding of outcome assessment, and other bias showed a similar direction of SMD favoring PT, whereas for incomplete outcome data, SMD became non-significant. All studies showed a high or unclear risk of bias for concealment allocation and for blinding of patients and therapists (S10 Other outcomes and quality of evidence. The results of analyses on data extracted for autonomy are presented in S11-S13 Figs and in S9 and S10 Tables. Moreover, the quality of evidence according to GRADE for all outcomes is presented in S11 Table.

Discussion
The present study found that the overall post-intervention effects were in favor of PT compared to NT for balance, mediolateral postural deviation EO, and postural stability (EO or EC), and compared to ST/UC for balance and postural stability (EO or EC) after stroke. Few categories of PT were more effective than NT in improving balance after stroke immediately after intervention. However, caution should be taken when interpreting these results owing to a small number of studies, participants, or substantial heterogeneity within subgroups. The findings therefore only support that functional task-training alone had a beneficial effect in improving balance compared to NT, owing to the absence of heterogeneity and a sufficient number of trials and participants. For instance, a beneficial effect for functional task-training associated with musculoskeletal intervention and/or cardiopulmonary intervention could be concluded if there was less heterogeneity. The present study also found limited evidence for the effect on balance compared to ST/UC in patients with stroke. The results allow only to conclude a beneficial effect immediately after intervention of functional task-training associated with musculoskeletal intervention and/or cardiopulmonary intervention but also the lack of efficacy of sensory interventions (such as vibration or tactile stimulation); substantial heterogeneity precludes conclusions as to the efficacy of functional task-training alone, or of musculoskeletal intervention by electrostimulation. Similarly, for persisting effects of PT, only the lack of efficacy for sensory interventions compared to ST/UC could be concluded. Another point of interest of the present study is the investigation of effects on postural control. We could conclude for post-intervention effects that assistive devices were more effective than NT in reducing mediolateral postural deviation EO, and that functional task-training alone and sensory interventions were, respectively, more effective than NT and ST/UC in increasing postural stability (either EO or EC). Limited evidence of physical therapy on balance after stroke Another point is that the beneficial effect of functional task-training alone on both balance, which is considered as activity according to the ICF, and postural stability (EO or EC), which is considered as body structure function according to the ICF, could suggest a transfer of learning from body structure function to activity level. Van Duijnhoven et al. (2016) [42] found ambiguous results for outcomes addressing body structure function and beneficial effects for balance (considered as activity) and suggested an optimization of compensatory balance strategies. Fewer studies (n = 36) were included in their meta-analysis than herein, which may go some way to explain this difference. Another important finding of the present meta-analysis is that with respect to comparisons made between PT and NT, those made between PT and ST/ UC had smaller effect sizes and/or greater heterogeneity, which leads us to question whether or not there are specific effects of PT. It should be also noted that the reduction or the non-significance of SMD, in most cases, between post-intervention and persisting effects supports a short-term effect of PT.
Treatment modalities, such as the dose or the way to apply the PT, were very different between studies within a category of PT. This could explain part of the heterogeneity, and a better understanding of the mechanisms of action of the various categories of PT could improve the interpretation of any potential effect. More generally, the weak methodological quality of studies and the absence of significant effect when only studies at a low risk of bias were considered indicates that caution should be taken when interpreting the results. Therefore, implications of the present findings for clinical practice are limited. To address this issue, priority should be given to conduct trials of better methodological quality, especially regarding random sequence generation, allocation concealment [55], blinding outcome [56], and incomplete outcome data. It is also of note that data regarding the included population, therapies, and the size and precision of effects were often unclear or missing in the studies identified herein, and could be a source of the heterogeneity observed. This underlines the importance of the quality of reporting, as also identified by the Stroke Recovery and Rehabilitation Roundtable [57]. The sample size of studies was often too small, increasing the risk of overestimate the effect size [58], and the outcome measures used to assess effects were too wide. Larger, multicenter trials with standardization and consensus of outcome measures, as well as a rigorous control of potential bias, should therefore be conducted to provide more robust data.

Conclusion
PT had beneficial overall post-intervention effects on balance and postural stability after stroke. Only functional task-training associated with musculoskeletal intervention and/or cardiopulmonary intervention and sensory interventions seemed to be immediately effective in improving balance or postural stability respectively. The heterogeneity of PT studied and the weak methodological quality of studies strongly limited the meaning and the confidence in findings.